LeishMANIAdb
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Putative inositol/phosphatidylinositol phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative inositol/phosphatidylinositol phosphatase
Gene product:
inositol/phosphatidylinositol phosphatase - putative
Species:
Leishmania infantum
UniProt:
E9AGM3_LEIIN
TriTrypDb:
LINF_150019700
Length:
792

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, inositol/phosphatidylinositol phosphatase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0010008 endosome membrane 5 11
GO:0012506 vesicle membrane 4 11
GO:0016020 membrane 2 11
GO:0030659 cytoplasmic vesicle membrane 5 11
GO:0030666 endocytic vesicle membrane 5 11
GO:0030670 phagocytic vesicle membrane 6 11
GO:0031090 organelle membrane 3 11
GO:0031901 early endosome membrane 6 11
GO:0098588 bounding membrane of organelle 4 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

E9AGM3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGM3

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 11
GO:0006644 phospholipid metabolic process 4 11
GO:0006650 glycerophospholipid metabolic process 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0007165 signal transduction 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016311 dephosphorylation 5 11
GO:0019637 organophosphate metabolic process 3 11
GO:0030258 lipid modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044255 cellular lipid metabolic process 3 11
GO:0046486 glycerolipid metabolic process 4 11
GO:0046488 phosphatidylinositol metabolic process 6 11
GO:0046839 phospholipid dephosphorylation 5 11
GO:0046856 phosphatidylinositol dephosphorylation 6 11
GO:0050789 regulation of biological process 2 11
GO:0050794 regulation of cellular process 3 11
GO:0065007 biological regulation 1 11
GO:0071704 organic substance metabolic process 2 11
GO:0005975 carbohydrate metabolic process 3 1
GO:0006066 alcohol metabolic process 3 1
GO:0009056 catabolic process 2 1
GO:0019751 polyol metabolic process 4 1
GO:0043647 inositol phosphate metabolic process 4 1
GO:0044262 obsolete cellular carbohydrate metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044282 small molecule catabolic process 3 1
GO:0046164 alcohol catabolic process 4 1
GO:0046174 polyol catabolic process 5 1
GO:0046434 organophosphate catabolic process 4 1
GO:0046838 obsolete phosphorylated carbohydrate dephosphorylation 4 1
GO:0046855 obsolete inositol phosphate dephosphorylation 5 1
GO:0071545 inositol phosphate catabolic process 5 1
GO:1901575 organic substance catabolic process 3 1
GO:1901615 organic hydroxy compound metabolic process 3 1
GO:1901616 organic hydroxy compound catabolic process 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0016787 hydrolase activity 2 11
GO:0016788 hydrolase activity, acting on ester bonds 3 11
GO:0016791 phosphatase activity 5 11
GO:0042578 phosphoric ester hydrolase activity 4 11
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 8 2
GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 7 2
GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 7 2
GO:0052866 phosphatidylinositol phosphate phosphatase activity 6 2
GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 8 2
GO:0004518 nuclease activity 4 1
GO:0004519 endonuclease activity 5 1
GO:0004527 exonuclease activity 5 1
GO:0004445 inositol-polyphosphate 5-phosphatase activity 8 1
GO:0046030 inositol trisphosphate phosphatase activity 7 1
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity 8 1
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity 8 1
GO:0052743 inositol tetrakisphosphate phosphatase activity 7 1
GO:0052745 inositol phosphate phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 156 160 PF00656 0.404
CLV_NRD_NRD_1 181 183 PF00675 0.309
CLV_NRD_NRD_1 23 25 PF00675 0.586
CLV_NRD_NRD_1 255 257 PF00675 0.421
CLV_NRD_NRD_1 360 362 PF00675 0.406
CLV_NRD_NRD_1 374 376 PF00675 0.303
CLV_PCSK_KEX2_1 181 183 PF00082 0.309
CLV_PCSK_KEX2_1 22 24 PF00082 0.583
CLV_PCSK_KEX2_1 237 239 PF00082 0.308
CLV_PCSK_KEX2_1 255 257 PF00082 0.309
CLV_PCSK_KEX2_1 359 361 PF00082 0.421
CLV_PCSK_KEX2_1 374 376 PF00082 0.293
CLV_PCSK_PC1ET2_1 237 239 PF00082 0.309
CLV_PCSK_PC1ET2_1 359 361 PF00082 0.421
CLV_PCSK_SKI1_1 182 186 PF00082 0.311
CLV_PCSK_SKI1_1 518 522 PF00082 0.553
CLV_PCSK_SKI1_1 662 666 PF00082 0.376
CLV_PCSK_SKI1_1 80 84 PF00082 0.454
CLV_Separin_Metazoa 591 595 PF03568 0.533
DEG_APCC_DBOX_1 181 189 PF00400 0.352
DEG_APCC_DBOX_1 380 388 PF00400 0.421
DEG_APCC_DBOX_1 533 541 PF00400 0.405
DEG_COP1_1 355 365 PF00400 0.306
DEG_SPOP_SBC_1 151 155 PF00917 0.425
DOC_CKS1_1 327 332 PF01111 0.421
DOC_CKS1_1 781 786 PF01111 0.524
DOC_CYCLIN_RxL_1 179 189 PF00134 0.421
DOC_CYCLIN_RxL_1 659 666 PF00134 0.376
DOC_CYCLIN_yCln2_LP_2 664 670 PF00134 0.304
DOC_MAPK_gen_1 22 29 PF00069 0.563
DOC_MAPK_gen_1 255 261 PF00069 0.398
DOC_MAPK_gen_1 383 393 PF00069 0.442
DOC_MAPK_gen_1 425 433 PF00069 0.436
DOC_MAPK_gen_1 684 691 PF00069 0.379
DOC_MAPK_gen_1 79 85 PF00069 0.421
DOC_MAPK_JIP1_4 104 110 PF00069 0.329
DOC_MAPK_MEF2A_6 104 113 PF00069 0.331
DOC_MAPK_MEF2A_6 169 178 PF00069 0.309
DOC_MAPK_MEF2A_6 325 334 PF00069 0.448
DOC_MAPK_MEF2A_6 406 413 PF00069 0.482
DOC_MAPK_MEF2A_6 493 501 PF00069 0.505
DOC_MAPK_RevD_3 67 80 PF00069 0.352
DOC_PP1_RVXF_1 445 451 PF00149 0.506
DOC_PP2B_LxvP_1 295 298 PF13499 0.421
DOC_PP4_FxxP_1 29 32 PF00568 0.681
DOC_SPAK_OSR1_1 346 350 PF12202 0.421
DOC_USP7_MATH_1 144 148 PF00917 0.420
DOC_USP7_MATH_1 151 155 PF00917 0.372
DOC_USP7_MATH_1 200 204 PF00917 0.329
DOC_USP7_MATH_1 230 234 PF00917 0.383
DOC_USP7_MATH_1 263 267 PF00917 0.367
DOC_USP7_MATH_1 32 36 PF00917 0.689
DOC_USP7_MATH_1 434 438 PF00917 0.503
DOC_USP7_MATH_1 503 507 PF00917 0.516
DOC_USP7_MATH_1 716 720 PF00917 0.443
DOC_USP7_MATH_1 84 88 PF00917 0.435
DOC_WW_Pin1_4 158 163 PF00397 0.355
DOC_WW_Pin1_4 323 328 PF00397 0.317
DOC_WW_Pin1_4 335 340 PF00397 0.294
DOC_WW_Pin1_4 492 497 PF00397 0.558
DOC_WW_Pin1_4 557 562 PF00397 0.458
DOC_WW_Pin1_4 780 785 PF00397 0.502
LIG_14-3-3_CanoR_1 24 30 PF00244 0.611
LIG_14-3-3_CanoR_1 374 379 PF00244 0.369
LIG_14-3-3_CanoR_1 386 393 PF00244 0.400
LIG_14-3-3_CanoR_1 394 401 PF00244 0.124
LIG_14-3-3_CanoR_1 406 412 PF00244 0.183
LIG_14-3-3_CanoR_1 518 523 PF00244 0.489
LIG_14-3-3_CanoR_1 532 538 PF00244 0.368
LIG_14-3-3_CanoR_1 623 629 PF00244 0.391
LIG_14-3-3_CanoR_1 715 724 PF00244 0.418
LIG_Actin_WH2_2 699 717 PF00022 0.304
LIG_BIR_III_2 159 163 PF00653 0.240
LIG_BRCT_BRCA1_1 247 251 PF00533 0.421
LIG_CaM_NSCaTE_8 134 141 PF13499 0.352
LIG_CtBP_PxDLS_1 496 500 PF00389 0.434
LIG_deltaCOP1_diTrp_1 13 21 PF00928 0.559
LIG_FHA_1 104 110 PF00498 0.395
LIG_FHA_1 191 197 PF00498 0.321
LIG_FHA_1 223 229 PF00498 0.402
LIG_FHA_1 327 333 PF00498 0.467
LIG_FHA_1 364 370 PF00498 0.305
LIG_FHA_1 443 449 PF00498 0.450
LIG_FHA_1 461 467 PF00498 0.509
LIG_FHA_1 536 542 PF00498 0.451
LIG_FHA_1 673 679 PF00498 0.337
LIG_FHA_1 71 77 PF00498 0.308
LIG_FHA_2 14 20 PF00498 0.565
LIG_FHA_2 493 499 PF00498 0.530
LIG_FHA_2 511 517 PF00498 0.360
LIG_FHA_2 60 66 PF00498 0.490
LIG_FHA_2 623 629 PF00498 0.359
LIG_GBD_Chelix_1 287 295 PF00786 0.382
LIG_LIR_Apic_2 161 167 PF02991 0.329
LIG_LIR_Apic_2 28 32 PF02991 0.660
LIG_LIR_Gen_1 12 21 PF02991 0.475
LIG_LIR_Gen_1 271 279 PF02991 0.389
LIG_LIR_Gen_1 329 339 PF02991 0.414
LIG_LIR_Gen_1 58 69 PF02991 0.485
LIG_LIR_Gen_1 588 596 PF02991 0.531
LIG_LIR_Nem_3 12 17 PF02991 0.499
LIG_LIR_Nem_3 161 166 PF02991 0.316
LIG_LIR_Nem_3 271 277 PF02991 0.389
LIG_LIR_Nem_3 329 334 PF02991 0.307
LIG_LIR_Nem_3 58 64 PF02991 0.482
LIG_LIR_Nem_3 588 592 PF02991 0.525
LIG_LYPXL_S_1 1 5 PF13949 0.621
LIG_LYPXL_yS_3 2 5 PF13949 0.616
LIG_NRBOX 170 176 PF00104 0.309
LIG_NRBOX 660 666 PF00104 0.376
LIG_NRBOX 709 715 PF00104 0.323
LIG_SH2_CRK 164 168 PF00017 0.329
LIG_SH2_NCK_1 61 65 PF00017 0.483
LIG_SH2_STAP1 299 303 PF00017 0.325
LIG_SH2_STAP1 317 321 PF00017 0.386
LIG_SH2_STAP1 365 369 PF00017 0.329
LIG_SH2_STAP1 57 61 PF00017 0.390
LIG_SH2_STAP1 583 587 PF00017 0.502
LIG_SH2_STAP1 674 678 PF00017 0.348
LIG_SH2_STAT5 365 368 PF00017 0.316
LIG_SH2_STAT5 606 609 PF00017 0.421
LIG_SH2_STAT5 61 64 PF00017 0.364
LIG_SH2_STAT5 674 677 PF00017 0.451
LIG_SH2_STAT5 705 708 PF00017 0.304
LIG_SH2_STAT5 712 715 PF00017 0.299
LIG_SH2_STAT5 779 782 PF00017 0.377
LIG_SH3_3 324 330 PF00018 0.347
LIG_SH3_3 408 414 PF00018 0.488
LIG_SH3_3 555 561 PF00018 0.442
LIG_SH3_3 595 601 PF00018 0.406
LIG_SH3_3 664 670 PF00018 0.304
LIG_SH3_3 78 84 PF00018 0.421
LIG_SH3_3 99 105 PF00018 0.435
LIG_SUMO_SIM_anti_2 106 112 PF11976 0.385
LIG_SUMO_SIM_anti_2 283 288 PF11976 0.309
LIG_SUMO_SIM_anti_2 471 477 PF11976 0.343
LIG_SUMO_SIM_anti_2 498 503 PF11976 0.488
LIG_SUMO_SIM_anti_2 569 576 PF11976 0.363
LIG_SUMO_SIM_anti_2 734 740 PF11976 0.286
LIG_SUMO_SIM_anti_2 769 778 PF11976 0.491
LIG_SUMO_SIM_par_1 407 412 PF11976 0.467
LIG_TRFH_1 712 716 PF08558 0.304
LIG_TYR_ITIM 315 320 PF00017 0.376
LIG_UBA3_1 633 640 PF00899 0.418
LIG_UBA3_1 657 662 PF00899 0.418
LIG_WRC_WIRS_1 657 662 PF05994 0.267
LIG_WRC_WIRS_1 71 76 PF05994 0.309
LIG_WRPW_2 526 529 PF00400 0.322
MOD_CK1_1 147 153 PF00069 0.447
MOD_CK1_1 186 192 PF00069 0.421
MOD_CK1_1 233 239 PF00069 0.454
MOD_CK1_1 326 332 PF00069 0.408
MOD_CK1_1 34 40 PF00069 0.587
MOD_CK1_1 377 383 PF00069 0.421
MOD_CK1_1 442 448 PF00069 0.406
MOD_CK1_1 487 493 PF00069 0.457
MOD_CK1_1 536 542 PF00069 0.412
MOD_CK2_1 492 498 PF00069 0.524
MOD_CK2_1 59 65 PF00069 0.482
MOD_CK2_1 622 628 PF00069 0.328
MOD_CK2_1 660 666 PF00069 0.240
MOD_GlcNHglycan 117 121 PF01048 0.312
MOD_GlcNHglycan 129 133 PF01048 0.425
MOD_GlcNHglycan 155 158 PF01048 0.445
MOD_GlcNHglycan 185 188 PF01048 0.421
MOD_GlcNHglycan 261 264 PF01048 0.374
MOD_GlcNHglycan 270 274 PF01048 0.305
MOD_GlcNHglycan 34 37 PF01048 0.689
MOD_GlcNHglycan 387 390 PF01048 0.454
MOD_GlcNHglycan 421 424 PF01048 0.421
MOD_GlcNHglycan 437 440 PF01048 0.401
MOD_GlcNHglycan 733 736 PF01048 0.458
MOD_GlcNHglycan 92 95 PF01048 0.420
MOD_GSK3_1 146 153 PF00069 0.353
MOD_GSK3_1 186 193 PF00069 0.365
MOD_GSK3_1 241 248 PF00069 0.356
MOD_GSK3_1 259 266 PF00069 0.413
MOD_GSK3_1 319 326 PF00069 0.376
MOD_GSK3_1 32 39 PF00069 0.612
MOD_GSK3_1 337 344 PF00069 0.309
MOD_GSK3_1 370 377 PF00069 0.350
MOD_GSK3_1 435 442 PF00069 0.432
MOD_GSK3_1 656 663 PF00069 0.289
MOD_GSK3_1 779 786 PF00069 0.501
MOD_GSK3_1 9 16 PF00069 0.562
MOD_N-GLC_1 147 152 PF02516 0.465
MOD_N-GLC_1 233 238 PF02516 0.412
MOD_N-GLC_1 32 37 PF02516 0.699
MOD_N-GLC_1 335 340 PF02516 0.454
MOD_N-GLC_1 59 64 PF02516 0.497
MOD_N-GLC_2 68 70 PF02516 0.403
MOD_NEK2_1 118 123 PF00069 0.309
MOD_NEK2_1 216 221 PF00069 0.300
MOD_NEK2_1 259 264 PF00069 0.454
MOD_NEK2_1 269 274 PF00069 0.212
MOD_NEK2_1 443 448 PF00069 0.468
MOD_NEK2_1 510 515 PF00069 0.349
MOD_NEK2_1 636 641 PF00069 0.411
MOD_NEK2_1 660 665 PF00069 0.240
MOD_PIKK_1 457 463 PF00454 0.526
MOD_PIKK_1 503 509 PF00454 0.509
MOD_PKA_1 374 380 PF00069 0.352
MOD_PKA_2 103 109 PF00069 0.421
MOD_PKA_2 217 223 PF00069 0.329
MOD_PKA_2 374 380 PF00069 0.352
MOD_PKA_2 385 391 PF00069 0.352
MOD_PKA_2 393 399 PF00069 0.352
MOD_PKA_2 533 539 PF00069 0.410
MOD_PKA_2 622 628 PF00069 0.449
MOD_Plk_1 269 275 PF00069 0.454
MOD_Plk_1 59 65 PF00069 0.444
MOD_Plk_2-3 13 19 PF00069 0.556
MOD_Plk_4 241 247 PF00069 0.352
MOD_Plk_4 25 31 PF00069 0.551
MOD_Plk_4 487 493 PF00069 0.519
MOD_Plk_4 518 524 PF00069 0.540
MOD_Plk_4 536 542 PF00069 0.400
MOD_Plk_4 559 565 PF00069 0.334
MOD_Plk_4 656 662 PF00069 0.427
MOD_Plk_4 705 711 PF00069 0.378
MOD_Plk_4 783 789 PF00069 0.484
MOD_ProDKin_1 158 164 PF00069 0.355
MOD_ProDKin_1 323 329 PF00069 0.317
MOD_ProDKin_1 335 341 PF00069 0.294
MOD_ProDKin_1 492 498 PF00069 0.556
MOD_ProDKin_1 557 563 PF00069 0.455
MOD_ProDKin_1 780 786 PF00069 0.513
MOD_SUMO_for_1 124 127 PF00179 0.309
MOD_SUMO_rev_2 318 327 PF00179 0.421
MOD_SUMO_rev_2 392 401 PF00179 0.309
MOD_SUMO_rev_2 635 642 PF00179 0.418
TRG_DiLeu_BaLyEn_6 180 185 PF01217 0.421
TRG_ENDOCYTIC_2 163 166 PF00928 0.296
TRG_ENDOCYTIC_2 2 5 PF00928 0.616
TRG_ENDOCYTIC_2 317 320 PF00928 0.386
TRG_ENDOCYTIC_2 61 64 PF00928 0.442
TRG_ER_diArg_1 180 182 PF00400 0.309
TRG_ER_diArg_1 21 24 PF00400 0.575
TRG_ER_diArg_1 293 296 PF00400 0.456
TRG_ER_diArg_1 360 362 PF00400 0.421
TRG_ER_diArg_1 381 384 PF00400 0.410
TRG_ER_diArg_1 479 482 PF00400 0.433
TRG_ER_diArg_1 532 535 PF00400 0.388
TRG_Pf-PMV_PEXEL_1 662 666 PF00026 0.418

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2E8 Leptomonas seymouri 77% 100%
A0A1X0NU91 Trypanosomatidae 52% 100%
A0A3S5H6V6 Leishmania donovani 99% 100%
A0A422NRC5 Trypanosoma rangeli 48% 100%
A4H885 Leishmania braziliensis 87% 100%
C9ZXT0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D3ZGS3 Rattus norvegicus 26% 88%
E9AQB3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
P32019 Homo sapiens 27% 80%
Q01968 Homo sapiens 26% 88%
Q4QF61 Leishmania major 95% 100%
Q6NVF0 Mus musculus 27% 88%
Q8K337 Mus musculus 27% 80%
V5DL78 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS