FAM91_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAM91 N-terminus/FAM91 C-terminus - putative

Species:

Leishmania infantum

UniProt:

E9AGJ4_LEIIN

TriTrypDb:

LINF_120017400

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AGJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGJ4

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.395
CLV_C14_Caspase3-7	376	380	PF00656	0.625
CLV_NRD_NRD_1	473	475	PF00675	0.292
CLV_NRD_NRD_1	651	653	PF00675	0.241
CLV_NRD_NRD_1	834	836	PF00675	0.290
CLV_PCSK_KEX2_1	190	192	PF00082	0.348
CLV_PCSK_KEX2_1	397	399	PF00082	0.268
CLV_PCSK_KEX2_1	423	425	PF00082	0.317
CLV_PCSK_KEX2_1	473	475	PF00082	0.338
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.348

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY17	Leptomonas seymouri	72%	96%
A0A1X0NP10	Trypanosomatidae	45%	89%
A0A3Q8I8D6	Leishmania donovani	100%	100%
A0A3R7KTC9	Trypanosoma rangeli	44%	99%
C9ZI44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	82%
E9AIN4	Leishmania braziliensis	87%	100%
E9AP31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q3UVG3	Mus musculus	30%	100%
Q4QGF7	Leishmania major	94%	100%
Q658Y4	Homo sapiens	31%	100%

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