Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGN3_LEIIN

TriTrypDb:

LINF_160012100

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	425	429	PF00656	0.667
CLV_C14_Caspase3-7	552	556	PF00656	0.500
CLV_NRD_NRD_1	268	270	PF00675	0.388
CLV_NRD_NRD_1	278	280	PF00675	0.285
CLV_NRD_NRD_1	345	347	PF00675	0.620
CLV_NRD_NRD_1	5	7	PF00675	0.597
CLV_NRD_NRD_1	664	666	PF00675	0.398
CLV_PCSK_KEX2_1	268	270	PF00082	0.388
CLV_PCSK_KEX2_1	278	280	PF00082	0.285
CLV_PCSK_KEX2_1	345	347	PF00082	0.620
CLV_PCSK_KEX2_1	5	7	PF00082	0.597
CLV_PCSK_KEX2_1	537	539	PF00082	0.587
CLV_PCSK_KEX2_1	671	673	PF00082	0.548
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.587
CLV_PCSK_PC1ET2_1	671	673	PF00082	0.555
CLV_PCSK_SKI1_1	119	123	PF00082	0.592
CLV_PCSK_SKI1_1	203	207	PF00082	0.642
CLV_PCSK_SKI1_1	268	272	PF00082	0.366
CLV_PCSK_SKI1_1	278	282	PF00082	0.269
CLV_PCSK_SKI1_1	31	35	PF00082	0.557
CLV_PCSK_SKI1_1	321	325	PF00082	0.490
DEG_Nend_Nbox_1	1	3	PF02207	0.630
DEG_SCF_FBW7_1	569	576	PF00400	0.628
DEG_SPOP_SBC_1	298	302	PF00917	0.340
DEG_SPOP_SBC_1	411	415	PF00917	0.408
DEG_SPOP_SBC_1	573	577	PF00917	0.678
DOC_CKS1_1	236	241	PF01111	0.520
DOC_CYCLIN_RxL_1	116	125	PF00134	0.546
DOC_CYCLIN_RxL_1	28	39	PF00134	0.586
DOC_PP4_FxxP_1	270	273	PF00568	0.312
DOC_PP4_MxPP_1	571	574	PF00568	0.603
DOC_USP7_MATH_1	117	121	PF00917	0.533
DOC_USP7_MATH_1	260	264	PF00917	0.388
DOC_USP7_MATH_1	411	415	PF00917	0.515
DOC_USP7_MATH_1	440	444	PF00917	0.622
DOC_USP7_MATH_1	48	52	PF00917	0.580
DOC_USP7_MATH_1	553	557	PF00917	0.679
DOC_USP7_MATH_1	565	569	PF00917	0.540
DOC_USP7_MATH_1	574	578	PF00917	0.571
DOC_USP7_MATH_1	599	603	PF00917	0.539
DOC_USP7_MATH_2	445	451	PF00917	0.588
DOC_WW_Pin1_4	235	240	PF00397	0.609
DOC_WW_Pin1_4	269	274	PF00397	0.312
DOC_WW_Pin1_4	370	375	PF00397	0.499
DOC_WW_Pin1_4	380	385	PF00397	0.446
DOC_WW_Pin1_4	41	46	PF00397	0.627
DOC_WW_Pin1_4	418	423	PF00397	0.602
DOC_WW_Pin1_4	512	517	PF00397	0.493
DOC_WW_Pin1_4	569	574	PF00397	0.681
DOC_WW_Pin1_4	577	582	PF00397	0.574
LIG_14-3-3_CanoR_1	126	132	PF00244	0.670
LIG_14-3-3_CanoR_1	203	208	PF00244	0.795
LIG_14-3-3_CanoR_1	262	270	PF00244	0.255
LIG_14-3-3_CanoR_1	321	326	PF00244	0.485
LIG_14-3-3_CanoR_1	36	41	PF00244	0.684
LIG_Actin_WH2_2	649	667	PF00022	0.382
LIG_APCC_ABBA_1	636	641	PF00400	0.439
LIG_BRCT_BRCA1_1	372	376	PF00533	0.510
LIG_Clathr_ClatBox_1	308	312	PF01394	0.388
LIG_FHA_1	113	119	PF00498	0.483
LIG_FHA_1	285	291	PF00498	0.342
LIG_FHA_1	300	306	PF00498	0.256
LIG_FHA_1	324	330	PF00498	0.464
LIG_FHA_1	495	501	PF00498	0.364
LIG_FHA_1	513	519	PF00498	0.525
LIG_FHA_1	578	584	PF00498	0.499
LIG_FHA_1	633	639	PF00498	0.394
LIG_FHA_1	97	103	PF00498	0.632
LIG_FHA_2	225	231	PF00498	0.574
LIG_FHA_2	287	293	PF00498	0.303
LIG_FHA_2	322	328	PF00498	0.502
LIG_FHA_2	423	429	PF00498	0.549
LIG_FHA_2	550	556	PF00498	0.517
LIG_FHA_2	621	627	PF00498	0.569
LIG_Integrin_RGD_1	548	550	PF01839	0.646
LIG_LIR_Apic_2	416	422	PF02991	0.480
LIG_LIR_Apic_2	536	542	PF02991	0.483
LIG_LIR_Gen_1	150	157	PF02991	0.564
LIG_LIR_Gen_1	470	478	PF02991	0.539
LIG_LIR_Nem_3	150	154	PF02991	0.569
LIG_LIR_Nem_3	373	379	PF02991	0.503
LIG_LIR_Nem_3	470	475	PF02991	0.605
LIG_MAD2	532	540	PF02301	0.547
LIG_NRBOX	117	123	PF00104	0.614
LIG_PCNA_yPIPBox_3	650	660	PF02747	0.464
LIG_PDZ_Wminus1_1	672	674	PF00595	0.481
LIG_Pex14_2	270	274	PF04695	0.312
LIG_Pex14_2	344	348	PF04695	0.532
LIG_Rb_LxCxE_1	182	202	PF01857	0.548
LIG_SH2_CRK	508	512	PF00017	0.406
LIG_SH2_GRB2like	460	463	PF00017	0.446
LIG_SH2_NCK_1	151	155	PF00017	0.578
LIG_SH2_NCK_1	461	465	PF00017	0.446
LIG_SH2_STAP1	433	437	PF00017	0.570
LIG_SH2_STAT5	504	507	PF00017	0.470
LIG_SH3_1	229	235	PF00018	0.577
LIG_SH3_3	229	235	PF00018	0.625
LIG_SH3_3	26	32	PF00018	0.572
LIG_SH3_3	371	377	PF00018	0.406
LIG_SH3_3	626	632	PF00018	0.552
LIG_SUMO_SIM_par_1	286	294	PF11976	0.388
LIG_TRAF2_1	289	292	PF00917	0.313
LIG_TRAF2_1	445	448	PF00917	0.605
LIG_TYR_ITIM	458	463	PF00017	0.389
MOD_CK1_1	112	118	PF00069	0.553
MOD_CK1_1	125	131	PF00069	0.529
MOD_CK1_1	256	262	PF00069	0.340
MOD_CK1_1	450	456	PF00069	0.660
MOD_CK1_1	556	562	PF00069	0.582
MOD_CK1_1	577	583	PF00069	0.549
MOD_CK1_1	602	608	PF00069	0.538
MOD_CK2_1	140	146	PF00069	0.608
MOD_CK2_1	176	182	PF00069	0.528
MOD_CK2_1	224	230	PF00069	0.673
MOD_CK2_1	238	244	PF00069	0.664
MOD_CK2_1	260	266	PF00069	0.402
MOD_CK2_1	286	292	PF00069	0.356
MOD_CK2_1	321	327	PF00069	0.463
MOD_CK2_1	410	416	PF00069	0.428
MOD_CMANNOS	499	502	PF00535	0.378
MOD_CMANNOS	670	673	PF00535	0.497
MOD_DYRK1A_RPxSP_1	380	384	PF00069	0.409
MOD_GlcNHglycan	129	132	PF01048	0.724
MOD_GlcNHglycan	166	169	PF01048	0.646
MOD_GlcNHglycan	240	243	PF01048	0.583
MOD_GlcNHglycan	258	261	PF01048	0.277
MOD_GlcNHglycan	302	305	PF01048	0.206
MOD_GlcNHglycan	562	565	PF01048	0.617
MOD_GlcNHglycan	576	579	PF01048	0.589
MOD_GlcNHglycan	60	64	PF01048	0.561
MOD_GSK3_1	122	129	PF00069	0.542
MOD_GSK3_1	203	210	PF00069	0.664
MOD_GSK3_1	256	263	PF00069	0.398
MOD_GSK3_1	366	373	PF00069	0.436
MOD_GSK3_1	418	425	PF00069	0.580
MOD_GSK3_1	549	556	PF00069	0.606
MOD_GSK3_1	565	572	PF00069	0.570
MOD_GSK3_1	573	580	PF00069	0.572
MOD_GSK3_1	599	606	PF00069	0.775
MOD_GSK3_1	614	621	PF00069	0.599
MOD_GSK3_1	96	103	PF00069	0.708
MOD_LATS_1	124	130	PF00433	0.655
MOD_N-GLC_1	224	229	PF02516	0.578
MOD_NEK2_1	1	6	PF00069	0.615
MOD_NEK2_1	122	127	PF00069	0.544
MOD_NEK2_1	274	279	PF00069	0.388
MOD_NEK2_1	297	302	PF00069	0.391
MOD_NEK2_1	311	316	PF00069	0.268
MOD_NEK2_1	366	371	PF00069	0.443
MOD_NEK2_1	664	669	PF00069	0.389
MOD_NEK2_2	340	345	PF00069	0.529
MOD_NEK2_2	48	53	PF00069	0.526
MOD_PIKK_1	109	115	PF00454	0.472
MOD_PIKK_1	218	224	PF00454	0.574
MOD_PIKK_1	80	86	PF00454	0.675
MOD_PK_1	557	563	PF00069	0.532
MOD_PKA_2	125	131	PF00069	0.665
MOD_PKA_2	140	146	PF00069	0.548
MOD_PKA_2	261	267	PF00069	0.291
MOD_PKA_2	488	494	PF00069	0.346
MOD_PKA_2	556	562	PF00069	0.591
MOD_PKA_2	664	670	PF00069	0.426
MOD_PKB_1	336	344	PF00069	0.556
MOD_Plk_1	311	317	PF00069	0.312
MOD_Plk_1	429	435	PF00069	0.608
MOD_Plk_4	100	106	PF00069	0.565
MOD_Plk_4	117	123	PF00069	0.572
MOD_Plk_4	405	411	PF00069	0.472
MOD_Plk_4	495	501	PF00069	0.380
MOD_ProDKin_1	235	241	PF00069	0.607
MOD_ProDKin_1	269	275	PF00069	0.312
MOD_ProDKin_1	370	376	PF00069	0.494
MOD_ProDKin_1	380	386	PF00069	0.437
MOD_ProDKin_1	41	47	PF00069	0.629
MOD_ProDKin_1	418	424	PF00069	0.600
MOD_ProDKin_1	512	518	PF00069	0.483
MOD_ProDKin_1	569	575	PF00069	0.682
MOD_ProDKin_1	577	583	PF00069	0.574
TRG_DiLeu_BaEn_1	293	298	PF01217	0.388
TRG_DiLeu_BaEn_2	265	271	PF01217	0.388
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.514
TRG_ENDOCYTIC_2	151	154	PF00928	0.581
TRG_ENDOCYTIC_2	460	463	PF00928	0.374
TRG_ER_diArg_1	268	270	PF00400	0.388
TRG_ER_diArg_1	331	334	PF00400	0.486
TRG_ER_diArg_1	344	346	PF00400	0.502
TRG_ER_diArg_1	377	380	PF00400	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUK6	Leptomonas seymouri	32%	100%
A0A3S7WTX7	Leishmania donovani	99%	100%
A4H8I9	Leishmania braziliensis	61%	100%
E9AQM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4QEV2	Leishmania major	86%	100%