Arginine N-methyltransferase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

arginine N-methyltransferase-like protein

Species:

Leishmania infantum

UniProt:

E9AGI9_LEIIN

TriTrypDb:

LINF_120016900

Length:

343

Annotations

Annotations by Jardim et al.

Protein modification, Arginine N-methyltransferase-like LINJ.12.0850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AGI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGI9

Function

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Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008213	protein alkylation	5	12
GO:0009987	cellular process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018195	peptidyl-arginine modification	6	12
GO:0018216	peptidyl-arginine methylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0032259	methylation	2	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016273	arginine N-methyltransferase activity	6	12
GO:0016274	protein-arginine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.297
CLV_NRD_NRD_1	84	86	PF00675	0.297
CLV_PCSK_KEX2_1	100	102	PF00082	0.366
CLV_PCSK_KEX2_1	200	202	PF00082	0.356
CLV_PCSK_KEX2_1	298	300	PF00082	0.458
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.356
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.458
CLV_PCSK_SKI1_1	63	67	PF00082	0.301
DOC_CKS1_1	156	161	PF01111	0.327
DOC_CKS1_1	260	265	PF01111	0.333

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A7	Leptomonas seymouri	25%	86%
A0A0N0P6T9	Leptomonas seymouri	88%	99%
A0A0N0P7Z0	Leptomonas seymouri	29%	95%
A0A0S4IRB2	Bodo saltans	26%	77%
A0A0S4JDH7	Bodo saltans	30%	98%
A0A0S4JQD8	Bodo saltans	26%	92%
A0A0S4JWH9	Bodo saltans	71%	99%
A0A1X0NKR3	Trypanosomatidae	28%	71%
A0A1X0NMC6	Trypanosomatidae	75%	100%
A0A1X0P0F1	Trypanosomatidae	30%	93%

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