LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase - putative
Species:
Leishmania infantum
UniProt:
E9AGL2_LEIIN
TriTrypDb:
LINF_140012400
Length:
299

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Annotations by Jardim et al.

Fatty acid metabolism, Elongation of fatty acids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0016020 membrane 2 48
GO:0110165 cellular anatomical entity 1 50
GO:0005737 cytoplasm 2 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AGL2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGL2

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 54
GO:0006629 lipid metabolic process 3 54
GO:0006631 fatty acid metabolic process 4 54
GO:0006633 fatty acid biosynthetic process 5 54
GO:0008152 metabolic process 1 54
GO:0008610 lipid biosynthetic process 4 54
GO:0009058 biosynthetic process 2 54
GO:0009987 cellular process 1 54
GO:0016053 organic acid biosynthetic process 4 54
GO:0019752 carboxylic acid metabolic process 5 54
GO:0032787 monocarboxylic acid metabolic process 6 54
GO:0043436 oxoacid metabolic process 4 54
GO:0044237 cellular metabolic process 2 54
GO:0044238 primary metabolic process 2 54
GO:0044249 cellular biosynthetic process 3 54
GO:0044255 cellular lipid metabolic process 3 54
GO:0044281 small molecule metabolic process 2 54
GO:0044283 small molecule biosynthetic process 3 54
GO:0046394 carboxylic acid biosynthetic process 5 54
GO:0071704 organic substance metabolic process 2 54
GO:0072330 monocarboxylic acid biosynthetic process 6 54
GO:1901576 organic substance biosynthetic process 3 54
GO:0000038 very long-chain fatty acid metabolic process 5 6
GO:0006643 membrane lipid metabolic process 4 6
GO:0006665 sphingolipid metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0019367 fatty acid elongation, saturated fatty acid 7 6
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 6
GO:0030148 sphingolipid biosynthetic process 5 6
GO:0030497 fatty acid elongation 6 6
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 6
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 6
GO:0042761 very long-chain fatty acid biosynthetic process 6 6
GO:0046467 membrane lipid biosynthetic process 4 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:1901566 organonitrogen compound biosynthetic process 4 6
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 54
GO:0004312 fatty acid synthase activity 5 54
GO:0009922 fatty acid elongase activity 6 54
GO:0016740 transferase activity 2 54
GO:0016746 acyltransferase activity 3 54
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 54
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 54

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 199 201 PF00675 0.228
CLV_NRD_NRD_1 237 239 PF00675 0.325
CLV_PCSK_KEX2_1 146 148 PF00082 0.284
CLV_PCSK_KEX2_1 237 239 PF00082 0.344
CLV_PCSK_PC1ET2_1 146 148 PF00082 0.284
CLV_PCSK_SKI1_1 112 116 PF00082 0.393
CLV_PCSK_SKI1_1 79 83 PF00082 0.469
DOC_CDC14_PxL_1 71 79 PF14671 0.258
DOC_MAPK_MEF2A_6 204 212 PF00069 0.388
DOC_PP1_RVXF_1 144 151 PF00149 0.418
DOC_PP1_RVXF_1 245 251 PF00149 0.339
DOC_PP2B_LxvP_1 36 39 PF13499 0.225
DOC_USP7_MATH_1 183 187 PF00917 0.347
LIG_Actin_WH2_2 256 272 PF00022 0.392
LIG_BRCT_BRCA1_1 260 264 PF00533 0.252
LIG_EH1_1 154 162 PF00400 0.297
LIG_EH1_1 181 189 PF00400 0.256
LIG_FHA_1 136 142 PF00498 0.251
LIG_FHA_1 156 162 PF00498 0.237
LIG_FHA_1 226 232 PF00498 0.291
LIG_FHA_1 78 84 PF00498 0.220
LIG_FHA_2 85 91 PF00498 0.291
LIG_LIR_Apic_2 266 271 PF02991 0.384
LIG_LIR_Apic_2 70 75 PF02991 0.198
LIG_LIR_Gen_1 137 148 PF02991 0.257
LIG_LIR_Gen_1 211 220 PF02991 0.335
LIG_LIR_Gen_1 255 265 PF02991 0.269
LIG_LIR_Nem_3 137 143 PF02991 0.262
LIG_LIR_Nem_3 186 192 PF02991 0.288
LIG_LIR_Nem_3 196 202 PF02991 0.424
LIG_LIR_Nem_3 211 215 PF02991 0.281
LIG_LIR_Nem_3 255 260 PF02991 0.254
LIG_LIR_Nem_3 70 74 PF02991 0.282
LIG_Pex14_2 123 127 PF04695 0.353
LIG_Pex14_2 150 154 PF04695 0.301
LIG_Pex14_2 260 264 PF04695 0.257
LIG_Pex14_2 82 86 PF04695 0.286
LIG_PTAP_UEV_1 204 209 PF05743 0.304
LIG_SH2_CRK 116 120 PF00017 0.235
LIG_SH2_CRK 72 76 PF00017 0.262
LIG_SH2_CRK 78 82 PF00017 0.214
LIG_SH2_GRB2like 109 112 PF00017 0.218
LIG_SH2_GRB2like 91 94 PF00017 0.135
LIG_SH2_PTP2 202 205 PF00017 0.479
LIG_SH2_STAP1 167 171 PF00017 0.243
LIG_SH2_STAP1 265 269 PF00017 0.448
LIG_SH2_STAT5 162 165 PF00017 0.274
LIG_SH2_STAT5 189 192 PF00017 0.287
LIG_SH2_STAT5 202 205 PF00017 0.434
LIG_SH2_STAT5 230 233 PF00017 0.226
LIG_SH2_STAT5 253 256 PF00017 0.260
LIG_SH2_STAT5 268 271 PF00017 0.410
LIG_SH2_STAT5 37 40 PF00017 0.263
LIG_SH2_STAT5 72 75 PF00017 0.284
LIG_SH2_STAT5 91 94 PF00017 0.198
LIG_SH3_1 202 208 PF00018 0.499
LIG_SH3_1 268 274 PF00018 0.434
LIG_SH3_3 202 208 PF00018 0.404
LIG_SH3_3 268 274 PF00018 0.409
LIG_SUMO_SIM_par_1 60 66 PF11976 0.258
LIG_TYR_ITIM 254 259 PF00017 0.297
LIG_UBA3_1 126 131 PF00899 0.291
LIG_WRC_WIRS_1 209 214 PF05994 0.343
LIG_WRC_WIRS_1 5 10 PF05994 0.363
MOD_CK1_1 7 13 PF00069 0.373
MOD_GlcNHglycan 171 174 PF01048 0.418
MOD_GlcNHglycan 205 208 PF01048 0.235
MOD_GlcNHglycan 275 278 PF01048 0.440
MOD_GSK3_1 63 70 PF00069 0.271
MOD_N-GLC_1 169 174 PF02516 0.417
MOD_N-GLC_2 12 14 PF02516 0.532
MOD_NEK2_1 127 132 PF00069 0.273
MOD_NEK2_1 135 140 PF00069 0.282
MOD_NEK2_1 169 174 PF00069 0.230
MOD_NEK2_1 193 198 PF00069 0.327
MOD_NEK2_1 232 237 PF00069 0.227
MOD_NEK2_1 252 257 PF00069 0.270
MOD_NEK2_1 264 269 PF00069 0.253
MOD_NEK2_1 4 9 PF00069 0.307
MOD_NEK2_1 60 65 PF00069 0.276
MOD_NEK2_1 77 82 PF00069 0.212
MOD_NEK2_2 84 89 PF00069 0.299
MOD_PKA_2 203 209 PF00069 0.315
MOD_Plk_1 282 288 PF00069 0.696
MOD_Plk_1 84 90 PF00069 0.278
MOD_Plk_4 156 162 PF00069 0.275
MOD_Plk_4 183 189 PF00069 0.258
MOD_Plk_4 225 231 PF00069 0.249
MOD_Plk_4 252 258 PF00069 0.265
MOD_Plk_4 264 270 PF00069 0.260
MOD_Plk_4 60 66 PF00069 0.281
MOD_Plk_4 67 73 PF00069 0.281
TRG_AP2beta_CARGO_1 137 147 PF09066 0.132
TRG_DiLeu_BaEn_1 22 27 PF01217 0.379
TRG_ENDOCYTIC_2 104 107 PF00928 0.241
TRG_ENDOCYTIC_2 191 194 PF00928 0.271
TRG_ENDOCYTIC_2 256 259 PF00928 0.259
TRG_ENDOCYTIC_2 31 34 PF00928 0.248
TRG_ENDOCYTIC_2 71 74 PF00928 0.266
TRG_ENDOCYTIC_2 78 81 PF00928 0.218
TRG_ER_diArg_1 147 150 PF00400 0.302
TRG_ER_diLys_1 296 299 PF00400 0.654
TRG_NLS_MonoExtC_3 144 149 PF00514 0.493
TRG_NLS_MonoExtN_4 145 150 PF00514 0.302

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0C5PHQ7 Tachysurus fulvidraco 24% 100%
A0A0N0P5E5 Leptomonas seymouri 42% 100%
A0A0N0P7D1 Leptomonas seymouri 61% 90%
A0A0N0P7D6 Leptomonas seymouri 33% 100%
A0A0N0P7R2 Leptomonas seymouri 71% 98%
A0A0N1HZJ8 Leptomonas seymouri 40% 92%
A0A0N1I9H5 Leptomonas seymouri 32% 100%
A0A0N1ILQ4 Leptomonas seymouri 39% 100%
A0A0N1IM10 Leptomonas seymouri 30% 100%
A0A0N1PDR8 Leptomonas seymouri 37% 100%
A0A0S4IS29 Bodo saltans 48% 100%
A0A0S4IVJ6 Bodo saltans 33% 94%
A0A0S4IVS6 Bodo saltans 42% 100%
A0A0S4IW98 Bodo saltans 45% 94%
A0A0S4KMP5 Bodo saltans 24% 91%
A0A1X0NNK7 Trypanosomatidae 39% 100%
A0A1X0NNL0 Trypanosomatidae 33% 99%
A0A1X0NNM4 Trypanosomatidae 35% 100%
A0A1X0NNM5 Trypanosomatidae 49% 97%
A0A1X0NP89 Trypanosomatidae 39% 94%
A0A3Q8I8T7 Leishmania donovani 32% 76%
A0A3Q8I9T2 Leishmania donovani 31% 80%
A0A3Q8I9U9 Leishmania donovani 40% 92%
A0A3Q8I9X8 Leishmania donovani 59% 89%
A0A3Q8IC05 Leishmania donovani 39% 98%
A0A3Q8ID51 Leishmania donovani 31% 75%
A0A3Q8IIA9 Leishmania donovani 34% 100%
A0A3R7KG78 Trypanosoma rangeli 43% 100%
A0A3R7MJR2 Trypanosoma rangeli 37% 100%
A0A3R7NSQ3 Trypanosoma rangeli 36% 100%
A0A3S5H6R7 Leishmania donovani 31% 100%
A0A3S5H6R8 Leishmania donovani 38% 100%
A0A3S7WSY8 Leishmania donovani 34% 100%
A0A3S7WSZ1 Leishmania donovani 99% 100%
A0A3S7WT03 Leishmania donovani 91% 100%
A0A3S7WT16 Leishmania donovani 45% 93%
A0A422NNP1 Trypanosoma rangeli 51% 100%
A0JNC4 Bos taurus 28% 100%
A1L3X0 Homo sapiens 28% 100%
A4H7M2 Leishmania braziliensis 32% 96%
A4H7M3 Leishmania braziliensis 32% 100%
A4H7M4 Leishmania braziliensis 33% 95%
A4H7M5 Leishmania braziliensis 35% 96%
A4H7M6 Leishmania braziliensis 77% 100%
A4H7M7 Leishmania braziliensis 43% 100%
A4H7M8 Leishmania braziliensis 28% 100%
A4H7M9 Leishmania braziliensis 30% 100%
A4H7N0 Leishmania braziliensis 39% 98%
A4HW07 Leishmania infantum 34% 98%
A4HW08 Leishmania infantum 31% 99%
A4HW09 Leishmania infantum 34% 97%
A4HW10 Leishmania infantum 35% 98%
A4HW12 Leishmania infantum 59% 100%
A4HW13 Leishmania infantum 40% 100%
A4HW14 Leishmania infantum 44% 100%
A4HW15 Leishmania infantum 31% 100%
A4HW16 Leishmania infantum 31% 100%
A4HW17 Leishmania infantum 32% 100%
A4HW18 Leishmania infantum 39% 99%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 99%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 98%
D4A612 Rattus norvegicus 25% 100%
D4ADY9 Rattus norvegicus 29% 100%
E8NHR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AGL0 Leishmania infantum 90% 100%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 97%
E9APR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 100%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
G5EEE5 Caenorhabditis elegans 33% 100%
O35949 Mus musculus 31% 100%
P39540 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 96%
P49191 Caenorhabditis elegans 32% 93%
Q03574 Caenorhabditis elegans 30% 100%
Q20300 Caenorhabditis elegans 30% 100%
Q20303 Caenorhabditis elegans 32% 100%
Q2KJD9 Bos taurus 23% 100%
Q32NI8 Xenopus laevis 25% 100%
Q3S8M4 Macaca mulatta 25% 95%
Q4QFQ9 Leishmania major 41% 100%
Q4QFR0 Leishmania major 33% 100%
Q4QFR1 Leishmania major 30% 100%
Q4QFR2 Leishmania major 31% 100%
Q4QFR3 Leishmania major 43% 100%
Q4QFR4 Leishmania major 40% 100%
Q4QFR5 Leishmania major 59% 100%
Q4QFR6 Leishmania major 89% 100%
Q4QFR7 Leishmania major 38% 100%
Q4QFR8 Leishmania major 33% 95%
Q4QFR9 Leishmania major 31% 100%
Q4QFS0 Leishmania major 34% 100%
Q4R516 Macaca fascicularis 23% 100%
Q5M8U1 Xenopus tropicalis 24% 100%
Q5RFL5 Pongo abelii 23% 100%
Q5ZJR8 Gallus gallus 32% 100%
Q6PC64 Danio rerio 35% 100%
Q7LKX0 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 82%
Q8BHI7 Mus musculus 24% 100%
Q920L5 Mus musculus 31% 100%
Q920L6 Rattus norvegicus 31% 100%
Q920L7 Rattus norvegicus 23% 100%
Q95K73 Macaca fascicularis 25% 95%
Q9BW60 Homo sapiens 25% 100%
Q9D2Y9 Mus musculus 29% 100%
Q9EQC4 Mus musculus 24% 96%
Q9GZR5 Homo sapiens 23% 95%
Q9H5J4 Homo sapiens 33% 100%
Q9HB03 Homo sapiens 30% 100%
Q9JLJ5 Mus musculus 25% 100%
Q9NYP7 Homo sapiens 23% 100%
Q9UTF7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 90%
Q9VV87 Drosophila melanogaster 35% 95%
Q9XVQ9 Caenorhabditis elegans 28% 100%
V5BE99 Trypanosoma cruzi 40% 100%
V5BIX9 Trypanosoma cruzi 40% 100%
V5BND3 Trypanosoma cruzi 52% 100%
V5DF68 Trypanosoma cruzi 36% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS