Putative ATG8/AUT7/APG8/PAZ2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATG8/AUT7/APG8/PAZ2 - putative

Species:

Leishmania infantum

UniProt:

E9AGS4_LEIIN

TriTrypDb:

LINF_190013760

Length:

136

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 54
NetGPI	no	yes: 0, no: 54

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	54
GO:0110165	cellular anatomical entity	1	54

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Expansion

Sequence features

E9AGS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGS4

Function

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Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	21
GO:0006950	response to stress	2	15
GO:0006995	cellular response to nitrogen starvation	5	15
GO:0007154	cell communication	2	15
GO:0008152	metabolic process	1	21
GO:0009056	catabolic process	2	21
GO:0009267	cellular response to starvation	4	15
GO:0009605	response to external stimulus	2	15
GO:0009987	cellular process	1	33
GO:0009991	response to extracellular stimulus	3	15

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.244
CLV_PCSK_KEX2_1	13	15	PF00082	0.334
CLV_PCSK_SKI1_1	47	51	PF00082	0.328
CLV_PCSK_SKI1_1	68	72	PF00082	0.380
DOC_MAPK_gen_1	67	73	PF00069	0.376
DOC_PP2B_LxvP_1	43	46	PF13499	0.350
DOC_SPAK_OSR1_1	41	45	PF12202	0.166
DOC_USP7_MATH_1	35	39	PF00917	0.208
DOC_WW_Pin1_4	74	79	PF00397	0.376
LIG_14-3-3_CanoR_1	59	63	PF00244	0.318

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR42	Leptomonas seymouri	49%	100%
A0A0N1P9V5	Leptomonas seymouri	52%	100%
A0A0N1PAQ9	Leptomonas seymouri	52%	68%
A0A0N1PD53	Leptomonas seymouri	32%	100%
A0A0S4JA79	Bodo saltans	32%	100%
A0A1X0P492	Trypanosomatidae	35%	96%
A0A1X0P5E7	Trypanosomatidae	34%	97%
A0A381MAT2	Leishmania infantum	39%	100%
A0A381MBG2	Leishmania infantum	39%	100%
A0A381MCF0	Leishmania infantum	39%	100%

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