Putative ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase - putative

Species:

Leishmania infantum

UniProt:

E9AGQ0_LEIIN

TriTrypDb:

LINF_170016300

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGQ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003676	nucleic acid binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004386	helicase activity	2	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	69	71	PF00675	0.444
CLV_NRD_NRD_1	96	98	PF00675	0.364
CLV_PCSK_KEX2_1	246	248	PF00082	0.199
CLV_PCSK_KEX2_1	69	71	PF00082	0.444
CLV_PCSK_KEX2_1	96	98	PF00082	0.364
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.199
CLV_PCSK_PC7_1	242	248	PF00082	0.199
CLV_PCSK_SKI1_1	150	154	PF00082	0.297
CLV_PCSK_SKI1_1	38	42	PF00082	0.343
CLV_Separin_Metazoa	239	243	PF03568	0.400
DEG_Nend_UBRbox_2	1	3	PF02207	0.364
DEG_SPOP_SBC_1	137	141	PF00917	0.377
DOC_CYCLIN_yCln2_LP_2	135	138	PF00134	0.351
DOC_MAPK_gen_1	246	253	PF00069	0.400
DOC_MAPK_MEF2A_6	246	255	PF00069	0.400
DOC_PP2B_LxvP_1	135	138	PF13499	0.351
DOC_PP2B_PxIxI_1	146	152	PF00149	0.318
DOC_USP7_MATH_1	138	142	PF00917	0.391
DOC_USP7_MATH_1	171	175	PF00917	0.400
DOC_USP7_MATH_1	180	184	PF00917	0.400
LIG_14-3-3_CanoR_1	11	15	PF00244	0.285
LIG_14-3-3_CanoR_1	116	120	PF00244	0.387
LIG_14-3-3_CanoR_1	125	129	PF00244	0.355
LIG_14-3-3_CanoR_1	150	156	PF00244	0.285
LIG_Actin_WH2_2	212	228	PF00022	0.400
LIG_Actin_WH2_2	82	98	PF00022	0.444
LIG_FHA_1	121	127	PF00498	0.352
LIG_FHA_1	215	221	PF00498	0.400
LIG_FHA_1	269	275	PF00498	0.400
LIG_FHA_1	61	67	PF00498	0.421
LIG_FHA_2	128	134	PF00498	0.350
LIG_FHA_2	252	258	PF00498	0.400
LIG_FHA_2	52	58	PF00498	0.362
LIG_HCF-1_HBM_1	47	50	PF13415	0.327
LIG_LIR_Gen_1	10	20	PF02991	0.287
LIG_LIR_Gen_1	47	58	PF02991	0.348
LIG_LIR_Nem_3	10	15	PF02991	0.284
LIG_LIR_Nem_3	47	53	PF02991	0.334
LIG_PCNA_yPIPBox_3	197	206	PF02747	0.400
LIG_Pex14_1	12	16	PF04695	0.274
LIG_SH2_CRK	50	54	PF00017	0.333
LIG_SH2_NCK_1	177	181	PF00017	0.400
LIG_SH2_PTP2	229	232	PF00017	0.400
LIG_SH2_STAP1	177	181	PF00017	0.400
LIG_SH2_STAT5	229	232	PF00017	0.400
LIG_SH3_3	131	137	PF00018	0.339
LIG_SH3_3	186	192	PF00018	0.400
LIG_SH3_3	87	93	PF00018	0.455
LIG_WRC_WIRS_1	241	246	PF05994	0.400
MOD_CK1_1	10	16	PF00069	0.278
MOD_CK1_1	141	147	PF00069	0.391
MOD_CK1_1	190	196	PF00069	0.400
MOD_CK2_1	127	133	PF00069	0.351
MOD_CK2_1	251	257	PF00069	0.400
MOD_CK2_1	51	57	PF00069	0.361
MOD_GlcNHglycan	189	192	PF01048	0.199
MOD_GlcNHglycan	257	261	PF01048	0.199
MOD_GlcNHglycan	71	74	PF01048	0.447
MOD_GSK3_1	120	127	PF00069	0.352
MOD_GSK3_1	137	144	PF00069	0.386
MOD_GSK3_1	247	254	PF00069	0.400
MOD_GSK3_1	80	87	PF00069	0.497
MOD_N-GLC_1	142	147	PF02516	0.391
MOD_NEK2_1	187	192	PF00069	0.400
MOD_NEK2_1	205	210	PF00069	0.400
MOD_NEK2_1	251	256	PF00069	0.400
MOD_NEK2_1	269	274	PF00069	0.400
MOD_NEK2_1	49	54	PF00069	0.329
MOD_NEK2_1	85	90	PF00069	0.483
MOD_PIKK_1	120	126	PF00454	0.352
MOD_PIKK_1	262	268	PF00454	0.400
MOD_PIKK_1	269	275	PF00454	0.400
MOD_PKA_1	69	75	PF00069	0.450
MOD_PKA_2	10	16	PF00069	0.278
MOD_PKA_2	115	121	PF00069	0.389
MOD_PKA_2	124	130	PF00069	0.357
MOD_PKA_2	69	75	PF00069	0.450
MOD_SUMO_rev_2	79	86	PF00179	0.498
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.355
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.423
TRG_ENDOCYTIC_2	50	53	PF00928	0.332
TRG_ER_diArg_1	95	97	PF00400	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A6UN73	METVS	31%	37%
B0R7Q2	HALS3	32%	36%
F0NDL2	SULIR	30%	39%
O59025	PYRHO	30%	39%
P0DMI1	ARCFU	34%	40%
Q465R3	METBF	29%	38%
Q4JC00	SULAC	32%	39%
Q5UYM9	HALMA	29%	35%
Q974S1	SULTO	29%	39%
Q97VY9	SACS2	30%	39%
Q9HMV6	HALSA	32%	36%
Q9V0A9	PYRAB	32%	39%