Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein Associated with Differentiation - putative

Species:

Leishmania infantum

UniProt:

E9AGK5_LEIIN

TriTrypDb:

LINF_130022400

Length:

607

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 118
NetGPI	no	yes: 0, no: 118

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	111
GO:0110165	cellular anatomical entity	1	111
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AGK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGK5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	55
GO:0022857	transmembrane transporter activity	2	55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	274	276	PF00675	0.459
CLV_NRD_NRD_1	306	308	PF00675	0.461
CLV_NRD_NRD_1	544	546	PF00675	0.517
CLV_NRD_NRD_1	574	576	PF00675	0.336
CLV_NRD_NRD_1	585	587	PF00675	0.357
CLV_PCSK_KEX2_1	306	308	PF00082	0.480
CLV_PCSK_KEX2_1	442	444	PF00082	0.319
CLV_PCSK_KEX2_1	574	576	PF00082	0.342
CLV_PCSK_KEX2_1	584	586	PF00082	0.349
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.330
CLV_PCSK_PC7_1	438	444	PF00082	0.313
CLV_PCSK_SKI1_1	365	369	PF00082	0.327
CLV_PCSK_SKI1_1	410	414	PF00082	0.303
CLV_PCSK_SKI1_1	469	473	PF00082	0.510
DEG_APCC_DBOX_1	26	34	PF00400	0.458
DEG_APCC_DBOX_1	409	417	PF00400	0.318
DEG_Nend_Nbox_1	1	3	PF02207	0.701
DOC_AGCK_PIF_1	43	48	PF00069	0.417
DOC_CYCLIN_RxL_1	362	369	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	207	213	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	472	478	PF00134	0.243
DOC_MAPK_FxFP_2	101	104	PF00069	0.411
DOC_MAPK_gen_1	275	281	PF00069	0.319
DOC_MAPK_gen_1	442	450	PF00069	0.461
DOC_MAPK_gen_1	5	13	PF00069	0.583
DOC_MAPK_gen_1	545	552	PF00069	0.331
DOC_MAPK_MEF2A_6	27	35	PF00069	0.486
DOC_MAPK_MEF2A_6	365	372	PF00069	0.554
DOC_MAPK_MEF2A_6	442	450	PF00069	0.470
DOC_MAPK_MEF2A_6	5	13	PF00069	0.659
DOC_MAPK_MEF2A_6	545	554	PF00069	0.296
DOC_PP1_RVXF_1	276	282	PF00149	0.267
DOC_PP2B_LxvP_1	207	210	PF13499	0.457
DOC_PP2B_LxvP_1	450	453	PF13499	0.299
DOC_PP2B_LxvP_1	465	468	PF13499	0.406
DOC_PP2B_LxvP_1	472	475	PF13499	0.288
DOC_PP4_FxxP_1	101	104	PF00568	0.415
DOC_PP4_FxxP_1	302	305	PF00568	0.663
DOC_PP4_FxxP_1	338	341	PF00568	0.714
DOC_USP7_MATH_1	18	22	PF00917	0.567
DOC_USP7_MATH_1	453	457	PF00917	0.378
DOC_USP7_MATH_1	513	517	PF00917	0.288
DOC_USP7_MATH_1	562	566	PF00917	0.386
DOC_WW_Pin1_4	306	311	PF00397	0.631
DOC_WW_Pin1_4	337	342	PF00397	0.730
DOC_WW_Pin1_4	599	604	PF00397	0.697
LIG_14-3-3_CanoR_1	20	28	PF00244	0.547
LIG_14-3-3_CanoR_1	410	416	PF00244	0.358
LIG_14-3-3_CanoR_1	425	431	PF00244	0.302
LIG_14-3-3_CanoR_1	574	581	PF00244	0.574
LIG_14-3-3_CanoR_1	58	66	PF00244	0.339
LIG_BRCT_BRCA1_1	393	397	PF00533	0.359
LIG_BRCT_BRCA1_1	44	48	PF00533	0.347
LIG_BRCT_BRCA1_1	99	103	PF00533	0.332
LIG_CORNRBOX	194	202	PF00104	0.167
LIG_eIF4E_1	187	193	PF01652	0.306
LIG_eIF4E_1	248	254	PF01652	0.279
LIG_EVH1_2	298	302	PF00568	0.567
LIG_FHA_1	262	268	PF00498	0.332
LIG_FHA_1	359	365	PF00498	0.499
LIG_FHA_1	407	413	PF00498	0.271
LIG_FHA_1	421	427	PF00498	0.347
LIG_FHA_1	445	451	PF00498	0.460
LIG_FHA_1	45	51	PF00498	0.310
LIG_FHA_1	452	458	PF00498	0.313
LIG_FHA_1	487	493	PF00498	0.286
LIG_FHA_2	213	219	PF00498	0.424
LIG_FHA_2	348	354	PF00498	0.543
LIG_HP1_1	157	161	PF01393	0.450
LIG_IRF3_LxIS_1	444	449	PF10401	0.596
LIG_LIR_Apic_2	300	305	PF02991	0.634
LIG_LIR_Apic_2	351	357	PF02991	0.517
LIG_LIR_Apic_2	88	92	PF02991	0.468
LIG_LIR_Apic_2	99	104	PF02991	0.316
LIG_LIR_Gen_1	130	139	PF02991	0.340
LIG_LIR_Gen_1	269	277	PF02991	0.295
LIG_LIR_Gen_1	280	289	PF02991	0.351
LIG_LIR_Gen_1	313	322	PF02991	0.658
LIG_LIR_Gen_1	378	388	PF02991	0.316
LIG_LIR_Gen_1	45	55	PF02991	0.344
LIG_LIR_Gen_1	84	95	PF02991	0.400
LIG_LIR_Nem_3	130	134	PF02991	0.306
LIG_LIR_Nem_3	136	141	PF02991	0.314
LIG_LIR_Nem_3	164	168	PF02991	0.330
LIG_LIR_Nem_3	175	180	PF02991	0.321
LIG_LIR_Nem_3	25	31	PF02991	0.494
LIG_LIR_Nem_3	269	273	PF02991	0.270
LIG_LIR_Nem_3	280	284	PF02991	0.307
LIG_LIR_Nem_3	313	318	PF02991	0.680
LIG_LIR_Nem_3	378	383	PF02991	0.301
LIG_LIR_Nem_3	394	400	PF02991	0.311
LIG_LIR_Nem_3	42	46	PF02991	0.336
LIG_LIR_Nem_3	47	51	PF02991	0.343
LIG_LIR_Nem_3	527	531	PF02991	0.300
LIG_LIR_Nem_3	572	576	PF02991	0.518
LIG_LIR_Nem_3	84	90	PF02991	0.352
LIG_PCNA_PIPBox_1	254	263	PF02747	0.301
LIG_PDZ_Class_1	602	607	PF00595	0.570
LIG_Pex14_1	245	249	PF04695	0.449
LIG_Pex14_1	376	380	PF04695	0.330
LIG_Pex14_2	177	181	PF04695	0.298
LIG_Pex14_2	191	195	PF04695	0.350
LIG_Pex14_2	247	251	PF04695	0.330
LIG_Pex14_2	288	292	PF04695	0.302
LIG_PTB_Apo_2	389	396	PF02174	0.307
LIG_PTB_Phospho_1	389	395	PF10480	0.391
LIG_SH2_CRK	249	253	PF00017	0.375
LIG_SH2_CRK	83	87	PF00017	0.312
LIG_SH2_PTP2	354	357	PF00017	0.510
LIG_SH2_PTP2	89	92	PF00017	0.421
LIG_SH2_SRC	217	220	PF00017	0.572
LIG_SH2_SRC	476	479	PF00017	0.316
LIG_SH2_SRC	87	90	PF00017	0.527
LIG_SH2_STAP1	46	50	PF00017	0.335
LIG_SH2_STAP1	576	580	PF00017	0.554
LIG_SH2_STAP1	83	87	PF00017	0.325
LIG_SH2_STAT3	529	532	PF00017	0.321
LIG_SH2_STAT5	150	153	PF00017	0.500
LIG_SH2_STAT5	187	190	PF00017	0.311
LIG_SH2_STAT5	270	273	PF00017	0.274
LIG_SH2_STAT5	354	357	PF00017	0.516
LIG_SH2_STAT5	395	398	PF00017	0.276
LIG_SH2_STAT5	430	433	PF00017	0.508
LIG_SH2_STAT5	46	49	PF00017	0.316
LIG_SH2_STAT5	476	479	PF00017	0.303
LIG_SH2_STAT5	529	532	PF00017	0.274
LIG_SH2_STAT5	89	92	PF00017	0.504
LIG_SH3_3	545	551	PF00018	0.308
LIG_SH3_3	76	82	PF00018	0.391
LIG_SUMO_SIM_anti_2	142	149	PF11976	0.358
LIG_SUMO_SIM_anti_2	411	417	PF11976	0.261
LIG_SUMO_SIM_par_1	444	449	PF11976	0.439
LIG_SUMO_SIM_par_1	489	494	PF11976	0.293
LIG_SUMO_SIM_par_1	93	100	PF11976	0.481
LIG_TRAF2_1	54	57	PF00917	0.261
LIG_TYR_ITIM	268	273	PF00017	0.284
LIG_TYR_ITIM	81	86	PF00017	0.316
LIG_UBA3_1	1	7	PF00899	0.497
LIG_UBA3_1	396	404	PF00899	0.382
LIG_UBA3_1	463	469	PF00899	0.373
LIG_WRC_WIRS_1	128	133	PF05994	0.360
LIG_WRC_WIRS_1	162	167	PF05994	0.363
LIG_WRC_WIRS_1	98	103	PF05994	0.316
MOD_CK1_1	143	149	PF00069	0.352
MOD_CK1_1	220	226	PF00069	0.536
MOD_CK1_1	406	412	PF00069	0.343
MOD_CK1_1	42	48	PF00069	0.273
MOD_CK1_1	67	73	PF00069	0.318
MOD_CK2_1	18	24	PF00069	0.546
MOD_CK2_1	212	218	PF00069	0.436
MOD_CK2_1	220	226	PF00069	0.430
MOD_CK2_1	426	432	PF00069	0.316
MOD_CK2_1	51	57	PF00069	0.329
MOD_CMANNOS	373	376	PF00535	0.357
MOD_Cter_Amidation	273	276	PF01082	0.541
MOD_GlcNHglycan	420	423	PF01048	0.295
MOD_GlcNHglycan	51	54	PF01048	0.459
MOD_GlcNHglycan	560	563	PF01048	0.350
MOD_GSK3_1	139	146	PF00069	0.358
MOD_GSK3_1	18	25	PF00069	0.570
MOD_GSK3_1	402	409	PF00069	0.340
MOD_GSK3_1	453	460	PF00069	0.316
MOD_GSK3_1	487	494	PF00069	0.347
MOD_GSK3_1	536	543	PF00069	0.375
MOD_GSK3_1	558	565	PF00069	0.367
MOD_GSK3_1	599	606	PF00069	0.652
MOD_GSK3_1	64	71	PF00069	0.264
MOD_N-GLC_1	326	331	PF02516	0.543
MOD_N-GLC_1	390	395	PF02516	0.413
MOD_NEK2_1	139	144	PF00069	0.342
MOD_NEK2_1	161	166	PF00069	0.390
MOD_NEK2_1	375	380	PF00069	0.296
MOD_NEK2_1	426	431	PF00069	0.307
MOD_NEK2_1	446	451	PF00069	0.329
MOD_NEK2_1	463	468	PF00069	0.307
MOD_NEK2_1	486	491	PF00069	0.351
MOD_NEK2_1	536	541	PF00069	0.371
MOD_NEK2_1	556	561	PF00069	0.307
MOD_PIKK_1	432	438	PF00454	0.517
MOD_PIKK_1	59	65	PF00454	0.248
MOD_PKA_1	574	580	PF00069	0.530
MOD_PKA_2	57	63	PF00069	0.294
MOD_PKA_2	574	580	PF00069	0.483
MOD_Plk_1	217	223	PF00069	0.534
MOD_Plk_1	390	396	PF00069	0.374
MOD_Plk_1	64	70	PF00069	0.256
MOD_Plk_2-3	314	320	PF00069	0.743
MOD_Plk_2-3	347	353	PF00069	0.635
MOD_Plk_4	127	133	PF00069	0.283
MOD_Plk_4	134	140	PF00069	0.325
MOD_Plk_4	146	152	PF00069	0.317
MOD_Plk_4	161	167	PF00069	0.376
MOD_Plk_4	172	178	PF00069	0.367
MOD_Plk_4	283	289	PF00069	0.338
MOD_Plk_4	359	365	PF00069	0.517
MOD_Plk_4	391	397	PF00069	0.295
MOD_Plk_4	411	417	PF00069	0.316
MOD_Plk_4	426	432	PF00069	0.290
MOD_Plk_4	453	459	PF00069	0.315
MOD_Plk_4	487	493	PF00069	0.324
MOD_Plk_4	536	542	PF00069	0.348
MOD_Plk_4	71	77	PF00069	0.356
MOD_Plk_4	81	87	PF00069	0.373
MOD_Plk_4	97	103	PF00069	0.304
MOD_ProDKin_1	306	312	PF00069	0.633
MOD_ProDKin_1	337	343	PF00069	0.728
MOD_ProDKin_1	599	605	PF00069	0.689
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.318
TRG_DiLeu_BaLyEn_6	548	553	PF01217	0.308
TRG_ENDOCYTIC_2	129	132	PF00928	0.278
TRG_ENDOCYTIC_2	190	193	PF00928	0.306
TRG_ENDOCYTIC_2	248	251	PF00928	0.355
TRG_ENDOCYTIC_2	270	273	PF00928	0.257
TRG_ENDOCYTIC_2	83	86	PF00928	0.317
TRG_ENDOCYTIC_2	87	90	PF00928	0.490
TRG_ER_diArg_1	305	307	PF00400	0.716
TRG_ER_diArg_1	573	575	PF00400	0.549
TRG_ER_diArg_1	584	586	PF00400	0.557
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	522	527	PF00026	0.326
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	39%	95%
A0A0N1HT40	Leptomonas seymouri	45%	100%
A0A0N1HZC2	Leptomonas seymouri	31%	97%
A0A0N1IKC5	Leptomonas seymouri	72%	100%
A0A0N1PAX2	Leptomonas seymouri	22%	100%
A0A0N1PB63	Leptomonas seymouri	28%	92%
A0A0N1PD04	Leptomonas seymouri	23%	95%
A0A0N1PFR4	Leptomonas seymouri	25%	92%
A0A0S4JR45	Bodo saltans	32%	100%
A0A1X0NKK0	Trypanosomatidae	31%	100%
A0A1X0NL32	Trypanosomatidae	34%	97%
A0A1X0NM09	Trypanosomatidae	31%	99%
A0A1X0NRW5	Trypanosomatidae	39%	87%
A0A1X0NV13	Trypanosomatidae	49%	93%
A0A1X0NV19	Trypanosomatidae	51%	100%
A0A1X0NV27	Trypanosomatidae	52%	100%
A0A1X0NVH8	Trypanosomatidae	46%	92%
A0A1X0NVM7	Trypanosomatidae	48%	94%
A0A1X0NWQ1	Trypanosomatidae	48%	95%
A0A1X0NZE6	Trypanosomatidae	34%	100%
A0A1X0NZU2	Trypanosomatidae	30%	94%
A0A1X0NZU5	Trypanosomatidae	33%	100%
A0A1X0NZW1	Trypanosomatidae	29%	100%
A0A1X0P0M7	Trypanosomatidae	34%	100%
A0A381MMW5	Leishmania infantum	32%	100%
A0A3Q8I7Y9	Leishmania donovani	45%	100%
A0A3Q8IEC4	Leishmania donovani	32%	94%
A0A3Q8IF95	Leishmania donovani	28%	96%
A0A3Q8ISY9	Leishmania donovani	40%	96%
A0A3R7JPZ0	Trypanosoma rangeli	25%	100%
A0A3R7JSQ9	Trypanosoma rangeli	26%	100%
A0A3R7KKN8	Trypanosoma rangeli	29%	100%
A0A3R7MAQ7	Trypanosoma rangeli	37%	86%
A0A3R7N415	Trypanosoma rangeli	28%	100%
A0A3R7N921	Trypanosoma rangeli	31%	100%
A0A3R7R443	Trypanosoma rangeli	29%	100%
A0A3R7R6N6	Trypanosoma rangeli	26%	100%
A0A3S7WRJ4	Leishmania donovani	55%	95%
A0A3S7WRJ5	Leishmania donovani	49%	87%
A0A3S7WRL4	Leishmania donovani	45%	98%
A0A3S7WRS3	Leishmania donovani	23%	97%
A0A3S7WSR4	Leishmania donovani	100%	100%
A0A3S7WWU1	Leishmania donovani	25%	91%
A0A3S7X2G0	Leishmania donovani	32%	93%
A0A3S7X2K5	Leishmania donovani	30%	100%
A0A3S7XB11	Leishmania donovani	31%	100%
A0A422MSE4	Trypanosoma rangeli	47%	100%
A0A422MSP6	Trypanosoma rangeli	34%	100%
A0A422MST9	Trypanosoma rangeli	28%	100%
A0A422MU68	Trypanosoma rangeli	27%	100%
A4H6J0	Leishmania braziliensis	53%	100%
A4H6J1	Leishmania braziliensis	51%	100%
A4H6J3	Leishmania braziliensis	46%	100%
A4H6Q5	Leishmania braziliensis	24%	100%
A4HC19	Leishmania braziliensis	27%	100%
A4HHG3	Leishmania braziliensis	31%	100%
A4HHG4	Leishmania braziliensis	30%	100%
A4HJW3	Leishmania braziliensis	39%	100%
A4HPE2	Leishmania braziliensis	32%	100%
A4HUX5	Leishmania infantum	55%	100%
A4HUX6	Leishmania infantum	49%	100%
A4HUX7	Leishmania infantum	45%	100%
A4HUX8	Leishmania infantum	46%	100%
A4HV40	Leishmania infantum	23%	100%
A4HZF5	Leishmania infantum	28%	100%
A4HZJ4	Leishmania infantum	25%	100%
A4I7C5	Leishmania infantum	41%	100%
A4ICI3	Leishmania infantum	30%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	89%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AE01	Leishmania major	31%	100%
E9AE11	Leishmania major	31%	100%
E9AHJ0	Leishmania infantum	32%	94%
E9AHJ1	Leishmania infantum	30%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
Q4Q1E4	Leishmania major	30%	100%
Q4Q5T8	Leishmania major	41%	100%
Q4QC27	Leishmania major	26%	100%
Q4QC28	Leishmania major	28%	100%
Q4QFY5	Leishmania major	94%	100%
Q4QGU8	Leishmania major	24%	100%
Q4QH10	Leishmania major	45%	99%
Q4QH11	Leishmania major	45%	96%
Q4QH12	Leishmania major	46%	96%
Q4QH13	Leishmania major	46%	96%
Q4QH14	Leishmania major	49%	100%
Q4QH15	Leishmania major	55%	100%
V5B647	Trypanosoma cruzi	47%	96%
V5B983	Trypanosoma cruzi	32%	100%
V5BBB1	Trypanosoma cruzi	46%	100%
V5BFV8	Trypanosoma cruzi	33%	91%
V5BQY6	Trypanosoma cruzi	37%	86%
V5BVP0	Trypanosoma cruzi	49%	100%
V5DT25	Trypanosoma cruzi	46%	98%