LeishMANIAdb
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Associated kinase of Tb14-3-3

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Associated kinase of Tb14-3-3
Gene product:
Associated kinase of Tb14-3-3 - putative
Species:
Leishmania infantum
UniProt:
E9AGR6_LEIIN
TriTrypDb:
LINF_190006200
Length:
631

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Annotations by Jardim et al.

Protein kinase, Ser/Thr kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Phosphorylation

Promastigote: 131, 132, 440

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AGR6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGR6

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 17
GO:0006793 phosphorus metabolic process 3 17
GO:0006796 phosphate-containing compound metabolic process 4 17
GO:0006807 nitrogen compound metabolic process 2 17
GO:0008152 metabolic process 1 17
GO:0009987 cellular process 1 17
GO:0016310 phosphorylation 5 17
GO:0019538 protein metabolic process 3 17
GO:0036211 protein modification process 4 17
GO:0043170 macromolecule metabolic process 3 17
GO:0043412 macromolecule modification 4 17
GO:0044237 cellular metabolic process 2 17
GO:0044238 primary metabolic process 2 17
GO:0071704 organic substance metabolic process 2 17
GO:1901564 organonitrogen compound metabolic process 3 17
GO:0007165 signal transduction 2 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0035556 intracellular signal transduction 3 1
GO:0046777 protein autophosphorylation 6 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 17
GO:0003824 catalytic activity 1 17
GO:0004672 protein kinase activity 3 17
GO:0005488 binding 1 17
GO:0005524 ATP binding 5 17
GO:0016301 kinase activity 4 17
GO:0016740 transferase activity 2 17
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 17
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 17
GO:0017076 purine nucleotide binding 4 17
GO:0030554 adenyl nucleotide binding 5 17
GO:0032553 ribonucleotide binding 3 17
GO:0032555 purine ribonucleotide binding 4 17
GO:0032559 adenyl ribonucleotide binding 5 17
GO:0035639 purine ribonucleoside triphosphate binding 4 17
GO:0036094 small molecule binding 2 17
GO:0043167 ion binding 2 17
GO:0043168 anion binding 3 17
GO:0097159 organic cyclic compound binding 2 17
GO:0097367 carbohydrate derivative binding 2 17
GO:0140096 catalytic activity, acting on a protein 2 17
GO:1901265 nucleoside phosphate binding 3 17
GO:1901363 heterocyclic compound binding 2 17
GO:0004674 protein serine/threonine kinase activity 4 6
GO:0004683 calmodulin-dependent protein kinase activity 5 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1
GO:0008017 microtubule binding 5 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 1
GO:0010857 calcium-dependent protein kinase activity 4 1
GO:0015631 tubulin binding 4 1
GO:0042802 identical protein binding 3 1
GO:0042803 protein homodimerization activity 4 1
GO:0046983 protein dimerization activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 22 26 PF00656 0.441
CLV_NRD_NRD_1 364 366 PF00675 0.418
CLV_NRD_NRD_1 403 405 PF00675 0.525
CLV_NRD_NRD_1 436 438 PF00675 0.539
CLV_NRD_NRD_1 451 453 PF00675 0.577
CLV_NRD_NRD_1 472 474 PF00675 0.523
CLV_PCSK_KEX2_1 186 188 PF00082 0.235
CLV_PCSK_KEX2_1 219 221 PF00082 0.200
CLV_PCSK_KEX2_1 315 317 PF00082 0.203
CLV_PCSK_KEX2_1 364 366 PF00082 0.418
CLV_PCSK_KEX2_1 403 405 PF00082 0.539
CLV_PCSK_KEX2_1 436 438 PF00082 0.539
CLV_PCSK_KEX2_1 451 453 PF00082 0.577
CLV_PCSK_KEX2_1 472 474 PF00082 0.523
CLV_PCSK_KEX2_1 83 85 PF00082 0.218
CLV_PCSK_PC1ET2_1 186 188 PF00082 0.235
CLV_PCSK_PC1ET2_1 219 221 PF00082 0.218
CLV_PCSK_PC1ET2_1 315 317 PF00082 0.220
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.189
CLV_PCSK_PC7_1 215 221 PF00082 0.218
CLV_PCSK_SKI1_1 109 113 PF00082 0.278
CLV_PCSK_SKI1_1 149 153 PF00082 0.241
CLV_PCSK_SKI1_1 162 166 PF00082 0.354
CLV_PCSK_SKI1_1 280 284 PF00082 0.189
CLV_PCSK_SKI1_1 486 490 PF00082 0.646
CLV_PCSK_SKI1_1 509 513 PF00082 0.605
CLV_PCSK_SKI1_1 515 519 PF00082 0.587
CLV_PCSK_SKI1_1 618 622 PF00082 0.191
DEG_Nend_UBRbox_3 1 3 PF02207 0.648
DOC_CKS1_1 227 232 PF01111 0.231
DOC_CKS1_1 287 292 PF01111 0.278
DOC_CKS1_1 39 44 PF01111 0.292
DOC_CYCLIN_yCln2_LP_2 323 329 PF00134 0.307
DOC_MAPK_gen_1 162 171 PF00069 0.267
DOC_MAPK_gen_1 568 576 PF00069 0.186
DOC_MAPK_JIP1_4 165 171 PF00069 0.229
DOC_PP2B_LxvP_1 206 209 PF13499 0.242
DOC_PP4_FxxP_1 612 615 PF00568 0.186
DOC_USP7_MATH_1 185 189 PF00917 0.198
DOC_USP7_MATH_1 292 296 PF00917 0.300
DOC_USP7_MATH_1 484 488 PF00917 0.553
DOC_USP7_MATH_1 513 517 PF00917 0.577
DOC_USP7_MATH_1 519 523 PF00917 0.623
DOC_USP7_MATH_1 530 534 PF00917 0.523
DOC_USP7_UBL2_3 311 315 PF12436 0.227
DOC_USP7_UBL2_3 56 60 PF12436 0.258
DOC_WW_Pin1_4 193 198 PF00397 0.317
DOC_WW_Pin1_4 226 231 PF00397 0.219
DOC_WW_Pin1_4 269 274 PF00397 0.326
DOC_WW_Pin1_4 286 291 PF00397 0.147
DOC_WW_Pin1_4 295 300 PF00397 0.234
DOC_WW_Pin1_4 314 319 PF00397 0.388
DOC_WW_Pin1_4 38 43 PF00397 0.230
DOC_WW_Pin1_4 404 409 PF00397 0.589
DOC_WW_Pin1_4 425 430 PF00397 0.510
DOC_WW_Pin1_4 457 462 PF00397 0.521
DOC_WW_Pin1_4 472 477 PF00397 0.518
DOC_WW_Pin1_4 480 485 PF00397 0.536
DOC_WW_Pin1_4 486 491 PF00397 0.479
DOC_WW_Pin1_4 509 514 PF00397 0.519
DOC_WW_Pin1_4 515 520 PF00397 0.505
DOC_WW_Pin1_4 526 531 PF00397 0.462
LIG_14-3-3_CanoR_1 220 230 PF00244 0.224
LIG_14-3-3_CanoR_1 284 290 PF00244 0.295
LIG_14-3-3_CanoR_1 31 37 PF00244 0.189
LIG_14-3-3_CanoR_1 344 348 PF00244 0.476
LIG_14-3-3_CanoR_1 413 420 PF00244 0.636
LIG_14-3-3_CanoR_1 425 429 PF00244 0.458
LIG_14-3-3_CanoR_1 451 456 PF00244 0.538
LIG_14-3-3_CanoR_1 503 513 PF00244 0.605
LIG_14-3-3_CanoR_1 623 630 PF00244 0.195
LIG_Actin_WH2_2 75 92 PF00022 0.246
LIG_APCC_ABBA_1 111 116 PF00400 0.187
LIG_BRCT_BRCA1_1 265 269 PF00533 0.186
LIG_BRCT_BRCA1_1 578 582 PF00533 0.278
LIG_Clathr_ClatBox_1 112 116 PF01394 0.186
LIG_Dynein_DLC8_1 239 245 PF01221 0.200
LIG_FHA_1 142 148 PF00498 0.223
LIG_FHA_1 252 258 PF00498 0.219
LIG_FHA_1 421 427 PF00498 0.500
LIG_FHA_1 541 547 PF00498 0.672
LIG_FHA_1 548 554 PF00498 0.607
LIG_FHA_2 20 26 PF00498 0.328
LIG_FHA_2 243 249 PF00498 0.186
LIG_FHA_2 98 104 PF00498 0.197
LIG_LIR_Apic_2 229 235 PF02991 0.267
LIG_LIR_Gen_1 108 118 PF02991 0.238
LIG_LIR_Gen_1 144 152 PF02991 0.186
LIG_LIR_Gen_1 236 247 PF02991 0.199
LIG_LIR_Gen_1 261 270 PF02991 0.213
LIG_LIR_Gen_1 317 328 PF02991 0.225
LIG_LIR_Nem_3 100 104 PF02991 0.248
LIG_LIR_Nem_3 108 114 PF02991 0.286
LIG_LIR_Nem_3 144 148 PF02991 0.189
LIG_LIR_Nem_3 236 242 PF02991 0.199
LIG_LIR_Nem_3 245 250 PF02991 0.284
LIG_LIR_Nem_3 261 265 PF02991 0.237
LIG_LIR_Nem_3 281 286 PF02991 0.197
LIG_LIR_Nem_3 317 323 PF02991 0.249
LIG_Pex14_2 111 115 PF04695 0.193
LIG_Pex14_2 238 242 PF04695 0.186
LIG_REV1ctd_RIR_1 112 121 PF16727 0.333
LIG_SH2_CRK 145 149 PF00017 0.186
LIG_SH2_CRK 320 324 PF00017 0.218
LIG_SH2_CRK 34 38 PF00017 0.364
LIG_SH2_PTP2 262 265 PF00017 0.283
LIG_SH2_PTP2 46 49 PF00017 0.333
LIG_SH2_SRC 145 148 PF00017 0.190
LIG_SH2_SRC 46 49 PF00017 0.200
LIG_SH2_SRC 66 69 PF00017 0.180
LIG_SH2_STAP1 143 147 PF00017 0.200
LIG_SH2_STAT3 143 146 PF00017 0.186
LIG_SH2_STAT3 21 24 PF00017 0.256
LIG_SH2_STAT5 104 107 PF00017 0.256
LIG_SH2_STAT5 143 146 PF00017 0.216
LIG_SH2_STAT5 21 24 PF00017 0.266
LIG_SH2_STAT5 262 265 PF00017 0.283
LIG_SH2_STAT5 46 49 PF00017 0.242
LIG_SH2_STAT5 57 60 PF00017 0.106
LIG_SH2_STAT5 611 614 PF00017 0.186
LIG_SH2_STAT5 66 69 PF00017 0.158
LIG_SH3_3 194 200 PF00018 0.305
LIG_SH3_3 267 273 PF00018 0.333
LIG_SH3_3 36 42 PF00018 0.196
LIG_SH3_3 387 393 PF00018 0.433
LIG_SH3_3 423 429 PF00018 0.535
LIG_SUMO_SIM_anti_2 85 90 PF11976 0.216
LIG_SUMO_SIM_par_1 199 204 PF11976 0.284
LIG_TRAF2_1 394 397 PF00917 0.666
LIG_TYR_ITIM 260 265 PF00017 0.283
LIG_UBA3_1 67 72 PF00899 0.218
LIG_WRC_WIRS_1 98 103 PF05994 0.200
MOD_CDC14_SPxK_1 428 431 PF00782 0.499
MOD_CDK_SPK_2 193 198 PF00069 0.179
MOD_CDK_SPK_2 226 231 PF00069 0.186
MOD_CDK_SPxK_1 425 431 PF00069 0.498
MOD_CDK_SPxK_1 472 478 PF00069 0.519
MOD_CDK_SPxK_1 480 486 PF00069 0.519
MOD_CDK_SPxK_1 509 515 PF00069 0.538
MOD_CDK_SPxK_1 526 532 PF00069 0.466
MOD_CDK_SPxxK_3 286 293 PF00069 0.340
MOD_CDK_SPxxK_3 457 464 PF00069 0.524
MOD_CK1_1 272 278 PF00069 0.333
MOD_CK1_1 295 301 PF00069 0.306
MOD_CK1_1 314 320 PF00069 0.390
MOD_CK1_1 346 352 PF00069 0.479
MOD_CK1_1 409 415 PF00069 0.582
MOD_CK1_1 440 446 PF00069 0.621
MOD_CK1_1 491 497 PF00069 0.524
MOD_CK1_1 533 539 PF00069 0.577
MOD_CK1_1 544 550 PF00069 0.481
MOD_CK2_1 275 281 PF00069 0.264
MOD_CK2_1 97 103 PF00069 0.197
MOD_Cter_Amidation 217 220 PF01082 0.200
MOD_DYRK1A_RPxSP_1 404 408 PF00069 0.514
MOD_DYRK1A_RPxSP_1 425 429 PF00069 0.552
MOD_DYRK1A_RPxSP_1 486 490 PF00069 0.506
MOD_DYRK1A_RPxSP_1 515 519 PF00069 0.524
MOD_DYRK1A_RPxSP_1 526 530 PF00069 0.525
MOD_GlcNHglycan 131 134 PF01048 0.341
MOD_GlcNHglycan 265 268 PF01048 0.240
MOD_GlcNHglycan 294 297 PF01048 0.319
MOD_GlcNHglycan 348 351 PF01048 0.444
MOD_GlcNHglycan 353 356 PF01048 0.411
MOD_GlcNHglycan 408 411 PF01048 0.619
MOD_GlcNHglycan 444 447 PF01048 0.594
MOD_GlcNHglycan 453 456 PF01048 0.505
MOD_GlcNHglycan 464 467 PF01048 0.482
MOD_GlcNHglycan 486 489 PF01048 0.517
MOD_GlcNHglycan 497 500 PF01048 0.454
MOD_GlcNHglycan 515 518 PF01048 0.604
MOD_GlcNHglycan 521 524 PF01048 0.624
MOD_GlcNHglycan 532 535 PF01048 0.503
MOD_GlcNHglycan 543 546 PF01048 0.508
MOD_GSK3_1 129 136 PF00069 0.255
MOD_GSK3_1 137 144 PF00069 0.225
MOD_GSK3_1 261 268 PF00069 0.199
MOD_GSK3_1 282 289 PF00069 0.238
MOD_GSK3_1 409 416 PF00069 0.605
MOD_GSK3_1 420 427 PF00069 0.565
MOD_GSK3_1 437 444 PF00069 0.514
MOD_GSK3_1 480 487 PF00069 0.697
MOD_GSK3_1 491 498 PF00069 0.457
MOD_GSK3_1 505 512 PF00069 0.556
MOD_GSK3_1 515 522 PF00069 0.502
MOD_GSK3_1 526 533 PF00069 0.519
MOD_GSK3_1 535 542 PF00069 0.589
MOD_GSK3_1 596 603 PF00069 0.186
MOD_LATS_1 435 441 PF00433 0.532
MOD_N-GLC_1 275 280 PF02516 0.333
MOD_N-GLC_1 539 544 PF02516 0.717
MOD_N-GLC_1 576 581 PF02516 0.278
MOD_NEK2_1 128 133 PF00069 0.327
MOD_NEK2_1 201 206 PF00069 0.344
MOD_NEK2_1 242 247 PF00069 0.240
MOD_NEK2_1 265 270 PF00069 0.203
MOD_NEK2_1 304 309 PF00069 0.323
MOD_NEK2_1 343 348 PF00069 0.482
MOD_NEK2_1 395 400 PF00069 0.665
MOD_NEK2_1 462 467 PF00069 0.528
MOD_NEK2_1 505 510 PF00069 0.644
MOD_NEK2_1 576 581 PF00069 0.316
MOD_NEK2_2 420 425 PF00069 0.613
MOD_PIKK_1 240 246 PF00454 0.238
MOD_PIKK_1 397 403 PF00454 0.445
MOD_PIKK_1 622 628 PF00454 0.186
MOD_PKA_1 451 457 PF00069 0.575
MOD_PKA_2 334 340 PF00069 0.443
MOD_PKA_2 343 349 PF00069 0.416
MOD_PKA_2 414 420 PF00069 0.633
MOD_PKA_2 424 430 PF00069 0.538
MOD_PKA_2 435 441 PF00069 0.541
MOD_PKA_2 451 457 PF00069 0.539
MOD_PKA_2 491 497 PF00069 0.551
MOD_PKA_2 622 628 PF00069 0.186
MOD_Plk_1 201 207 PF00069 0.362
MOD_Plk_2-3 601 607 PF00069 0.186
MOD_Plk_4 258 264 PF00069 0.237
MOD_Plk_4 304 310 PF00069 0.310
MOD_Plk_4 32 38 PF00069 0.315
MOD_Plk_4 334 340 PF00069 0.388
MOD_Plk_4 343 349 PF00069 0.383
MOD_Plk_4 601 607 PF00069 0.199
MOD_Plk_4 97 103 PF00069 0.197
MOD_ProDKin_1 193 199 PF00069 0.317
MOD_ProDKin_1 226 232 PF00069 0.219
MOD_ProDKin_1 269 275 PF00069 0.326
MOD_ProDKin_1 286 292 PF00069 0.147
MOD_ProDKin_1 295 301 PF00069 0.234
MOD_ProDKin_1 314 320 PF00069 0.388
MOD_ProDKin_1 38 44 PF00069 0.230
MOD_ProDKin_1 404 410 PF00069 0.586
MOD_ProDKin_1 425 431 PF00069 0.513
MOD_ProDKin_1 457 463 PF00069 0.521
MOD_ProDKin_1 472 478 PF00069 0.519
MOD_ProDKin_1 480 486 PF00069 0.519
MOD_ProDKin_1 509 515 PF00069 0.520
MOD_ProDKin_1 526 532 PF00069 0.465
MOD_SUMO_for_1 164 167 PF00179 0.267
MOD_SUMO_for_1 82 85 PF00179 0.186
MOD_SUMO_rev_2 131 140 PF00179 0.213
MOD_SUMO_rev_2 158 166 PF00179 0.186
TRG_DiLeu_BaEn_1 108 113 PF01217 0.200
TRG_DiLeu_BaEn_1 63 68 PF01217 0.200
TRG_DiLeu_BaEn_4 137 143 PF01217 0.278
TRG_DiLeu_BaEn_4 361 367 PF01217 0.462
TRG_DiLeu_BaLyEn_6 212 217 PF01217 0.218
TRG_ENDOCYTIC_2 145 148 PF00928 0.186
TRG_ENDOCYTIC_2 239 242 PF00928 0.203
TRG_ENDOCYTIC_2 247 250 PF00928 0.295
TRG_ENDOCYTIC_2 262 265 PF00928 0.340
TRG_ENDOCYTIC_2 320 323 PF00928 0.271
TRG_ENDOCYTIC_2 34 37 PF00928 0.349
TRG_ER_diArg_1 364 367 PF00400 0.369
TRG_ER_diArg_1 450 452 PF00400 0.578
TRG_ER_diArg_1 456 459 PF00400 0.552
TRG_ER_diArg_1 471 473 PF00400 0.493
TRG_ER_diLys_1 628 631 PF00400 0.479

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1M7 Leptomonas seymouri 83% 98%
A0A0S4IX25 Bodo saltans 45% 97%
A0A0S4J320 Bodo saltans 24% 100%
A0A0S4JVD7 Bodo saltans 25% 100%
A0A1X0P6L8 Trypanosomatidae 67% 100%
A0A3R7LU08 Trypanosoma rangeli 65% 100%
A0A3S5H5G0 Leishmania donovani 28% 100%
A0A3S7WV74 Leishmania donovani 100% 100%
A0A3S7WY10 Leishmania donovani 26% 100%
A0A3S7X8Z8 Leishmania donovani 26% 100%
A0A422P2B2 Trypanosoma rangeli 25% 100%
A4H459 Leishmania braziliensis 29% 100%
A4H4S9 Leishmania braziliensis 27% 100%
A4H9X1 Leishmania braziliensis 92% 100%
A4HCD7 Leishmania braziliensis 29% 100%
A4HSE2 Leishmania infantum 28% 100%
A4IB02 Leishmania infantum 26% 100%
D0A0D2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 99%
E9AET0 Leishmania major 25% 100%
E9AH34 Leishmania infantum 26% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9ARW5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 99%
E9AWL2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
Q42396 Arabidopsis thaliana 28% 100%
Q4QAV8 Leishmania major 26% 100%
Q4QDK7 Leishmania major 98% 100%
Q4QIV8 Leishmania major 25% 100%
Q4QJJ0 Leishmania major 27% 100%
Q7TNJ7 Rattus norvegicus 28% 100%
Q852Q2 Oryza sativa subsp. japonica 26% 100%
V5DTI3 Trypanosoma cruzi 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS