DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379) - putative

Species:

Leishmania infantum

UniProt:

E9AGQ2_LEIIN

TriTrypDb:

LINF_180008200

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.377
CLV_NRD_NRD_1	105	107	PF00675	0.291
CLV_NRD_NRD_1	255	257	PF00675	0.462
CLV_NRD_NRD_1	92	94	PF00675	0.291
CLV_PCSK_KEX2_1	250	252	PF00082	0.498
CLV_PCSK_KEX2_1	254	256	PF00082	0.450
CLV_PCSK_KEX2_1	73	75	PF00082	0.461
CLV_PCSK_KEX2_1	92	94	PF00082	0.158
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.631
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.469
CLV_PCSK_PC7_1	251	257	PF00082	0.515
CLV_PCSK_SKI1_1	97	101	PF00082	0.405
CLV_Separin_Metazoa	129	133	PF03568	0.444
DEG_Nend_Nbox_1	1	3	PF02207	0.550
DOC_MAPK_gen_1	73	81	PF00069	0.306
DOC_MAPK_MEF2A_6	132	140	PF00069	0.517
DOC_MAPK_MEF2A_6	74	83	PF00069	0.291
DOC_PP1_RVXF_1	42	49	PF00149	0.433
DOC_PP1_RVXF_1	90	97	PF00149	0.291
DOC_WW_Pin1_4	132	137	PF00397	0.494
LIG_14-3-3_CanoR_1	106	112	PF00244	0.301
LIG_14-3-3_CanoR_1	18	23	PF00244	0.455
LIG_14-3-3_CanoR_1	189	195	PF00244	0.407
LIG_14-3-3_CanoR_1	217	225	PF00244	0.337
LIG_14-3-3_CanoR_1	254	259	PF00244	0.404
LIG_14-3-3_CanoR_1	62	67	PF00244	0.342
LIG_14-3-3_CterR_2	256	260	PF00244	0.492
LIG_FHA_1	133	139	PF00498	0.524
LIG_FHA_1	220	226	PF00498	0.385
LIG_FHA_1	3	9	PF00498	0.490
LIG_HP1_1	136	140	PF01393	0.477
LIG_LIR_Gen_1	17	26	PF02991	0.413
LIG_LIR_Nem_3	146	151	PF02991	0.426
LIG_LIR_Nem_3	17	22	PF02991	0.408
LIG_LIR_Nem_3	230	236	PF02991	0.441
LIG_Pex14_1	96	100	PF04695	0.306
LIG_Pex14_2	169	173	PF04695	0.291
LIG_SH2_CRK	63	67	PF00017	0.357
LIG_SH2_GRB2like	32	35	PF00017	0.463
LIG_SH2_STAP1	126	130	PF00017	0.499
LIG_SH2_STAP1	63	67	PF00017	0.376
LIG_SH2_STAT5	233	236	PF00017	0.535
LIG_SH2_STAT5	32	35	PF00017	0.407
LIG_SH3_3	196	202	PF00018	0.326
LIG_SUMO_SIM_par_1	135	142	PF11976	0.479
LIG_TRAF2_1	227	230	PF00917	0.588
LIG_UBA3_1	147	156	PF00899	0.383
MOD_CK1_1	110	116	PF00069	0.303
MOD_CK1_1	164	170	PF00069	0.422
MOD_CK1_1	17	23	PF00069	0.419
MOD_CK2_1	236	242	PF00069	0.514
MOD_CK2_1	62	68	PF00069	0.464
MOD_Cter_Amidation	248	251	PF01082	0.631
MOD_GlcNHglycan	206	210	PF01048	0.310
MOD_GlcNHglycan	244	247	PF01048	0.508
MOD_GSK3_1	14	21	PF00069	0.468
MOD_GSK3_1	159	166	PF00069	0.303
MOD_GSK3_1	50	57	PF00069	0.396
MOD_N-GLC_1	107	112	PF02516	0.426
MOD_N-GLC_1	218	223	PF02516	0.491
MOD_N-GLC_1	33	38	PF02516	0.463
MOD_N-GLC_2	120	122	PF02516	0.321
MOD_NEK2_1	100	105	PF00069	0.294
MOD_NEK2_1	163	168	PF00069	0.291
MOD_NEK2_1	236	241	PF00069	0.527
MOD_NEK2_1	33	38	PF00069	0.390
MOD_NEK2_2	182	187	PF00069	0.291
MOD_PK_1	107	113	PF00069	0.326
MOD_PK_1	18	24	PF00069	0.452
MOD_PK_1	62	68	PF00069	0.432
MOD_PKA_1	254	260	PF00069	0.358
MOD_PKA_2	17	23	PF00069	0.322
MOD_PKA_2	182	188	PF00069	0.291
MOD_PKA_2	2	8	PF00069	0.503
MOD_PKA_2	202	208	PF00069	0.420
MOD_PKA_2	254	260	PF00069	0.358
MOD_PKA_2	50	56	PF00069	0.382
MOD_PKA_2	61	67	PF00069	0.375
MOD_Plk_1	107	113	PF00069	0.426
MOD_Plk_1	218	224	PF00069	0.520
MOD_Plk_1	236	242	PF00069	0.522
MOD_Plk_1	33	39	PF00069	0.461
MOD_Plk_4	18	24	PF00069	0.452
MOD_Plk_4	62	68	PF00069	0.408
MOD_ProDKin_1	132	138	PF00069	0.492
TRG_DiLeu_BaEn_4	229	235	PF01217	0.477
TRG_ENDOCYTIC_2	233	236	PF00928	0.535
TRG_ENDOCYTIC_2	28	31	PF00928	0.402
TRG_ENDOCYTIC_2	63	66	PF00928	0.358
TRG_ER_diArg_1	186	189	PF00400	0.306
TRG_ER_diArg_1	253	256	PF00400	0.468
TRG_ER_diArg_1	92	94	PF00400	0.291
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIG6	Leptomonas seymouri	73%	100%
A0A0S4JHH1	Bodo saltans	51%	100%
A0A1X0P874	Trypanosomatidae	67%	100%
A0A3Q8IB20	Leishmania donovani	100%	100%
A0A422NWN7	Trypanosoma rangeli	72%	100%
A4H9D6	Leishmania braziliensis	90%	100%
D0A038	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9ARG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B6F4	Trypanosoma cruzi	68%	100%