QA-SNARE protein putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania infantum

UniProt:

E9AGR4_LEIIN

TriTrypDb:

LINF_190006000

Length:

229

Annotations

Annotations by Jardim et al.

Vesicle mediated transport, QA-SNARE

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

E9AGR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGR4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0016192	vesicle-mediated transport	4	6
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0006886	intracellular protein transport	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.609
CLV_NRD_NRD_1	197	199	PF00675	0.272
CLV_NRD_NRD_1	202	204	PF00675	0.282
CLV_NRD_NRD_1	43	45	PF00675	0.335
CLV_NRD_NRD_1	90	92	PF00675	0.383
CLV_PCSK_FUR_1	41	45	PF00082	0.390
CLV_PCSK_KEX2_1	197	199	PF00082	0.266
CLV_PCSK_KEX2_1	43	45	PF00082	0.420
CLV_PCSK_KEX2_1	90	92	PF00082	0.410
CLV_PCSK_PC7_1	39	45	PF00082	0.416
CLV_PCSK_SKI1_1	78	82	PF00082	0.439
DEG_APCC_DBOX_1	38	46	PF00400	0.601
DOC_MAPK_gen_1	39	47	PF00069	0.580
DOC_MAPK_MEF2A_6	41	49	PF00069	0.547
DOC_USP7_MATH_1	23	27	PF00917	0.623
LIG_14-3-3_CanoR_1	197	203	PF00244	0.562
LIG_14-3-3_CanoR_1	93	97	PF00244	0.658
LIG_BIR_III_2	62	66	PF00653	0.652
LIG_FHA_1	173	179	PF00498	0.496
LIG_FHA_1	216	222	PF00498	0.415
LIG_FHA_2	115	121	PF00498	0.753
LIG_FHA_2	30	36	PF00498	0.574
LIG_FHA_2	87	93	PF00498	0.619
LIG_LIR_Gen_1	159	164	PF02991	0.598
LIG_LIR_Nem_3	159	163	PF02991	0.597
LIG_LIR_Nem_3	201	205	PF02991	0.546
LIG_PCNA_yPIPBox_3	46	60	PF02747	0.597
LIG_PCNA_yPIPBox_3	71	84	PF02747	0.569
LIG_SH2_STAT3	74	77	PF00017	0.587
LIG_SUMO_SIM_anti_2	218	225	PF11976	0.412
LIG_SUMO_SIM_par_1	212	218	PF11976	0.433
LIG_SUMO_SIM_par_1	219	225	PF11976	0.452
LIG_TRAF2_1	156	159	PF00917	0.639
MOD_CK2_1	100	106	PF00069	0.731
MOD_CK2_1	114	120	PF00069	0.752
MOD_CK2_1	139	145	PF00069	0.673
MOD_CK2_1	180	186	PF00069	0.496
MOD_CK2_1	23	29	PF00069	0.659
MOD_CK2_1	51	57	PF00069	0.548
MOD_CK2_1	58	64	PF00069	0.609
MOD_CK2_1	86	92	PF00069	0.626
MOD_GlcNHglycan	141	144	PF01048	0.502
MOD_GlcNHglycan	208	211	PF01048	0.480
MOD_GSK3_1	124	131	PF00069	0.624
MOD_GSK3_1	172	179	PF00069	0.501
MOD_GSK3_1	18	25	PF00069	0.619
MOD_GSK3_1	92	99	PF00069	0.648
MOD_N-GLC_1	124	129	PF02516	0.474
MOD_N-GLC_1	176	181	PF02516	0.313
MOD_NEK2_1	66	71	PF00069	0.615
MOD_NEK2_2	23	28	PF00069	0.631
MOD_PKA_2	172	178	PF00069	0.533
MOD_PKA_2	92	98	PF00069	0.638
MOD_Plk_2-3	100	106	PF00069	0.727
MOD_Plk_2-3	128	134	PF00069	0.665
MOD_Plk_2-3	180	186	PF00069	0.562
MOD_Plk_2-3	58	64	PF00069	0.637
MOD_Plk_4	159	165	PF00069	0.620
MOD_Plk_4	215	221	PF00069	0.342
MOD_SUMO_rev_2	147	156	PF00179	0.636
TRG_DiLeu_BaEn_1	159	164	PF01217	0.570
TRG_DiLeu_BaEn_1	180	185	PF01217	0.562
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.578
TRG_ENDOCYTIC_2	157	160	PF00928	0.590
TRG_ER_diArg_1	197	200	PF00400	0.521
TRG_ER_diArg_1	41	44	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K8	Leptomonas seymouri	73%	100%
A0A0S4IVI2	Bodo saltans	37%	93%
A0A1X0P7H4	Trypanosomatidae	45%	96%
A0A3Q8IJV6	Leishmania donovani	100%	100%
A0A422ND16	Trypanosoma rangeli	45%	97%
A4H9W9	Leishmania braziliensis	80%	100%
E9ARW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QDK9	Leishmania major	94%	100%
V5BBT6	Trypanosoma cruzi	47%	97%