Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGQ1_LEIIN

TriTrypDb:

LINF_170020500

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGQ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.746
CLV_NRD_NRD_1	305	307	PF00675	0.571
CLV_PCSK_KEX2_1	399	401	PF00082	0.476
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.476
CLV_PCSK_SKI1_1	264	268	PF00082	0.668
CLV_PCSK_SKI1_1	328	332	PF00082	0.566
DEG_Nend_UBRbox_3	1	3	PF02207	0.544
DEG_SCF_FBW7_1	20	26	PF00400	0.824
DEG_SCF_TRCP1_1	12	17	PF00400	0.820
DOC_CKS1_1	20	25	PF01111	0.822
DOC_PP4_FxxP_1	145	148	PF00568	0.704
DOC_PP4_FxxP_1	234	237	PF00568	0.670
DOC_USP7_MATH_1	136	140	PF00917	0.735
DOC_USP7_MATH_1	152	156	PF00917	0.586
DOC_USP7_MATH_1	180	184	PF00917	0.685
DOC_USP7_MATH_1	237	241	PF00917	0.716
DOC_USP7_MATH_1	356	360	PF00917	0.643
DOC_USP7_MATH_1	451	455	PF00917	0.571
DOC_USP7_UBL2_3	307	311	PF12436	0.534
DOC_WW_Pin1_4	119	124	PF00397	0.809
DOC_WW_Pin1_4	125	130	PF00397	0.763
DOC_WW_Pin1_4	171	176	PF00397	0.708
DOC_WW_Pin1_4	19	24	PF00397	0.805
DOC_WW_Pin1_4	229	234	PF00397	0.681
DOC_WW_Pin1_4	28	33	PF00397	0.722
DOC_WW_Pin1_4	333	338	PF00397	0.646
DOC_WW_Pin1_4	363	368	PF00397	0.616
DOC_WW_Pin1_4	65	70	PF00397	0.769
DOC_WW_Pin1_4	89	94	PF00397	0.731
DOC_WW_Pin1_4	99	104	PF00397	0.715
LIG_14-3-3_CanoR_1	181	187	PF00244	0.651
LIG_14-3-3_CanoR_1	374	384	PF00244	0.504
LIG_14-3-3_CanoR_1	456	462	PF00244	0.738
LIG_BRCT_BRCA1_1	182	186	PF00533	0.641
LIG_BRCT_BRCA1_1	210	214	PF00533	0.704
LIG_BRCT_BRCA1_1	230	234	PF00533	0.640
LIG_BRCT_BRCA1_1	358	362	PF00533	0.604
LIG_EVH1_2	197	201	PF00568	0.690
LIG_FHA_1	261	267	PF00498	0.600
LIG_FHA_1	313	319	PF00498	0.480
LIG_FHA_1	418	424	PF00498	0.495
LIG_FHA_2	266	272	PF00498	0.676
LIG_LIR_Apic_2	138	143	PF02991	0.723
LIG_LIR_Apic_2	174	180	PF02991	0.724
LIG_LIR_Apic_2	217	222	PF02991	0.594
LIG_LIR_Apic_2	231	237	PF02991	0.564
LIG_LIR_Gen_1	359	370	PF02991	0.605
LIG_LIR_Gen_1	383	391	PF02991	0.497
LIG_LIR_Nem_3	359	365	PF02991	0.605
LIG_LIR_Nem_3	383	387	PF02991	0.451
LIG_LIR_Nem_3	389	393	PF02991	0.423
LIG_LIR_Nem_3	397	401	PF02991	0.402
LIG_PDZ_Class_3	459	464	PF00595	0.623
LIG_PROFILIN_1	103	109	PF00235	0.702
LIG_PTB_Apo_2	91	98	PF02174	0.833
LIG_PTB_Phospho_1	91	97	PF10480	0.834
LIG_SH2_CRK	140	144	PF00017	0.598
LIG_SH2_CRK	219	223	PF00017	0.572
LIG_SH2_NCK_1	140	144	PF00017	0.676
LIG_SH2_SRC	140	143	PF00017	0.680
LIG_SH2_STAT3	401	404	PF00017	0.486
LIG_SH2_STAT3	71	74	PF00017	0.739
LIG_SH2_STAT5	228	231	PF00017	0.706
LIG_SH2_STAT5	376	379	PF00017	0.478
LIG_SH2_STAT5	401	404	PF00017	0.486
LIG_SH2_STAT5	97	100	PF00017	0.837
LIG_SH3_3	100	106	PF00018	0.766
LIG_SH3_3	17	23	PF00018	0.725
LIG_SH3_3	26	32	PF00018	0.721
LIG_SH3_3	289	295	PF00018	0.558
LIG_SH3_3	337	343	PF00018	0.711
LIG_SH3_3	364	370	PF00018	0.575
LIG_WRC_WIRS_1	395	400	PF05994	0.441
LIG_WW_2	107	110	PF00397	0.742
LIG_WW_3	27	31	PF00397	0.718
MOD_CDK_SPxxK_3	65	72	PF00069	0.739
MOD_CK1_1	10	16	PF00069	0.734
MOD_CK1_1	124	130	PF00069	0.727
MOD_CK1_1	185	191	PF00069	0.698
MOD_CK1_1	240	246	PF00069	0.825
MOD_CK1_1	258	264	PF00069	0.624
MOD_CK1_1	275	281	PF00069	0.590
MOD_CK1_1	282	288	PF00069	0.620
MOD_CK1_1	3	9	PF00069	0.717
MOD_CK1_1	363	369	PF00069	0.580
MOD_CK1_1	39	45	PF00069	0.740
MOD_CK1_1	76	82	PF00069	0.728
MOD_CK2_1	338	344	PF00069	0.541
MOD_CK2_1	443	449	PF00069	0.530
MOD_DYRK1A_RPxSP_1	89	93	PF00069	0.831
MOD_GlcNHglycan	12	15	PF01048	0.782
MOD_GlcNHglycan	158	161	PF01048	0.713
MOD_GlcNHglycan	16	19	PF01048	0.819
MOD_GlcNHglycan	190	193	PF01048	0.739
MOD_GlcNHglycan	239	242	PF01048	0.814
MOD_GlcNHglycan	282	285	PF01048	0.748
MOD_GlcNHglycan	346	349	PF01048	0.651
MOD_GlcNHglycan	37	41	PF01048	0.751
MOD_GlcNHglycan	410	413	PF01048	0.528
MOD_GlcNHglycan	453	456	PF01048	0.578
MOD_GlcNHglycan	47	50	PF01048	0.690
MOD_GlcNHglycan	75	78	PF01048	0.793
MOD_GSK3_1	121	128	PF00069	0.742
MOD_GSK3_1	132	139	PF00069	0.698
MOD_GSK3_1	152	159	PF00069	0.679
MOD_GSK3_1	169	176	PF00069	0.602
MOD_GSK3_1	182	189	PF00069	0.693
MOD_GSK3_1	19	26	PF00069	0.646
MOD_GSK3_1	210	217	PF00069	0.739
MOD_GSK3_1	237	244	PF00069	0.668
MOD_GSK3_1	258	265	PF00069	0.659
MOD_GSK3_1	270	277	PF00069	0.700
MOD_GSK3_1	278	285	PF00069	0.487
MOD_GSK3_1	3	10	PF00069	0.732
MOD_GSK3_1	356	363	PF00069	0.610
MOD_GSK3_1	413	420	PF00069	0.506
MOD_GSK3_1	85	92	PF00069	0.728
MOD_GSK3_1	95	102	PF00069	0.725
MOD_N-GLC_1	10	15	PF02516	0.689
MOD_N-GLC_1	132	137	PF02516	0.656
MOD_N-GLC_1	360	365	PF02516	0.598
MOD_N-GLC_1	380	385	PF02516	0.296
MOD_NEK2_1	214	219	PF00069	0.695
MOD_NEK2_1	274	279	PF00069	0.795
MOD_NEK2_1	312	317	PF00069	0.526
MOD_NEK2_1	350	355	PF00069	0.702
MOD_NEK2_1	73	78	PF00069	0.723
MOD_PIKK_1	121	127	PF00454	0.759
MOD_PIKK_1	169	175	PF00454	0.705
MOD_PIKK_1	87	93	PF00454	0.730
MOD_PK_1	150	156	PF00069	0.695
MOD_PKA_2	180	186	PF00069	0.653
MOD_Plk_1	270	276	PF00069	0.755
MOD_Plk_1	360	366	PF00069	0.599
MOD_Plk_1	380	386	PF00069	0.286
MOD_Plk_1	437	443	PF00069	0.489
MOD_Plk_1	449	455	PF00069	0.632
MOD_Plk_4	298	304	PF00069	0.671
MOD_Plk_4	413	419	PF00069	0.483
MOD_Plk_4	437	443	PF00069	0.501
MOD_ProDKin_1	119	125	PF00069	0.809
MOD_ProDKin_1	171	177	PF00069	0.709
MOD_ProDKin_1	19	25	PF00069	0.806
MOD_ProDKin_1	229	235	PF00069	0.681
MOD_ProDKin_1	28	34	PF00069	0.721
MOD_ProDKin_1	333	339	PF00069	0.640
MOD_ProDKin_1	363	369	PF00069	0.608
MOD_ProDKin_1	65	71	PF00069	0.770
MOD_ProDKin_1	89	95	PF00069	0.729
MOD_ProDKin_1	99	105	PF00069	0.709
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.551
TRG_ENDOCYTIC_2	384	387	PF00928	0.454
TRG_NES_CRM1_1	426	439	PF08389	0.616
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I056	Leptomonas seymouri	51%	71%
A0A3S7WUM9	Leishmania donovani	100%	79%
A4H977	Leishmania braziliensis	69%	100%
E9ARA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QE58	Leishmania major	93%	100%