Exostosin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3184) - putative

Species:

Leishmania infantum

UniProt:

E9AGN7_LEIIN

TriTrypDb:

LINF_160015600

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.411
CLV_MEL_PAP_1	92	98	PF00089	0.357
CLV_NRD_NRD_1	115	117	PF00675	0.345
CLV_NRD_NRD_1	48	50	PF00675	0.493
CLV_NRD_NRD_1	84	86	PF00675	0.421
CLV_PCSK_KEX2_1	48	50	PF00082	0.493
CLV_PCSK_KEX2_1	84	86	PF00082	0.420
CLV_PCSK_SKI1_1	228	232	PF00082	0.395
CLV_PCSK_SKI1_1	85	89	PF00082	0.388
DEG_APCC_DBOX_1	194	202	PF00400	0.383
DOC_CDC14_PxL_1	121	129	PF14671	0.360
DOC_MAPK_gen_1	206	215	PF00069	0.360
DOC_USP7_MATH_1	144	148	PF00917	0.562
DOC_USP7_MATH_1	242	246	PF00917	0.430
DOC_USP7_MATH_1	32	36	PF00917	0.569
DOC_WW_Pin1_4	150	155	PF00397	0.416
DOC_WW_Pin1_4	213	218	PF00397	0.358
DOC_WW_Pin1_4	85	90	PF00397	0.548
LIG_14-3-3_CanoR_1	116	122	PF00244	0.343
LIG_14-3-3_CanoR_1	195	199	PF00244	0.394
LIG_14-3-3_CanoR_1	251	256	PF00244	0.371
LIG_14-3-3_CanoR_1	266	270	PF00244	0.409
LIG_14-3-3_CanoR_1	48	56	PF00244	0.619
LIG_14-3-3_CanoR_1	84	88	PF00244	0.395
LIG_Actin_WH2_2	236	253	PF00022	0.418
LIG_FHA_1	16	22	PF00498	0.464
LIG_FHA_1	189	195	PF00498	0.428
LIG_FHA_1	97	103	PF00498	0.361
LIG_FHA_2	132	138	PF00498	0.393
LIG_FHA_2	220	226	PF00498	0.403
LIG_FHA_2	86	92	PF00498	0.370
LIG_LIR_Apic_2	120	125	PF02991	0.352
LIG_LIR_Gen_1	100	111	PF02991	0.365
LIG_LIR_Gen_1	171	182	PF02991	0.348
LIG_LIR_Gen_1	38	43	PF02991	0.476
LIG_LIR_Nem_3	100	106	PF02991	0.358
LIG_LIR_Nem_3	38	42	PF02991	0.450
LIG_MYND_1	74	78	PF01753	0.434
LIG_PTB_Apo_2	129	136	PF02174	0.382
LIG_PTB_Phospho_1	129	135	PF10480	0.376
LIG_SH2_CRK	103	107	PF00017	0.349
LIG_SH2_CRK	115	119	PF00017	0.332
LIG_SH2_CRK	165	169	PF00017	0.621
LIG_SH2_GRB2like	165	168	PF00017	0.355
LIG_SH2_GRB2like	39	42	PF00017	0.452
LIG_SH2_PTP2	39	42	PF00017	0.452
LIG_SH2_SRC	165	168	PF00017	0.326
LIG_SH2_SRC	39	42	PF00017	0.452
LIG_SH2_SRC	64	67	PF00017	0.487
LIG_SH2_STAT5	160	163	PF00017	0.345
LIG_SH2_STAT5	39	42	PF00017	0.465
LIG_SH2_STAT5	69	72	PF00017	0.418
LIG_SH3_3	68	74	PF00018	0.587
LIG_SUMO_SIM_par_1	211	216	PF11976	0.347
LIG_TYR_ITIM	101	106	PF00017	0.357
LIG_WRC_WIRS_1	102	107	PF05994	0.354
MOD_CK1_1	16	22	PF00069	0.493
MOD_CK1_1	197	203	PF00069	0.403
MOD_CK1_1	245	251	PF00069	0.469
MOD_CK1_1	35	41	PF00069	0.475
MOD_CK2_1	131	137	PF00069	0.391
MOD_CK2_1	85	91	PF00069	0.381
MOD_GlcNHglycan	15	18	PF01048	0.464
MOD_GlcNHglycan	245	248	PF01048	0.499
MOD_GSK3_1	144	151	PF00069	0.415
MOD_GSK3_1	16	23	PF00069	0.491
MOD_GSK3_1	31	38	PF00069	0.649
MOD_LATS_1	249	255	PF00433	0.379
MOD_N-GLC_1	106	111	PF02516	0.362
MOD_N-GLC_1	131	136	PF02516	0.390
MOD_N-GLC_2	112	114	PF02516	0.308
MOD_NEK2_1	148	153	PF00069	0.392
MOD_NEK2_1	194	199	PF00069	0.443
MOD_NEK2_1	243	248	PF00069	0.485
MOD_NEK2_1	250	255	PF00069	0.447
MOD_PIKK_1	42	48	PF00454	0.485
MOD_PKA_2	188	194	PF00069	0.428
MOD_PKA_2	243	249	PF00069	0.427
MOD_PKA_2	250	256	PF00069	0.376
MOD_PKA_2	265	271	PF00069	0.385
MOD_PKA_2	47	53	PF00069	0.480
MOD_PKA_2	83	89	PF00069	0.405
MOD_Plk_1	131	137	PF00069	0.391
MOD_Plk_2-3	131	137	PF00069	0.391
MOD_Plk_2-3	188	194	PF00069	0.428
MOD_Plk_4	101	107	PF00069	0.366
MOD_Plk_4	117	123	PF00069	0.298
MOD_Plk_4	131	137	PF00069	0.351
MOD_Plk_4	144	150	PF00069	0.389
MOD_Plk_4	219	225	PF00069	0.398
MOD_Plk_4	35	41	PF00069	0.450
MOD_ProDKin_1	150	156	PF00069	0.405
MOD_ProDKin_1	213	219	PF00069	0.367
MOD_ProDKin_1	85	91	PF00069	0.542
MOD_TYR_CSK	60	68	PF07714	0.478
TRG_DiLeu_BaEn_1	72	77	PF01217	0.432
TRG_DiLeu_BaEn_4	72	78	PF01217	0.437
TRG_ENDOCYTIC_2	103	106	PF00928	0.343
TRG_ENDOCYTIC_2	115	118	PF00928	0.336
TRG_ENDOCYTIC_2	165	168	PF00928	0.355
TRG_ENDOCYTIC_2	39	42	PF00928	0.465
TRG_ER_diArg_1	209	212	PF00400	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P472	Leptomonas seymouri	50%	79%