LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184) - putative
Species:
Leishmania infantum
UniProt:
E9AGN8_LEIIN
TriTrypDb:
LINF_160015600
Length:
429

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGN8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGN8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016740 transferase activity 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 100 104 PF00656 0.502
CLV_NRD_NRD_1 11 13 PF00675 0.635
CLV_NRD_NRD_1 162 164 PF00675 0.494
CLV_NRD_NRD_1 308 310 PF00675 0.600
CLV_NRD_NRD_1 46 48 PF00675 0.634
CLV_NRD_NRD_1 8 10 PF00675 0.690
CLV_NRD_NRD_1 84 86 PF00675 0.763
CLV_PCSK_FUR_1 82 86 PF00082 0.748
CLV_PCSK_FUR_1 9 13 PF00082 0.672
CLV_PCSK_KEX2_1 11 13 PF00082 0.635
CLV_PCSK_KEX2_1 162 164 PF00082 0.494
CLV_PCSK_KEX2_1 308 310 PF00082 0.600
CLV_PCSK_KEX2_1 45 47 PF00082 0.425
CLV_PCSK_KEX2_1 8 10 PF00082 0.690
CLV_PCSK_KEX2_1 84 86 PF00082 0.724
CLV_PCSK_SKI1_1 12 16 PF00082 0.602
CLV_PCSK_SKI1_1 162 166 PF00082 0.701
CLV_PCSK_SKI1_1 270 274 PF00082 0.680
CLV_PCSK_SKI1_1 354 358 PF00082 0.646
DOC_CKS1_1 169 174 PF01111 0.741
DOC_CYCLIN_yCln2_LP_2 52 58 PF00134 0.371
DOC_MAPK_DCC_7 137 146 PF00069 0.490
DOC_MAPK_gen_1 137 146 PF00069 0.694
DOC_MAPK_gen_1 45 56 PF00069 0.371
DOC_MAPK_HePTP_8 165 177 PF00069 0.762
DOC_MAPK_MEF2A_6 168 177 PF00069 0.777
DOC_MAPK_MEF2A_6 251 258 PF00069 0.641
DOC_MAPK_MEF2A_6 47 56 PF00069 0.371
DOC_PP1_RVXF_1 391 398 PF00149 0.550
DOC_PP2B_LxvP_1 357 360 PF13499 0.498
DOC_PP2B_LxvP_1 52 55 PF13499 0.371
DOC_PP4_FxxP_1 169 172 PF00568 0.748
DOC_USP7_MATH_1 346 350 PF00917 0.672
DOC_USP7_MATH_1 38 42 PF00917 0.225
DOC_USP7_MATH_1 401 405 PF00917 0.641
DOC_WW_Pin1_4 168 173 PF00397 0.723
DOC_WW_Pin1_4 67 72 PF00397 0.602
LIG_14-3-3_CanoR_1 11 21 PF00244 0.409
LIG_14-3-3_CanoR_1 255 259 PF00244 0.598
LIG_14-3-3_CanoR_1 276 284 PF00244 0.509
LIG_14-3-3_CanoR_1 425 429 PF00244 0.655
LIG_14-3-3_CanoR_1 45 54 PF00244 0.243
LIG_Actin_WH2_2 95 113 PF00022 0.460
LIG_BIR_III_2 90 94 PF00653 0.736
LIG_BRCT_BRCA1_1 213 217 PF00533 0.669
LIG_BRCT_BRCA1_1 69 73 PF00533 0.603
LIG_FHA_1 361 367 PF00498 0.552
LIG_FHA_1 407 413 PF00498 0.566
LIG_FHA_1 93 99 PF00498 0.682
LIG_FHA_2 127 133 PF00498 0.552
LIG_LIR_Apic_2 409 413 PF02991 0.568
LIG_LIR_Apic_2 423 429 PF02991 0.592
LIG_LIR_Gen_1 118 125 PF02991 0.473
LIG_LIR_Gen_1 171 182 PF02991 0.720
LIG_LIR_Gen_1 415 424 PF02991 0.549
LIG_LIR_LC3C_4 380 385 PF02991 0.617
LIG_LIR_Nem_3 118 124 PF02991 0.678
LIG_LIR_Nem_3 171 177 PF02991 0.743
LIG_LIR_Nem_3 214 220 PF02991 0.535
LIG_LIR_Nem_3 36 42 PF02991 0.392
LIG_LIR_Nem_3 367 372 PF02991 0.548
LIG_LIR_Nem_3 415 420 PF02991 0.346
LIG_LIR_Nem_3 51 56 PF02991 0.358
LIG_LIR_Nem_3 70 76 PF02991 0.399
LIG_MAD2 276 284 PF02301 0.509
LIG_PTB_Apo_2 139 146 PF02174 0.701
LIG_PTB_Phospho_1 139 145 PF10480 0.704
LIG_RPA_C_Fungi 382 394 PF08784 0.523
LIG_SH2_CRK 39 43 PF00017 0.321
LIG_SH2_GRB2like 145 148 PF00017 0.685
LIG_SH2_NCK_1 417 421 PF00017 0.327
LIG_SH2_SRC 174 177 PF00017 0.763
LIG_SH2_SRC 231 234 PF00017 0.496
LIG_SH2_SRC 417 420 PF00017 0.310
LIG_SH2_STAP1 13 17 PF00017 0.393
LIG_SH2_STAP1 33 37 PF00017 0.321
LIG_SH2_STAT3 288 291 PF00017 0.474
LIG_SH2_STAT5 145 148 PF00017 0.685
LIG_SH2_STAT5 174 177 PF00017 0.822
LIG_SH2_STAT5 21 24 PF00017 0.388
LIG_SH2_STAT5 53 56 PF00017 0.254
LIG_SH2_STAT5 76 79 PF00017 0.618
LIG_SH3_3 315 321 PF00018 0.577
LIG_SH3_3 405 411 PF00018 0.593
LIG_SH3_CIN85_PxpxPR_1 3 8 PF14604 0.521
LIG_SUMO_SIM_anti_2 380 386 PF11976 0.501
LIG_SUMO_SIM_par_1 362 368 PF11976 0.553
LIG_SUMO_SIM_par_1 380 386 PF11976 0.501
LIG_TRAF2_1 207 210 PF00917 0.514
LIG_TRAF2_1 230 233 PF00917 0.495
MOD_CDK_SPK_2 67 72 PF00069 0.602
MOD_CK2_1 126 132 PF00069 0.571
MOD_CK2_1 150 156 PF00069 0.698
MOD_CK2_1 227 233 PF00069 0.533
MOD_CK2_1 299 305 PF00069 0.563
MOD_GlcNHglycan 153 156 PF01048 0.531
MOD_GlcNHglycan 278 281 PF01048 0.618
MOD_GlcNHglycan 348 351 PF01048 0.696
MOD_GlcNHglycan 47 50 PF01048 0.234
MOD_LATS_1 10 16 PF00433 0.529
MOD_LATS_1 43 49 PF00433 0.234
MOD_N-GLC_1 126 131 PF02516 0.537
MOD_NEK2_1 125 130 PF00069 0.438
MOD_NEK2_1 238 243 PF00069 0.486
MOD_NEK2_1 28 33 PF00069 0.515
MOD_NEK2_1 406 411 PF00069 0.564
MOD_NEK2_1 80 85 PF00069 0.742
MOD_NEK2_2 38 43 PF00069 0.257
MOD_PK_1 299 305 PF00069 0.467
MOD_PKA_1 45 51 PF00069 0.234
MOD_PKA_2 254 260 PF00069 0.550
MOD_PKA_2 45 51 PF00069 0.257
MOD_Plk_2-3 290 296 PF00069 0.465
MOD_ProDKin_1 168 174 PF00069 0.730
MOD_ProDKin_1 67 73 PF00069 0.599
MOD_SUMO_rev_2 386 395 PF00179 0.595
TRG_DiLeu_BaEn_1 403 408 PF01217 0.540
TRG_ENDOCYTIC_2 145 148 PF00928 0.685
TRG_ENDOCYTIC_2 174 177 PF00928 0.822
TRG_ENDOCYTIC_2 39 42 PF00928 0.453
TRG_ENDOCYTIC_2 417 420 PF00928 0.514
TRG_ENDOCYTIC_2 53 56 PF00928 0.395
TRG_ENDOCYTIC_2 58 61 PF00928 0.430
TRG_ER_diArg_1 11 13 PF00400 0.625
TRG_ER_diArg_1 161 163 PF00400 0.495
TRG_ER_diArg_1 331 334 PF00400 0.509
TRG_ER_diArg_1 45 47 PF00400 0.481
TRG_ER_diArg_1 7 9 PF00400 0.696
TRG_ER_diArg_1 82 85 PF00400 0.749

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Q7 Leptomonas seymouri 49% 73%
A4H8M6 Leishmania braziliensis 81% 100%
A4H8M8 Leishmania braziliensis 79% 96%
E9AGP0 Leishmania infantum 93% 69%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS