LeishMANIAdb
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Putative heat shock protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative heat shock protein
Gene product:
heat shock protein 110 - putative
Species:
Leishmania infantum
UniProt:
E9AGQ5_LEIIN
TriTrypDb:
LINF_180019100
Length:
822

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Annotations by Jardim et al.

Chaperone/Protein Folding, heat shock

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 2
Pissara et al. yes yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0043226 organelle 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Phosphorylation

Amastigote: 419, 421

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AGQ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGQ5

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0044183 protein folding chaperone 1 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140657 ATP-dependent activity 1 12
GO:0140662 ATP-dependent protein folding chaperone 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 525 529 PF00656 0.504
CLV_NRD_NRD_1 159 161 PF00675 0.265
CLV_NRD_NRD_1 586 588 PF00675 0.454
CLV_NRD_NRD_1 664 666 PF00675 0.482
CLV_PCSK_KEX2_1 159 161 PF00082 0.279
CLV_PCSK_KEX2_1 267 269 PF00082 0.272
CLV_PCSK_KEX2_1 32 34 PF00082 0.274
CLV_PCSK_KEX2_1 357 359 PF00082 0.333
CLV_PCSK_KEX2_1 664 666 PF00082 0.427
CLV_PCSK_KEX2_1 68 70 PF00082 0.264
CLV_PCSK_PC1ET2_1 267 269 PF00082 0.272
CLV_PCSK_PC1ET2_1 32 34 PF00082 0.279
CLV_PCSK_PC1ET2_1 357 359 PF00082 0.333
CLV_PCSK_PC1ET2_1 68 70 PF00082 0.264
CLV_PCSK_SKI1_1 281 285 PF00082 0.264
CLV_PCSK_SKI1_1 396 400 PF00082 0.410
CLV_PCSK_SKI1_1 431 435 PF00082 0.365
CLV_PCSK_SKI1_1 555 559 PF00082 0.517
CLV_PCSK_SKI1_1 82 86 PF00082 0.270
CLV_PCSK_SKI1_1 98 102 PF00082 0.248
DEG_APCC_DBOX_1 267 275 PF00400 0.279
DEG_APCC_KENBOX_2 540 544 PF00400 0.766
DOC_CDC14_PxL_1 403 411 PF14671 0.451
DOC_CYCLIN_RxL_1 278 285 PF00134 0.264
DOC_CYCLIN_RxL_1 79 88 PF00134 0.263
DOC_MAPK_gen_1 256 263 PF00069 0.267
DOC_MAPK_gen_1 267 273 PF00069 0.261
DOC_MAPK_gen_1 444 450 PF00069 0.495
DOC_MAPK_gen_1 558 567 PF00069 0.399
DOC_MAPK_gen_1 679 688 PF00069 0.452
DOC_MAPK_MEF2A_6 561 569 PF00069 0.389
DOC_PP1_RVXF_1 701 708 PF00149 0.490
DOC_PP1_RVXF_1 80 87 PF00149 0.373
DOC_PP1_RVXF_1 96 102 PF00149 0.214
DOC_PP2B_LxvP_1 741 744 PF13499 0.544
DOC_USP7_MATH_1 286 290 PF00917 0.329
DOC_USP7_MATH_1 334 338 PF00917 0.209
DOC_USP7_MATH_1 374 378 PF00917 0.391
DOC_USP7_MATH_1 438 442 PF00917 0.477
DOC_USP7_MATH_1 451 455 PF00917 0.411
DOC_USP7_MATH_1 551 555 PF00917 0.733
DOC_USP7_MATH_1 779 783 PF00917 0.665
DOC_USP7_UBL2_3 555 559 PF12436 0.478
DOC_USP7_UBL2_3 769 773 PF12436 0.571
DOC_WW_Pin1_4 387 392 PF00397 0.264
DOC_WW_Pin1_4 416 421 PF00397 0.555
DOC_WW_Pin1_4 527 532 PF00397 0.495
LIG_14-3-3_CanoR_1 124 129 PF00244 0.329
LIG_14-3-3_CanoR_1 191 196 PF00244 0.264
LIG_14-3-3_CanoR_1 309 313 PF00244 0.291
LIG_14-3-3_CanoR_1 418 424 PF00244 0.466
LIG_14-3-3_CanoR_1 449 459 PF00244 0.413
LIG_14-3-3_CanoR_1 618 628 PF00244 0.441
LIG_14-3-3_CanoR_1 664 670 PF00244 0.448
LIG_14-3-3_CanoR_1 98 104 PF00244 0.389
LIG_Actin_WH2_2 182 198 PF00022 0.410
LIG_BIR_II_1 1 5 PF00653 0.279
LIG_BIR_III_2 528 532 PF00653 0.562
LIG_BRCT_BRCA1_1 389 393 PF00533 0.264
LIG_BRCT_BRCA1_1 421 425 PF00533 0.471
LIG_Clathr_ClatBox_1 297 301 PF01394 0.324
LIG_deltaCOP1_diTrp_1 644 656 PF00928 0.384
LIG_FHA_1 12 18 PF00498 0.264
LIG_FHA_1 25 31 PF00498 0.264
LIG_FHA_1 33 39 PF00498 0.256
LIG_FHA_1 403 409 PF00498 0.441
LIG_FHA_1 86 92 PF00498 0.279
LIG_FHA_2 196 202 PF00498 0.324
LIG_FHA_2 492 498 PF00498 0.322
LIG_FHA_2 656 662 PF00498 0.472
LIG_FHA_2 680 686 PF00498 0.543
LIG_FHA_2 713 719 PF00498 0.456
LIG_LIR_Apic_2 629 633 PF02991 0.380
LIG_LIR_Gen_1 339 347 PF02991 0.298
LIG_LIR_Gen_1 653 662 PF02991 0.541
LIG_LIR_Gen_1 674 684 PF02991 0.514
LIG_LIR_Nem_3 18 23 PF02991 0.291
LIG_LIR_Nem_3 186 190 PF02991 0.266
LIG_LIR_Nem_3 242 248 PF02991 0.279
LIG_LIR_Nem_3 339 344 PF02991 0.386
LIG_LIR_Nem_3 405 409 PF02991 0.374
LIG_LIR_Nem_3 653 659 PF02991 0.515
LIG_LIR_Nem_3 674 680 PF02991 0.559
LIG_LIR_Nem_3 7 11 PF02991 0.274
LIG_LYPXL_yS_3 406 409 PF13949 0.447
LIG_NRBOX 279 285 PF00104 0.279
LIG_PCNA_TLS_4 607 614 PF02747 0.331
LIG_Pex14_2 4 8 PF04695 0.279
LIG_Pex14_2 66 70 PF04695 0.209
LIG_REV1ctd_RIR_1 63 73 PF16727 0.209
LIG_SH2_CRK 677 681 PF00017 0.482
LIG_SH2_GRB2like 128 131 PF00017 0.264
LIG_SH2_GRB2like 464 467 PF00017 0.457
LIG_SH2_NCK_1 630 634 PF00017 0.426
LIG_SH2_SRC 478 481 PF00017 0.493
LIG_SH2_SRC 651 654 PF00017 0.380
LIG_SH2_STAP1 248 252 PF00017 0.358
LIG_SH2_STAP1 662 666 PF00017 0.423
LIG_SH2_STAT3 113 116 PF00017 0.264
LIG_SH2_STAT5 105 108 PF00017 0.279
LIG_SH2_STAT5 128 131 PF00017 0.336
LIG_SH2_STAT5 154 157 PF00017 0.264
LIG_SH2_STAT5 245 248 PF00017 0.376
LIG_SH2_STAT5 282 285 PF00017 0.279
LIG_SH2_STAT5 478 481 PF00017 0.380
LIG_SH2_STAT5 56 59 PF00017 0.279
LIG_SH2_STAT5 613 616 PF00017 0.349
LIG_SH3_1 773 779 PF00018 0.519
LIG_SH3_2 550 555 PF14604 0.707
LIG_SH3_3 299 305 PF00018 0.358
LIG_SH3_3 401 407 PF00018 0.344
LIG_SH3_3 414 420 PF00018 0.392
LIG_SH3_3 421 427 PF00018 0.251
LIG_SH3_3 445 451 PF00018 0.481
LIG_SH3_3 547 553 PF00018 0.621
LIG_SH3_3 771 777 PF00018 0.542
LIG_SH3_3 809 815 PF00018 0.789
LIG_SH3_4 555 562 PF00018 0.590
LIG_SUMO_SIM_par_1 13 18 PF11976 0.279
LIG_SUMO_SIM_par_1 507 513 PF11976 0.375
LIG_TRAF2_1 198 201 PF00917 0.335
LIG_TRAF2_1 658 661 PF00917 0.413
LIG_TRAF2_1 682 685 PF00917 0.397
LIG_TRAF2_1 715 718 PF00917 0.443
LIG_TYR_ITSM 16 23 PF00017 0.391
LIG_WRC_WIRS_1 38 43 PF05994 0.279
LIG_WRC_WIRS_1 656 661 PF05994 0.384
MOD_CDK_SPK_2 387 392 PF00069 0.279
MOD_CK1_1 322 328 PF00069 0.419
MOD_CK1_1 375 381 PF00069 0.410
MOD_CK1_1 419 425 PF00069 0.448
MOD_CK1_1 579 585 PF00069 0.502
MOD_CK2_1 191 197 PF00069 0.264
MOD_CK2_1 28 34 PF00069 0.264
MOD_CK2_1 322 328 PF00069 0.284
MOD_CK2_1 491 497 PF00069 0.333
MOD_CK2_1 654 660 PF00069 0.418
MOD_CK2_1 679 685 PF00069 0.514
MOD_CK2_1 712 718 PF00069 0.471
MOD_CK2_1 758 764 PF00069 0.469
MOD_Cter_Amidation 708 711 PF01082 0.582
MOD_GlcNHglycan 182 185 PF01048 0.482
MOD_GlcNHglycan 284 287 PF01048 0.264
MOD_GlcNHglycan 288 291 PF01048 0.264
MOD_GlcNHglycan 453 456 PF01048 0.520
MOD_GlcNHglycan 578 581 PF01048 0.560
MOD_GlcNHglycan 622 625 PF01048 0.494
MOD_GSK3_1 11 18 PF00069 0.264
MOD_GSK3_1 191 198 PF00069 0.292
MOD_GSK3_1 24 31 PF00069 0.264
MOD_GSK3_1 282 289 PF00069 0.410
MOD_GSK3_1 33 40 PF00069 0.260
MOD_GSK3_1 368 375 PF00069 0.267
MOD_GSK3_1 398 405 PF00069 0.255
MOD_GSK3_1 743 750 PF00069 0.396
MOD_N-GLC_1 11 16 PF02516 0.278
MOD_N-GLC_1 177 182 PF02516 0.264
MOD_N-GLC_1 286 291 PF02516 0.386
MOD_N-GLC_1 372 377 PF02516 0.270
MOD_N-GLC_2 104 106 PF02516 0.279
MOD_NEK2_1 146 151 PF00069 0.386
MOD_NEK2_1 99 104 PF00069 0.410
MOD_NEK2_2 212 217 PF00069 0.276
MOD_NEK2_2 60 65 PF00069 0.298
MOD_PIKK_1 261 267 PF00454 0.467
MOD_PIKK_1 743 749 PF00454 0.598
MOD_PKA_1 32 38 PF00069 0.264
MOD_PKA_1 758 764 PF00069 0.462
MOD_PKA_2 235 241 PF00069 0.285
MOD_PKA_2 308 314 PF00069 0.298
MOD_PKA_2 32 38 PF00069 0.264
MOD_PKA_2 595 601 PF00069 0.437
MOD_PKA_2 619 625 PF00069 0.403
MOD_PKB_1 618 626 PF00069 0.322
MOD_Plk_1 11 17 PF00069 0.273
MOD_Plk_1 300 306 PF00069 0.329
MOD_Plk_1 33 39 PF00069 0.264
MOD_Plk_1 654 660 PF00069 0.434
MOD_Plk_1 747 753 PF00069 0.368
MOD_Plk_2-3 308 314 PF00069 0.410
MOD_Plk_2-3 340 346 PF00069 0.329
MOD_Plk_2-3 655 661 PF00069 0.431
MOD_Plk_2-3 712 718 PF00069 0.472
MOD_Plk_4 172 178 PF00069 0.264
MOD_Plk_4 212 218 PF00069 0.276
MOD_Plk_4 322 328 PF00069 0.353
MOD_Plk_4 34 40 PF00069 0.266
MOD_Plk_4 579 585 PF00069 0.437
MOD_Plk_4 60 66 PF00069 0.279
MOD_Plk_4 609 615 PF00069 0.353
MOD_ProDKin_1 387 393 PF00069 0.264
MOD_ProDKin_1 416 422 PF00069 0.555
MOD_ProDKin_1 527 533 PF00069 0.501
MOD_SUMO_rev_2 102 112 PF00179 0.410
MOD_SUMO_rev_2 249 257 PF00179 0.314
MOD_SUMO_rev_2 712 722 PF00179 0.536
MOD_SUMO_rev_2 752 761 PF00179 0.576
MOD_SUMO_rev_2 77 87 PF00179 0.410
TRG_DiLeu_BaEn_1 157 162 PF01217 0.264
TRG_DiLeu_BaLyEn_6 269 274 PF01217 0.238
TRG_ENDOCYTIC_2 187 190 PF00928 0.264
TRG_ENDOCYTIC_2 20 23 PF00928 0.391
TRG_ENDOCYTIC_2 248 251 PF00928 0.290
TRG_ENDOCYTIC_2 406 409 PF00928 0.447
TRG_ENDOCYTIC_2 677 680 PF00928 0.436
TRG_ER_diArg_1 159 161 PF00400 0.279
TRG_ER_diArg_1 268 271 PF00400 0.341
TRG_ER_diArg_1 498 501 PF00400 0.372
TRG_ER_diArg_1 601 604 PF00400 0.485
TRG_ER_diArg_1 617 620 PF00400 0.257
TRG_ER_diArg_1 664 666 PF00400 0.466
TRG_ER_diArg_1 680 683 PF00400 0.262
TRG_Pf-PMV_PEXEL_1 159 164 PF00026 0.264
TRG_Pf-PMV_PEXEL_1 357 361 PF00026 0.410
TRG_Pf-PMV_PEXEL_1 46 50 PF00026 0.264
TRG_Pf-PMV_PEXEL_1 670 674 PF00026 0.365

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDD3 Leptomonas seymouri 73% 98%
A0A0S4JJU2 Bodo saltans 24% 100%
A0A0S4JRV7 Bodo saltans 50% 99%
A0A1X0NER7 Trypanosomatidae 25% 100%
A0A1X0P8H2 Trypanosomatidae 59% 100%
A0A3Q8IB80 Leishmania donovani 25% 100%
A0A3Q8IQX0 Leishmania donovani 25% 100%
A0A3R7L0X2 Trypanosoma rangeli 56% 99%
A0A3S5H744 Leishmania donovani 100% 100%
A0A3S5H808 Leishmania donovani 24% 100%
A0A3S7X203 Leishmania donovani 25% 100%
A0A422MQ05 Trypanosoma rangeli 25% 100%
A4H9P0 Leishmania braziliensis 83% 100%
A4HGY1 Leishmania braziliensis 25% 96%
A4HGY5 Leishmania braziliensis 26% 100%
A4HND7 Leishmania braziliensis 27% 100%
A4I412 Leishmania infantum 25% 96%
A4I417 Leishmania infantum 25% 100%
A4IC10 Leishmania infantum 24% 100%
C9ZYJ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
D0A590 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9AFU8 Leishmania major 25% 100%
E9AHH1 Leishmania infantum 25% 100%
E9ARS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B099 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 96%
E9B0A4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B700 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
F4HQD4 Arabidopsis thaliana 31% 99%
F4JMJ1 Arabidopsis thaliana 24% 95%
O59838 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
O74225 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 32% 100%
O88600 Rattus norvegicus 29% 98%
O93866 Trichophyton rubrum 27% 100%
O97125 Drosophila melanogaster 26% 100%
P08108 Oncorhynchus mykiss 26% 100%
P09435 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P09446 Caenorhabditis elegans 26% 100%
P11147 Drosophila melanogaster 25% 100%
P17066 Homo sapiens 27% 100%
P17804 Leishmania donovani 25% 100%
P27541 Brugia malayi 25% 100%
P29844 Drosophila melanogaster 24% 100%
P29845 Drosophila melanogaster 25% 100%
P32589 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
P32590 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
P36604 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
P41825 Anopheles albimanus 27% 100%
P41826 Anopheles albimanus 27% 100%
P41827 Anopheles albimanus 26% 100%
P48722 Mus musculus 29% 98%
P49118 Solanum lycopersicum 25% 100%
P78695 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 24% 100%
Q01233 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 100%
Q02028 Pisum sativum 26% 100%
Q05036 Caenorhabditis elegans 31% 100%
Q05944 Hydra vulgaris 27% 100%
Q39043 Arabidopsis thaliana 25% 100%
Q4Q7Y0 Leishmania major 25% 100%
Q4Q7Y4 Leishmania major 25% 97%
Q4QDQ2 Leishmania major 96% 100%
Q557E0 Dictyostelium discoideum 24% 100%
Q5B0C0 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 25% 100%
Q5B2V1 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 28% 100%
Q61699 Mus musculus 29% 96%
Q6FJI3 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 31% 100%
Q6TMK3 Dictyostelium discoideum 32% 100%
Q74ZJ0 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 31% 100%
Q75C78 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 26% 100%
Q875P5 Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) 29% 100%
Q875V0 Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630) 30% 100%
Q91233 Oncorhynchus tshawytscha 27% 100%
Q91291 Pleurodeles waltl 25% 100%
Q96VB9 Candida albicans (strain SC5314 / ATCC MYA-2876) 31% 100%
Q96W30 Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) 28% 100%
Q99170 Yarrowia lipolytica (strain CLIB 122 / E 150) 25% 100%
Q9LKR3 Arabidopsis thaliana 25% 100%
Q9S7C0 Arabidopsis thaliana 31% 99%
Q9SAB1 Arabidopsis thaliana 28% 100%
V5DFF3 Trypanosoma cruzi 58% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS