Ribonuclease H2 subunit C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribonuclease H2 non-catalytic subunit (Ylr154p-like) - putative

Species:

Leishmania infantum

UniProt:

E9AGJ3_LEIIN

TriTrypDb:

LINF_120017300

Length:

103

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032299	ribonuclease H2 complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140535	intracellular protein-containing complex	2	7
GO:1902494	catalytic complex	2	7
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGJ3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006401	RNA catabolic process	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0019439	aromatic compound catabolic process	4	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034655	nucleobase-containing compound catabolic process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0044270	cellular nitrogen compound catabolic process	4	7
GO:0046483	heterocycle metabolic process	3	7
GO:0046700	heterocycle catabolic process	4	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901361	organic cyclic compound catabolic process	4	7
GO:1901575	organic substance catabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	2	4	PF00082	0.436
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.451
CLV_PCSK_SKI1_1	10	14	PF00082	0.316
CLV_PCSK_SKI1_1	17	21	PF00082	0.281
DEG_Nend_UBRbox_1	1	4	PF02207	0.433
DOC_CKS1_1	47	52	PF01111	0.318
DOC_CYCLIN_RxL_1	11	23	PF00134	0.337
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.236
DOC_PP1_RVXF_1	78	85	PF00149	0.341
DOC_PP2B_LxvP_1	66	69	PF13499	0.236
DOC_PP4_FxxP_1	73	76	PF00568	0.236
DOC_USP7_MATH_2	69	75	PF00917	0.213
DOC_WW_Pin1_4	42	47	PF00397	0.292
LIG_14-3-3_CanoR_1	10	15	PF00244	0.372
LIG_FHA_1	53	59	PF00498	0.331
LIG_LIR_Apic_2	70	76	PF02991	0.236
LIG_LIR_Gen_1	28	37	PF02991	0.270
LIG_LIR_Gen_1	97	103	PF02991	0.283
LIG_LIR_Nem_3	28	33	PF02991	0.363
LIG_LIR_Nem_3	97	102	PF02991	0.283
LIG_SH2_CRK	30	34	PF00017	0.236
LIG_SH2_STAP1	30	34	PF00017	0.306
LIG_SH2_STAT5	81	84	PF00017	0.284
LIG_SH3_3	21	27	PF00018	0.283
LIG_SH3_3	73	79	PF00018	0.236
LIG_WRC_WIRS_1	53	58	PF05994	0.283
MOD_CK1_1	40	46	PF00069	0.373
MOD_CK1_1	52	58	PF00069	0.235
MOD_GSK3_1	32	39	PF00069	0.470
MOD_GSK3_1	42	49	PF00069	0.318
MOD_GSK3_1	88	95	PF00069	0.341
MOD_LATS_1	86	92	PF00433	0.283
MOD_PIKK_1	94	100	PF00454	0.343
MOD_PK_1	92	98	PF00069	0.236
MOD_ProDKin_1	42	48	PF00069	0.292
TRG_ENDOCYTIC_2	30	33	PF00928	0.361
TRG_ER_diArg_1	14	17	PF00400	0.297
TRG_NES_CRM1_1	59	71	PF08389	0.294
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL20	Leptomonas seymouri	42%	73%
A0A1X0NN29	Trypanosomatidae	32%	68%
A0A3S7WSA4	Leishmania donovani	99%	100%
E9AIN5	Leishmania braziliensis	64%	100%
Q4QGF8	Leishmania major	79%	100%