LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

40S ribosomal protein S2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
40S ribosomal protein S2
Gene product:
40S ribosomal protein S2
Species:
Leishmania infantum
UniProt:
E9AGQ8_LEIIN
TriTrypDb:
LINF_190005400
Length:
265

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal S2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 21
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0015935 small ribosomal subunit 4 16
GO:0032991 protein-containing complex 1 16
GO:0044391 ribosomal subunit 3 16
GO:1990904 ribonucleoprotein complex 2 16
GO:0022627 cytosolic small ribosomal subunit 5 2
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AGQ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGQ8

PDB structure(s): 6az1_F

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 16
GO:0006518 peptide metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009058 biosynthetic process 2 16
GO:0009059 macromolecule biosynthetic process 4 16
GO:0009987 cellular process 1 16
GO:0019538 protein metabolic process 3 16
GO:0034641 cellular nitrogen compound metabolic process 3 16
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 16
GO:0043043 peptide biosynthetic process 5 16
GO:0043170 macromolecule metabolic process 3 16
GO:0043603 amide metabolic process 3 16
GO:0043604 amide biosynthetic process 4 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0044249 cellular biosynthetic process 3 16
GO:0044260 obsolete cellular macromolecule metabolic process 3 16
GO:0044271 cellular nitrogen compound biosynthetic process 4 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
GO:1901566 organonitrogen compound biosynthetic process 4 16
GO:1901576 organic substance biosynthetic process 3 16
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 16
GO:0003723 RNA binding 4 16
GO:0003735 structural constituent of ribosome 2 16
GO:0005198 structural molecule activity 1 16
GO:0005488 binding 1 16
GO:0097159 organic cyclic compound binding 2 16
GO:1901363 heterocyclic compound binding 2 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 125 131 PF00089 0.347
CLV_NRD_NRD_1 152 154 PF00675 0.393
CLV_NRD_NRD_1 230 232 PF00675 0.347
CLV_PCSK_KEX2_1 152 154 PF00082 0.393
CLV_PCSK_SKI1_1 197 201 PF00082 0.367
CLV_PCSK_SKI1_1 53 57 PF00082 0.452
DEG_SPOP_SBC_1 208 212 PF00917 0.347
DOC_CKS1_1 236 241 PF01111 0.347
DOC_CYCLIN_RxL_1 195 206 PF00134 0.347
DOC_MAPK_gen_1 128 137 PF00069 0.347
DOC_MAPK_HePTP_8 125 137 PF00069 0.347
DOC_MAPK_MEF2A_6 128 137 PF00069 0.347
DOC_MAPK_MEF2A_6 173 181 PF00069 0.347
DOC_PP1_RVXF_1 196 203 PF00149 0.344
DOC_PP4_FxxP_1 236 239 PF00568 0.347
DOC_PP4_FxxP_1 69 72 PF00568 0.453
DOC_USP7_UBL2_3 169 173 PF12436 0.436
DOC_WW_Pin1_4 235 240 PF00397 0.347
LIG_14-3-3_CanoR_1 138 142 PF00244 0.347
LIG_14-3-3_CanoR_1 231 235 PF00244 0.361
LIG_BIR_II_1 1 5 PF00653 0.685
LIG_FHA_1 186 192 PF00498 0.367
LIG_FHA_1 236 242 PF00498 0.335
LIG_FHA_2 59 65 PF00498 0.440
LIG_LIR_Apic_2 233 239 PF02991 0.347
LIG_LIR_Nem_3 108 113 PF02991 0.347
LIG_LIR_Nem_3 201 205 PF02991 0.349
LIG_LIR_Nem_3 226 230 PF02991 0.347
LIG_LIR_Nem_3 233 237 PF02991 0.347
LIG_PCNA_yPIPBox_3 215 228 PF02747 0.347
LIG_PDZ_Class_1 260 265 PF00595 0.618
LIG_SH2_CRK 234 238 PF00017 0.347
LIG_SH2_STAT3 96 99 PF00017 0.491
LIG_SH2_STAT5 209 212 PF00017 0.347
LIG_SH3_3 179 185 PF00018 0.346
LIG_SH3_3 188 194 PF00018 0.333
LIG_TRAF2_1 39 42 PF00917 0.730
LIG_TRAF2_1 6 9 PF00917 0.614
LIG_TRAF2_1 62 65 PF00917 0.445
LIG_UBA3_1 68 74 PF00899 0.475
LIG_UBA3_1 92 100 PF00899 0.367
LIG_WRC_WIRS_1 224 229 PF05994 0.347
MOD_CK2_1 58 64 PF00069 0.459
MOD_GlcNHglycan 102 105 PF01048 0.347
MOD_GSK3_1 209 216 PF00069 0.334
MOD_GSK3_1 245 252 PF00069 0.515
MOD_NEK2_1 1 6 PF00069 0.585
MOD_NEK2_1 168 173 PF00069 0.476
MOD_NEK2_1 230 235 PF00069 0.347
MOD_NEK2_1 67 72 PF00069 0.458
MOD_PIKK_1 1 7 PF00454 0.582
MOD_PK_1 173 179 PF00069 0.347
MOD_PKA_2 137 143 PF00069 0.347
MOD_PKA_2 185 191 PF00069 0.367
MOD_PKA_2 230 236 PF00069 0.361
MOD_Plk_1 131 137 PF00069 0.347
MOD_Plk_4 137 143 PF00069 0.342
MOD_Plk_4 223 229 PF00069 0.347
MOD_Plk_4 78 84 PF00069 0.535
MOD_ProDKin_1 235 241 PF00069 0.347
TRG_DiLeu_BaEn_1 254 259 PF01217 0.633
TRG_ENDOCYTIC_2 234 237 PF00928 0.347
TRG_ER_diArg_1 107 110 PF00400 0.347
TRG_ER_diArg_1 151 153 PF00400 0.341

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8J1 Leptomonas seymouri 92% 100%
A0A0S4IWW3 Bodo saltans 84% 99%
A0A1X0P6Q2 Trypanosomatidae 91% 100%
A0A3Q8IED5 Leishmania donovani 100% 100%
A0A3S7X558 Leishmania donovani 97% 100%
A0A422N1E2 Trypanosoma rangeli 89% 100%
A0B9V0 Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) 46% 100%
A0RUE7 Cenarchaeum symbiosum (strain A) 40% 100%
A1RU37 Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) 47% 100%
A1RWR6 Thermofilum pendens (strain DSM 2475 / Hrk 5) 45% 100%
A2BMD9 Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) 46% 100%
A2SPM2 Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) 45% 100%
A3CT17 Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) 44% 100%
A3DNC7 Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) 46% 100%
A3MU88 Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) 46% 100%
A4FWA1 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 41% 100%
A4H9W3 Leishmania braziliensis 92% 100%
A4HK25 Leishmania braziliensis 92% 100%
A4I7K9 Leishmania infantum 97% 100%
A4WHQ8 Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) 45% 100%
A4YCY6 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) 45% 100%
A5UL68 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 43% 100%
A6UQ64 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 41% 100%
A6UWV8 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) 40% 100%
A6VH05 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 41% 100%
A7I5Q9 Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8) 42% 100%
A8AC00 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) 47% 100%
A9A9P4 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 41% 100%
C3NH89 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 44% 100%
D0A0B4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 89% 100%
E9ARV7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 100%
E9B2G6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O05641 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 43% 100%
O18789 Bos taurus 62% 90%
O26131 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 43% 100%
O28374 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 44% 100%
O43992 Leishmania amazonensis 98% 100%
O59439 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 43% 100%
O74892 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 62% 100%
P14036 Methanococcus vannielii 41% 100%
P15880 Homo sapiens 62% 90%
P25443 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 62% 100%
P25444 Mus musculus 62% 90%
P26815 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 40% 100%
P27685 Dictyostelium discoideum 61% 100%
P27952 Rattus norvegicus 62% 90%
P31009 Drosophila melanogaster 61% 99%
P46791 Cricetulus griseus 66% 100%
P49154 Urechis caupo 62% 95%
P49688 Arabidopsis thaliana 65% 93%
P51403 Caenorhabditis elegans 62% 97%
P54045 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 44% 100%
Q0W1W8 Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) 44% 100%
Q12ZT1 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 44% 100%
Q18GG9 Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) 40% 100%
Q2FSG3 Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1) 46% 100%
Q2NFX7 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 38% 100%
Q3IMW8 Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) 41% 100%
Q46GB5 Methanosarcina barkeri (strain Fusaro / DSM 804) 45% 100%
Q4Q5P0 Leishmania major 97% 100%
Q4QDL5 Leishmania major 99% 100%
Q5A900 Candida albicans (strain SC5314 / ATCC MYA-2876) 59% 100%
Q5JJG8 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 45% 100%
Q6L1A7 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) 42% 100%
Q6LXD3 Methanococcus maripaludis (strain S2 / LL) 41% 100%
Q74MD4 Nanoarchaeum equitans (strain Kin4-M) 43% 100%
Q8L8Y0 Arabidopsis thaliana 65% 93%
Q8PV30 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 43% 100%
Q8TRS7 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 43% 100%
Q8TZA6 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 46% 100%
Q8U017 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 44% 100%
Q8ZXN9 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 46% 100%
Q90YS3 Ictalurus punctatus 61% 96%
Q93VB8 Arabidopsis thaliana 65% 93%
Q975K0 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 46% 100%
Q97BV6 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 41% 100%
Q9HIS7 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 41% 100%
Q9HPB4 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 43% 100%
Q9RSL1 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) 29% 100%
Q9SCM3 Arabidopsis thaliana 65% 96%
Q9UX87 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 43% 100%
Q9V1V5 Pyrococcus abyssi (strain GE5 / Orsay) 42% 100%
Q9YF95 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 47% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS