LeishMANIAdb
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Putative elongation factor Tu

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative elongation factor Tu
Gene product:
Elongation factor Tu - mitochondrial - putative
Species:
Leishmania infantum
UniProt:
E9AGQ3_LEIIN
TriTrypDb:
LINF_180012600
Length:
466

Annotations

Annotations by Jardim et al.

Translation, elongation factor Tu

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AGQ3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGQ3

Function

Biological processes
TermNameLevelCount
GO:0006414 translational elongation 5 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 12
GO:0003676 nucleic acid binding 3 12
GO:0003746 translation elongation factor activity 4 12
GO:0003824 catalytic activity 1 12
GO:0003924 GTPase activity 7 12
GO:0005488 binding 1 12
GO:0005525 GTP binding 5 12
GO:0008135 translation factor activity, RNA binding 3 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 203 205 PF00675 0.243
CLV_NRD_NRD_1 69 71 PF00675 0.192
CLV_PCSK_KEX2_1 453 455 PF00082 0.651
CLV_PCSK_KEX2_1 49 51 PF00082 0.299
CLV_PCSK_KEX2_1 85 87 PF00082 0.192
CLV_PCSK_PC1ET2_1 453 455 PF00082 0.651
CLV_PCSK_PC1ET2_1 49 51 PF00082 0.299
CLV_PCSK_PC1ET2_1 85 87 PF00082 0.203
CLV_PCSK_SKI1_1 14 18 PF00082 0.437
CLV_PCSK_SKI1_1 219 223 PF00082 0.333
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P2Q3 Leptomonas seymouri 92% 100%
A0A0S4IUT7 Bodo saltans 26% 100%
A0A0S4IX91 Bodo saltans 26% 69%
A0A0S4J558 Bodo saltans 76% 100%
A0A0S4JRG2 Bodo saltans 27% 100%
A0A1X0NJD8 Trypanosomatidae 25% 98%
A0A1X0NXE4 Trypanosomatidae 28% 100%
A0A1X0NXE5 Trypanosomatidae 28% 100%
A0A1X0P746 Trypanosomatidae 79% 99%
A0A1X0PAN1 Trypanosomatidae 27% 70%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS