RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGI8_LEIIN

TriTrypDb:

LINF_120016800

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 5
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGI8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.775
CLV_C14_Caspase3-7	320	324	PF00656	0.628
CLV_C14_Caspase3-7	425	429	PF00656	0.551
CLV_NRD_NRD_1	153	155	PF00675	0.615
CLV_NRD_NRD_1	157	159	PF00675	0.591
CLV_NRD_NRD_1	161	163	PF00675	0.616
CLV_NRD_NRD_1	337	339	PF00675	0.483
CLV_NRD_NRD_1	387	389	PF00675	0.528
CLV_NRD_NRD_1	412	414	PF00675	0.785
CLV_NRD_NRD_1	422	424	PF00675	0.681
CLV_PCSK_KEX2_1	152	154	PF00082	0.625
CLV_PCSK_KEX2_1	157	159	PF00082	0.589
CLV_PCSK_KEX2_1	161	163	PF00082	0.613
CLV_PCSK_KEX2_1	262	264	PF00082	0.542
CLV_PCSK_KEX2_1	337	339	PF00082	0.483
CLV_PCSK_KEX2_1	389	391	PF00082	0.549
CLV_PCSK_KEX2_1	412	414	PF00082	0.778
CLV_PCSK_KEX2_1	421	423	PF00082	0.650
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.526
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.462
CLV_PCSK_PC7_1	153	159	PF00082	0.641
CLV_PCSK_SKI1_1	129	133	PF00082	0.679
CLV_PCSK_SKI1_1	21	25	PF00082	0.547
CLV_PCSK_SKI1_1	350	354	PF00082	0.369
CLV_PCSK_SKI1_1	390	394	PF00082	0.533
CLV_PCSK_SKI1_1	412	416	PF00082	0.772
DEG_Nend_Nbox_1	1	3	PF02207	0.699
DEG_SPOP_SBC_1	145	149	PF00917	0.625
DEG_SPOP_SBC_1	427	431	PF00917	0.542
DOC_ANK_TNKS_1	272	279	PF00023	0.406
DOC_CYCLIN_RxL_1	387	397	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.482
DOC_MAPK_gen_1	327	336	PF00069	0.399
DOC_MAPK_gen_1	388	396	PF00069	0.552
DOC_MAPK_JIP1_4	390	396	PF00069	0.490
DOC_MAPK_MEF2A_6	21	30	PF00069	0.455
DOC_MAPK_MEF2A_6	388	396	PF00069	0.582
DOC_MAPK_NFAT4_5	21	29	PF00069	0.387
DOC_PP2B_LxvP_1	392	395	PF13499	0.489
DOC_PP2B_PxIxI_1	306	312	PF00149	0.389
DOC_USP7_MATH_1	145	149	PF00917	0.637
DOC_USP7_MATH_1	17	21	PF00917	0.475
DOC_USP7_MATH_1	184	188	PF00917	0.570
DOC_USP7_MATH_1	250	254	PF00917	0.478
DOC_USP7_MATH_1	37	41	PF00917	0.512
DOC_USP7_MATH_1	405	409	PF00917	0.619
DOC_WW_Pin1_4	241	246	PF00397	0.408
DOC_WW_Pin1_4	394	399	PF00397	0.535
DOC_WW_Pin1_4	88	93	PF00397	0.647
LIG_14-3-3_CanoR_1	183	189	PF00244	0.562
LIG_BRCT_BRCA1_1	204	208	PF00533	0.464
LIG_BRCT_BRCA1_1	280	284	PF00533	0.276
LIG_DCNL_PONY_1	1	4	PF03556	0.698
LIG_FHA_1	134	140	PF00498	0.790
LIG_FHA_1	174	180	PF00498	0.590
LIG_FHA_1	293	299	PF00498	0.380
LIG_FHA_1	358	364	PF00498	0.468
LIG_FHA_1	79	85	PF00498	0.623
LIG_FHA_2	115	121	PF00498	0.646
LIG_FHA_2	163	169	PF00498	0.540
LIG_FHA_2	303	309	PF00498	0.342
LIG_FHA_2	318	324	PF00498	0.686
LIG_LIR_Gen_1	192	201	PF02991	0.421
LIG_LIR_Gen_1	205	216	PF02991	0.426
LIG_LIR_Gen_1	217	226	PF02991	0.469
LIG_LIR_Gen_1	40	49	PF02991	0.658
LIG_LIR_Gen_1	63	71	PF02991	0.507
LIG_LIR_LC3C_4	397	401	PF02991	0.450
LIG_LIR_Nem_3	205	211	PF02991	0.463
LIG_LIR_Nem_3	212	218	PF02991	0.392
LIG_LIR_Nem_3	40	45	PF02991	0.657
LIG_NRBOX	25	31	PF00104	0.485
LIG_Pex14_1	375	379	PF04695	0.358
LIG_RPA_C_Fungi	333	345	PF08784	0.391
LIG_SH2_CRK	280	284	PF00017	0.339
LIG_SH2_SRC	367	370	PF00017	0.353
LIG_SH2_STAP1	237	241	PF00017	0.454
LIG_SH2_STAP1	280	284	PF00017	0.388
LIG_SH2_STAT3	369	372	PF00017	0.370
LIG_SH2_STAT3	379	382	PF00017	0.388
LIG_SH2_STAT5	226	229	PF00017	0.405
LIG_SH2_STAT5	335	338	PF00017	0.358
LIG_SH2_STAT5	367	370	PF00017	0.382
LIG_SH3_1	11	17	PF00018	0.655
LIG_SH3_2	89	94	PF14604	0.569
LIG_SH3_3	11	17	PF00018	0.657
LIG_SH3_3	230	236	PF00018	0.534
LIG_SH3_3	392	398	PF00018	0.504
LIG_SH3_3	86	92	PF00018	0.679
LIG_SH3_3	97	103	PF00018	0.633
LIG_SUMO_SIM_par_1	28	35	PF11976	0.549
LIG_SUMO_SIM_par_1	397	404	PF11976	0.385
LIG_TRAF2_1	71	74	PF00917	0.527
LIG_WRC_WIRS_1	61	66	PF05994	0.526
MOD_CDC14_SPxK_1	91	94	PF00782	0.569
MOD_CDK_SPK_2	241	246	PF00069	0.469
MOD_CDK_SPxK_1	88	94	PF00069	0.568
MOD_CK1_1	144	150	PF00069	0.727
MOD_CK1_1	202	208	PF00069	0.518
MOD_CK1_1	253	259	PF00069	0.390
MOD_CK1_1	40	46	PF00069	0.655
MOD_CK1_1	404	410	PF00069	0.659
MOD_CK1_1	431	437	PF00069	0.545
MOD_CK1_1	53	59	PF00069	0.604
MOD_CK2_1	114	120	PF00069	0.622
MOD_CK2_1	355	361	PF00069	0.450
MOD_Cter_Amidation	260	263	PF01082	0.471
MOD_Cter_Amidation	419	422	PF01082	0.598
MOD_GlcNHglycan	109	112	PF01048	0.662
MOD_GlcNHglycan	143	146	PF01048	0.634
MOD_GlcNHglycan	162	165	PF01048	0.676
MOD_GlcNHglycan	179	182	PF01048	0.632
MOD_GlcNHglycan	402	406	PF01048	0.496
MOD_GlcNHglycan	407	410	PF01048	0.589
MOD_GlcNHglycan	54	58	PF01048	0.607
MOD_GSK3_1	101	108	PF00069	0.779
MOD_GSK3_1	112	119	PF00069	0.652
MOD_GSK3_1	121	128	PF00069	0.721
MOD_GSK3_1	129	136	PF00069	0.534
MOD_GSK3_1	140	147	PF00069	0.698
MOD_GSK3_1	160	167	PF00069	0.613
MOD_GSK3_1	173	180	PF00069	0.536
MOD_GSK3_1	249	256	PF00069	0.392
MOD_GSK3_1	40	47	PF00069	0.603
MOD_GSK3_1	401	408	PF00069	0.578
MOD_GSK3_1	422	429	PF00069	0.672
MOD_LATS_1	114	120	PF00433	0.698
MOD_LATS_1	160	166	PF00433	0.612
MOD_N-GLC_1	141	146	PF02516	0.569
MOD_NEK2_1	127	132	PF00069	0.678
MOD_NEK2_1	179	184	PF00069	0.613
MOD_NEK2_1	199	204	PF00069	0.488
MOD_NEK2_1	249	254	PF00069	0.396
MOD_NEK2_1	28	33	PF00069	0.554
MOD_NEK2_1	302	307	PF00069	0.325
MOD_NEK2_2	330	335	PF00069	0.444
MOD_PIKK_1	189	195	PF00454	0.416
MOD_PIKK_1	37	43	PF00454	0.612
MOD_PK_1	422	428	PF00069	0.557
MOD_PKA_1	412	418	PF00069	0.802
MOD_PKA_1	422	428	PF00069	0.678
MOD_PKA_2	160	166	PF00069	0.709
MOD_PKA_2	253	259	PF00069	0.519
MOD_PKA_2	267	273	PF00069	0.279
MOD_PKA_2	412	418	PF00069	0.735
MOD_PKA_2	422	428	PF00069	0.631
MOD_Plk_1	17	23	PF00069	0.582
MOD_Plk_1	427	433	PF00069	0.567
MOD_Plk_2-3	355	361	PF00069	0.477
MOD_Plk_4	28	34	PF00069	0.545
MOD_Plk_4	294	300	PF00069	0.370
MOD_Plk_4	330	336	PF00069	0.382
MOD_Plk_4	44	50	PF00069	0.569
MOD_ProDKin_1	241	247	PF00069	0.407
MOD_ProDKin_1	394	400	PF00069	0.536
MOD_ProDKin_1	88	94	PF00069	0.650
TRG_DiLeu_BaEn_1	339	344	PF01217	0.405
TRG_DiLeu_BaEn_2	17	23	PF01217	0.579
TRG_ENDOCYTIC_2	218	221	PF00928	0.427
TRG_ENDOCYTIC_2	280	283	PF00928	0.325
TRG_ER_diArg_1	152	154	PF00400	0.617
TRG_ER_diArg_1	272	275	PF00400	0.525
TRG_ER_diArg_1	336	338	PF00400	0.457
TRG_ER_diArg_1	387	390	PF00400	0.451
TRG_ER_diArg_1	412	414	PF00400	0.768
TRG_ER_diArg_1	421	423	PF00400	0.662
TRG_NLS_MonoExtC_3	9	14	PF00514	0.585
TRG_NLS_MonoExtN_4	8	14	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W8	Leptomonas seymouri	58%	97%
A0A3R7L7Q9	Trypanosoma rangeli	34%	98%
A0A3S7WS83	Leishmania donovani	100%	100%
A4H706	Leishmania braziliensis	75%	100%
E9AP26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QGG3	Leishmania major	94%	100%
V5DFZ8	Trypanosoma cruzi	34%	99%