LeishMANIAdb
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Adenylate cyclase regulatory protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Adenylate cyclase regulatory protein
Gene product:
adenylate cyclase regulatory protein-like protein
Species:
Leishmania infantum
UniProt:
E9AGT5_LEIIN
TriTrypDb:
LINF_190023000 *
Length:
560

Annotations

Annotations by Jardim et al.

Hydrolase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005929 cilium 4 19
GO:0042995 cell projection 2 19
GO:0043226 organelle 2 19
GO:0043227 membrane-bounded organelle 3 19
GO:0110165 cellular anatomical entity 1 19
GO:0120025 plasma membrane bounded cell projection 3 19
GO:0005743 mitochondrial inner membrane 5 1
GO:0016020 membrane 2 2
GO:0019866 organelle inner membrane 4 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0000151 ubiquitin ligase complex 3 1
GO:0019005 SCF ubiquitin ligase complex 5 1
GO:0031461 cullin-RING ubiquitin ligase complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

E9AGT5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGT5

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 1
GO:0006952 defense response 3 1
GO:0050896 response to stimulus 1 1
GO:0006468 protein phosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 2
GO:0006796 phosphate-containing compound metabolic process 4 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 3
GO:0009987 cellular process 1 3
GO:0016310 phosphorylation 5 2
GO:0019538 protein metabolic process 3 2
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 2
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 3
GO:0044238 primary metabolic process 2 2
GO:0071704 organic substance metabolic process 2 2
GO:1901564 organonitrogen compound metabolic process 3 2
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 7 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016787 hydrolase activity 2 4
GO:0005488 binding 1 2
GO:0043167 ion binding 2 2
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0000166 nucleotide binding 3 1
GO:0004672 protein kinase activity 3 1
GO:0005524 ATP binding 5 1
GO:0016301 kinase activity 4 2
GO:0016740 transferase activity 2 2
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 2
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 1
GO:0017076 purine nucleotide binding 4 1
GO:0030554 adenyl nucleotide binding 5 1
GO:0032553 ribonucleotide binding 3 1
GO:0032555 purine ribonucleotide binding 4 1
GO:0032559 adenyl ribonucleotide binding 5 1
GO:0035639 purine ribonucleoside triphosphate binding 4 1
GO:0036094 small molecule binding 2 1
GO:0043168 anion binding 3 1
GO:0097159 organic cyclic compound binding 2 1
GO:0097367 carbohydrate derivative binding 2 1
GO:0140096 catalytic activity, acting on a protein 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 238 242 PF00656 0.557
CLV_NRD_NRD_1 158 160 PF00675 0.470
CLV_NRD_NRD_1 290 292 PF00675 0.298
CLV_PCSK_KEX2_1 158 160 PF00082 0.476
CLV_PCSK_KEX2_1 290 292 PF00082 0.298
CLV_PCSK_SKI1_1 158 162 PF00082 0.475
CLV_PCSK_SKI1_1 3 7 PF00082 0.490
CLV_PCSK_SKI1_1 310 314 PF00082 0.455
CLV_PCSK_SKI1_1 380 384 PF00082 0.497
CLV_Separin_Metazoa 477 481 PF03568 0.301
DEG_APCC_DBOX_1 290 298 PF00400 0.489
DEG_APCC_KENBOX_2 70 74 PF00400 0.315
DOC_CDC14_PxL_1 447 455 PF14671 0.495
DOC_CYCLIN_RxL_1 310 323 PF00134 0.434
DOC_CYCLIN_RxL_1 451 462 PF00134 0.517
DOC_CYCLIN_yClb5_NLxxxL_5 337 346 PF00134 0.313
DOC_MAPK_gen_1 158 168 PF00069 0.490
DOC_MAPK_gen_1 287 297 PF00069 0.422
DOC_MAPK_gen_1 310 320 PF00069 0.437
DOC_MAPK_gen_1 377 387 PF00069 0.528
DOC_MAPK_gen_1 69 77 PF00069 0.397
DOC_MAPK_MEF2A_6 100 107 PF00069 0.438
DOC_MAPK_MEF2A_6 158 167 PF00069 0.365
DOC_MAPK_MEF2A_6 471 478 PF00069 0.528
DOC_MAPK_MEF2A_6 63 70 PF00069 0.336
DOC_MAPK_NFAT4_5 158 166 PF00069 0.368
DOC_MIT_MIM_1 155 163 PF04212 0.376
DOC_PP2B_LxvP_1 129 132 PF13499 0.420
DOC_PP2B_LxvP_1 517 520 PF13499 0.566
DOC_PP4_FxxP_1 253 256 PF00568 0.380
DOC_USP7_MATH_1 246 250 PF00917 0.516
DOC_USP7_MATH_1 308 312 PF00917 0.259
DOC_USP7_MATH_1 452 456 PF00917 0.523
DOC_USP7_MATH_1 553 557 PF00917 0.768
DOC_USP7_MATH_1 84 88 PF00917 0.536
DOC_WW_Pin1_4 264 269 PF00397 0.469
DOC_WW_Pin1_4 439 444 PF00397 0.529
DOC_WW_Pin1_4 510 515 PF00397 0.566
LIG_14-3-3_CanoR_1 100 106 PF00244 0.426
LIG_14-3-3_CanoR_1 188 192 PF00244 0.448
LIG_14-3-3_CanoR_1 218 224 PF00244 0.502
LIG_14-3-3_CanoR_1 248 253 PF00244 0.414
LIG_14-3-3_CanoR_1 279 284 PF00244 0.481
LIG_14-3-3_CanoR_1 347 352 PF00244 0.467
LIG_Actin_WH2_2 369 385 PF00022 0.446
LIG_Actin_WH2_2 486 502 PF00022 0.516
LIG_BIR_III_2 203 207 PF00653 0.380
LIG_BIR_III_2 449 453 PF00653 0.470
LIG_BIR_III_2 80 84 PF00653 0.423
LIG_DLG_GKlike_1 279 286 PF00625 0.363
LIG_DLG_GKlike_1 347 354 PF00625 0.313
LIG_FHA_1 102 108 PF00498 0.539
LIG_FHA_1 197 203 PF00498 0.516
LIG_FHA_1 40 46 PF00498 0.456
LIG_FHA_1 525 531 PF00498 0.529
LIG_FHA_1 539 545 PF00498 0.532
LIG_FHA_2 150 156 PF00498 0.418
LIG_FHA_2 333 339 PF00498 0.473
LIG_FHA_2 366 372 PF00498 0.481
LIG_FHA_2 404 410 PF00498 0.528
LIG_FHA_2 411 417 PF00498 0.483
LIG_LIR_Apic_2 251 256 PF02991 0.368
LIG_LIR_Apic_2 440 444 PF02991 0.412
LIG_LIR_Gen_1 209 217 PF02991 0.199
LIG_LIR_Gen_1 4 14 PF02991 0.386
LIG_LIR_Gen_1 409 418 PF02991 0.363
LIG_LIR_Nem_3 209 213 PF02991 0.188
LIG_LIR_Nem_3 4 9 PF02991 0.455
LIG_LIR_Nem_3 409 415 PF02991 0.480
LIG_LIR_Nem_3 80 85 PF02991 0.569
LIG_LYPXL_yS_3 82 85 PF13949 0.407
LIG_RPA_C_Fungi 274 286 PF08784 0.295
LIG_SH2_CRK 441 445 PF00017 0.426
LIG_SH2_STAT5 113 116 PF00017 0.472
LIG_SH2_STAT5 317 320 PF00017 0.487
LIG_SH2_STAT5 8 11 PF00017 0.591
LIG_SH3_3 143 149 PF00018 0.371
LIG_Sin3_3 74 81 PF02671 0.323
LIG_SUMO_SIM_anti_2 488 495 PF11976 0.395
LIG_SUMO_SIM_par_1 164 170 PF11976 0.448
LIG_SUMO_SIM_par_1 500 505 PF11976 0.502
LIG_TRAF2_1 233 236 PF00917 0.593
LIG_TYR_ITIM 315 320 PF00017 0.313
LIG_WW_3 472 476 PF00397 0.391
MOD_CDC14_SPxK_1 513 516 PF00782 0.438
MOD_CDK_SPxK_1 510 516 PF00069 0.436
MOD_CDK_SPxxK_3 264 271 PF00069 0.368
MOD_CK1_1 101 107 PF00069 0.538
MOD_CK1_1 230 236 PF00069 0.640
MOD_CK1_1 332 338 PF00069 0.367
MOD_CK1_1 350 356 PF00069 0.196
MOD_CK1_1 366 372 PF00069 0.271
MOD_CK1_1 403 409 PF00069 0.440
MOD_CK1_1 462 468 PF00069 0.548
MOD_CK1_1 488 494 PF00069 0.468
MOD_CK1_1 508 514 PF00069 0.538
MOD_CK2_1 230 236 PF00069 0.676
MOD_CK2_1 332 338 PF00069 0.455
MOD_CK2_1 365 371 PF00069 0.437
MOD_CK2_1 422 428 PF00069 0.508
MOD_CK2_1 462 468 PF00069 0.549
MOD_DYRK1A_RPxSP_1 510 514 PF00069 0.433
MOD_GlcNHglycan 236 240 PF01048 0.705
MOD_GlcNHglycan 264 267 PF01048 0.525
MOD_GlcNHglycan 310 313 PF01048 0.452
MOD_GlcNHglycan 37 40 PF01048 0.505
MOD_GlcNHglycan 386 390 PF01048 0.484
MOD_GlcNHglycan 424 427 PF01048 0.489
MOD_GlcNHglycan 494 497 PF01048 0.528
MOD_GSK3_1 230 237 PF00069 0.641
MOD_GSK3_1 33 40 PF00069 0.520
MOD_GSK3_1 365 372 PF00069 0.470
MOD_GSK3_1 422 429 PF00069 0.442
MOD_GSK3_1 452 459 PF00069 0.458
MOD_GSK3_1 488 495 PF00069 0.426
MOD_GSK3_1 504 511 PF00069 0.288
MOD_GSK3_1 524 531 PF00069 0.545
MOD_N-GLC_1 459 464 PF02516 0.384
MOD_N-GLC_1 505 510 PF02516 0.560
MOD_N-GLC_2 343 345 PF02516 0.423
MOD_N-GLC_2 482 484 PF02516 0.504
MOD_NEK2_1 1 6 PF00069 0.491
MOD_NEK2_1 196 201 PF00069 0.473
MOD_NEK2_1 222 227 PF00069 0.498
MOD_NEK2_1 234 239 PF00069 0.638
MOD_NEK2_1 318 323 PF00069 0.356
MOD_NEK2_1 33 38 PF00069 0.663
MOD_NEK2_1 363 368 PF00069 0.375
MOD_NEK2_1 410 415 PF00069 0.383
MOD_NEK2_1 456 461 PF00069 0.389
MOD_NEK2_1 504 509 PF00069 0.493
MOD_NEK2_1 538 543 PF00069 0.693
MOD_NEK2_1 98 103 PF00069 0.423
MOD_NEK2_2 140 145 PF00069 0.499
MOD_NEK2_2 426 431 PF00069 0.361
MOD_OFUCOSY 97 102 PF10250 0.399
MOD_PIKK_1 222 228 PF00454 0.543
MOD_PIKK_1 329 335 PF00454 0.403
MOD_PIKK_1 400 406 PF00454 0.514
MOD_PK_1 248 254 PF00069 0.501
MOD_PKA_2 187 193 PF00069 0.389
MOD_PKA_2 217 223 PF00069 0.508
MOD_PKA_2 278 284 PF00069 0.502
MOD_PKA_2 366 372 PF00069 0.465
MOD_Plk_1 408 414 PF00069 0.425
MOD_Plk_1 416 422 PF00069 0.370
MOD_Plk_1 459 465 PF00069 0.472
MOD_Plk_1 488 494 PF00069 0.477
MOD_Plk_1 504 510 PF00069 0.470
MOD_Plk_1 528 534 PF00069 0.538
MOD_Plk_1 98 104 PF00069 0.534
MOD_Plk_2-3 187 193 PF00069 0.297
MOD_Plk_4 206 212 PF00069 0.264
MOD_Plk_4 248 254 PF00069 0.444
MOD_Plk_4 369 375 PF00069 0.497
MOD_ProDKin_1 264 270 PF00069 0.463
MOD_ProDKin_1 439 445 PF00069 0.542
MOD_ProDKin_1 510 516 PF00069 0.436
TRG_DiLeu_LyEn_5 181 186 PF01217 0.371
TRG_ENDOCYTIC_2 317 320 PF00928 0.487
TRG_ENDOCYTIC_2 424 427 PF00928 0.390
TRG_ENDOCYTIC_2 82 85 PF00928 0.509
TRG_ER_diArg_1 157 159 PF00400 0.489
TRG_ER_diArg_1 290 292 PF00400 0.298
TRG_ER_diArg_1 346 349 PF00400 0.441
TRG_ER_diArg_1 430 433 PF00400 0.480
TRG_ER_diArg_1 498 501 PF00400 0.503
TRG_Pf-PMV_PEXEL_1 159 164 PF00026 0.497

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8N9 Leptomonas seymouri 28% 85%
A0A0N1P921 Leptomonas seymouri 25% 69%
A0A0S4J2Y5 Bodo saltans 24% 66%
A0A0S4JC97 Bodo saltans 25% 67%
A0A1X0P4M6 Trypanosomatidae 24% 96%
A0A3Q8IAE2 Leishmania donovani 100% 89%
A0A3S7X2V4 Leishmania donovani 28% 72%
A4H3R1 Leishmania braziliensis 27% 81%
C9ZK22 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 69%
C9ZS86 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
C9ZZI9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 92%
D0A4F4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 66%
E9AEF0 Leishmania major 28% 72%
E9AHJ6 Leishmania infantum 28% 72%
Q4QD45 Leishmania major 81% 100%
Q4QJ80 Leishmania major 81% 100%
V5BMQ2 Trypanosoma cruzi 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS