Putative glycerol uptake protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerol uptake protein - putative

Species:

Leishmania infantum

UniProt:

E9AGS9_LEIIN

TriTrypDb:

LINF_190018700

Length:

412

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17
GO:0005737	cytoplasm	2	1
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AGS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.217
CLV_NRD_NRD_1	173	175	PF00675	0.239
CLV_NRD_NRD_1	255	257	PF00675	0.223
CLV_NRD_NRD_1	343	345	PF00675	0.254
CLV_NRD_NRD_1	390	392	PF00675	0.264
CLV_PCSK_KEX2_1	255	257	PF00082	0.223
CLV_PCSK_KEX2_1	343	345	PF00082	0.254
CLV_PCSK_KEX2_1	390	392	PF00082	0.264
CLV_PCSK_PC7_1	386	392	PF00082	0.176
CLV_PCSK_SKI1_1	178	182	PF00082	0.267
CLV_PCSK_SKI1_1	292	296	PF00082	0.326
DEG_APCC_DBOX_1	291	299	PF00400	0.458
DEG_SPOP_SBC_1	166	170	PF00917	0.458
DOC_CDC14_PxL_1	196	204	PF14671	0.311
DOC_CYCLIN_yCln2_LP_2	144	150	PF00134	0.303
DOC_MAPK_DCC_7	292	302	PF00069	0.414
DOC_MAPK_gen_1	290	297	PF00069	0.417
DOC_MAPK_gen_1	53	60	PF00069	0.257
DOC_MAPK_MEF2A_6	290	297	PF00069	0.520
DOC_PP1_RVXF_1	64	71	PF00149	0.217
DOC_PP1_SILK_1	181	186	PF00149	0.441
DOC_PP2B_LxvP_1	144	147	PF13499	0.295
DOC_USP7_MATH_1	153	157	PF00917	0.290
DOC_USP7_MATH_1	159	163	PF00917	0.443
DOC_USP7_MATH_1	167	171	PF00917	0.440
DOC_WW_Pin1_4	21	26	PF00397	0.164
LIG_14-3-3_CanoR_1	165	173	PF00244	0.526
LIG_14-3-3_CanoR_1	185	194	PF00244	0.128
LIG_14-3-3_CanoR_1	211	215	PF00244	0.241
LIG_14-3-3_CanoR_1	292	298	PF00244	0.458
LIG_14-3-3_CanoR_1	358	367	PF00244	0.411
LIG_14-3-3_CanoR_1	61	66	PF00244	0.244
LIG_Actin_WH2_2	217	233	PF00022	0.241
LIG_Actin_WH2_2	51	68	PF00022	0.226
LIG_BRCT_BRCA1_1	203	207	PF00533	0.335
LIG_BRCT_BRCA1_1	238	242	PF00533	0.515
LIG_BRCT_BRCA1_1	331	335	PF00533	0.403
LIG_CtBP_PxDLS_1	251	255	PF00389	0.417
LIG_deltaCOP1_diTrp_1	270	278	PF00928	0.419
LIG_eIF4E_1	139	145	PF01652	0.311
LIG_FHA_1	22	28	PF00498	0.333
LIG_FHA_1	259	265	PF00498	0.457
LIG_FHA_1	29	35	PF00498	0.353
LIG_FHA_1	352	358	PF00498	0.608
LIG_FHA_1	62	68	PF00498	0.261
LIG_FHA_1	92	98	PF00498	0.341
LIG_FHA_2	211	217	PF00498	0.241
LIG_LIR_Gen_1	133	142	PF02991	0.223
LIG_LIR_Gen_1	155	164	PF02991	0.276
LIG_LIR_Gen_1	189	199	PF02991	0.373
LIG_LIR_Gen_1	204	215	PF02991	0.241
LIG_LIR_Gen_1	239	250	PF02991	0.487
LIG_LIR_Nem_3	133	139	PF02991	0.242
LIG_LIR_Nem_3	155	160	PF02991	0.244
LIG_LIR_Nem_3	189	194	PF02991	0.352
LIG_LIR_Nem_3	204	210	PF02991	0.172
LIG_LIR_Nem_3	239	245	PF02991	0.510
LIG_LIR_Nem_3	24	29	PF02991	0.273
LIG_Pex14_1	26	30	PF04695	0.238
LIG_Pex14_1	271	275	PF04695	0.414
LIG_Pex14_1	278	282	PF04695	0.414
LIG_Pex14_1	56	60	PF04695	0.224
LIG_Pex14_2	232	236	PF04695	0.253
LIG_Pex14_2	267	271	PF04695	0.414
LIG_Pex14_2	303	307	PF04695	0.264
LIG_SH2_CRK	134	138	PF00017	0.239
LIG_SH2_CRK	191	195	PF00017	0.411
LIG_SH2_CRK	205	209	PF00017	0.286
LIG_SH2_CRK	282	286	PF00017	0.414
LIG_SH2_STAP1	139	143	PF00017	0.286
LIG_SH2_STAP1	205	209	PF00017	0.350
LIG_SH2_STAP1	30	34	PF00017	0.297
LIG_SH2_STAP1	363	367	PF00017	0.370
LIG_SH2_STAT5	13	16	PF00017	0.305
LIG_SH2_STAT5	142	145	PF00017	0.262
LIG_SH2_STAT5	149	152	PF00017	0.255
LIG_SH2_STAT5	187	190	PF00017	0.261
LIG_SH2_STAT5	191	194	PF00017	0.258
LIG_SH2_STAT5	227	230	PF00017	0.360
LIG_SH2_STAT5	284	287	PF00017	0.414
LIG_SH2_STAT5	30	33	PF00017	0.243
LIG_SH2_STAT5	375	378	PF00017	0.543
LIG_SH3_3	140	146	PF00018	0.376
LIG_SH3_3	194	200	PF00018	0.311
LIG_SUMO_SIM_par_1	13	19	PF11976	0.326
LIG_TRAF2_1	40	43	PF00917	0.175
LIG_TRFH_1	142	146	PF08558	0.403
LIG_TYR_ITIM	225	230	PF00017	0.320
LIG_TYR_ITIM	280	285	PF00017	0.408
LIG_UBA3_1	224	231	PF00899	0.286
LIG_WRC_WIRS_1	154	159	PF05994	0.260
LIG_WW_1	146	149	PF00397	0.354
MOD_CK1_1	361	367	PF00069	0.405
MOD_CK1_1	382	388	PF00069	0.380
MOD_CK2_1	210	216	PF00069	0.290
MOD_CK2_1	243	249	PF00069	0.429
MOD_CMANNOS	268	271	PF00535	0.214
MOD_GlcNHglycan	108	111	PF01048	0.472
MOD_GlcNHglycan	245	248	PF01048	0.259
MOD_GlcNHglycan	331	334	PF01048	0.289
MOD_GSK3_1	29	36	PF00069	0.245
MOD_GSK3_1	361	368	PF00069	0.406
MOD_LATS_1	163	169	PF00433	0.423
MOD_NEK2_1	210	215	PF00069	0.222
MOD_NEK2_1	230	235	PF00069	0.174
MOD_NEK2_1	258	263	PF00069	0.434
MOD_NEK2_1	369	374	PF00069	0.416
MOD_NEK2_1	60	65	PF00069	0.244
MOD_PIKK_1	358	364	PF00454	0.395
MOD_PKA_2	210	216	PF00069	0.241
MOD_PKA_2	365	371	PF00069	0.428
MOD_PKA_2	382	388	PF00069	0.434
MOD_PKA_2	60	66	PF00069	0.280
MOD_Plk_1	189	195	PF00069	0.452
MOD_Plk_4	189	195	PF00069	0.383
MOD_Plk_4	210	216	PF00069	0.336
MOD_Plk_4	293	299	PF00069	0.392
MOD_Plk_4	371	377	PF00069	0.385
MOD_Plk_4	398	404	PF00069	0.329
MOD_Plk_4	7	13	PF00069	0.242
MOD_ProDKin_1	21	27	PF00069	0.165
TRG_DiLeu_BaEn_2	215	221	PF01217	0.247
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.261
TRG_ENDOCYTIC_2	134	137	PF00928	0.234
TRG_ENDOCYTIC_2	142	145	PF00928	0.300
TRG_ENDOCYTIC_2	191	194	PF00928	0.276
TRG_ENDOCYTIC_2	205	208	PF00928	0.226
TRG_ENDOCYTIC_2	227	230	PF00928	0.299
TRG_ENDOCYTIC_2	282	285	PF00928	0.414
TRG_ER_diArg_1	254	256	PF00400	0.423
TRG_ER_diArg_1	290	293	PF00400	0.429
TRG_ER_diArg_1	342	344	PF00400	0.445
TRG_ER_diArg_1	389	391	PF00400	0.465
TRG_ER_diArg_1	53	56	PF00400	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IRP6	Bodo saltans	43%	69%
A0A1X0P614	Trypanosomatidae	39%	66%
A0A1X0P616	Trypanosomatidae	55%	67%
A0A3Q8IBC3	Leishmania donovani	99%	68%
A0A3R7KT56	Trypanosoma rangeli	46%	100%
A0A3R7NNW7	Trypanosoma rangeli	47%	94%
A0A3S5IRW9	Trypanosoma rangeli	43%	66%
A0A3S7WVS3	Leishmania donovani	94%	100%
A4HA79	Leishmania braziliensis	67%	100%
D0A0T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	68%
E8NHJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AGT1	Leishmania infantum	94%	72%
E9AGT2	Leishmania infantum	100%	75%
E9AS84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
P53154	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	74%
Q08929	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	68%
Q09758	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	71%
Q4QD82	Leishmania major	88%	100%
Q5AKZ2	Candida albicans (strain SC5314 / ATCC MYA-2876)	31%	71%
Q7Z877	Candida tropicalis	29%	71%