LeishMANIAdb
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Putative glycerol uptake protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative glycerol uptake protein
Gene product:
glycerol uptake protein - putative
Species:
Leishmania infantum
UniProt:
E9AGT2_LEIIN
TriTrypDb:
LINF_190019600 *
Length:
549

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 33
NetGPI no yes: 0, no: 33
Cellular components
Term Name Level Count
GO:0016020 membrane 2 34
GO:0110165 cellular anatomical entity 1 34
GO:0005737 cytoplasm 2 6
GO:0005783 endoplasmic reticulum 5 6
GO:0043226 organelle 2 6
GO:0043227 membrane-bounded organelle 3 6
GO:0043229 intracellular organelle 3 6
GO:0043231 intracellular membrane-bounded organelle 4 6

Expansion

Sequence features

E9AGT2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGT2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016740 transferase activity 2 7
GO:0016746 acyltransferase activity 3 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 209 213 PF00656 0.330
CLV_NRD_NRD_1 135 137 PF00675 0.392
CLV_NRD_NRD_1 366 368 PF00675 0.297
CLV_NRD_NRD_1 448 450 PF00675 0.266
CLV_NRD_NRD_1 541 543 PF00675 0.456
CLV_PCSK_KEX2_1 134 136 PF00082 0.479
CLV_PCSK_KEX2_1 448 450 PF00082 0.266
CLV_PCSK_KEX2_1 541 543 PF00082 0.456
CLV_PCSK_SKI1_1 14 18 PF00082 0.630
CLV_PCSK_SKI1_1 371 375 PF00082 0.297
CLV_PCSK_SKI1_1 485 489 PF00082 0.439
CLV_PCSK_SKI1_1 71 75 PF00082 0.385
DEG_APCC_DBOX_1 484 492 PF00400 0.398
DEG_MDM2_SWIB_1 17 24 PF02201 0.301
DEG_Nend_Nbox_1 1 3 PF02207 0.257
DEG_SPOP_SBC_1 359 363 PF00917 0.535
DOC_CDC14_PxL_1 389 397 PF14671 0.398
DOC_CYCLIN_RxL_1 68 78 PF00134 0.385
DOC_CYCLIN_yCln2_LP_2 337 343 PF00134 0.361
DOC_MAPK_DCC_7 485 495 PF00069 0.314
DOC_MAPK_gen_1 246 253 PF00069 0.342
DOC_MAPK_gen_1 483 490 PF00069 0.457
DOC_MAPK_MEF2A_6 483 490 PF00069 0.551
DOC_PP1_RVXF_1 257 264 PF00149 0.282
DOC_PP1_SILK_1 374 379 PF00149 0.347
DOC_PP2B_LxvP_1 337 340 PF13499 0.361
DOC_PP4_FxxP_1 167 170 PF00568 0.304
DOC_USP7_MATH_1 346 350 PF00917 0.316
DOC_USP7_MATH_1 352 356 PF00917 0.470
DOC_USP7_MATH_1 360 364 PF00917 0.470
DOC_USP7_MATH_1 83 87 PF00917 0.784
DOC_USP7_MATH_1 94 98 PF00917 0.598
DOC_WW_Pin1_4 126 131 PF00397 0.599
DOC_WW_Pin1_4 214 219 PF00397 0.259
DOC_WW_Pin1_4 79 84 PF00397 0.617
DOC_WW_Pin1_4 90 95 PF00397 0.590
LIG_14-3-3_CanoR_1 123 128 PF00244 0.744
LIG_14-3-3_CanoR_1 254 259 PF00244 0.315
LIG_14-3-3_CanoR_1 358 366 PF00244 0.559
LIG_14-3-3_CanoR_1 378 387 PF00244 0.246
LIG_14-3-3_CanoR_1 404 408 PF00244 0.292
LIG_14-3-3_CanoR_1 485 491 PF00244 0.415
LIG_14-3-3_CanoR_1 71 77 PF00244 0.575
LIG_Actin_WH2_2 244 261 PF00022 0.299
LIG_Actin_WH2_2 410 426 PF00022 0.288
LIG_BRCT_BRCA1_1 396 400 PF00533 0.286
LIG_BRCT_BRCA1_1 431 435 PF00533 0.575
LIG_BRCT_BRCA1_1 524 528 PF00533 0.398
LIG_CSL_BTD_1 110 113 PF09270 0.588
LIG_CtBP_PxDLS_1 444 448 PF00389 0.468
LIG_deltaCOP1_diTrp_1 43 49 PF00928 0.313
LIG_deltaCOP1_diTrp_1 463 471 PF00928 0.475
LIG_EH_1 26 30 PF12763 0.304
LIG_eIF4E_1 332 338 PF01652 0.335
LIG_FHA_1 136 142 PF00498 0.673
LIG_FHA_1 215 221 PF00498 0.425
LIG_FHA_1 222 228 PF00498 0.435
LIG_FHA_1 255 261 PF00498 0.344
LIG_FHA_1 285 291 PF00498 0.415
LIG_FHA_1 452 458 PF00498 0.462
LIG_FHA_2 404 410 PF00498 0.292
LIG_LIR_Apic_2 144 148 PF02991 0.436
LIG_LIR_Gen_1 18 29 PF02991 0.401
LIG_LIR_Gen_1 326 335 PF02991 0.271
LIG_LIR_Gen_1 348 357 PF02991 0.336
LIG_LIR_Gen_1 382 392 PF02991 0.400
LIG_LIR_Gen_1 397 408 PF02991 0.231
LIG_LIR_Gen_1 432 443 PF02991 0.543
LIG_LIR_Gen_1 51 61 PF02991 0.270
LIG_LIR_Nem_3 10 16 PF02991 0.373
LIG_LIR_Nem_3 18 24 PF02991 0.373
LIG_LIR_Nem_3 217 222 PF02991 0.385
LIG_LIR_Nem_3 326 332 PF02991 0.280
LIG_LIR_Nem_3 348 353 PF02991 0.362
LIG_LIR_Nem_3 382 387 PF02991 0.389
LIG_LIR_Nem_3 397 403 PF02991 0.210
LIG_LIR_Nem_3 43 49 PF02991 0.304
LIG_LIR_Nem_3 432 438 PF02991 0.561
LIG_LIR_Nem_3 51 56 PF02991 0.231
LIG_LIR_Nem_3 67 73 PF02991 0.473
LIG_NRBOX 58 64 PF00104 0.420
LIG_Pex14_1 219 223 PF04695 0.390
LIG_Pex14_1 249 253 PF04695 0.294
LIG_Pex14_1 464 468 PF04695 0.468
LIG_Pex14_1 471 475 PF04695 0.468
LIG_Pex14_2 17 21 PF04695 0.302
LIG_Pex14_2 425 429 PF04695 0.329
LIG_Pex14_2 460 464 PF04695 0.470
LIG_Pex14_2 496 500 PF04695 0.324
LIG_PTB_Apo_2 24 31 PF02174 0.316
LIG_REV1ctd_RIR_1 27 36 PF16727 0.318
LIG_SH2_CRK 151 155 PF00017 0.283
LIG_SH2_CRK 327 331 PF00017 0.270
LIG_SH2_CRK 384 388 PF00017 0.437
LIG_SH2_CRK 398 402 PF00017 0.312
LIG_SH2_CRK 475 479 PF00017 0.468
LIG_SH2_CRK 70 74 PF00017 0.498
LIG_SH2_NCK_1 151 155 PF00017 0.301
LIG_SH2_SRC 38 41 PF00017 0.301
LIG_SH2_STAP1 223 227 PF00017 0.371
LIG_SH2_STAP1 332 336 PF00017 0.292
LIG_SH2_STAP1 38 42 PF00017 0.333
LIG_SH2_STAP1 398 402 PF00017 0.290
LIG_SH2_STAT5 151 154 PF00017 0.314
LIG_SH2_STAT5 178 181 PF00017 0.367
LIG_SH2_STAT5 206 209 PF00017 0.480
LIG_SH2_STAT5 223 226 PF00017 0.290
LIG_SH2_STAT5 335 338 PF00017 0.327
LIG_SH2_STAT5 342 345 PF00017 0.315
LIG_SH2_STAT5 380 383 PF00017 0.319
LIG_SH2_STAT5 384 387 PF00017 0.327
LIG_SH2_STAT5 420 423 PF00017 0.363
LIG_SH2_STAT5 477 480 PF00017 0.468
LIG_SH3_3 107 113 PF00018 0.615
LIG_SH3_3 159 165 PF00018 0.388
LIG_SH3_3 333 339 PF00018 0.433
LIG_SH3_3 387 393 PF00018 0.398
LIG_SUMO_SIM_par_1 206 212 PF11976 0.502
LIG_TRAF2_1 233 236 PF00917 0.283
LIG_TRFH_1 335 339 PF08558 0.438
LIG_TYR_ITIM 418 423 PF00017 0.414
LIG_TYR_ITIM 473 478 PF00017 0.466
LIG_UBA3_1 417 424 PF00899 0.347
LIG_WRC_WIRS_1 347 352 PF05994 0.333
LIG_WRC_WIRS_1 8 13 PF05994 0.294
LIG_WW_1 339 342 PF00397 0.393
LIG_WW_3 112 116 PF00397 0.537
MOD_CK1_1 75 81 PF00069 0.596
MOD_CK1_1 86 92 PF00069 0.613
MOD_CK1_1 95 101 PF00069 0.636
MOD_CK2_1 403 409 PF00069 0.346
MOD_CK2_1 436 442 PF00069 0.482
MOD_CMANNOS 461 464 PF00535 0.270
MOD_Cter_Amidation 539 542 PF01082 0.357
MOD_GlcNHglycan 130 133 PF01048 0.496
MOD_GlcNHglycan 301 304 PF01048 0.575
MOD_GlcNHglycan 438 441 PF01048 0.335
MOD_GlcNHglycan 524 527 PF01048 0.329
MOD_GlcNHglycan 66 69 PF01048 0.438
MOD_GlcNHglycan 79 82 PF01048 0.549
MOD_GlcNHglycan 94 97 PF01048 0.395
MOD_GlcNHglycan 99 103 PF01048 0.444
MOD_GSK3_1 119 126 PF00069 0.728
MOD_GSK3_1 222 229 PF00069 0.464
MOD_GSK3_1 541 548 PF00069 0.648
MOD_GSK3_1 72 79 PF00069 0.593
MOD_GSK3_1 86 93 PF00069 0.603
MOD_GSK3_1 94 101 PF00069 0.600
MOD_LATS_1 356 362 PF00433 0.446
MOD_NEK2_1 141 146 PF00069 0.550
MOD_NEK2_1 253 258 PF00069 0.286
MOD_NEK2_1 403 408 PF00069 0.295
MOD_NEK2_1 423 428 PF00069 0.240
MOD_NEK2_1 451 456 PF00069 0.475
MOD_NEK2_1 74 79 PF00069 0.633
MOD_PKA_1 135 141 PF00069 0.537
MOD_PKA_1 541 547 PF00069 0.567
MOD_PKA_2 135 141 PF00069 0.558
MOD_PKA_2 253 259 PF00069 0.326
MOD_PKA_2 403 409 PF00069 0.292
MOD_PKA_2 541 547 PF00069 0.591
MOD_PKB_1 121 129 PF00069 0.560
MOD_Plk_1 38 44 PF00069 0.328
MOD_Plk_1 382 388 PF00069 0.478
MOD_Plk_4 149 155 PF00069 0.415
MOD_Plk_4 200 206 PF00069 0.344
MOD_Plk_4 382 388 PF00069 0.389
MOD_Plk_4 403 409 PF00069 0.317
MOD_Plk_4 486 492 PF00069 0.405
MOD_ProDKin_1 126 132 PF00069 0.597
MOD_ProDKin_1 214 220 PF00069 0.255
MOD_ProDKin_1 79 85 PF00069 0.620
MOD_ProDKin_1 90 96 PF00069 0.590
TRG_DiLeu_BaEn_2 408 414 PF01217 0.322
TRG_DiLeu_BaLyEn_6 167 172 PF01217 0.347
TRG_DiLeu_BaLyEn_6 256 261 PF01217 0.351
TRG_ENDOCYTIC_2 13 16 PF00928 0.393
TRG_ENDOCYTIC_2 151 154 PF00928 0.292
TRG_ENDOCYTIC_2 178 181 PF00928 0.322
TRG_ENDOCYTIC_2 190 193 PF00928 0.435
TRG_ENDOCYTIC_2 327 330 PF00928 0.270
TRG_ENDOCYTIC_2 335 338 PF00928 0.316
TRG_ENDOCYTIC_2 384 387 PF00928 0.340
TRG_ENDOCYTIC_2 398 401 PF00928 0.287
TRG_ENDOCYTIC_2 420 423 PF00928 0.359
TRG_ENDOCYTIC_2 475 478 PF00928 0.468
TRG_ENDOCYTIC_2 53 56 PF00928 0.427
TRG_ENDOCYTIC_2 70 73 PF00928 0.588
TRG_ER_diArg_1 120 123 PF00400 0.698
TRG_ER_diArg_1 134 136 PF00400 0.611
TRG_ER_diArg_1 246 249 PF00400 0.395
TRG_ER_diArg_1 447 449 PF00400 0.466
TRG_ER_diArg_1 483 486 PF00400 0.486

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IRP6 Bodo saltans 42% 92%
A0A1X0P614 Trypanosomatidae 38% 88%
A0A1X0P616 Trypanosomatidae 48% 90%
A0A1X0P718 Trypanosomatidae 45% 85%
A0A3Q8IAC1 Leishmania donovani 99% 71%
A0A3Q8IBC3 Leishmania donovani 98% 91%
A0A3Q8IDD7 Leishmania donovani 99% 71%
A0A3S5H769 Leishmania donovani 98% 80%
A0A3S5IRW9 Trypanosoma rangeli 40% 88%
A0A3S7WVK4 Leishmania donovani 95% 71%
A0A3S7WVS3 Leishmania donovani 94% 100%
A4HA75 Leishmania braziliensis 62% 100%
A4HA76 Leishmania braziliensis 62% 100%
A4HA77 Leishmania braziliensis 65% 100%
A4HA79 Leishmania braziliensis 74% 100%
A4HA81 Leishmania braziliensis 68% 100%
A4HA82 Leishmania braziliensis 68% 100%
D0A0T4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 90%
E8NHJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AGS9 Leishmania infantum 100% 100%
E9AGT1 Leishmania infantum 95% 100%
E9AGT3 Leishmania infantum 96% 71%
E9AGT4 Leishmania infantum 100% 71%
E9AS84 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9AS85 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AS86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 73%
P53154 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 98%
Q09758 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 94%
Q4QD77 Leishmania major 28% 75%
Q4QD78 Leishmania major 92% 100%
Q4QD79 Leishmania major 88% 100%
Q4QD80 Leishmania major 88% 100%
Q4QD81 Leishmania major 71% 100%
Q4QD82 Leishmania major 89% 100%
Q5AKZ2 Candida albicans (strain SC5314 / ATCC MYA-2876) 28% 94%
Q7Z877 Candida tropicalis 28% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS