LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase - putative
Species:
Leishmania infantum
UniProt:
E9AGL0_LEIIN
TriTrypDb:
LINF_140012500
Length:
299

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 49
NetGPI no yes: 0, no: 49
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 2
GO:0016020 membrane 2 44
GO:0110165 cellular anatomical entity 1 46
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Expansion

Sequence features

E9AGL0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGL0

Function

Biological processes
TermNameLevelCount
GO:0000038 very long-chain fatty acid metabolic process 5 6
GO:0006082 organic acid metabolic process 3 50
GO:0006629 lipid metabolic process 3 50
GO:0006631 fatty acid metabolic process 4 50
GO:0006633 fatty acid biosynthetic process 5 50
GO:0006643 membrane lipid metabolic process 4 6
GO:0006665 sphingolipid metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 50
GO:0008610 lipid biosynthetic process 4 50
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 50
GO:0004312 fatty acid synthase activity 5 50
GO:0009922 fatty acid elongase activity 6 50
GO:0016740 transferase activity 2 50
GO:0016746 acyltransferase activity 3 50
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 50
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 50
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 199 201 PF00675 0.265
CLV_NRD_NRD_1 237 239 PF00675 0.525
CLV_PCSK_KEX2_1 237 239 PF00082 0.540
CLV_PCSK_SKI1_1 79 83 PF00082 0.527
DOC_CDC14_PxL_1 71 79 PF14671 0.235
DOC_MAPK_gen_1 145 151 PF00069 0.418
DOC_PP1_RVXF_1 144 151 PF00149 0.433
DOC_PP1_RVXF_1 245 251 PF00149 0.339
DOC_PP2B_LxvP_1 36 39 PF13499 0.237
DOC_USP7_MATH_1 205 209 PF00917 0.531
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0C5PHQ7 Tachysurus fulvidraco 24% 100%
A0A0N0P5E5 Leptomonas seymouri 44% 100%
A0A0N0P7D1 Leptomonas seymouri 64% 90%
A0A0N0P7D6 Leptomonas seymouri 31% 100%
A0A0N0P7R2 Leptomonas seymouri 78% 98%
A0A0N1HZJ8 Leptomonas seymouri 42% 92%
A0A0N1I9H5 Leptomonas seymouri 32% 100%
A0A0N1IIZ8 Leptomonas seymouri 23% 97%
A0A0N1ILQ4 Leptomonas seymouri 36% 100%
A0A0N1IM10 Leptomonas seymouri 28% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS