Clathrin light chain

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Clathrin light chain - putative

Species:

Leishmania infantum

UniProt:

E9AGR3_LEIIN

TriTrypDb:

LINF_190005900

Length:

291

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0030117	membrane coat	3	3
GO:0030118	clathrin coat	4	3
GO:0030120	vesicle coat	4	3
GO:0030125	clathrin vesicle coat	5	3
GO:0030130	clathrin coat of trans-Golgi network vesicle	6	3
GO:0030132	clathrin coat of coated pit	4	3
GO:0032991	protein-containing complex	1	3
GO:0098796	membrane protein complex	2	3
GO:0098797	plasma membrane protein complex	3	3
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGR3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006886	intracellular protein transport	4	3
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016192	vesicle-mediated transport	4	3
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046907	intracellular transport	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	222	224	PF00082	0.556
CLV_PCSK_KEX2_1	249	251	PF00082	0.434
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.540
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.434
CLV_PCSK_SKI1_1	207	211	PF00082	0.423
CLV_PCSK_SKI1_1	278	282	PF00082	0.511
DEG_APCC_DBOX_1	277	285	PF00400	0.540
DEG_Nend_UBRbox_2	1	3	PF02207	0.623
DOC_CKS1_1	168	173	PF01111	0.814
DOC_CKS1_1	95	100	PF01111	0.856
DOC_PP2B_LxvP_1	114	117	PF13499	0.740
DOC_PP2B_LxvP_1	74	77	PF13499	0.665
DOC_PP4_MxPP_1	147	150	PF00568	0.824
DOC_USP7_MATH_1	102	106	PF00917	0.757
DOC_USP7_MATH_1	230	234	PF00917	0.434
DOC_USP7_MATH_1	34	38	PF00917	0.852
DOC_USP7_MATH_1	6	10	PF00917	0.827
DOC_USP7_MATH_1	66	70	PF00917	0.752
DOC_USP7_MATH_1	77	81	PF00917	0.633
DOC_USP7_MATH_2	171	177	PF00917	0.809
DOC_USP7_UBL2_3	231	235	PF12436	0.540
DOC_WW_Pin1_4	12	17	PF00397	0.840
DOC_WW_Pin1_4	133	138	PF00397	0.790
DOC_WW_Pin1_4	140	145	PF00397	0.689
DOC_WW_Pin1_4	157	162	PF00397	0.586
DOC_WW_Pin1_4	167	172	PF00397	0.571
DOC_WW_Pin1_4	22	27	PF00397	0.692
DOC_WW_Pin1_4	30	35	PF00397	0.564
DOC_WW_Pin1_4	61	66	PF00397	0.851
DOC_WW_Pin1_4	94	99	PF00397	0.849
LIG_14-3-3_CanoR_1	278	288	PF00244	0.508
LIG_APCC_ABBA_1	50	55	PF00400	0.855
LIG_BRCT_BRCA1_1	151	155	PF00533	0.827
LIG_EVH1_1	114	118	PF00568	0.740
LIG_FHA_2	168	174	PF00498	0.698
LIG_LIR_Apic_2	2	8	PF02991	0.822
LIG_LIR_Apic_2	92	98	PF02991	0.847
LIG_MYND_1	16	20	PF01753	0.848
LIG_SH2_STAT5	215	218	PF00017	0.540
LIG_SH3_2	169	174	PF14604	0.714
LIG_SH3_3	10	16	PF00018	0.838
LIG_SH3_3	112	118	PF00018	0.574
LIG_SH3_3	131	137	PF00018	0.540
LIG_SH3_3	162	168	PF00018	0.824
LIG_SH3_3	169	175	PF00018	0.706
LIG_SH3_3	59	65	PF00018	0.788
LIG_SH3_3	82	88	PF00018	0.743
LIG_SH3_3	95	101	PF00018	0.779
LIG_SUMO_SIM_par_1	124	130	PF11976	0.857
LIG_TRAF2_1	211	214	PF00917	0.540
LIG_UBA3_1	260	266	PF00899	0.540
MOD_CDC14_SPxK_1	164	167	PF00782	0.718
MOD_CDK_SPxK_1	161	167	PF00069	0.723
MOD_CDK_SPxxK_3	167	174	PF00069	0.817
MOD_CK1_1	22	28	PF00069	0.643
MOD_CK1_1	271	277	PF00069	0.540
MOD_CK1_1	33	39	PF00069	0.679
MOD_CK1_1	43	49	PF00069	0.691
MOD_CK1_1	9	15	PF00069	0.835
MOD_CK2_1	124	130	PF00069	0.809
MOD_CK2_1	133	139	PF00069	0.758
MOD_CK2_1	167	173	PF00069	0.815
MOD_CK2_1	230	236	PF00069	0.434
MOD_CK2_1	66	72	PF00069	0.724
MOD_DYRK1A_RPxSP_1	167	171	PF00069	0.780
MOD_GlcNHglycan	104	107	PF01048	0.761
MOD_GlcNHglycan	175	178	PF01048	0.783
MOD_GlcNHglycan	2	5	PF01048	0.676
MOD_GlcNHglycan	250	253	PF01048	0.540
MOD_GlcNHglycan	255	258	PF01048	0.402
MOD_GlcNHglycan	68	71	PF01048	0.860
MOD_GlcNHglycan	74	77	PF01048	0.755
MOD_GlcNHglycan	8	11	PF01048	0.697
MOD_GSK3_1	129	136	PF00069	0.692
MOD_GSK3_1	145	152	PF00069	0.796
MOD_GSK3_1	157	164	PF00069	0.628
MOD_GSK3_1	203	210	PF00069	0.434
MOD_GSK3_1	276	283	PF00069	0.434
MOD_GSK3_1	30	37	PF00069	0.845
MOD_GSK3_1	57	64	PF00069	0.858
MOD_N-GLC_1	43	48	PF02516	0.850
MOD_NEK2_1	155	160	PF00069	0.836
MOD_NEK2_1	40	45	PF00069	0.849
MOD_PKA_2	6	12	PF00069	0.726
MOD_Plk_1	43	49	PF00069	0.848
MOD_ProDKin_1	12	18	PF00069	0.841
MOD_ProDKin_1	133	139	PF00069	0.790
MOD_ProDKin_1	140	146	PF00069	0.690
MOD_ProDKin_1	157	163	PF00069	0.583
MOD_ProDKin_1	167	173	PF00069	0.573
MOD_ProDKin_1	22	28	PF00069	0.691
MOD_ProDKin_1	30	36	PF00069	0.565
MOD_ProDKin_1	61	67	PF00069	0.853
MOD_ProDKin_1	94	100	PF00069	0.852
MOD_SUMO_for_1	221	224	PF00179	0.434
MOD_SUMO_rev_2	203	209	PF00179	0.427
MOD_SUMO_rev_2	243	251	PF00179	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H749	Leishmania donovani	100%	74%