Putative fibrillarin

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fibrillarin - putative

Species:

Leishmania infantum

UniProt:

E9AGR2_LEIIN

TriTrypDb:

LINF_190005800

Length:

294

Annotations

Annotations by Jardim et al.

RNA Processing, fibrillarin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	2
GO:0030684	preribosome	3	2
GO:0031428	box C/D RNP complex	4	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2
GO:0005634	nucleus	5	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

E9AGR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGR2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	24
GO:0006364	rRNA processing	8	24
GO:0006396	RNA processing	6	24
GO:0006725	cellular aromatic compound metabolic process	3	24
GO:0006807	nitrogen compound metabolic process	2	24
GO:0008152	metabolic process	1	24
GO:0009987	cellular process	1	24
GO:0016070	RNA metabolic process	5	24
GO:0016072	rRNA metabolic process	7	24
GO:0032259	methylation	2	24
GO:0034470	ncRNA processing	7	24
GO:0034641	cellular nitrogen compound metabolic process	3	24
GO:0034660	ncRNA metabolic process	6	24
GO:0043170	macromolecule metabolic process	3	24
GO:0044237	cellular metabolic process	2	24
GO:0044238	primary metabolic process	2	24
GO:0046483	heterocycle metabolic process	3	24
GO:0071704	organic substance metabolic process	2	24
GO:0090304	nucleic acid metabolic process	4	24
GO:1901360	organic cyclic compound metabolic process	3	24
GO:0000154	rRNA modification	6	2
GO:0000494	box C/D RNA 3'-end processing	10	2
GO:0001510	RNA methylation	4	2
GO:0006479	protein methylation	4	2
GO:0008213	protein alkylation	5	2
GO:0009451	RNA modification	5	2
GO:0016074	sno(s)RNA metabolic process	7	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018364	peptidyl-glutamine methylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0031123	RNA 3'-end processing	7	2
GO:0031126	sno(s)RNA 3'-end processing	9	2
GO:0031167	rRNA methylation	5	2
GO:0033967	box C/D RNA metabolic process	8	2
GO:0034963	box C/D RNA processing	9	2
GO:0036211	protein modification process	4	2
GO:0043144	sno(s)RNA processing	8	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0043628	regulatory ncRNA 3'-end processing	8	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1990258	histone glutamine methylation	6	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	24
GO:0003723	RNA binding	4	24
GO:0003824	catalytic activity	1	24
GO:0005488	binding	1	24
GO:0008168	methyltransferase activity	4	24
GO:0016740	transferase activity	2	24
GO:0016741	transferase activity, transferring one-carbon groups	3	24
GO:0097159	organic cyclic compound binding	2	24
GO:1901363	heterocyclic compound binding	2	24
GO:0008170	N-methyltransferase activity	5	2
GO:0008173	RNA methyltransferase activity	4	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008649	rRNA methyltransferase activity	5	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0036009	protein-glutamine N-methyltransferase activity	4	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140102	catalytic activity, acting on a rRNA	4	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1990259	histone H2AQ104 methyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.217
CLV_PCSK_KEX2_1	178	180	PF00082	0.233
CLV_PCSK_KEX2_1	92	94	PF00082	0.198
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.209
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.198
DEG_Nend_UBRbox_1	1	4	PF02207	0.463
DOC_ANK_TNKS_1	79	86	PF00023	0.349
DOC_MAPK_DCC_7	80	88	PF00069	0.198
DOC_MAPK_gen_1	178	186	PF00069	0.198
DOC_MAPK_gen_1	266	273	PF00069	0.298
DOC_MAPK_MEF2A_6	80	88	PF00069	0.206
DOC_USP7_MATH_1	112	116	PF00917	0.184
DOC_USP7_MATH_1	84	88	PF00917	0.174
DOC_USP7_MATH_1	99	103	PF00917	0.223
DOC_USP7_MATH_2	267	273	PF00917	0.212
DOC_WW_Pin1_4	50	55	PF00397	0.415
LIG_APCC_ABBA_1	86	91	PF00400	0.198
LIG_BRCT_BRCA1_1	103	107	PF00533	0.198
LIG_FHA_1	77	83	PF00498	0.270
LIG_IBAR_NPY_1	111	113	PF08397	0.198
LIG_LIR_Apic_2	127	132	PF02991	0.351
LIG_LIR_Gen_1	205	214	PF02991	0.212
LIG_LIR_Nem_3	119	125	PF02991	0.331
LIG_LIR_Nem_3	205	211	PF02991	0.215
LIG_LIR_Nem_3	284	290	PF02991	0.262
LIG_MYND_3	184	188	PF01753	0.211
LIG_SH2_CRK	122	126	PF00017	0.207
LIG_SH2_CRK	196	200	PF00017	0.233
LIG_SH2_CRK	287	291	PF00017	0.360
LIG_SH2_STAP1	161	165	PF00017	0.198
LIG_SH2_STAT5	138	141	PF00017	0.198
LIG_SH2_STAT5	69	72	PF00017	0.250
LIG_SH3_3	106	112	PF00018	0.258
LIG_SH3_3	208	214	PF00018	0.198
MOD_CDK_SPK_2	50	55	PF00069	0.415
MOD_CK1_1	143	149	PF00069	0.190
MOD_CK1_1	166	172	PF00069	0.190
MOD_CK1_1	78	84	PF00069	0.254
MOD_CK1_1	87	93	PF00069	0.245
MOD_GlcNHglycan	118	121	PF01048	0.303
MOD_GlcNHglycan	133	136	PF01048	0.141
MOD_GlcNHglycan	142	145	PF01048	0.144
MOD_GlcNHglycan	168	171	PF01048	0.161
MOD_GlcNHglycan	262	265	PF01048	0.234
MOD_GlcNHglycan	30	33	PF01048	0.607
MOD_GlcNHglycan	38	41	PF01048	0.617
MOD_GSK3_1	112	119	PF00069	0.349
MOD_GSK3_1	174	181	PF00069	0.263
MOD_N-GLC_1	94	99	PF02516	0.349
MOD_N-GLC_2	66	68	PF02516	0.349
MOD_NEK2_1	234	239	PF00069	0.196
MOD_NEK2_1	260	265	PF00069	0.212
MOD_NEK2_2	124	129	PF00069	0.265
MOD_NEK2_2	84	89	PF00069	0.198
MOD_PKA_1	178	184	PF00069	0.263
MOD_PKA_2	178	184	PF00069	0.263
MOD_PKA_2	28	34	PF00069	0.616
MOD_PKA_2	36	42	PF00069	0.619
MOD_Plk_2-3	269	275	PF00069	0.198
MOD_Plk_4	124	130	PF00069	0.295
MOD_Plk_4	84	90	PF00069	0.174
MOD_ProDKin_1	50	56	PF00069	0.401
TRG_ENDOCYTIC_2	122	125	PF00928	0.198
TRG_ENDOCYTIC_2	196	199	PF00928	0.233
TRG_ENDOCYTIC_2	287	290	PF00928	0.429
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.204

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A3	Leptomonas seymouri	68%	96%
A0A0N1PA75	Leptomonas seymouri	95%	98%
A0A0S4IYN2	Bodo saltans	75%	95%
A0A0S4J8H3	Bodo saltans	69%	99%
A0A1X0NKM9	Trypanosomatidae	69%	97%
A0A1X0P6R0	Trypanosomatidae	88%	96%
A0A3Q8ID71	Leishmania donovani	100%	98%
A0A3S5H830	Leishmania donovani	68%	96%
A0A422NCX2	Trypanosoma rangeli	88%	100%
A0A422NM05	Trypanosoma rangeli	69%	100%
A0B6X7	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	40%	100%
A1RRJ7	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	44%	100%
A3DNY7	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	44%	100%
A3MV65	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	45%	100%
A4FYN1	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	43%	100%
A4H9W7	Leishmania braziliensis	99%	68%
A4HPH3	Leishmania braziliensis	68%	98%
A4ID95	Leishmania infantum	68%	98%
A4WKL2	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	45%	100%
A6NHQ2	Homo sapiens	61%	88%
A6UV22	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	42%	100%
A6VJQ1	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	43%	100%
A9A6C8	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	44%	100%
B1YAJ6	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	46%	100%
B6YXH6	Thermococcus onnurineus (strain NA1)	49%	100%
C3MPR8	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	44%	100%
C3MYR2	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	44%	100%
C3N5E4	Sulfolobus islandicus (strain M.16.27)	44%	100%
C3NDZ8	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	44%	100%
C3NHQ5	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	44%	100%
C4KH10	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	44%	100%
C5A403	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	49%	100%
C6A2L3	Thermococcus sibiricus (strain DSM 12597 / MM 739)	47%	100%
D0A0B7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	92%	100%
D0A0D0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	91%	97%
D0A3I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	98%
E9ARW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9AT85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	98%
O27283	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	42%	100%
O28192	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	42%	100%
O57811	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	45%	100%
P0CW09	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	46%	100%
P15646	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	61%	90%
P22087	Homo sapiens	61%	92%
P22232	Xenopus laevis	61%	91%
P22509	Rattus norvegicus	61%	90%
P35549	Leishmania major	68%	99%
P35550	Mus musculus	61%	90%
P35551	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	61%	96%
P35552	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	43%	100%
P35553	Methanococcus voltae	42%	100%
P58032	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	44%	100%
Q22053	Caenorhabditis elegans	62%	84%
Q24957	Giardia intestinalis	55%	90%
Q27200	Tetrahymena thermophila	60%	100%
Q46EB1	Methanosarcina barkeri (strain Fusaro / DSM 804)	47%	100%
Q4Q1B2	Leishmania major	68%	98%
Q4QDL1	Leishmania major	99%	100%
Q55CW0	Dictyostelium discoideum	54%	88%
Q58108	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	43%	100%
Q5JFN1	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	49%	100%
Q6BQ34	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	58%	89%
Q6FN88	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	59%	91%
Q6LZM7	Methanococcus maripaludis (strain S2 / LL)	45%	100%
Q74N89	Nanoarchaeum equitans (strain Kin4-M)	40%	100%
Q756P0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	58%	90%
Q80WS3	Mus musculus	63%	94%
Q8I1F4	Drosophila erecta	64%	85%
Q8SR42	Encephalitozoon cuniculi (strain GB-M1)	57%	100%
Q8TTT4	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	44%	100%
Q8TXU9	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	44%	100%
Q8U4M2	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	45%	100%
Q8ZTI9	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	44%	100%
Q94AH9	Arabidopsis thaliana	66%	92%
Q971W2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	44%	100%
Q979P2	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	36%	100%
Q9FEF8	Arabidopsis thaliana	66%	95%
Q9FHB3	Arabidopsis thaliana	52%	100%
Q9HE26	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	60%	91%
Q9HH35	Methanothermobacter wolfeii	44%	100%
Q9HJL8	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	35%	100%
Q9P9M0	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	44%	100%
Q9V2L5	Pyrococcus abyssi (strain GE5 / Orsay)	45%	100%
Q9W1V3	Drosophila melanogaster	64%	85%
Q9Y9U3	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	45%	100%
V5BFQ9	Trypanosoma cruzi	67%	94%
V5BS95	Trypanosoma cruzi	89%	100%