LeishMANIAdb
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DNA-(apurinic or apyrimidinic site) endonuclease

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA-(apurinic or apyrimidinic site) endonuclease
Gene product:
apurinic/apyrimidinic endonuclease-redox protein
Species:
Leishmania infantum
UniProt:
E9AGN4_LEIIN
TriTrypDb:
LINF_160012200
Length:
447

Annotations

Annotations by Jardim et al.

DNA repair, Apurinic/apyrimidinic endonuclease-redox AP-endonuclease

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

E9AGN4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGN4

PDB structure(s): 2j63_A , 2j63_B

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006259 DNA metabolic process 4 11
GO:0006281 DNA repair 5 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0006950 response to stress 2 11
GO:0006974 DNA damage response 4 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0033554 cellular response to stress 3 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0046483 heterocycle metabolic process 3 11
GO:0050896 response to stimulus 1 11
GO:0051716 cellular response to stimulus 2 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:0006284 base-excision repair 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 8
GO:0003677 DNA binding 4 8
GO:0003824 catalytic activity 1 11
GO:0004518 nuclease activity 4 11
GO:0004519 endonuclease activity 5 11
GO:0005488 binding 1 11
GO:0016787 hydrolase activity 2 11
GO:0016788 hydrolase activity, acting on ester bonds 3 11
GO:0016829 lyase activity 2 8
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0097159 organic cyclic compound binding 2 8
GO:1901363 heterocyclic compound binding 2 8
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4 1
GO:0004527 exonuclease activity 5 1
GO:0004529 DNA exonuclease activity 5 1
GO:0004536 DNA nuclease activity 4 1
GO:0008081 phosphoric diester hydrolase activity 5 1
GO:0008296 3'-5'-DNA exonuclease activity 7 1
GO:0008309 double-stranded DNA exodeoxyribonuclease activity 7 1
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity 8 1
GO:0008408 3'-5' exonuclease activity 6 1
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 1
GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 6 1
GO:0042578 phosphoric ester hydrolase activity 4 1
GO:0140097 catalytic activity, acting on DNA 3 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 173 177 PF00656 0.418
CLV_C14_Caspase3-7 82 86 PF00656 0.511
CLV_C14_Caspase3-7 9 13 PF00656 0.686
CLV_NRD_NRD_1 117 119 PF00675 0.449
CLV_NRD_NRD_1 6 8 PF00675 0.703
CLV_NRD_NRD_1 73 75 PF00675 0.769
CLV_PCSK_KEX2_1 117 119 PF00082 0.429
CLV_PCSK_KEX2_1 197 199 PF00082 0.457
CLV_PCSK_KEX2_1 214 216 PF00082 0.176
CLV_PCSK_KEX2_1 4 6 PF00082 0.720
CLV_PCSK_KEX2_1 73 75 PF00082 0.742
CLV_PCSK_PC1ET2_1 197 199 PF00082 0.457
CLV_PCSK_PC1ET2_1 214 216 PF00082 0.176
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.759
CLV_PCSK_SKI1_1 131 135 PF00082 0.365
CLV_PCSK_SKI1_1 141 145 PF00082 0.283
CLV_PCSK_SKI1_1 251 255 PF00082 0.312
CLV_PCSK_SKI1_1 269 273 PF00082 0.385
CLV_PCSK_SKI1_1 64 68 PF00082 0.658
DEG_APCC_DBOX_1 298 306 PF00400 0.312
DEG_COP1_1 310 318 PF00400 0.379
DEG_SPOP_SBC_1 14 18 PF00917 0.661
DEG_SPOP_SBC_1 264 268 PF00917 0.404
DOC_CYCLIN_yClb5_NLxxxL_5 402 410 PF00134 0.457
DOC_MAPK_JIP1_4 159 165 PF00069 0.415
DOC_PP1_RVXF_1 129 136 PF00149 0.343
DOC_PP1_RVXF_1 363 369 PF00149 0.424
DOC_PP1_RVXF_1 402 409 PF00149 0.332
DOC_PP4_FxxP_1 224 227 PF00568 0.424
DOC_PP4_FxxP_1 256 259 PF00568 0.411
DOC_PP4_FxxP_1 427 430 PF00568 0.312
DOC_USP7_MATH_1 14 18 PF00917 0.744
DOC_USP7_MATH_1 225 229 PF00917 0.379
DOC_USP7_MATH_1 264 268 PF00917 0.404
DOC_USP7_MATH_1 314 318 PF00917 0.450
DOC_USP7_MATH_2 362 368 PF00917 0.312
DOC_USP7_UBL2_3 102 106 PF12436 0.531
DOC_WW_Pin1_4 235 240 PF00397 0.358
DOC_WW_Pin1_4 255 260 PF00397 0.345
DOC_WW_Pin1_4 323 328 PF00397 0.395
DOC_WW_Pin1_4 67 72 PF00397 0.740
LIG_14-3-3_CanoR_1 117 126 PF00244 0.457
LIG_14-3-3_CanoR_1 251 257 PF00244 0.332
LIG_14-3-3_CanoR_1 290 295 PF00244 0.361
LIG_14-3-3_CanoR_1 365 369 PF00244 0.312
LIG_14-3-3_CanoR_1 37 44 PF00244 0.638
LIG_14-3-3_CanoR_1 374 379 PF00244 0.312
LIG_14-3-3_CanoR_1 418 423 PF00244 0.379
LIG_14-3-3_CanoR_1 73 79 PF00244 0.647
LIG_14-3-3_CanoR_1 88 96 PF00244 0.477
LIG_BIR_II_1 1 5 PF00653 0.780
LIG_deltaCOP1_diTrp_1 107 115 PF00928 0.530
LIG_FHA_1 132 138 PF00498 0.350
LIG_FHA_1 178 184 PF00498 0.404
LIG_FHA_1 21 27 PF00498 0.725
LIG_FHA_1 252 258 PF00498 0.385
LIG_FHA_1 373 379 PF00498 0.340
LIG_FHA_2 118 124 PF00498 0.465
LIG_Integrin_isoDGR_2 400 402 PF01839 0.332
LIG_LIR_Apic_2 221 227 PF02991 0.457
LIG_LIR_Apic_2 254 259 PF02991 0.411
LIG_LIR_Apic_2 425 430 PF02991 0.312
LIG_LIR_Gen_1 107 116 PF02991 0.464
LIG_LIR_Gen_1 185 195 PF02991 0.424
LIG_LIR_Nem_3 107 112 PF02991 0.457
LIG_LIR_Nem_3 127 133 PF02991 0.469
LIG_LIR_Nem_3 185 190 PF02991 0.388
LIG_LIR_Nem_3 340 346 PF02991 0.297
LIG_LIR_Nem_3 379 384 PF02991 0.308
LIG_LIR_Nem_3 411 415 PF02991 0.312
LIG_MAD2 251 259 PF02301 0.411
LIG_NRBOX 139 145 PF00104 0.332
LIG_Pex14_1 408 412 PF04695 0.312
LIG_SH2_CRK 130 134 PF00017 0.455
LIG_SH2_STAP1 343 347 PF00017 0.312
LIG_SH2_STAT3 289 292 PF00017 0.385
LIG_SH2_STAT5 276 279 PF00017 0.312
LIG_SH2_STAT5 301 304 PF00017 0.385
LIG_SH2_STAT5 412 415 PF00017 0.312
LIG_SH2_STAT5 422 425 PF00017 0.312
LIG_SH3_3 187 193 PF00018 0.379
LIG_SH3_3 224 230 PF00018 0.457
LIG_SUMO_SIM_anti_2 265 275 PF11976 0.419
LIG_SUMO_SIM_par_1 238 243 PF11976 0.360
LIG_TRAF2_1 353 356 PF00917 0.345
LIG_TRAF2_1 361 364 PF00917 0.275
LIG_TYR_ITIM 410 415 PF00017 0.312
LIG_WRC_WIRS_1 253 258 PF05994 0.424
LIG_WRC_WIRS_1 291 296 PF05994 0.424
LIG_WRC_WIRS_1 391 396 PF05994 0.372
MOD_CDC14_SPxK_1 70 73 PF00782 0.731
MOD_CDK_SPxK_1 67 73 PF00069 0.731
MOD_CDK_SPxxK_3 67 74 PF00069 0.734
MOD_CK1_1 10 16 PF00069 0.787
MOD_CK1_1 17 23 PF00069 0.726
MOD_CK1_1 263 269 PF00069 0.433
MOD_CK1_1 393 399 PF00069 0.424
MOD_CK2_1 101 107 PF00069 0.486
MOD_CK2_1 19 25 PF00069 0.742
MOD_CK2_1 294 300 PF00069 0.340
MOD_CK2_1 350 356 PF00069 0.345
MOD_CK2_1 364 370 PF00069 0.250
MOD_GlcNHglycan 148 151 PF01048 0.411
MOD_GlcNHglycan 200 203 PF01048 0.312
MOD_GlcNHglycan 262 265 PF01048 0.422
MOD_GlcNHglycan 279 282 PF01048 0.332
MOD_GlcNHglycan 316 319 PF01048 0.423
MOD_GlcNHglycan 356 360 PF01048 0.319
MOD_GlcNHglycan 52 55 PF01048 0.726
MOD_GlcNHglycan 76 79 PF01048 0.717
MOD_GlcNHglycan 9 12 PF01048 0.771
MOD_GlcNHglycan 91 94 PF01048 0.479
MOD_GSK3_1 14 21 PF00069 0.651
MOD_GSK3_1 198 205 PF00069 0.312
MOD_GSK3_1 251 258 PF00069 0.358
MOD_GSK3_1 260 267 PF00069 0.351
MOD_GSK3_1 290 297 PF00069 0.340
MOD_GSK3_1 364 371 PF00069 0.297
MOD_GSK3_1 414 421 PF00069 0.402
MOD_GSK3_1 428 435 PF00069 0.280
MOD_GSK3_1 45 52 PF00069 0.670
MOD_GSK3_1 6 13 PF00069 0.704
MOD_N-GLC_1 146 151 PF02516 0.457
MOD_N-GLC_1 177 182 PF02516 0.340
MOD_N-GLC_1 208 213 PF02516 0.443
MOD_NEK2_1 165 170 PF00069 0.323
MOD_NEK2_1 207 212 PF00069 0.424
MOD_NEK2_1 272 277 PF00069 0.332
MOD_NEK2_1 282 287 PF00069 0.332
MOD_NEK2_1 368 373 PF00069 0.297
MOD_NEK2_1 413 418 PF00069 0.312
MOD_NEK2_2 347 352 PF00069 0.424
MOD_PIKK_1 393 399 PF00454 0.457
MOD_PK_1 374 380 PF00069 0.457
MOD_PKA_1 117 123 PF00069 0.464
MOD_PKA_1 6 12 PF00069 0.655
MOD_PKA_1 64 70 PF00069 0.757
MOD_PKA_1 73 79 PF00069 0.690
MOD_PKA_2 116 122 PF00069 0.443
MOD_PKA_2 218 224 PF00069 0.451
MOD_PKA_2 36 42 PF00069 0.673
MOD_PKA_2 364 370 PF00069 0.312
MOD_PKA_2 6 12 PF00069 0.731
MOD_PKA_2 72 78 PF00069 0.725
MOD_PKB_1 5 13 PF00069 0.786
MOD_Plk_1 146 152 PF00069 0.457
MOD_Plk_1 177 183 PF00069 0.340
MOD_Plk_1 208 214 PF00069 0.443
MOD_Plk_2-3 185 191 PF00069 0.457
MOD_Plk_2-3 364 370 PF00069 0.385
MOD_Plk_4 185 191 PF00069 0.457
MOD_Plk_4 252 258 PF00069 0.312
MOD_Plk_4 272 278 PF00069 0.332
MOD_Plk_4 390 396 PF00069 0.329
MOD_Plk_4 418 424 PF00069 0.431
MOD_Plk_4 428 434 PF00069 0.415
MOD_ProDKin_1 235 241 PF00069 0.358
MOD_ProDKin_1 255 261 PF00069 0.345
MOD_ProDKin_1 323 329 PF00069 0.395
MOD_ProDKin_1 67 73 PF00069 0.742
MOD_SUMO_rev_2 161 170 PF00179 0.312
TRG_DiLeu_BaEn_4 248 254 PF01217 0.385
TRG_DiLeu_BaLyEn_6 85 90 PF01217 0.408
TRG_ENDOCYTIC_2 130 133 PF00928 0.457
TRG_ENDOCYTIC_2 187 190 PF00928 0.332
TRG_ENDOCYTIC_2 412 415 PF00928 0.311
TRG_ER_diArg_1 116 118 PF00400 0.527
TRG_ER_diArg_1 5 7 PF00400 0.704
TRG_NLS_MonoCore_2 3 8 PF00514 0.603

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIW7 Leptomonas seymouri 65% 100%
A0A0S4JDZ9 Bodo saltans 47% 100%
A0A3R7KY33 Trypanosoma rangeli 55% 99%
A0A3S7WTW9 Leishmania donovani 100% 100%
A0MTA1 Danio rerio 32% 100%
A1YES6 Gorilla gorilla gorilla 32% 100%
A1YFZ3 Pan paniscus 33% 100%
A2T6Y4 Pan troglodytes 33% 100%
A2T7I6 Pongo pygmaeus 33% 100%
A4H8J0 Leishmania braziliensis 83% 99%
C9ZW21 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9AQM7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
O15922 Leishmania major 95% 100%
P23196 Bos taurus 32% 100%
P27695 Homo sapiens 33% 100%
P28352 Mus musculus 32% 100%
P43138 Rattus norvegicus 33% 100%
P45951 Arabidopsis thaliana 35% 83%
P51173 Dictyostelium discoideum 34% 100%
P87175 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 85%
Q5XF07 Arabidopsis thaliana 23% 100%
V5AT33 Trypanosoma cruzi 57% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS