LeishMANIAdb
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FAM91_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
FAM91_N domain-containing protein
Gene product:
FAM91 N-terminus/FAM91 C-terminus - putative
Species:
Leishmania infantum
UniProt:
E9AGJ4_LEIIN
TriTrypDb:
LINF_120017400
Length:
870

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AGJ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGJ4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 123 127 PF00656 0.395
CLV_C14_Caspase3-7 376 380 PF00656 0.625
CLV_NRD_NRD_1 473 475 PF00675 0.292
CLV_NRD_NRD_1 651 653 PF00675 0.241
CLV_NRD_NRD_1 834 836 PF00675 0.290
CLV_PCSK_KEX2_1 190 192 PF00082 0.348
CLV_PCSK_KEX2_1 397 399 PF00082 0.268
CLV_PCSK_KEX2_1 423 425 PF00082 0.317
CLV_PCSK_KEX2_1 473 475 PF00082 0.338
CLV_PCSK_PC1ET2_1 190 192 PF00082 0.348
CLV_PCSK_PC1ET2_1 397 399 PF00082 0.346
CLV_PCSK_PC1ET2_1 423 425 PF00082 0.317
CLV_PCSK_SKI1_1 241 245 PF00082 0.444
CLV_PCSK_SKI1_1 398 402 PF00082 0.268
CLV_PCSK_SKI1_1 473 477 PF00082 0.287
CLV_Separin_Metazoa 70 74 PF03568 0.378
DEG_APCC_DBOX_1 297 305 PF00400 0.268
DEG_APCC_DBOX_1 472 480 PF00400 0.287
DEG_SIAH_1 167 175 PF03145 0.241
DOC_CDC14_PxL_1 264 272 PF14671 0.377
DOC_CKS1_1 222 227 PF01111 0.317
DOC_CKS1_1 735 740 PF01111 0.379
DOC_CYCLIN_yCln2_LP_2 760 766 PF00134 0.395
DOC_MAPK_DCC_7 557 567 PF00069 0.287
DOC_MAPK_gen_1 423 430 PF00069 0.317
DOC_MAPK_gen_1 557 567 PF00069 0.395
DOC_MAPK_MEF2A_6 560 569 PF00069 0.397
DOC_MAPK_MEF2A_6 751 760 PF00069 0.286
DOC_MAPK_RevD_3 639 653 PF00069 0.241
DOC_MIT_MIM_1 186 195 PF04212 0.395
DOC_PP1_RVXF_1 146 152 PF00149 0.245
DOC_PP1_RVXF_1 356 363 PF00149 0.459
DOC_PP1_RVXF_1 447 453 PF00149 0.378
DOC_PP2B_LxvP_1 565 568 PF13499 0.312
DOC_PP2B_LxvP_1 760 763 PF13499 0.312
DOC_PP2B_PxIxI_1 527 533 PF00149 0.268
DOC_USP7_MATH_1 13 17 PF00917 0.253
DOC_USP7_MATH_1 388 392 PF00917 0.653
DOC_USP7_MATH_1 393 397 PF00917 0.458
DOC_USP7_MATH_1 594 598 PF00917 0.326
DOC_WW_Pin1_4 193 198 PF00397 0.378
DOC_WW_Pin1_4 221 226 PF00397 0.396
DOC_WW_Pin1_4 257 262 PF00397 0.347
DOC_WW_Pin1_4 29 34 PF00397 0.395
DOC_WW_Pin1_4 329 334 PF00397 0.317
DOC_WW_Pin1_4 519 524 PF00397 0.268
DOC_WW_Pin1_4 544 549 PF00397 0.270
DOC_WW_Pin1_4 734 739 PF00397 0.379
DOC_WW_Pin1_4 94 99 PF00397 0.268
LIG_14-3-3_CanoR_1 278 286 PF00244 0.264
LIG_14-3-3_CanoR_1 290 296 PF00244 0.313
LIG_14-3-3_CanoR_1 298 302 PF00244 0.206
LIG_14-3-3_CanoR_1 507 511 PF00244 0.268
LIG_14-3-3_CanoR_1 608 613 PF00244 0.317
LIG_14-3-3_CanoR_1 718 724 PF00244 0.317
LIG_14-3-3_CanoR_1 806 811 PF00244 0.342
LIG_AP2alpha_2 173 175 PF02296 0.395
LIG_BIR_II_1 1 5 PF00653 0.566
LIG_BIR_III_2 775 779 PF00653 0.378
LIG_BIR_III_2 862 866 PF00653 0.605
LIG_CaM_IQ_9 316 331 PF13499 0.366
LIG_Clathr_ClatBox_1 307 311 PF01394 0.245
LIG_Clathr_ClatBox_1 493 497 PF01394 0.395
LIG_Clathr_ClatBox_1 529 533 PF01394 0.395
LIG_Clathr_ClatBox_1 849 853 PF01394 0.395
LIG_deltaCOP1_diTrp_1 451 458 PF00928 0.378
LIG_eIF4E_1 161 167 PF01652 0.377
LIG_FHA_1 140 146 PF00498 0.268
LIG_FHA_1 182 188 PF00498 0.301
LIG_FHA_1 209 215 PF00498 0.395
LIG_FHA_1 234 240 PF00498 0.286
LIG_FHA_1 36 42 PF00498 0.347
LIG_FHA_1 406 412 PF00498 0.270
LIG_FHA_1 519 525 PF00498 0.287
LIG_FHA_1 596 602 PF00498 0.240
LIG_FHA_1 609 615 PF00498 0.360
LIG_FHA_1 634 640 PF00498 0.310
LIG_FHA_1 709 715 PF00498 0.435
LIG_FHA_1 809 815 PF00498 0.395
LIG_FHA_1 824 830 PF00498 0.395
LIG_FHA_2 121 127 PF00498 0.268
LIG_FHA_2 277 283 PF00498 0.268
LIG_FHA_2 292 298 PF00498 0.268
LIG_FHA_2 30 36 PF00498 0.395
LIG_FHA_2 387 393 PF00498 0.583
LIG_FHA_2 617 623 PF00498 0.205
LIG_FHA_2 696 702 PF00498 0.378
LIG_FHA_2 763 769 PF00498 0.395
LIG_Integrin_RGD_1 702 704 PF01839 0.210
LIG_LIR_Apic_2 236 240 PF02991 0.395
LIG_LIR_Gen_1 103 110 PF02991 0.289
LIG_LIR_Gen_1 113 124 PF02991 0.271
LIG_LIR_Gen_1 262 270 PF02991 0.392
LIG_LIR_Gen_1 408 416 PF02991 0.346
LIG_LIR_Gen_1 505 515 PF02991 0.268
LIG_LIR_Gen_1 546 555 PF02991 0.271
LIG_LIR_Gen_1 617 628 PF02991 0.346
LIG_LIR_Gen_1 65 76 PF02991 0.348
LIG_LIR_Gen_1 660 671 PF02991 0.311
LIG_LIR_Gen_1 704 715 PF02991 0.371
LIG_LIR_Gen_1 722 732 PF02991 0.395
LIG_LIR_Gen_1 745 755 PF02991 0.313
LIG_LIR_Gen_1 805 814 PF02991 0.346
LIG_LIR_Nem_3 100 105 PF02991 0.331
LIG_LIR_Nem_3 113 119 PF02991 0.199
LIG_LIR_Nem_3 173 178 PF02991 0.346
LIG_LIR_Nem_3 262 267 PF02991 0.392
LIG_LIR_Nem_3 505 511 PF02991 0.268
LIG_LIR_Nem_3 546 552 PF02991 0.271
LIG_LIR_Nem_3 617 623 PF02991 0.346
LIG_LIR_Nem_3 660 666 PF02991 0.311
LIG_LIR_Nem_3 704 710 PF02991 0.371
LIG_LIR_Nem_3 722 728 PF02991 0.348
LIG_LIR_Nem_3 729 735 PF02991 0.349
LIG_LIR_Nem_3 745 750 PF02991 0.313
LIG_LIR_Nem_3 799 803 PF02991 0.315
LIG_LIR_Nem_3 805 810 PF02991 0.316
LIG_LIR_Nem_3 851 855 PF02991 0.322
LIG_LYPXL_S_1 81 85 PF13949 0.312
LIG_LYPXL_yS_3 82 85 PF13949 0.289
LIG_NRBOX 303 309 PF00104 0.268
LIG_Pex14_1 549 553 PF04695 0.268
LIG_Rb_pABgroove_1 397 405 PF01858 0.268
LIG_SH2_CRK 102 106 PF00017 0.368
LIG_SH2_CRK 116 120 PF00017 0.182
LIG_SH2_CRK 20 24 PF00017 0.346
LIG_SH2_CRK 203 207 PF00017 0.324
LIG_SH2_CRK 289 293 PF00017 0.290
LIG_SH2_CRK 508 512 PF00017 0.268
LIG_SH2_CRK 555 559 PF00017 0.395
LIG_SH2_CRK 603 607 PF00017 0.395
LIG_SH2_CRK 807 811 PF00017 0.312
LIG_SH2_GRB2like 157 160 PF00017 0.346
LIG_SH2_GRB2like 465 468 PF00017 0.395
LIG_SH2_NCK_1 437 441 PF00017 0.378
LIG_SH2_PTP2 264 267 PF00017 0.395
LIG_SH2_SRC 161 164 PF00017 0.310
LIG_SH2_SRC 465 468 PF00017 0.346
LIG_SH2_STAP1 183 187 PF00017 0.395
LIG_SH2_STAP1 235 239 PF00017 0.282
LIG_SH2_STAP1 403 407 PF00017 0.268
LIG_SH2_STAP1 603 607 PF00017 0.448
LIG_SH2_STAT3 34 37 PF00017 0.340
LIG_SH2_STAT3 365 368 PF00017 0.503
LIG_SH2_STAT3 84 87 PF00017 0.395
LIG_SH2_STAT5 102 105 PF00017 0.192
LIG_SH2_STAT5 138 141 PF00017 0.268
LIG_SH2_STAT5 157 160 PF00017 0.268
LIG_SH2_STAT5 161 164 PF00017 0.277
LIG_SH2_STAT5 183 186 PF00017 0.377
LIG_SH2_STAT5 235 238 PF00017 0.336
LIG_SH2_STAT5 264 267 PF00017 0.383
LIG_SH2_STAT5 465 468 PF00017 0.275
LIG_SH2_STAT5 518 521 PF00017 0.268
LIG_SH2_STAT5 555 558 PF00017 0.321
LIG_SH2_STAT5 620 623 PF00017 0.264
LIG_SH2_STAT5 725 728 PF00017 0.391
LIG_SH2_STAT5 754 757 PF00017 0.375
LIG_SH2_STAT5 84 87 PF00017 0.305
LIG_SH2_STAT5 93 96 PF00017 0.256
LIG_SH3_2 333 338 PF14604 0.210
LIG_SH3_3 262 268 PF00018 0.315
LIG_SH3_3 330 336 PF00018 0.312
LIG_SH3_3 479 485 PF00018 0.287
LIG_SH3_3 665 671 PF00018 0.287
LIG_SUMO_SIM_anti_2 624 632 PF11976 0.291
LIG_SUMO_SIM_anti_2 695 701 PF11976 0.455
LIG_SUMO_SIM_par_1 306 314 PF11976 0.268
LIG_SUMO_SIM_par_1 528 533 PF11976 0.346
LIG_SUMO_SIM_par_1 624 632 PF11976 0.291
LIG_TRAF2_1 350 353 PF00917 0.377
LIG_TRFH_1 20 24 PF08558 0.395
LIG_TYR_ITIM 201 206 PF00017 0.317
LIG_TYR_ITIM 287 292 PF00017 0.310
LIG_TYR_ITIM 601 606 PF00017 0.386
LIG_TYR_ITIM 618 623 PF00017 0.233
LIG_UBA3_1 105 111 PF00899 0.225
LIG_UBA3_1 550 557 PF00899 0.348
LIG_WRC_WIRS_1 254 259 PF05994 0.395
LIG_WRC_WIRS_1 725 730 PF05994 0.378
LIG_WRC_WIRS_1 849 854 PF05994 0.378
MOD_CK1_1 100 106 PF00069 0.282
MOD_CK1_1 177 183 PF00069 0.381
MOD_CK1_1 208 214 PF00069 0.350
MOD_CK1_1 334 340 PF00069 0.210
MOD_CK1_1 522 528 PF00069 0.285
MOD_CK1_1 540 546 PF00069 0.192
MOD_CK1_1 589 595 PF00069 0.429
MOD_CK1_1 708 714 PF00069 0.378
MOD_CK1_1 808 814 PF00069 0.290
MOD_CK1_1 822 828 PF00069 0.299
MOD_CK2_1 347 353 PF00069 0.324
MOD_CK2_1 495 501 PF00069 0.287
MOD_CK2_1 739 745 PF00069 0.356
MOD_CK2_1 762 768 PF00069 0.443
MOD_GlcNHglycan 163 166 PF01048 0.371
MOD_GlcNHglycan 168 171 PF01048 0.357
MOD_GlcNHglycan 524 527 PF01048 0.395
MOD_GlcNHglycan 590 594 PF01048 0.378
MOD_GlcNHglycan 672 675 PF01048 0.334
MOD_GlcNHglycan 692 695 PF01048 0.352
MOD_GlcNHglycan 821 824 PF01048 0.192
MOD_GSK3_1 177 184 PF00069 0.399
MOD_GSK3_1 253 260 PF00069 0.347
MOD_GSK3_1 414 421 PF00069 0.290
MOD_GSK3_1 502 509 PF00069 0.268
MOD_GSK3_1 518 525 PF00069 0.268
MOD_GSK3_1 540 547 PF00069 0.268
MOD_GSK3_1 618 625 PF00069 0.317
MOD_GSK3_1 666 673 PF00069 0.341
MOD_GSK3_1 724 731 PF00069 0.329
MOD_GSK3_1 779 786 PF00069 0.407
MOD_GSK3_1 819 826 PF00069 0.328
MOD_GSK3_1 853 860 PF00069 0.387
MOD_N-GLC_1 120 125 PF02516 0.268
MOD_N-GLC_1 153 158 PF02516 0.286
MOD_N-GLC_1 276 281 PF02516 0.268
MOD_N-GLC_1 414 419 PF02516 0.268
MOD_NEK2_1 205 210 PF00069 0.386
MOD_NEK2_1 367 372 PF00069 0.472
MOD_NEK2_1 411 416 PF00069 0.286
MOD_NEK2_1 502 507 PF00069 0.395
MOD_NEK2_1 553 558 PF00069 0.395
MOD_NEK2_1 623 628 PF00069 0.346
MOD_NEK2_1 666 671 PF00069 0.284
MOD_NEK2_1 672 677 PF00069 0.304
MOD_NEK2_1 682 687 PF00069 0.262
MOD_NEK2_1 710 715 PF00069 0.344
MOD_NEK2_1 719 724 PF00069 0.237
MOD_NEK2_1 726 731 PF00069 0.196
MOD_NEK2_2 210 215 PF00069 0.382
MOD_NEK2_2 230 235 PF00069 0.307
MOD_PIKK_1 672 678 PF00454 0.365
MOD_PIKK_1 827 833 PF00454 0.312
MOD_PK_1 653 659 PF00069 0.395
MOD_PKA_2 277 283 PF00069 0.268
MOD_PKA_2 297 303 PF00069 0.119
MOD_PKA_2 506 512 PF00069 0.268
MOD_PKA_2 805 811 PF00069 0.342
MOD_Plk_1 112 118 PF00069 0.268
MOD_Plk_1 120 126 PF00069 0.268
MOD_Plk_1 153 159 PF00069 0.286
MOD_Plk_1 296 302 PF00069 0.287
MOD_Plk_1 403 409 PF00069 0.268
MOD_Plk_1 532 538 PF00069 0.321
MOD_Plk_1 616 622 PF00069 0.268
MOD_Plk_1 666 672 PF00069 0.299
MOD_Plk_1 683 689 PF00069 0.384
MOD_Plk_2-3 340 346 PF00069 0.395
MOD_Plk_2-3 739 745 PF00069 0.210
MOD_Plk_4 224 230 PF00069 0.431
MOD_Plk_4 465 471 PF00069 0.312
MOD_Plk_4 506 512 PF00069 0.268
MOD_Plk_4 540 546 PF00069 0.268
MOD_Plk_4 561 567 PF00069 0.311
MOD_Plk_4 568 574 PF00069 0.346
MOD_Plk_4 595 601 PF00069 0.264
MOD_Plk_4 623 629 PF00069 0.274
MOD_Plk_4 695 701 PF00069 0.404
MOD_Plk_4 702 708 PF00069 0.386
MOD_Plk_4 845 851 PF00069 0.358
MOD_Plk_4 86 92 PF00069 0.352
MOD_Plk_4 97 103 PF00069 0.208
MOD_ProDKin_1 193 199 PF00069 0.378
MOD_ProDKin_1 221 227 PF00069 0.396
MOD_ProDKin_1 257 263 PF00069 0.347
MOD_ProDKin_1 29 35 PF00069 0.395
MOD_ProDKin_1 329 335 PF00069 0.317
MOD_ProDKin_1 519 525 PF00069 0.268
MOD_ProDKin_1 544 550 PF00069 0.270
MOD_ProDKin_1 734 740 PF00069 0.379
MOD_ProDKin_1 94 100 PF00069 0.268
MOD_SUMO_for_1 110 113 PF00179 0.239
MOD_SUMO_for_1 494 497 PF00179 0.268
MOD_SUMO_for_1 62 65 PF00179 0.241
MOD_SUMO_rev_2 448 455 PF00179 0.404
TRG_DiLeu_BaEn_1 768 773 PF01217 0.378
TRG_DiLeu_BaEn_2 798 804 PF01217 0.395
TRG_DiLeu_BaLyEn_6 471 476 PF01217 0.317
TRG_DiLeu_BaLyEn_6 525 530 PF01217 0.268
TRG_DiLeu_BaLyEn_6 776 781 PF01217 0.395
TRG_ENDOCYTIC_2 102 105 PF00928 0.119
TRG_ENDOCYTIC_2 116 119 PF00928 0.271
TRG_ENDOCYTIC_2 138 141 PF00928 0.268
TRG_ENDOCYTIC_2 20 23 PF00928 0.268
TRG_ENDOCYTIC_2 203 206 PF00928 0.346
TRG_ENDOCYTIC_2 264 267 PF00928 0.395
TRG_ENDOCYTIC_2 289 292 PF00928 0.290
TRG_ENDOCYTIC_2 437 440 PF00928 0.378
TRG_ENDOCYTIC_2 508 511 PF00928 0.268
TRG_ENDOCYTIC_2 51 54 PF00928 0.266
TRG_ENDOCYTIC_2 555 558 PF00928 0.268
TRG_ENDOCYTIC_2 603 606 PF00928 0.386
TRG_ENDOCYTIC_2 620 623 PF00928 0.233
TRG_ENDOCYTIC_2 663 666 PF00928 0.346
TRG_ENDOCYTIC_2 68 71 PF00928 0.268
TRG_ENDOCYTIC_2 725 728 PF00928 0.395
TRG_ENDOCYTIC_2 732 735 PF00928 0.395
TRG_ENDOCYTIC_2 807 810 PF00928 0.312
TRG_ENDOCYTIC_2 82 85 PF00928 0.280
TRG_ER_diArg_1 14 17 PF00400 0.324
TRG_ER_diArg_1 472 474 PF00400 0.326
TRG_Pf-PMV_PEXEL_1 779 783 PF00026 0.368

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY17 Leptomonas seymouri 72% 96%
A0A1X0NP10 Trypanosomatidae 45% 89%
A0A3Q8I8D6 Leishmania donovani 100% 100%
A0A3R7KTC9 Trypanosoma rangeli 44% 99%
C9ZI44 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 82%
E9AIN4 Leishmania braziliensis 87% 100%
E9AP31 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q3UVG3 Mus musculus 30% 100%
Q4QGF7 Leishmania major 94% 100%
Q658Y4 Homo sapiens 31% 100%
Q6TEP1 Danio rerio 31% 100%
V5AZM4 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS