LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184) - putative
Species:
Leishmania infantum
UniProt:
E9AGP0_LEIIN
TriTrypDb:
LINF_160015850
Length:
619

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 75
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 24
NetGPI no yes: 0, no: 24
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 14
GO:0005794 Golgi apparatus 5 6
GO:0043226 organelle 2 6
GO:0043227 membrane-bounded organelle 3 6
GO:0043229 intracellular organelle 3 6
GO:0043231 intracellular membrane-bounded organelle 4 6

Expansion

Sequence features

E9AGP0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGP0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 24
GO:0016740 transferase activity 2 24
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 290 294 PF00656 0.421
CLV_C14_Caspase3-7 9 13 PF00656 0.609
CLV_NRD_NRD_1 198 200 PF00675 0.610
CLV_NRD_NRD_1 201 203 PF00675 0.546
CLV_NRD_NRD_1 236 238 PF00675 0.598
CLV_NRD_NRD_1 274 276 PF00675 0.622
CLV_NRD_NRD_1 352 354 PF00675 0.506
CLV_NRD_NRD_1 498 500 PF00675 0.627
CLV_PCSK_FUR_1 199 203 PF00082 0.583
CLV_PCSK_FUR_1 272 276 PF00082 0.603
CLV_PCSK_KEX2_1 156 158 PF00082 0.515
CLV_PCSK_KEX2_1 198 200 PF00082 0.608
CLV_PCSK_KEX2_1 201 203 PF00082 0.543
CLV_PCSK_KEX2_1 274 276 PF00082 0.631
CLV_PCSK_KEX2_1 352 354 PF00082 0.506
CLV_PCSK_KEX2_1 498 500 PF00082 0.627
CLV_PCSK_PC1ET2_1 156 158 PF00082 0.503
CLV_PCSK_SKI1_1 123 127 PF00082 0.574
CLV_PCSK_SKI1_1 15 19 PF00082 0.625
CLV_PCSK_SKI1_1 240 244 PF00082 0.545
CLV_PCSK_SKI1_1 352 356 PF00082 0.512
CLV_PCSK_SKI1_1 460 464 PF00082 0.633
CLV_PCSK_SKI1_1 544 548 PF00082 0.589
CLV_PCSK_SKI1_1 69 73 PF00082 0.528
DOC_CKS1_1 359 364 PF01111 0.715
DOC_CYCLIN_yCln2_LP_2 242 248 PF00134 0.328
DOC_MAPK_DCC_7 327 336 PF00069 0.518
DOC_MAPK_gen_1 235 244 PF00069 0.403
DOC_MAPK_gen_1 327 336 PF00069 0.544
DOC_MAPK_gen_1 67 76 PF00069 0.508
DOC_MAPK_HePTP_8 355 367 PF00069 0.659
DOC_MAPK_MEF2A_6 237 246 PF00069 0.403
DOC_MAPK_MEF2A_6 358 367 PF00069 0.675
DOC_MAPK_MEF2A_6 441 448 PF00069 0.604
DOC_MAPK_MEF2A_6 69 78 PF00069 0.511
DOC_PP1_RVXF_1 581 588 PF00149 0.417
DOC_PP2B_LxvP_1 242 245 PF13499 0.404
DOC_PP2B_LxvP_1 547 550 PF13499 0.468
DOC_PP4_FxxP_1 359 362 PF00568 0.575
DOC_USP7_MATH_1 115 119 PF00917 0.386
DOC_USP7_MATH_1 191 195 PF00917 0.543
DOC_USP7_MATH_1 29 33 PF00917 0.657
DOC_USP7_MATH_1 304 308 PF00917 0.453
DOC_USP7_MATH_1 536 540 PF00917 0.581
DOC_USP7_MATH_1 591 595 PF00917 0.598
DOC_WW_Pin1_4 257 262 PF00397 0.494
DOC_WW_Pin1_4 358 363 PF00397 0.692
DOC_WW_Pin1_4 69 74 PF00397 0.379
LIG_14-3-3_CanoR_1 117 122 PF00244 0.533
LIG_14-3-3_CanoR_1 157 167 PF00244 0.603
LIG_14-3-3_CanoR_1 201 211 PF00244 0.395
LIG_14-3-3_CanoR_1 38 43 PF00244 0.514
LIG_14-3-3_CanoR_1 445 449 PF00244 0.621
LIG_14-3-3_CanoR_1 466 474 PF00244 0.581
LIG_14-3-3_CanoR_1 53 57 PF00244 0.434
LIG_14-3-3_CanoR_1 615 619 PF00244 0.657
LIG_Actin_WH2_2 141 158 PF00022 0.415
LIG_Actin_WH2_2 23 40 PF00022 0.709
LIG_BIR_III_2 280 284 PF00653 0.542
LIG_BRCT_BRCA1_1 259 263 PF00533 0.418
LIG_BRCT_BRCA1_1 403 407 PF00533 0.623
LIG_eIF4E_1 143 149 PF01652 0.474
LIG_FHA_1 283 289 PF00498 0.625
LIG_FHA_1 551 557 PF00498 0.457
LIG_FHA_1 597 603 PF00498 0.506
LIG_FHA_2 219 225 PF00498 0.300
LIG_FHA_2 303 309 PF00498 0.406
LIG_FHA_2 317 323 PF00498 0.526
LIG_FHA_2 7 13 PF00498 0.609
LIG_LIR_Apic_2 599 603 PF02991 0.501
LIG_LIR_Apic_2 613 619 PF02991 0.563
LIG_LIR_Gen_1 128 139 PF02991 0.379
LIG_LIR_Gen_1 308 318 PF02991 0.470
LIG_LIR_Gen_1 361 372 PF02991 0.596
LIG_LIR_Gen_1 605 614 PF02991 0.599
LIG_LIR_LC3C_4 570 575 PF02991 0.536
LIG_LIR_Nem_3 213 219 PF02991 0.296
LIG_LIR_Nem_3 241 246 PF02991 0.310
LIG_LIR_Nem_3 260 266 PF02991 0.552
LIG_LIR_Nem_3 308 314 PF02991 0.448
LIG_LIR_Nem_3 361 367 PF02991 0.685
LIG_LIR_Nem_3 404 410 PF02991 0.454
LIG_LIR_Nem_3 557 562 PF02991 0.510
LIG_LIR_Nem_3 91 97 PF02991 0.520
LIG_MAD2 466 474 PF02301 0.609
LIG_PTB_Apo_2 329 336 PF02174 0.489
LIG_PTB_Apo_2 76 83 PF02174 0.493
LIG_PTB_Phospho_1 329 335 PF10480 0.566
LIG_PTB_Phospho_1 76 82 PF10480 0.497
LIG_REV1ctd_RIR_1 216 226 PF16727 0.315
LIG_RPA_C_Fungi 572 584 PF08784 0.430
LIG_SH2_GRB2like 335 338 PF00017 0.535
LIG_SH2_GRB2like 77 80 PF00017 0.616
LIG_SH2_SRC 364 367 PF00017 0.696
LIG_SH2_SRC 421 424 PF00017 0.538
LIG_SH2_STAP1 203 207 PF00017 0.430
LIG_SH2_STAP1 223 227 PF00017 0.208
LIG_SH2_STAT3 478 481 PF00017 0.581
LIG_SH2_STAT5 143 146 PF00017 0.523
LIG_SH2_STAT5 203 206 PF00017 0.443
LIG_SH2_STAT5 211 214 PF00017 0.357
LIG_SH2_STAT5 266 269 PF00017 0.434
LIG_SH2_STAT5 335 338 PF00017 0.531
LIG_SH2_STAT5 364 367 PF00017 0.696
LIG_SH2_STAT5 82 85 PF00017 0.438
LIG_SH3_2 197 202 PF14604 0.448
LIG_SH3_3 194 200 PF00018 0.456
LIG_SH3_3 505 511 PF00018 0.514
LIG_SH3_3 595 601 PF00018 0.487
LIG_SUMO_SIM_anti_2 135 142 PF11976 0.507
LIG_SUMO_SIM_anti_2 570 576 PF11976 0.483
LIG_SUMO_SIM_par_1 552 558 PF11976 0.480
LIG_SUMO_SIM_par_1 570 576 PF11976 0.490
LIG_SxIP_EBH_1 189 202 PF03271 0.401
LIG_TRAF2_1 397 400 PF00917 0.632
LIG_TRAF2_1 420 423 PF00917 0.525
MOD_CDK_SPK_2 257 262 PF00069 0.442
MOD_CK1_1 299 305 PF00069 0.453
MOD_CK1_1 32 38 PF00069 0.696
MOD_CK2_1 218 224 PF00069 0.335
MOD_CK2_1 316 322 PF00069 0.541
MOD_CK2_1 340 346 PF00069 0.562
MOD_CK2_1 417 423 PF00069 0.447
MOD_CK2_1 489 495 PF00069 0.566
MOD_GlcNHglycan 116 120 PF01048 0.543
MOD_GlcNHglycan 160 163 PF01048 0.609
MOD_GlcNHglycan 301 304 PF01048 0.419
MOD_GlcNHglycan 32 35 PF01048 0.689
MOD_GlcNHglycan 343 346 PF01048 0.493
MOD_GlcNHglycan 468 471 PF01048 0.582
MOD_GlcNHglycan 538 541 PF01048 0.604
MOD_GSK3_1 97 104 PF00069 0.427
MOD_LATS_1 36 42 PF00433 0.522
MOD_N-GLC_1 158 163 PF02516 0.471
MOD_N-GLC_1 69 74 PF02516 0.484
MOD_NEK2_1 151 156 PF00069 0.423
MOD_NEK2_1 218 223 PF00069 0.485
MOD_NEK2_1 227 232 PF00069 0.392
MOD_NEK2_1 270 275 PF00069 0.567
MOD_NEK2_1 30 35 PF00069 0.677
MOD_NEK2_1 37 42 PF00069 0.528
MOD_NEK2_1 428 433 PF00069 0.416
MOD_NEK2_1 596 601 PF00069 0.484
MOD_PIKK_1 125 131 PF00454 0.390
MOD_PK_1 489 495 PF00069 0.557
MOD_PKA_1 201 207 PF00069 0.324
MOD_PKA_2 201 207 PF00069 0.333
MOD_PKA_2 30 36 PF00069 0.637
MOD_PKA_2 37 43 PF00069 0.465
MOD_PKA_2 444 450 PF00069 0.542
MOD_PKA_2 52 58 PF00069 0.477
MOD_PKB_1 199 207 PF00069 0.350
MOD_Plk_1 316 322 PF00069 0.484
MOD_Plk_2-3 480 486 PF00069 0.620
MOD_Plk_4 191 197 PF00069 0.475
MOD_Plk_4 296 302 PF00069 0.414
MOD_Plk_4 6 12 PF00069 0.601
MOD_Plk_4 97 103 PF00069 0.421
MOD_ProDKin_1 257 263 PF00069 0.492
MOD_ProDKin_1 358 364 PF00069 0.701
MOD_ProDKin_1 69 75 PF00069 0.372
MOD_SUMO_rev_2 576 585 PF00179 0.468
TRG_DiLeu_BaEn_1 593 598 PF01217 0.480
TRG_ENDOCYTIC_2 248 251 PF00928 0.360
TRG_ENDOCYTIC_2 335 338 PF00928 0.542
TRG_ENDOCYTIC_2 364 367 PF00928 0.717
TRG_ENDOCYTIC_2 607 610 PF00928 0.455
TRG_ER_diArg_1 197 199 PF00400 0.552
TRG_ER_diArg_1 200 202 PF00400 0.515
TRG_ER_diArg_1 232 235 PF00400 0.423
TRG_ER_diArg_1 272 275 PF00400 0.594
TRG_ER_diArg_1 351 353 PF00400 0.511
TRG_ER_diArg_1 521 524 PF00400 0.536
TRG_ER_diArg_1 66 69 PF00400 0.501

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Q7 Leptomonas seymouri 46% 100%
A0A1X0NYY7 Trypanosomatidae 44% 78%
A0A3Q8IJ32 Leishmania donovani 88% 75%
A0A422NAR5 Trypanosoma rangeli 45% 78%
A4H8M5 Leishmania braziliensis 81% 69%
A4H8M6 Leishmania braziliensis 75% 96%
A4H8M7 Leishmania braziliensis 76% 100%
A4H8N0 Leishmania braziliensis 52% 79%
A4HWZ6 Leishmania infantum 100% 68%
A4HWZ8 Leishmania infantum 100% 100%
A4HX01 Leishmania infantum 56% 100%
A4I0N5 Leishmania infantum 32% 79%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 66%
E9AGN8 Leishmania infantum 93% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 67%
Q4QER4 Leishmania major 92% 100%
Q4QER5 Leishmania major 82% 100%
Q4QER6 Leishmania major 82% 100%
Q4QER7 Leishmania major 92% 100%
Q4QER9 Leishmania major 92% 100%
Q4QES0 Leishmania major 81% 100%
V5ANJ8 Trypanosoma cruzi 45% 77%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS