Dihydroorotate dehydrogenase (fumarate)

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydroorotate dehydrogenase (fumarate)

Species:

Leishmania infantum

UniProt:

E9AGN2_LEIIN

TriTrypDb:

LINF_160010400

Length:

313

Annotations

Annotations by Jardim et al.

Pyrimidine metabolism, Dihydroorotate dehydrogenase DHODH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005654	nucleoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AGN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGN2

PDB structure(s): 3gye_A , 3gye_B , 3gz3_A , 3gz3_B , 3mhu_A , 3mhu_B , 3mjy_A , 3mjy_B , 3tjx_A , 3tjx_B , 3tq0_A , 3tq0_B , 3tro_A , 3tro_B , 4ef8_A , 4ef8_B , 4ef9_A , 4ef9_B , 4wzh_A , 4wzh_B , 6dgs_A , 6dgs_B , 6dwg_A , 6dwg_B , 6ebs_A , 6ebs_B , 7mx6_AAA , 7mx6_BBB , 7myd_AAA , 7myd_BBB

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006220	pyrimidine nucleotide metabolic process	5	11
GO:0006221	pyrimidine nucleotide biosynthetic process	6	11
GO:0006222	UMP biosynthetic process	8	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009123	nucleoside monophosphate metabolic process	5	11
GO:0009124	nucleoside monophosphate biosynthetic process	6	11
GO:0009129	pyrimidine nucleoside monophosphate metabolic process	6	11
GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process	7	11
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	11
GO:0009161	ribonucleoside monophosphate metabolic process	6	11
GO:0009165	nucleotide biosynthetic process	6	11
GO:0009173	pyrimidine ribonucleoside monophosphate metabolic process	7	11
GO:0009174	pyrimidine ribonucleoside monophosphate biosynthetic process	8	11
GO:0009218	pyrimidine ribonucleotide metabolic process	6	11
GO:0009220	pyrimidine ribonucleotide biosynthetic process	7	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009260	ribonucleotide biosynthetic process	6	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044205	'de novo' UMP biosynthetic process	9	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046049	UMP metabolic process	7	11
GO:0046390	ribose phosphate biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072527	pyrimidine-containing compound metabolic process	4	11
GO:0072528	pyrimidine-containing compound biosynthetic process	5	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901293	nucleoside phosphate biosynthetic process	5	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006082	organic acid metabolic process	3	1
GO:0006106	fumarate metabolic process	7	1
GO:0006206	pyrimidine nucleobase metabolic process	5	2
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	7	2
GO:0009112	nucleobase metabolic process	4	2
GO:0019752	carboxylic acid metabolic process	5	1
GO:0019856	pyrimidine nucleobase biosynthetic process	6	2
GO:0043436	oxoacid metabolic process	4	1
GO:0043648	dicarboxylic acid metabolic process	6	1
GO:0046112	nucleobase biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004152	dihydroorotate dehydrogenase activity	4	11
GO:0016491	oxidoreductase activity	2	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	11
GO:1990663	dihydroorotate dehydrogenase (fumarate) activity	5	11
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0036094	small molecule binding	2	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	239	241	PF00675	0.280
CLV_NRD_NRD_1	91	93	PF00675	0.278
CLV_PCSK_KEX2_1	112	114	PF00082	0.355
CLV_PCSK_KEX2_1	239	241	PF00082	0.280
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.413
CLV_PCSK_SKI1_1	224	228	PF00082	0.271
CLV_PCSK_SKI1_1	244	248	PF00082	0.194
CLV_PCSK_SKI1_1	93	97	PF00082	0.280
DEG_APCC_DBOX_1	147	155	PF00400	0.280
DOC_CYCLIN_RxL_1	57	66	PF00134	0.350
DOC_CYCLIN_yClb1_LxF_4	242	247	PF00134	0.320
DOC_MAPK_gen_1	239	247	PF00069	0.280
DOC_MAPK_JIP1_4	93	99	PF00069	0.276
DOC_MAPK_MEF2A_6	121	129	PF00069	0.299
DOC_MAPK_MEF2A_6	92	99	PF00069	0.300
DOC_PP1_RVXF_1	242	248	PF00149	0.296
DOC_PP4_FxxP_1	12	15	PF00568	0.296
DOC_USP7_MATH_1	264	268	PF00917	0.280
DOC_USP7_MATH_1	37	41	PF00917	0.396
DOC_USP7_MATH_1	63	67	PF00917	0.297
DOC_WW_Pin1_4	44	49	PF00397	0.413
DOC_WW_Pin1_4	53	58	PF00397	0.413
LIG_14-3-3_CanoR_1	148	158	PF00244	0.414
LIG_14-3-3_CanoR_1	285	294	PF00244	0.355
LIG_APCC_ABBA_1	166	171	PF00400	0.280
LIG_BIR_II_1	1	5	PF00653	0.299
LIG_EH_1	13	17	PF12763	0.296
LIG_eIF4E_1	90	96	PF01652	0.296
LIG_FHA_1	205	211	PF00498	0.296
LIG_FHA_1	25	31	PF00498	0.271
LIG_FHA_1	285	291	PF00498	0.322
LIG_FHA_1	45	51	PF00498	0.228
LIG_FHA_2	24	30	PF00498	0.308
LIG_FHA_2	252	258	PF00498	0.355
LIG_FHA_2	299	305	PF00498	0.331
LIG_LIR_Apic_2	11	15	PF02991	0.296
LIG_LIR_Gen_1	143	151	PF02991	0.296
LIG_LIR_Gen_1	171	179	PF02991	0.322
LIG_LIR_Gen_1	256	266	PF02991	0.280
LIG_LIR_Nem_3	171	175	PF02991	0.386
LIG_LIR_Nem_3	184	188	PF02991	0.231
LIG_LIR_Nem_3	256	262	PF02991	0.280
LIG_LIR_Nem_3	56	62	PF02991	0.282
LIG_LIR_Nem_3	78	83	PF02991	0.335
LIG_Pex14_2	12	16	PF04695	0.320
LIG_PTB_Apo_2	6	13	PF02174	0.392
LIG_PTB_Apo_2	71	78	PF02174	0.287
LIG_SH2_CRK	59	63	PF00017	0.301
LIG_SH2_PTP2	225	228	PF00017	0.280
LIG_SH2_STAP1	142	146	PF00017	0.322
LIG_SH2_STAT5	169	172	PF00017	0.480
LIG_SH2_STAT5	225	228	PF00017	0.280
LIG_SH2_STAT5	253	256	PF00017	0.355
LIG_SH2_STAT5	80	83	PF00017	0.287
LIG_SH3_2	132	137	PF14604	0.280
LIG_SH3_3	129	135	PF00018	0.280
LIG_SH3_3	161	167	PF00018	0.280
LIG_SH3_3	208	214	PF00018	0.330
LIG_SUMO_SIM_anti_2	287	295	PF11976	0.385
LIG_UBA3_1	290	297	PF00899	0.375
LIG_Vh1_VBS_1	16	34	PF01044	0.392
MOD_CDK_SPK_2	53	58	PF00069	0.392
MOD_CDK_SPxxK_3	44	51	PF00069	0.413
MOD_CDK_SPxxK_3	53	60	PF00069	0.413
MOD_CK1_1	100	106	PF00069	0.280
MOD_CK1_1	40	46	PF00069	0.308
MOD_CK1_1	66	72	PF00069	0.280
MOD_CK2_1	100	106	PF00069	0.280
MOD_CK2_1	22	28	PF00069	0.320
MOD_CK2_1	298	304	PF00069	0.345
MOD_Cter_Amidation	90	93	PF01082	0.392
MOD_GlcNHglycan	35	38	PF01048	0.341
MOD_GlcNHglycan	99	102	PF01048	0.265
MOD_GSK3_1	189	196	PF00069	0.280
MOD_GSK3_1	31	38	PF00069	0.282
MOD_GSK3_1	40	47	PF00069	0.280
MOD_N-GLC_1	127	132	PF02516	0.280
MOD_N-GLC_1	8	13	PF02516	0.392
MOD_NEK2_1	127	132	PF00069	0.280
MOD_NEK2_1	33	38	PF00069	0.296
MOD_NEK2_1	8	13	PF00069	0.365
MOD_NEK2_1	95	100	PF00069	0.279
MOD_PKA_2	284	290	PF00069	0.322
MOD_Plk_1	8	14	PF00069	0.392
MOD_Plk_4	206	212	PF00069	0.320
MOD_Plk_4	264	270	PF00069	0.280
MOD_Plk_4	37	43	PF00069	0.282
MOD_ProDKin_1	44	50	PF00069	0.413
MOD_ProDKin_1	53	59	PF00069	0.413
TRG_ENDOCYTIC_2	169	172	PF00928	0.280
TRG_ENDOCYTIC_2	299	302	PF00928	0.341
TRG_ENDOCYTIC_2	59	62	PF00928	0.283
TRG_ER_diArg_1	238	240	PF00400	0.280
TRG_ER_FFAT_2	184	196	PF00635	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ26	Leptomonas seymouri	81%	100%
A0A0S4J3D1	Bodo saltans	64%	100%
A0A1X0NZ27	Trypanosomatidae	78%	100%
A0A3S7WTV8	Leishmania donovani	100%	100%
A0A422N937	Trypanosoma rangeli	75%	100%
A0AJT8	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	30%	100%
A0KKK9	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	26%	93%
A0QZY9	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	24%	88%
A0RHQ6	Bacillus thuringiensis (strain Al Hakam)	29%	100%
A1ASB3	Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)	31%	100%
A1UHW0	Mycobacterium sp. (strain KMS)	25%	88%
A1URL3	Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)	26%	86%
A1VQJ1	Polaromonas naphthalenivorans (strain CJ2)	27%	89%
A1W7S6	Acidovorax sp. (strain JS42)	25%	89%
A1WJ81	Verminephrobacter eiseniae (strain EF01-2)	26%	87%
A2RDV3	Streptococcus pyogenes serotype M5 (strain Manfredo)	56%	100%
A2RJT9	Lactococcus lactis subsp. cremoris (strain MG1363)	55%	100%
A3N0D6	Actinobacillus pleuropneumoniae serotype 5b (strain L20)	23%	93%
A3Q1C6	Mycobacterium sp. (strain JLS)	25%	88%
A4G7T7	Herminiimonas arsenicoxydans	27%	90%
A4IM35	Geobacillus thermodenitrificans (strain NG80-2)	31%	100%
A4J560	Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)	31%	100%
A4QEA4	Corynebacterium glutamicum (strain R)	25%	84%
A4SME2	Aeromonas salmonicida (strain A449)	27%	93%
A4W8V7	Enterobacter sp. (strain 638)	25%	93%
A4XKT6	Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)	28%	100%
A4Z2G7	Bradyrhizobium sp. (strain ORS 278)	25%	86%
A5EA61	Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)	25%	86%
A5G3H0	Geotalea uraniireducens (strain Rf4)	30%	100%
A5IK84	Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)	28%	100%
A5UX75	Roseiflexus sp. (strain RS-1)	26%	87%
A5VHS3	Limosilactobacillus reuteri (strain DSM 20016)	29%	100%
A6L5H1	Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154)	29%	100%
A6LB11	Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)	30%	100%
A6Q8G0	Sulfurovum sp. (strain NBC37-1)	26%	88%
A6T106	Janthinobacterium sp. (strain Marseille)	26%	91%
A6TVS0	Alkaliphilus metalliredigens (strain QYMF)	28%	100%
A7GRK9	Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)	28%	100%
A7HQ77	Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)	28%	90%
A7IBC2	Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)	27%	88%
A7N0L2	Vibrio campbellii (strain ATCC BAA-1116)	25%	93%
A7NLW9	Roseiflexus castenholzii (strain DSM 13941 / HLO8)	25%	85%
A7Z4H4	Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)	30%	100%
A8FD19	Bacillus pumilus (strain SAFR-032)	31%	100%
A8HZX8	Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571)	26%	88%
A8MIU4	Alkaliphilus oremlandii (strain OhILAs)	29%	100%
A8YVZ9	Lactobacillus helveticus (strain DPC 4571)	31%	100%
A9AJX4	Burkholderia multivorans (strain ATCC 17616 / 249)	25%	91%
A9BJH4	Petrotoga mobilis (strain DSM 10674 / SJ95)	27%	100%
A9BWU2	Delftia acidovorans (strain DSM 14801 / SPH-1)	27%	90%
A9CK85	Agrobacterium fabrum (strain C58 / ATCC 33970)	27%	86%
A9I8M0	Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)	26%	90%
A9KKR5	Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)	30%	100%
A9VTC4	Bacillus mycoides (strain KBAB4)	29%	100%
B0CA74	Acaryochloris marina (strain MBIC 11017)	27%	84%
B0K2E5	Thermoanaerobacter sp. (strain X514)	29%	100%
B0KA32	Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E)	29%	100%
B0R808	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	26%	90%
B0RTS3	Xanthomonas campestris pv. campestris (strain B100)	25%	89%
B0TGQ8	Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)	33%	100%
B1GYY3	Endomicrobium trichonymphae	28%	100%
B1I4M6	Desulforudis audaxviator (strain MP104C)	28%	100%
B1MPD4	Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)	24%	89%
B1W464	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)	28%	85%
B1XV77	Polynucleobacter necessarius subsp. necessarius (strain STIR1)	26%	91%
B1YIR7	Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15)	28%	100%
B2A2U4	Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)	26%	100%
B2G5A3	Limosilactobacillus reuteri (strain JCM 1112)	29%	100%
B2IU79	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	25%	83%
B2UNA2	Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)	26%	90%
B2USR9	Helicobacter pylori (strain Shi470)	22%	89%
B2V726	Sulfurihydrogenibium sp. (strain YO3AOP1)	28%	100%
B3DX48	Methylacidiphilum infernorum (isolate V4)	24%	90%
B3E4T4	Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)	28%	100%
B3PIL8	Cellvibrio japonicus (strain Ueda107)	26%	92%
B3QEE3	Rhodopseudomonas palustris (strain TIE-1)	24%	86%
B4STK4	Stenotrophomonas maltophilia (strain R551-3)	28%	89%
B5EFU4	Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem)	29%	100%
B5EL46	Acidithiobacillus ferrooxidans (strain ATCC 53993 / BNL-5-31)	28%	86%
B5YJH1	Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)	29%	100%
B6YRL9	Azobacteroides pseudotrichonymphae genomovar. CFP2	28%	100%
B7GFA1	Anoxybacillus flavithermus (strain DSM 21510 / WK1)	30%	100%
B7H6M0	Bacillus cereus (strain B4264)	29%	100%
B7HLL8	Bacillus cereus (strain AH187)	28%	100%
B7IUP4	Bacillus cereus (strain G9842)	29%	100%
B7J5Q1	Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455)	28%	86%
B7JJX1	Bacillus cereus (strain AH820)	28%	100%
B7JXU8	Rippkaea orientalis (strain PCC 8801)	26%	83%
B7KIU7	Gloeothece citriformis (strain PCC 7424)	23%	83%
B8DDR9	Listeria monocytogenes serotype 4a (strain HCC23)	30%	100%
B8HW33	Cyanothece sp. (strain PCC 7425 / ATCC 29141)	28%	83%
B8JDF0	Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)	28%	86%
B9DPN4	Staphylococcus carnosus (strain TM300)	28%	100%
B9DUS7	Streptococcus uberis (strain ATCC BAA-854 / 0140J)	56%	100%
B9IVW1	Bacillus cereus (strain Q1)	28%	100%
B9J901	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)	25%	86%
B9M211	Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32)	27%	100%
B9MIU2	Acidovorax ebreus (strain TPSY)	27%	89%
B9MS26	Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)	28%	100%
C0M8R7	Streptococcus equi subsp. equi (strain 4047)	57%	100%
C0MCW6	Streptococcus equi subsp. zooepidemicus (strain H70)	58%	100%
C0QYH6	Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)	29%	100%
C0ZZY4	Rhodococcus erythropolis (strain PR4 / NBRC 100887)	28%	88%
C1ASU1	Rhodococcus opacus (strain B4)	26%	88%
C1CX89	Deinococcus deserti (strain DSM 17065 / CIP 109153 / LMG 22923 / VCD115)	25%	87%
C1EPP8	Bacillus cereus (strain 03BB102)	28%	100%
C1KWD2	Listeria monocytogenes serotype 4b (strain CLIP80459)	31%	100%
C3L742	Bacillus anthracis (strain CDC 684 / NRRL 3495)	28%	100%
C3P654	Bacillus anthracis (strain A0248)	28%	100%
C4XPD6	Solidesulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1)	29%	100%
C5D8Q2	Geobacillus sp. (strain WCH70)	28%	100%
C6BW12	Maridesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIMB 8403 / VKM B-1763)	29%	100%
C6E6N2	Geobacter sp. (strain M21)	29%	100%
C9ZPR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9AI53	Leishmania braziliensis	87%	100%
E9AQL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
F2MMN9	Enterococcus faecalis (strain ATCC 47077 / OG1RF)	30%	100%
O08358	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	25%	100%
O27281	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	30%	100%
O29513	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	29%	100%
O35435	Mus musculus	27%	79%
O59185	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	29%	100%
O66461	Aquifex aeolicus (strain VF5)	31%	100%
P0DD66	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	56%	100%
P0DD67	Streptococcus pyogenes serotype M3 (strain SSI-1)	56%	100%
P0DH74	Enterococcus faecalis (strain ATCC 700802 / V583)	29%	100%
P25889	Escherichia coli (strain K12)	27%	76%
P25996	Bacillus subtilis (strain 168)	32%	100%
P28272	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	55%	100%
P32746	Arabidopsis thaliana	26%	68%
P32747	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	71%
P32748	Drosophila melanogaster	26%	77%
P46539	Bacillus caldolyticus	31%	100%
P54322	Lactococcus lactis subsp. cremoris (strain MG1363)	27%	100%
P57858	Pasteurella multocida (strain Pm70)	24%	92%
P59626	Enterococcus faecalis (strain ATCC 700802 / V583)	52%	100%
P77887	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	32%	100%
Q01YA2	Solibacter usitatus (strain Ellin6076)	30%	100%
Q02127	Homo sapiens	27%	79%
Q038Z3	Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441)	30%	100%
Q03HA9	Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)	29%	100%
Q047M3	Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365 / Lb-18)	31%	100%
Q0AIB4	Nitrosomonas eutropha (strain DSM 101675 / C91 / Nm57)	25%	92%
Q0AXG6	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	28%	100%
Q0BFR0	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	26%	91%
Q0W8E1	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	28%	100%
Q113R9	Trichodesmium erythraeum (strain IMS101)	26%	83%
Q11M76	Chelativorans sp. (strain BNC1)	27%	86%
Q129L9	Polaromonas sp. (strain JS666 / ATCC BAA-500)	26%	89%
Q13D13	Rhodopseudomonas palustris (strain BisB5)	26%	86%
Q17WU9	Helicobacter acinonychis (strain Sheeba)	24%	89%
Q18CS6	Clostridioides difficile (strain 630)	24%	100%
Q1B765	Mycobacterium sp. (strain MCS)	25%	88%
Q1CU70	Helicobacter pylori (strain HPAG1)	23%	89%
Q1D7Y6	Myxococcus xanthus (strain DK1622)	28%	86%
Q1G864	Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14)	31%	100%
Q1GVC1	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)	26%	88%
Q1J132	Deinococcus geothermalis (strain DSM 11300 / AG-3a)	30%	87%
Q21WC4	Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)	28%	88%
Q2GBY1	Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199)	27%	90%
Q2JRL7	Synechococcus sp. (strain JA-3-3Ab)	24%	83%
Q2KW44	Bordetella avium (strain 197N)	26%	90%
Q2N6N6	Erythrobacter litoralis (strain HTCC2594)	29%	91%
Q2NU82	Sodalis glossinidius (strain morsitans)	25%	93%
Q2RX27	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	25%	85%
Q2SVL9	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	27%	91%
Q30R79	Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251)	24%	89%
Q38X22	Latilactobacillus sakei subsp. sakei (strain 23K)	29%	100%
Q39UK4	Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)	28%	100%
Q3AC05	Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)	30%	100%
Q3BUJ7	Xanthomonas campestris pv. vesicatoria (strain 85-10)	25%	89%
Q3IU78	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	26%	89%
Q3K2G4	Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)	54%	100%
Q3MDU0	Trichormus variabilis (strain ATCC 29413 / PCC 7937)	25%	83%
Q47RF2	Thermobifida fusca (strain YX)	24%	83%
Q4D3W2	Trypanosoma cruzi (strain CL Brener)	76%	100%
Q4QEW7	Leishmania major	96%	100%
Q4UTX5	Xanthomonas campestris pv. campestris (strain 8004)	25%	89%
Q53ZE5	Lactococcus lactis subsp. cremoris	55%	100%
Q57U83	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	74%	100%
Q58070	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	27%	100%
Q5E9W3	Bos taurus	27%	79%
Q5FJB5	Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)	31%	100%
Q5JHR7	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	29%	100%
Q5L0U1	Geobacillus kaustophilus (strain HTA426)	32%	100%
Q5LCI2	Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)	29%	100%
Q5P1A9	Aromatoleum aromaticum (strain EbN1)	25%	89%
Q5R6X6	Pongo abelii	27%	79%
Q5WFJ4	Alkalihalobacillus clausii (strain KSM-K16)	29%	100%
Q5YVM8	Nocardia farcinica (strain IFM 10152)	29%	85%
Q636E2	Bacillus cereus (strain ZK / E33L)	28%	100%
Q63707	Rattus norvegicus	27%	79%
Q64TN0	Bacteroides fragilis (strain YCH46)	29%	100%
Q6A912	Cutibacterium acnes (strain DSM 16379 / KPA171202)	30%	100%
Q6CTX8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	70%
Q6G159	Bartonella quintana (strain Toulouse)	25%	86%
Q6G4F7	Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)	25%	86%
Q6HET0	Bacillus thuringiensis subsp. konkukian (strain 97-27)	28%	100%
Q6NH79	Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)	25%	86%
Q6SZS5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	71%
Q6SZS6	Kluyveromyces marxianus	24%	70%
Q6V3W9	Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651)	24%	70%
Q6V3X0	Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630)	55%	100%
Q71YI3	Listeria monocytogenes serotype 4b (strain F2365)	30%	100%
Q72KU3	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	28%	90%
Q732I5	Bacillus cereus (strain ATCC 10987 / NRS 248)	28%	100%
Q74CB9	Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)	30%	100%
Q74J29	Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)	29%	100%
Q75CE1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	70%
Q7MVJ6	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	28%	100%
Q7NC99	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	28%	89%
Q7XKC8	Oryza sativa subsp. japonica	25%	67%
Q7Z891	Saccharomyces paradoxus	54%	100%
Q7Z892	Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651)	57%	100%
Q7Z893	Saccharomyces mikatae	56%	100%
Q7Z894	Saccharomyces bayanus	55%	100%
Q7Z895	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	55%	99%
Q819S5	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	29%	100%
Q81WF4	Bacillus anthracis	28%	100%
Q874I4	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	70%
Q87PB7	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	25%	93%
Q89VA7	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	24%	86%
Q8A9C3	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	28%	100%
Q8CWG1	Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)	26%	100%
Q8DQ37	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	30%	100%
Q8DQG9	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	51%	100%
Q8E155	Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)	54%	100%
Q8E6L0	Streptococcus agalactiae serotype III (strain NEM316)	54%	100%
Q8EUY2	Malacoplasma penetrans (strain HF-2)	27%	100%
Q8FTC6	Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)	26%	83%
Q8NQC0	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	26%	84%
Q8P0C0	Streptococcus pyogenes serotype M18 (strain MGAS8232)	56%	100%
Q8P9R0	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	25%	89%
Q8PLJ2	Xanthomonas axonopodis pv. citri (strain 306)	25%	89%
Q8PW56	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	31%	100%
Q8R9R7	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	29%	100%
Q8RG85	Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)	28%	100%
Q8TT55	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	30%	100%
Q8TXU6	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	29%	98%
Q8U0P6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	29%	100%
Q8X643	Escherichia coli O157:H7	27%	76%
Q8Y667	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	30%	100%
Q8YPC6	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	26%	83%
Q8ZNL7	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	27%	76%
Q92AH5	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	30%	100%
Q979G6	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	29%	100%
Q97R65	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	30%	100%
Q99Z28	Streptococcus pyogenes serotype M1	56%	100%
Q9CFC9	Lactococcus lactis subsp. lactis (strain IL1403)	56%	100%
Q9CFW8	Lactococcus lactis subsp. lactis (strain IL1403)	27%	100%
Q9F1U7	Flavobacterium lutescens	29%	89%
Q9FB59	Corynebacterium striatum	27%	87%
Q9HL35	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	26%	100%
Q9HMK2	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	26%	90%
Q9K9W1	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	27%	100%
Q9KXR7	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	30%	85%
Q9LVI9	Arabidopsis thaliana	25%	73%
Q9PAE7	Xylella fastidiosa (strain 9a5c)	26%	89%
Q9RX14	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	26%	85%
Q9UX04	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	27%	100%
Q9V0Y6	Pyrococcus abyssi (strain GE5 / Orsay)	31%	100%
Q9WYG8	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	28%	100%
Q9X9S0	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	51%	100%
Q9YFI6	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	28%	100%
Q9ZM11	Helicobacter pylori (strain J99 / ATCC 700824)	23%	89%