Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGL4_LEIIN

TriTrypDb:

LINF_140016600

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AGL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.350
CLV_NRD_NRD_1	203	205	PF00675	0.556
DEG_Nend_UBRbox_2	1	3	PF02207	0.585
DEG_SPOP_SBC_1	44	48	PF00917	0.279
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.547
DOC_MAPK_DCC_7	98	106	PF00069	0.549
DOC_PP1_RVXF_1	155	162	PF00149	0.314
DOC_PP4_FxxP_1	16	19	PF00568	0.538
DOC_PP4_FxxP_1	21	24	PF00568	0.309
DOC_USP7_MATH_1	184	188	PF00917	0.587
DOC_WW_Pin1_4	86	91	PF00397	0.537
LIG_BRCT_BRCA1_1	12	16	PF00533	0.516
LIG_BRCT_BRCA1_1	122	126	PF00533	0.315
LIG_BRCT_BRCA1_1	70	74	PF00533	0.286
LIG_FHA_1	127	133	PF00498	0.370
LIG_FHA_1	174	180	PF00498	0.430
LIG_FHA_1	18	24	PF00498	0.544
LIG_FHA_1	183	189	PF00498	0.567
LIG_FHA_1	55	61	PF00498	0.314
LIG_FHA_1	64	70	PF00498	0.265
LIG_FHA_1	79	85	PF00498	0.594
LIG_LIR_Apic_2	13	19	PF02991	0.503
LIG_LIR_Apic_2	148	154	PF02991	0.306
LIG_LIR_Apic_2	193	199	PF02991	0.749
LIG_LIR_Apic_2	2	7	PF02991	0.518
LIG_LIR_Apic_2	20	24	PF02991	0.309
LIG_LIR_Gen_1	64	72	PF02991	0.408
LIG_LIR_Gen_1	9	19	PF02991	0.597
LIG_LIR_LC3C_4	129	132	PF02991	0.343
LIG_LIR_Nem_3	148	153	PF02991	0.350
LIG_LIR_Nem_3	162	168	PF02991	0.300
LIG_LIR_Nem_3	64	68	PF02991	0.408
LIG_LIR_Nem_3	9	15	PF02991	0.555
LIG_PCNA_PIPBox_1	152	161	PF02747	0.336
LIG_PCNA_yPIPBox_3	152	166	PF02747	0.291
LIG_Pex14_2	12	16	PF04695	0.564
LIG_Pex14_2	21	25	PF04695	0.374
LIG_PTB_Apo_2	144	151	PF02174	0.309
LIG_SH2_CRK	122	126	PF00017	0.374
LIG_SH2_CRK	196	200	PF00017	0.644
LIG_SH2_NCK_1	122	126	PF00017	0.357
LIG_SH2_STAP1	122	126	PF00017	0.366
LIG_SH2_STAT5	158	161	PF00017	0.346
LIG_SH2_STAT5	178	181	PF00017	0.334
LIG_SH2_STAT5	37	40	PF00017	0.324
LIG_SH2_STAT5	4	7	PF00017	0.530
LIG_SH3_3	185	191	PF00018	0.593
LIG_Sin3_3	49	56	PF02671	0.226
LIG_SUMO_SIM_par_1	128	134	PF11976	0.408
LIG_TYR_ITIM	120	125	PF00017	0.374
LIG_WRC_WIRS_1	62	67	PF05994	0.337
MOD_CDK_SPxxK_3	86	93	PF00069	0.554
MOD_CK1_1	192	198	PF00069	0.693
MOD_CK1_1	26	32	PF00069	0.343
MOD_CK1_1	75	81	PF00069	0.612
MOD_CK2_1	39	45	PF00069	0.368
MOD_Cter_Amidation	202	205	PF01082	0.526
MOD_GlcNHglycan	47	50	PF01048	0.656
MOD_GSK3_1	168	175	PF00069	0.314
MOD_GSK3_1	23	30	PF00069	0.330
MOD_GSK3_1	39	46	PF00069	0.448
MOD_GSK3_1	6	13	PF00069	0.530
MOD_GSK3_1	68	75	PF00069	0.354
MOD_GSK3_1	92	99	PF00069	0.546
MOD_N-GLC_1	75	80	PF02516	0.306
MOD_NEK2_1	145	150	PF00069	0.427
MOD_NEK2_1	159	164	PF00069	0.344
MOD_NEK2_1	39	44	PF00069	0.341
MOD_NEK2_1	63	68	PF00069	0.358
MOD_NEK2_1	74	79	PF00069	0.572
MOD_NEK2_1	92	97	PF00069	0.511
MOD_PIKK_1	10	16	PF00454	0.516
MOD_PIKK_1	182	188	PF00454	0.520
MOD_PIKK_1	75	81	PF00454	0.615
MOD_PKA_2	17	23	PF00069	0.514
MOD_Plk_1	145	151	PF00069	0.269
MOD_Plk_1	39	45	PF00069	0.352
MOD_Plk_1	75	81	PF00069	0.479
MOD_Plk_2-3	40	46	PF00069	0.330
MOD_Plk_4	102	108	PF00069	0.550
MOD_Plk_4	120	126	PF00069	0.326
MOD_Plk_4	145	151	PF00069	0.357
MOD_Plk_4	184	190	PF00069	0.579
MOD_Plk_4	92	98	PF00069	0.534
MOD_ProDKin_1	86	92	PF00069	0.533
TRG_ENDOCYTIC_2	122	125	PF00928	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I195	Leptomonas seymouri	64%	100%
A0A0S4IKP2	Bodo saltans	30%	96%
A0A0S4JKJ4	Bodo saltans	25%	90%
A0A3Q8I8V9	Leishmania donovani	100%	100%
A4H7Q8	Leishmania braziliensis	79%	100%
E9ACR4	Leishmania major	93%	100%
E9APV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%