Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2 - putative

Species:

Leishmania infantum

UniProt:

E9AGJ5_LEIIN

TriTrypDb:

LINF_120017500

Length:

971

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGJ5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0016192	vesicle-mediated transport	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0006906	vesicle fusion	6	1
GO:0006914	autophagy	3	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0034058	endosomal vesicle fusion	7	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0061919	process utilizing autophagic mechanism	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	554	558	PF00656	0.215
CLV_C14_Caspase3-7	607	611	PF00656	0.580
CLV_C14_Caspase3-7	68	72	PF00656	0.449
CLV_C14_Caspase3-7	848	852	PF00656	0.404
CLV_MEL_PAP_1	49	55	PF00089	0.290
CLV_NRD_NRD_1	144	146	PF00675	0.356
CLV_NRD_NRD_1	186	188	PF00675	0.393
CLV_NRD_NRD_1	526	528	PF00675	0.292
CLV_NRD_NRD_1	630	632	PF00675	0.401
CLV_NRD_NRD_1	73	75	PF00675	0.470
CLV_NRD_NRD_1	782	784	PF00675	0.472
CLV_NRD_NRD_1	86	88	PF00675	0.455
CLV_NRD_NRD_1	925	927	PF00675	0.390
CLV_PCSK_FUR_1	524	528	PF00082	0.292
CLV_PCSK_KEX2_1	146	148	PF00082	0.503
CLV_PCSK_KEX2_1	526	528	PF00082	0.292
CLV_PCSK_KEX2_1	629	631	PF00082	0.388
CLV_PCSK_KEX2_1	73	75	PF00082	0.470
CLV_PCSK_KEX2_1	782	784	PF00082	0.421
CLV_PCSK_KEX2_1	86	88	PF00082	0.455
CLV_PCSK_KEX2_1	925	927	PF00082	0.376
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.410
CLV_PCSK_SKI1_1	115	119	PF00082	0.446
CLV_PCSK_SKI1_1	146	150	PF00082	0.393
CLV_PCSK_SKI1_1	234	238	PF00082	0.490
CLV_PCSK_SKI1_1	306	310	PF00082	0.467
CLV_PCSK_SKI1_1	465	469	PF00082	0.490
CLV_PCSK_SKI1_1	571	575	PF00082	0.467
CLV_PCSK_SKI1_1	658	662	PF00082	0.468
CLV_PCSK_SKI1_1	688	692	PF00082	0.460
CLV_PCSK_SKI1_1	730	734	PF00082	0.455
CLV_PCSK_SKI1_1	746	750	PF00082	0.409
CLV_PCSK_SKI1_1	78	82	PF00082	0.392
CLV_PCSK_SKI1_1	792	796	PF00082	0.331
CLV_PCSK_SKI1_1	86	90	PF00082	0.257
CLV_Separin_Metazoa	506	510	PF03568	0.292
DEG_APCC_DBOX_1	464	472	PF00400	0.389
DEG_APCC_DBOX_1	85	93	PF00400	0.362
DEG_Nend_UBRbox_3	1	3	PF02207	0.618
DEG_SCF_FBW7_2	216	223	PF00400	0.396
DEG_SCF_FBW7_2	250	257	PF00400	0.454
DOC_CKS1_1	204	209	PF01111	0.544
DOC_CKS1_1	217	222	PF01111	0.482
DOC_CKS1_1	251	256	PF01111	0.455
DOC_CYCLIN_RxL_1	33	44	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.446
DOC_MAPK_gen_1	132	142	PF00069	0.323
DOC_MAPK_gen_1	524	534	PF00069	0.385
DOC_MAPK_gen_1	715	725	PF00069	0.383
DOC_MAPK_gen_1	86	92	PF00069	0.356
DOC_MAPK_gen_1	925	935	PF00069	0.376
DOC_MAPK_MEF2A_6	526	534	PF00069	0.376
DOC_PP1_RVXF_1	144	151	PF00149	0.349
DOC_PP1_RVXF_1	171	178	PF00149	0.324
DOC_PP1_RVXF_1	246	252	PF00149	0.545
DOC_PP1_RVXF_1	34	41	PF00149	0.397
DOC_PP1_RVXF_1	343	349	PF00149	0.278
DOC_PP1_RVXF_1	656	662	PF00149	0.516
DOC_PP2B_LxvP_1	214	217	PF13499	0.486
DOC_PP2B_LxvP_1	443	446	PF13499	0.464
DOC_PP4_FxxP_1	428	431	PF00568	0.480
DOC_PP4_FxxP_1	725	728	PF00568	0.467
DOC_USP7_MATH_1	105	109	PF00917	0.481
DOC_USP7_MATH_1	244	248	PF00917	0.528
DOC_USP7_MATH_1	321	325	PF00917	0.476
DOC_USP7_MATH_1	350	354	PF00917	0.416
DOC_USP7_MATH_1	434	438	PF00917	0.513
DOC_USP7_MATH_1	608	612	PF00917	0.535
DOC_USP7_MATH_1	813	817	PF00917	0.461
DOC_USP7_MATH_1	866	870	PF00917	0.335
DOC_WW_Pin1_4	203	208	PF00397	0.490
DOC_WW_Pin1_4	216	221	PF00397	0.389
DOC_WW_Pin1_4	250	255	PF00397	0.501
DOC_WW_Pin1_4	332	337	PF00397	0.462
DOC_WW_Pin1_4	432	437	PF00397	0.582
DOC_WW_Pin1_4	683	688	PF00397	0.449
DOC_WW_Pin1_4	724	729	PF00397	0.533
DOC_WW_Pin1_4	749	754	PF00397	0.435
DOC_WW_Pin1_4	831	836	PF00397	0.504
LIG_14-3-3_CanoR_1	135	141	PF00244	0.347
LIG_14-3-3_CanoR_1	145	151	PF00244	0.356
LIG_14-3-3_CanoR_1	17	22	PF00244	0.474
LIG_14-3-3_CanoR_1	351	355	PF00244	0.495
LIG_14-3-3_CanoR_1	576	584	PF00244	0.567
LIG_14-3-3_CanoR_1	600	606	PF00244	0.594
LIG_14-3-3_CanoR_1	658	667	PF00244	0.426
LIG_14-3-3_CanoR_1	704	710	PF00244	0.475
LIG_14-3-3_CanoR_1	78	83	PF00244	0.447
LIG_14-3-3_CanoR_1	836	844	PF00244	0.487
LIG_14-3-3_CanoR_1	884	892	PF00244	0.339
LIG_14-3-3_CanoR_1	904	914	PF00244	0.378
LIG_APCC_ABBA_1	697	702	PF00400	0.350
LIG_APCC_ABBA_1	933	938	PF00400	0.215
LIG_FHA_1	163	169	PF00498	0.490
LIG_FHA_1	198	204	PF00498	0.485
LIG_FHA_1	299	305	PF00498	0.442
LIG_FHA_1	531	537	PF00498	0.464
LIG_FHA_1	558	564	PF00498	0.436
LIG_FHA_1	668	674	PF00498	0.461
LIG_FHA_1	684	690	PF00498	0.552
LIG_FHA_1	819	825	PF00498	0.464
LIG_FHA_1	832	838	PF00498	0.556
LIG_FHA_2	147	153	PF00498	0.400
LIG_FHA_2	154	160	PF00498	0.443
LIG_FHA_2	283	289	PF00498	0.513
LIG_FHA_2	496	502	PF00498	0.323
LIG_FHA_2	590	596	PF00498	0.536
LIG_FHA_2	676	682	PF00498	0.463
LIG_FHA_2	731	737	PF00498	0.506
LIG_FHA_2	954	960	PF00498	0.351
LIG_HCF-1_HBM_1	261	264	PF13415	0.466
LIG_LIR_Apic_2	257	263	PF02991	0.348
LIG_LIR_Apic_2	722	728	PF02991	0.433
LIG_LIR_Gen_1	296	307	PF02991	0.415
LIG_LIR_Gen_1	694	705	PF02991	0.341
LIG_LIR_Gen_1	817	828	PF02991	0.357
LIG_LIR_Gen_1	862	873	PF02991	0.259
LIG_LIR_Gen_1	886	895	PF02991	0.281
LIG_LIR_Gen_1	963	971	PF02991	0.568
LIG_LIR_Nem_3	14	19	PF02991	0.429
LIG_LIR_Nem_3	296	302	PF02991	0.410
LIG_LIR_Nem_3	33	38	PF02991	0.464
LIG_LIR_Nem_3	694	700	PF02991	0.318
LIG_LIR_Nem_3	714	720	PF02991	0.313
LIG_LIR_Nem_3	817	823	PF02991	0.381
LIG_LIR_Nem_3	862	868	PF02991	0.259
LIG_LIR_Nem_3	886	892	PF02991	0.281
LIG_LIR_Nem_3	963	968	PF02991	0.490
LIG_NRBOX	157	163	PF00104	0.429
LIG_NRBOX	232	238	PF00104	0.419
LIG_NRBOX	503	509	PF00104	0.335
LIG_NRBOX	531	537	PF00104	0.335
LIG_NRBOX	719	725	PF00104	0.357
LIG_NRBOX	823	829	PF00104	0.354
LIG_PCNA_yPIPBox_3	583	597	PF02747	0.503
LIG_PDZ_Class_3	966	971	PF00595	0.493
LIG_Pex14_2	636	640	PF04695	0.342
LIG_PTAP_UEV_1	269	274	PF05743	0.466
LIG_REV1ctd_RIR_1	625	631	PF16727	0.444
LIG_RPA_C_Fungi	130	142	PF08784	0.333
LIG_RPA_C_Fungi	778	790	PF08784	0.493
LIG_SH2_CRK	16	20	PF00017	0.472
LIG_SH2_CRK	35	39	PF00017	0.393
LIG_SH2_CRK	820	824	PF00017	0.350
LIG_SH2_CRK	889	893	PF00017	0.349
LIG_SH2_NCK_1	260	264	PF00017	0.464
LIG_SH2_NCK_1	542	546	PF00017	0.292
LIG_SH2_SRC	260	263	PF00017	0.330
LIG_SH2_SRC	542	545	PF00017	0.335
LIG_SH2_SRC	812	815	PF00017	0.476
LIG_SH2_STAP1	318	322	PF00017	0.445
LIG_SH2_STAP1	542	546	PF00017	0.404
LIG_SH2_STAP1	669	673	PF00017	0.358
LIG_SH2_STAP1	713	717	PF00017	0.456
LIG_SH2_STAP1	807	811	PF00017	0.361
LIG_SH2_STAP1	820	824	PF00017	0.329
LIG_SH2_STAP1	889	893	PF00017	0.326
LIG_SH2_STAT3	587	590	PF00017	0.467
LIG_SH2_STAT3	695	698	PF00017	0.368
LIG_SH2_STAT5	190	193	PF00017	0.342
LIG_SH2_STAT5	264	267	PF00017	0.348
LIG_SH2_STAT5	347	350	PF00017	0.320
LIG_SH2_STAT5	404	407	PF00017	0.352
LIG_SH2_STAT5	460	463	PF00017	0.409
LIG_SH2_STAT5	669	672	PF00017	0.478
LIG_SH2_STAT5	679	682	PF00017	0.573
LIG_SH2_STAT5	695	698	PF00017	0.436
LIG_SH2_STAT5	763	766	PF00017	0.398
LIG_SH2_STAT5	820	823	PF00017	0.378
LIG_SH3_3	163	169	PF00018	0.479
LIG_SH3_3	214	220	PF00018	0.427
LIG_SH3_3	267	273	PF00018	0.487
LIG_SH3_3	276	282	PF00018	0.307
LIG_SH3_3	433	439	PF00018	0.569
LIG_SH3_3	473	479	PF00018	0.447
LIG_SH3_3	704	710	PF00018	0.578
LIG_SH3_3	854	860	PF00018	0.289
LIG_SUMO_SIM_anti_2	62	68	PF11976	0.438
LIG_SUMO_SIM_anti_2	838	846	PF11976	0.304
LIG_SUMO_SIM_par_1	163	170	PF11976	0.459
LIG_SUMO_SIM_par_1	335	341	PF11976	0.353
LIG_SUMO_SIM_par_1	467	472	PF11976	0.588
LIG_SUMO_SIM_par_1	532	537	PF11976	0.335
LIG_SUMO_SIM_par_1	689	694	PF11976	0.443
LIG_SUMO_SIM_par_1	88	94	PF11976	0.313
LIG_TRAF2_1	734	737	PF00917	0.623
LIG_Vh1_VBS_1	605	623	PF01044	0.394
LIG_WRC_WIRS_1	492	497	PF05994	0.292
LIG_WRC_WIRS_1	868	873	PF05994	0.259
MOD_CDC14_SPxK_1	727	730	PF00782	0.521
MOD_CDK_SPK_2	203	208	PF00069	0.533
MOD_CDK_SPK_2	683	688	PF00069	0.449
MOD_CDK_SPK_2	831	836	PF00069	0.515
MOD_CDK_SPxK_1	724	730	PF00069	0.475
MOD_CK1_1	196	202	PF00069	0.465
MOD_CK1_1	31	37	PF00069	0.345
MOD_CK1_1	413	419	PF00069	0.543
MOD_CK1_1	59	65	PF00069	0.461
MOD_CK1_1	599	605	PF00069	0.559
MOD_CK2_1	146	152	PF00069	0.373
MOD_CK2_1	282	288	PF00069	0.463
MOD_CK2_1	409	415	PF00069	0.493
MOD_CK2_1	469	475	PF00069	0.402
MOD_CK2_1	495	501	PF00069	0.332
MOD_CK2_1	589	595	PF00069	0.508
MOD_CK2_1	635	641	PF00069	0.400
MOD_CK2_1	675	681	PF00069	0.458
MOD_CK2_1	730	736	PF00069	0.475
MOD_Cter_Amidation	185	188	PF01082	0.456
MOD_Cter_Amidation	84	87	PF01082	0.402
MOD_GlcNHglycan	107	110	PF01048	0.578
MOD_GlcNHglycan	162	165	PF01048	0.362
MOD_GlcNHglycan	208	211	PF01048	0.488
MOD_GlcNHglycan	270	273	PF01048	0.489
MOD_GlcNHglycan	319	322	PF01048	0.366
MOD_GlcNHglycan	391	394	PF01048	0.333
MOD_GlcNHglycan	471	474	PF01048	0.529
MOD_GlcNHglycan	566	569	PF01048	0.461
MOD_GlcNHglycan	57	61	PF01048	0.530
MOD_GlcNHglycan	579	582	PF01048	0.575
MOD_GlcNHglycan	601	604	PF01048	0.612
MOD_GlcNHglycan	606	609	PF01048	0.547
MOD_GlcNHglycan	758	761	PF01048	0.509
MOD_GlcNHglycan	770	773	PF01048	0.485
MOD_GlcNHglycan	885	888	PF01048	0.301
MOD_GlcNHglycan	889	892	PF01048	0.318
MOD_GlcNHglycan	953	956	PF01048	0.295
MOD_GSK3_1	193	200	PF00069	0.513
MOD_GSK3_1	264	271	PF00069	0.449
MOD_GSK3_1	289	296	PF00069	0.414
MOD_GSK3_1	30	37	PF00069	0.388
MOD_GSK3_1	317	324	PF00069	0.375
MOD_GSK3_1	409	416	PF00069	0.541
MOD_GSK3_1	491	498	PF00069	0.307
MOD_GSK3_1	595	602	PF00069	0.557
MOD_GSK3_1	604	611	PF00069	0.546
MOD_GSK3_1	616	623	PF00069	0.334
MOD_GSK3_1	677	684	PF00069	0.482
MOD_GSK3_1	724	731	PF00069	0.546
MOD_GSK3_1	814	821	PF00069	0.573
MOD_GSK3_1	831	838	PF00069	0.362
MOD_GSK3_1	883	890	PF00069	0.344
MOD_LATS_1	781	787	PF00433	0.431
MOD_N-GLC_1	795	800	PF02516	0.384
MOD_N-GLC_1	878	883	PF02516	0.384
MOD_N-GLC_2	512	514	PF02516	0.267
MOD_N-GLC_2	845	847	PF02516	0.349
MOD_NEK2_1	123	128	PF00069	0.411
MOD_NEK2_1	151	156	PF00069	0.530
MOD_NEK2_1	160	165	PF00069	0.486
MOD_NEK2_1	178	183	PF00069	0.458
MOD_NEK2_1	349	354	PF00069	0.490
MOD_NEK2_1	491	496	PF00069	0.495
MOD_NEK2_2	589	594	PF00069	0.354
MOD_NEK2_2	7	12	PF00069	0.357
MOD_NEK2_2	807	812	PF00069	0.352
MOD_NEK2_2	953	958	PF00069	0.354
MOD_PIKK_1	460	466	PF00454	0.392
MOD_PIKK_1	544	550	PF00454	0.335
MOD_PK_1	28	34	PF00069	0.362
MOD_PKA_1	146	152	PF00069	0.348
MOD_PKA_1	783	789	PF00069	0.395
MOD_PKA_2	146	152	PF00069	0.463
MOD_PKA_2	350	356	PF00069	0.495
MOD_PKA_2	599	605	PF00069	0.453
MOD_PKA_2	835	841	PF00069	0.445
MOD_PKA_2	883	889	PF00069	0.326
MOD_PKB_1	926	934	PF00069	0.335
MOD_Plk_1	115	121	PF00069	0.423
MOD_Plk_1	288	294	PF00069	0.591
MOD_Plk_1	409	415	PF00069	0.453
MOD_Plk_1	609	615	PF00069	0.448
MOD_Plk_1	802	808	PF00069	0.426
MOD_Plk_1	878	884	PF00069	0.384
MOD_Plk_2-3	410	416	PF00069	0.416
MOD_Plk_4	146	152	PF00069	0.490
MOD_Plk_4	162	168	PF00069	0.396
MOD_Plk_4	173	179	PF00069	0.451
MOD_Plk_4	530	536	PF00069	0.421
MOD_Plk_4	61	67	PF00069	0.502
MOD_Plk_4	623	629	PF00069	0.342
MOD_Plk_4	635	641	PF00069	0.434
MOD_Plk_4	642	648	PF00069	0.396
MOD_Plk_4	78	84	PF00069	0.514
MOD_Plk_4	867	873	PF00069	0.454
MOD_Plk_4	928	934	PF00069	0.349
MOD_ProDKin_1	203	209	PF00069	0.497
MOD_ProDKin_1	216	222	PF00069	0.396
MOD_ProDKin_1	250	256	PF00069	0.501
MOD_ProDKin_1	332	338	PF00069	0.452
MOD_ProDKin_1	432	438	PF00069	0.580
MOD_ProDKin_1	683	689	PF00069	0.443
MOD_ProDKin_1	724	730	PF00069	0.546
MOD_ProDKin_1	749	755	PF00069	0.429
MOD_ProDKin_1	831	837	PF00069	0.498
MOD_SUMO_rev_2	44	49	PF00179	0.418
TRG_AP2beta_CARGO_1	694	704	PF09066	0.394
TRG_DiLeu_BaEn_4	736	742	PF01217	0.515
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.455
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.383
TRG_ENDOCYTIC_2	16	19	PF00928	0.456
TRG_ENDOCYTIC_2	299	302	PF00928	0.535
TRG_ENDOCYTIC_2	35	38	PF00928	0.493
TRG_ENDOCYTIC_2	637	640	PF00928	0.408
TRG_ENDOCYTIC_2	820	823	PF00928	0.520
TRG_ENDOCYTIC_2	889	892	PF00928	0.349
TRG_ENDOCYTIC_2	965	968	PF00928	0.491
TRG_ER_diArg_1	145	148	PF00400	0.485
TRG_ER_diArg_1	628	631	PF00400	0.380
TRG_ER_diArg_1	738	741	PF00400	0.401
TRG_ER_diArg_1	86	88	PF00400	0.381
TRG_ER_diArg_1	925	928	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	896	901	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	925	930	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT4	Leptomonas seymouri	52%	99%
A0A1X0NP42	Trypanosomatidae	29%	97%
A0A3R7M5A4	Trypanosoma rangeli	31%	99%
A0A3S7WSC2	Leishmania donovani	100%	100%
C9ZI46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
E9AIN3	Leishmania braziliensis	79%	100%
E9AP32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QGF6	Leishmania major	91%	100%
V5BF34	Trypanosoma cruzi	31%	98%