Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGL5_LEIIN

TriTrypDb:

LINF_140017900

Length:

347

Annotations

LeishMANIAdb annotations

Very putatively an organellar or non-TM protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.521
CLV_C14_Caspase3-7	44	48	PF00656	0.687
CLV_NRD_NRD_1	102	104	PF00675	0.586
CLV_NRD_NRD_1	16	18	PF00675	0.495
CLV_NRD_NRD_1	191	193	PF00675	0.586
CLV_NRD_NRD_1	63	65	PF00675	0.370
CLV_NRD_NRD_1	73	75	PF00675	0.354
CLV_PCSK_KEX2_1	102	104	PF00082	0.586
CLV_PCSK_KEX2_1	132	134	PF00082	0.745
CLV_PCSK_KEX2_1	16	18	PF00082	0.495
CLV_PCSK_KEX2_1	193	195	PF00082	0.591
CLV_PCSK_KEX2_1	63	65	PF00082	0.362
CLV_PCSK_KEX2_1	73	75	PF00082	0.316
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.745
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.669
CLV_PCSK_PC7_1	12	18	PF00082	0.497
CLV_PCSK_PC7_1	189	195	PF00082	0.572
CLV_PCSK_SKI1_1	193	197	PF00082	0.619
CLV_PCSK_SKI1_1	30	34	PF00082	0.528
CLV_PCSK_SKI1_1	312	316	PF00082	0.665
CLV_PCSK_SKI1_1	65	69	PF00082	0.431
DEG_SCF_FBW7_1	32	39	PF00400	0.702
DEG_SPOP_SBC_1	118	122	PF00917	0.404
DEG_SPOP_SBC_1	137	141	PF00917	0.418
DEG_SPOP_SBC_1	279	283	PF00917	0.606
DEG_SPOP_SBC_1	38	42	PF00917	0.723
DOC_CYCLIN_RxL_1	189	200	PF00134	0.432
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.416
DOC_MAPK_gen_1	189	197	PF00069	0.406
DOC_MAPK_gen_1	224	234	PF00069	0.477
DOC_MAPK_gen_1	325	335	PF00069	0.409
DOC_MAPK_gen_1	63	69	PF00069	0.612
DOC_PP1_RVXF_1	191	198	PF00149	0.429
DOC_PP1_RVXF_1	63	70	PF00149	0.634
DOC_PP2B_LxvP_1	105	108	PF13499	0.382
DOC_PP2B_LxvP_1	75	78	PF13499	0.344
DOC_USP7_MATH_1	20	24	PF00917	0.785
DOC_USP7_MATH_1	243	247	PF00917	0.481
DOC_USP7_MATH_1	279	283	PF00917	0.522
DOC_USP7_MATH_1	297	301	PF00917	0.430
DOC_USP7_MATH_1	36	40	PF00917	0.770
DOC_WW_Pin1_4	139	144	PF00397	0.617
DOC_WW_Pin1_4	212	217	PF00397	0.467
DOC_WW_Pin1_4	267	272	PF00397	0.532
DOC_WW_Pin1_4	286	291	PF00397	0.436
DOC_WW_Pin1_4	298	303	PF00397	0.480
DOC_WW_Pin1_4	32	37	PF00397	0.746
LIG_14-3-3_CanoR_1	248	254	PF00244	0.367
LIG_14-3-3_CanoR_1	30	36	PF00244	0.757
LIG_Actin_WH2_2	81	99	PF00022	0.543
LIG_CSL_BTD_1	111	114	PF09270	0.453
LIG_deltaCOP1_diTrp_1	170	178	PF00928	0.429
LIG_FHA_1	279	285	PF00498	0.547
LIG_FHA_1	315	321	PF00498	0.331
LIG_FHA_2	206	212	PF00498	0.566
LIG_FHA_2	40	46	PF00498	0.728
LIG_LIR_Nem_3	66	72	PF02991	0.588
LIG_LIR_Nem_3	81	86	PF02991	0.378
LIG_LIR_Nem_3	92	98	PF02991	0.308
LIG_MYND_1	154	158	PF01753	0.436
LIG_PDZ_Class_3	342	347	PF00595	0.461
LIG_Pex14_2	109	113	PF04695	0.386
LIG_SH2_STAP1	249	253	PF00017	0.491
LIG_SH2_STAT5	98	101	PF00017	0.371
LIG_SH3_3	199	205	PF00018	0.548
LIG_SH3_3	265	271	PF00018	0.507
LIG_SH3_3	284	290	PF00018	0.571
LIG_SH3_3	296	302	PF00018	0.511
LIG_SUMO_SIM_par_1	114	123	PF11976	0.543
LIG_TRFH_1	86	90	PF08558	0.503
MOD_CK1_1	119	125	PF00069	0.559
MOD_CK1_1	139	145	PF00069	0.582
MOD_CK1_1	23	29	PF00069	0.770
MOD_CK1_1	270	276	PF00069	0.537
MOD_CK1_1	289	295	PF00069	0.411
MOD_CK1_1	31	37	PF00069	0.737
MOD_CK1_1	39	45	PF00069	0.738
MOD_CK2_1	117	123	PF00069	0.509
MOD_CK2_1	181	187	PF00069	0.470
MOD_CK2_1	205	211	PF00069	0.518
MOD_CK2_1	212	218	PF00069	0.451
MOD_CK2_1	238	244	PF00069	0.477
MOD_GlcNHglycan	22	25	PF01048	0.577
MOD_GlcNHglycan	51	54	PF01048	0.416
MOD_GlcNHglycan	6	9	PF01048	0.551
MOD_GSK3_1	119	126	PF00069	0.529
MOD_GSK3_1	133	140	PF00069	0.454
MOD_GSK3_1	160	167	PF00069	0.522
MOD_GSK3_1	205	212	PF00069	0.532
MOD_GSK3_1	26	33	PF00069	0.751
MOD_GSK3_1	310	317	PF00069	0.463
MOD_GSK3_1	34	41	PF00069	0.719
MOD_GSK3_1	4	11	PF00069	0.761
MOD_NEK2_1	314	319	PF00069	0.342
MOD_NEK2_1	4	9	PF00069	0.741
MOD_NEK2_2	78	83	PF00069	0.485
MOD_NMyristoyl	1	7	PF02799	0.629
MOD_OFUCOSY	22	27	PF10250	0.527
MOD_PIKK_1	289	295	PF00454	0.443
MOD_PKA_1	181	187	PF00069	0.500
MOD_PKA_2	4	10	PF00069	0.762
MOD_PKA_2	88	94	PF00069	0.430
MOD_Plk_1	205	211	PF00069	0.561
MOD_Plk_1	310	316	PF00069	0.466
MOD_Plk_4	160	166	PF00069	0.481
MOD_Plk_4	205	211	PF00069	0.539
MOD_ProDKin_1	139	145	PF00069	0.618
MOD_ProDKin_1	212	218	PF00069	0.462
MOD_ProDKin_1	267	273	PF00069	0.533
MOD_ProDKin_1	286	292	PF00069	0.436
MOD_ProDKin_1	298	304	PF00069	0.475
MOD_ProDKin_1	32	38	PF00069	0.747
TRG_DiLeu_BaEn_4	221	227	PF01217	0.522
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.408
TRG_ENDOCYTIC_2	83	86	PF00928	0.401
TRG_ER_diArg_1	192	195	PF00400	0.413
TRG_ER_diArg_1	62	64	PF00400	0.574
TRG_ER_diArg_1	72	74	PF00400	0.364
TRG_NLS_Bipartite_1	181	196	PF00514	0.446
TRG_NLS_MonoExtN_4	189	196	PF00514	0.463
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P306	Leptomonas seymouri	47%	99%
A0A1X0NQ49	Trypanosomatidae	36%	100%
A0A3R7M3H5	Trypanosoma rangeli	33%	100%
A0A3S5H6S8	Leishmania donovani	98%	99%
A4H7R9	Leishmania braziliensis	66%	90%
C9ZSW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ACR5	Leishmania major	92%	100%
E9APW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%