LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
MYND finger/SET domain containing protein - putative
Species:
Leishmania infantum
UniProt:
E9AGJ2_LEIIN
TriTrypDb:
LINF_120017200
Length:
622

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized LINJ.12.0880

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AGJ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGJ2

Function

Biological processes
Term Name Level Count
GO:0006479 protein methylation 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008213 protein alkylation 5 1
GO:0009987 cellular process 1 1
GO:0016570 histone modification 5 1
GO:0016571 histone methylation 5 1
GO:0018022 peptidyl-lysine methylation 5 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018205 peptidyl-lysine modification 6 1
GO:0019538 protein metabolic process 3 1
GO:0032259 methylation 2 1
GO:0034968 histone lysine methylation 6 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043414 macromolecule methylation 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0005488 binding 1 5
GO:0008168 methyltransferase activity 4 1
GO:0008170 N-methyltransferase activity 5 1
GO:0008276 protein methyltransferase activity 3 1
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 1
GO:0016278 lysine N-methyltransferase activity 6 1
GO:0016279 protein-lysine N-methyltransferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016741 transferase activity, transferring one-carbon groups 3 1
GO:0018024 obsolete histone lysine N-methyltransferase activity 5 1
GO:0042054 histone methyltransferase activity 4 1
GO:0043167 ion binding 2 5
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.734
CLV_C14_Caspase3-7 513 517 PF00656 0.409
CLV_MEL_PAP_1 154 160 PF00089 0.482
CLV_NRD_NRD_1 302 304 PF00675 0.369
CLV_NRD_NRD_1 449 451 PF00675 0.350
CLV_NRD_NRD_1 485 487 PF00675 0.523
CLV_PCSK_FUR_1 447 451 PF00082 0.431
CLV_PCSK_KEX2_1 328 330 PF00082 0.347
CLV_PCSK_KEX2_1 449 451 PF00082 0.350
CLV_PCSK_KEX2_1 580 582 PF00082 0.371
CLV_PCSK_PC1ET2_1 328 330 PF00082 0.347
CLV_PCSK_PC1ET2_1 580 582 PF00082 0.371
CLV_PCSK_SKI1_1 102 106 PF00082 0.384
CLV_PCSK_SKI1_1 334 338 PF00082 0.280
CLV_PCSK_SKI1_1 487 491 PF00082 0.525
CLV_PCSK_SKI1_1 580 584 PF00082 0.360
CLV_PCSK_SKI1_1 611 615 PF00082 0.479
DEG_APCC_DBOX_1 541 549 PF00400 0.314
DOC_CDC14_PxL_1 132 140 PF14671 0.497
DOC_CDC14_PxL_1 186 194 PF14671 0.450
DOC_CDC14_PxL_1 436 444 PF14671 0.481
DOC_CKS1_1 198 203 PF01111 0.476
DOC_CYCLIN_RxL_1 328 339 PF00134 0.480
DOC_CYCLIN_yClb1_LxF_4 542 548 PF00134 0.330
DOC_CYCLIN_yCln2_LP_2 198 204 PF00134 0.426
DOC_MAPK_DCC_7 187 195 PF00069 0.447
DOC_MAPK_gen_1 173 183 PF00069 0.541
DOC_MAPK_MEF2A_6 187 195 PF00069 0.447
DOC_PP2B_LxvP_1 305 308 PF13499 0.547
DOC_USP7_MATH_1 3 7 PF00917 0.634
DOC_USP7_MATH_1 354 358 PF00917 0.479
DOC_USP7_MATH_1 397 401 PF00917 0.480
DOC_USP7_UBL2_3 487 491 PF12436 0.321
DOC_WW_Pin1_4 164 169 PF00397 0.575
DOC_WW_Pin1_4 197 202 PF00397 0.452
DOC_WW_Pin1_4 268 273 PF00397 0.547
DOC_WW_Pin1_4 407 412 PF00397 0.528
LIG_14-3-3_CanoR_1 157 161 PF00244 0.521
LIG_14-3-3_CanoR_1 292 300 PF00244 0.553
LIG_14-3-3_CanoR_1 334 339 PF00244 0.577
LIG_14-3-3_CanoR_1 452 460 PF00244 0.449
LIG_14-3-3_CanoR_1 465 474 PF00244 0.280
LIG_14-3-3_CanoR_1 542 548 PF00244 0.330
LIG_AP2alpha_2 472 474 PF02296 0.439
LIG_APCC_ABBA_1 41 46 PF00400 0.501
LIG_BIR_III_4 617 621 PF00653 0.484
LIG_BRCT_BRCA1_1 113 117 PF00533 0.457
LIG_BRCT_BRCA1_1 356 360 PF00533 0.559
LIG_BRCT_BRCA1_1 5 9 PF00533 0.610
LIG_eIF4E_1 100 106 PF01652 0.429
LIG_FHA_1 149 155 PF00498 0.489
LIG_FHA_1 337 343 PF00498 0.545
LIG_FHA_1 36 42 PF00498 0.487
LIG_FHA_1 364 370 PF00498 0.503
LIG_FHA_1 423 429 PF00498 0.448
LIG_FHA_2 260 266 PF00498 0.407
LIG_FHA_2 53 59 PF00498 0.454
LIG_LIR_Gen_1 313 323 PF02991 0.519
LIG_LIR_Gen_1 368 376 PF02991 0.520
LIG_LIR_Nem_3 309 314 PF02991 0.493
LIG_LIR_Nem_3 368 373 PF02991 0.520
LIG_LIR_Nem_3 454 460 PF02991 0.453
LIG_LIR_Nem_3 490 496 PF02991 0.457
LIG_LIR_Nem_3 546 552 PF02991 0.326
LIG_MYND_1 136 140 PF01753 0.482
LIG_MYND_3 135 139 PF01753 0.512
LIG_NRBOX 519 525 PF00104 0.379
LIG_NRBOX 562 568 PF00104 0.398
LIG_SH2_CRK 269 273 PF00017 0.522
LIG_SH2_CRK 316 320 PF00017 0.547
LIG_SH2_CRK 370 374 PF00017 0.480
LIG_SH2_CRK 549 553 PF00017 0.386
LIG_SH2_NCK_1 133 137 PF00017 0.500
LIG_SH2_NCK_1 370 374 PF00017 0.480
LIG_SH2_STAP1 37 41 PF00017 0.485
LIG_SH2_STAT3 36 39 PF00017 0.477
LIG_SH2_STAT3 438 441 PF00017 0.349
LIG_SH2_STAT5 269 272 PF00017 0.460
LIG_SH2_STAT5 37 40 PF00017 0.457
LIG_SH2_STAT5 370 373 PF00017 0.522
LIG_SH2_STAT5 438 441 PF00017 0.364
LIG_SH2_STAT5 458 461 PF00017 0.375
LIG_SH2_STAT5 536 539 PF00017 0.312
LIG_SH3_3 348 354 PF00018 0.547
LIG_SH3_3 380 386 PF00018 0.470
LIG_SUMO_SIM_anti_2 194 200 PF11976 0.459
LIG_SUMO_SIM_anti_2 610 617 PF11976 0.476
LIG_SUMO_SIM_par_1 191 197 PF11976 0.396
LIG_SUMO_SIM_par_1 333 339 PF11976 0.556
LIG_TRAF2_1 231 234 PF00917 0.777
LIG_TYR_ITIM 314 319 PF00017 0.547
LIG_TYR_ITSM 366 373 PF00017 0.522
LIG_UBA3_1 296 304 PF00899 0.553
LIG_UBA3_1 355 361 PF00899 0.522
LIG_WRC_WIRS_1 401 406 PF05994 0.547
MOD_CK1_1 109 115 PF00069 0.579
MOD_CK1_1 197 203 PF00069 0.380
MOD_CK1_1 259 265 PF00069 0.532
MOD_CK1_1 400 406 PF00069 0.475
MOD_CK1_1 525 531 PF00069 0.308
MOD_CK1_1 599 605 PF00069 0.414
MOD_CK2_1 138 144 PF00069 0.383
MOD_CK2_1 156 162 PF00069 0.441
MOD_CK2_1 52 58 PF00069 0.496
MOD_GlcNHglycan 120 123 PF01048 0.465
MOD_GlcNHglycan 385 389 PF01048 0.285
MOD_GlcNHglycan 5 8 PF01048 0.667
MOD_GlcNHglycan 600 604 PF01048 0.459
MOD_GlcNHglycan 61 64 PF01048 0.401
MOD_GSK3_1 112 119 PF00069 0.545
MOD_GSK3_1 256 263 PF00069 0.509
MOD_GSK3_1 496 503 PF00069 0.456
MOD_GSK3_1 518 525 PF00069 0.505
MOD_LATS_1 332 338 PF00433 0.480
MOD_N-GLC_1 405 410 PF02516 0.255
MOD_N-GLC_2 23 25 PF02516 0.525
MOD_NEK2_1 336 341 PF00069 0.522
MOD_NEK2_1 405 410 PF00069 0.463
MOD_NEK2_1 59 64 PF00069 0.458
MOD_NEK2_2 414 419 PF00069 0.522
MOD_NEK2_2 500 505 PF00069 0.383
MOD_PIKK_1 35 41 PF00454 0.399
MOD_PIKK_1 510 516 PF00454 0.485
MOD_PKA_2 156 162 PF00069 0.523
MOD_PKA_2 288 294 PF00069 0.550
MOD_PKA_2 451 457 PF00069 0.509
MOD_Plk_1 432 438 PF00069 0.448
MOD_Plk_2-3 156 162 PF00069 0.560
MOD_Plk_4 194 200 PF00069 0.484
MOD_Plk_4 365 371 PF00069 0.518
MOD_Plk_4 400 406 PF00069 0.448
MOD_Plk_4 543 549 PF00069 0.330
MOD_ProDKin_1 164 170 PF00069 0.575
MOD_ProDKin_1 197 203 PF00069 0.447
MOD_ProDKin_1 268 274 PF00069 0.547
MOD_ProDKin_1 407 413 PF00069 0.528
MOD_SUMO_for_1 253 256 PF00179 0.576
MOD_SUMO_for_1 360 363 PF00179 0.522
MOD_SUMO_for_1 582 585 PF00179 0.381
TRG_DiLeu_BaEn_1 194 199 PF01217 0.455
TRG_DiLeu_BaEn_1 519 524 PF01217 0.480
TRG_DiLeu_BaEn_2 454 460 PF01217 0.453
TRG_DiLeu_BaEn_4 364 370 PF01217 0.449
TRG_DiLeu_BaLyEn_6 149 154 PF01217 0.427
TRG_ENDOCYTIC_2 316 319 PF00928 0.533
TRG_ENDOCYTIC_2 370 373 PF00928 0.522
TRG_ENDOCYTIC_2 457 460 PF00928 0.540
TRG_ENDOCYTIC_2 549 552 PF00928 0.330
TRG_ER_diArg_1 447 450 PF00400 0.354
TRG_ER_diArg_1 504 507 PF00400 0.486
TRG_NES_CRM1_1 148 162 PF08389 0.424
TRG_NES_CRM1_1 557 570 PF08389 0.448
TRG_NLS_MonoExtC_3 579 585 PF00514 0.376
TRG_NLS_MonoExtN_4 578 584 PF00514 0.369
TRG_Pf-PMV_PEXEL_1 130 134 PF00026 0.441
TRG_Pf-PMV_PEXEL_1 152 156 PF00026 0.394
TRG_Pf-PMV_PEXEL_1 476 481 PF00026 0.415

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDV1 Leptomonas seymouri 62% 100%
A0A0S4IJK9 Bodo saltans 40% 100%
A0A1X0NMI4 Trypanosomatidae 43% 100%
A0A3S7WS98 Leishmania donovani 99% 100%
A0A422NUZ8 Trypanosoma rangeli 46% 100%
C9ZI42 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 99%
E9AIN6 Leishmania braziliensis 84% 100%
E9AP30 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QGF9 Leishmania major 93% 100%
V5DFZ1 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS