LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGI6_LEIIN
TriTrypDb:
LINF_120016600
Length:
866

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized LINJ.12.0820

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGI6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGI6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 4
GO:0043167 ion binding 2 4
GO:0043169 cation binding 3 4
GO:0046872 metal ion binding 4 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 138 142 PF00656 0.598
CLV_C14_Caspase3-7 194 198 PF00656 0.473
CLV_C14_Caspase3-7 395 399 PF00656 0.468
CLV_NRD_NRD_1 126 128 PF00675 0.563
CLV_NRD_NRD_1 321 323 PF00675 0.419
CLV_NRD_NRD_1 332 334 PF00675 0.384
CLV_NRD_NRD_1 391 393 PF00675 0.543
CLV_NRD_NRD_1 437 439 PF00675 0.552
CLV_NRD_NRD_1 457 459 PF00675 0.366
CLV_NRD_NRD_1 475 477 PF00675 0.367
CLV_NRD_NRD_1 488 490 PF00675 0.496
CLV_NRD_NRD_1 494 496 PF00675 0.454
CLV_NRD_NRD_1 5 7 PF00675 0.653
CLV_NRD_NRD_1 638 640 PF00675 0.472
CLV_NRD_NRD_1 67 69 PF00675 0.659
CLV_PCSK_FUR_1 329 333 PF00082 0.415
CLV_PCSK_KEX2_1 126 128 PF00082 0.563
CLV_PCSK_KEX2_1 321 323 PF00082 0.419
CLV_PCSK_KEX2_1 331 333 PF00082 0.396
CLV_PCSK_KEX2_1 391 393 PF00082 0.543
CLV_PCSK_KEX2_1 439 441 PF00082 0.550
CLV_PCSK_KEX2_1 457 459 PF00082 0.385
CLV_PCSK_KEX2_1 475 477 PF00082 0.367
CLV_PCSK_KEX2_1 488 490 PF00082 0.496
CLV_PCSK_KEX2_1 494 496 PF00082 0.454
CLV_PCSK_KEX2_1 5 7 PF00082 0.653
CLV_PCSK_KEX2_1 855 857 PF00082 0.639
CLV_PCSK_PC1ET2_1 439 441 PF00082 0.550
CLV_PCSK_PC1ET2_1 855 857 PF00082 0.639
CLV_PCSK_PC7_1 317 323 PF00082 0.429
CLV_PCSK_SKI1_1 200 204 PF00082 0.533
CLV_PCSK_SKI1_1 306 310 PF00082 0.520
CLV_PCSK_SKI1_1 321 325 PF00082 0.431
CLV_PCSK_SKI1_1 332 336 PF00082 0.429
CLV_PCSK_SKI1_1 343 347 PF00082 0.511
CLV_PCSK_SKI1_1 365 369 PF00082 0.480
CLV_PCSK_SKI1_1 537 541 PF00082 0.521
CLV_PCSK_SKI1_1 576 580 PF00082 0.567
CLV_PCSK_SKI1_1 623 627 PF00082 0.548
CLV_Separin_Metazoa 279 283 PF03568 0.504
CLV_Separin_Metazoa 326 330 PF03568 0.460
DEG_APCC_DBOX_1 316 324 PF00400 0.451
DEG_APCC_DBOX_1 437 445 PF00400 0.546
DEG_APCC_DBOX_1 82 90 PF00400 0.607
DEG_SCF_FBW7_1 818 824 PF00400 0.432
DOC_CKS1_1 818 823 PF01111 0.438
DOC_MAPK_gen_1 548 557 PF00069 0.451
DOC_MAPK_gen_1 80 89 PF00069 0.612
DOC_MAPK_gen_1 854 862 PF00069 0.487
DOC_MAPK_JIP1_4 83 89 PF00069 0.413
DOC_MAPK_MEF2A_6 551 559 PF00069 0.529
DOC_MAPK_MEF2A_6 83 91 PF00069 0.600
DOC_MAPK_MEF2A_6 854 862 PF00069 0.487
DOC_PIKK_1 436 444 PF02985 0.482
DOC_PP1_RVXF_1 401 408 PF00149 0.502
DOC_USP7_MATH_1 270 274 PF00917 0.574
DOC_USP7_MATH_1 377 381 PF00917 0.551
DOC_USP7_MATH_1 741 745 PF00917 0.501
DOC_USP7_MATH_1 793 797 PF00917 0.619
DOC_USP7_MATH_1 821 825 PF00917 0.466
DOC_USP7_UBL2_3 65 69 PF12436 0.632
DOC_USP7_UBL2_3 850 854 PF12436 0.529
DOC_WW_Pin1_4 69 74 PF00397 0.627
DOC_WW_Pin1_4 78 83 PF00397 0.510
DOC_WW_Pin1_4 817 822 PF00397 0.602
LIG_14-3-3_CanoR_1 190 199 PF00244 0.480
LIG_14-3-3_CanoR_1 379 383 PF00244 0.516
LIG_14-3-3_CanoR_1 5 11 PF00244 0.637
LIG_14-3-3_CanoR_1 535 540 PF00244 0.500
LIG_14-3-3_CanoR_1 699 705 PF00244 0.456
LIG_14-3-3_CanoR_1 778 783 PF00244 0.512
LIG_14-3-3_CanoR_1 816 821 PF00244 0.520
LIG_Actin_WH2_2 273 288 PF00022 0.527
LIG_eIF4E_1 768 774 PF01652 0.426
LIG_FHA_1 145 151 PF00498 0.540
LIG_FHA_1 272 278 PF00498 0.589
LIG_FHA_1 342 348 PF00498 0.427
LIG_FHA_1 383 389 PF00498 0.547
LIG_FHA_1 494 500 PF00498 0.452
LIG_FHA_1 586 592 PF00498 0.628
LIG_FHA_1 603 609 PF00498 0.390
LIG_FHA_1 810 816 PF00498 0.600
LIG_FHA_1 99 105 PF00498 0.663
LIG_FHA_2 132 138 PF00498 0.589
LIG_FHA_2 274 280 PF00498 0.584
LIG_FHA_2 300 306 PF00498 0.489
LIG_FHA_2 307 313 PF00498 0.477
LIG_FHA_2 427 433 PF00498 0.505
LIG_FHA_2 536 542 PF00498 0.501
LIG_FHA_2 614 620 PF00498 0.455
LIG_FHA_2 715 721 PF00498 0.496
LIG_FHA_2 835 841 PF00498 0.477
LIG_LIR_Apic_2 753 758 PF02991 0.530
LIG_LIR_Gen_1 167 175 PF02991 0.492
LIG_LIR_Gen_1 633 642 PF02991 0.526
LIG_LIR_Nem_3 197 202 PF02991 0.504
LIG_LIR_Nem_3 633 637 PF02991 0.520
LIG_LIR_Nem_3 720 724 PF02991 0.602
LIG_NRBOX 323 329 PF00104 0.452
LIG_NRBOX 857 863 PF00104 0.439
LIG_PCNA_yPIPBox_3 806 815 PF02747 0.422
LIG_Rb_LxCxE_1 820 840 PF01857 0.490
LIG_RPA_C_Fungi 490 502 PF08784 0.475
LIG_SH2_CRK 755 759 PF00017 0.436
LIG_SH2_SRC 543 546 PF00017 0.483
LIG_SH2_STAP1 570 574 PF00017 0.571
LIG_SH2_STAT3 570 573 PF00017 0.574
LIG_SH2_STAT5 295 298 PF00017 0.560
LIG_SH2_STAT5 75 78 PF00017 0.549
LIG_SH2_STAT5 755 758 PF00017 0.520
LIG_SH2_STAT5 768 771 PF00017 0.565
LIG_SH3_3 25 31 PF00018 0.657
LIG_SH3_3 836 842 PF00018 0.443
LIG_SH3_4 65 72 PF00018 0.558
LIG_SUMO_SIM_anti_2 276 282 PF11976 0.521
LIG_SUMO_SIM_anti_2 85 91 PF11976 0.499
LIG_SUMO_SIM_anti_2 857 862 PF11976 0.496
LIG_TRAF2_1 302 305 PF00917 0.516
LIG_TRAF2_1 334 337 PF00917 0.530
LIG_TRAF2_1 429 432 PF00917 0.542
LIG_TRAF2_1 542 545 PF00917 0.452
LIG_TRAF2_1 689 692 PF00917 0.462
LIG_TRAF2_1 706 709 PF00917 0.408
LIG_UBA3_1 843 850 PF00899 0.445
LIG_WW_2 28 31 PF00397 0.631
MOD_CDK_SPK_2 78 83 PF00069 0.539
MOD_CK1_1 216 222 PF00069 0.496
MOD_CK1_1 22 28 PF00069 0.567
MOD_CK1_1 273 279 PF00069 0.585
MOD_CK1_1 781 787 PF00069 0.538
MOD_CK2_1 131 137 PF00069 0.576
MOD_CK2_1 223 229 PF00069 0.525
MOD_CK2_1 273 279 PF00069 0.585
MOD_CK2_1 299 305 PF00069 0.482
MOD_CK2_1 306 312 PF00069 0.485
MOD_CK2_1 377 383 PF00069 0.513
MOD_CK2_1 411 417 PF00069 0.571
MOD_CK2_1 426 432 PF00069 0.491
MOD_CK2_1 535 541 PF00069 0.492
MOD_CK2_1 613 619 PF00069 0.453
MOD_CK2_1 737 743 PF00069 0.484
MOD_CK2_1 793 799 PF00069 0.658
MOD_CK2_1 834 840 PF00069 0.485
MOD_GlcNHglycan 11 15 PF01048 0.661
MOD_GlcNHglycan 114 117 PF01048 0.589
MOD_GlcNHglycan 137 140 PF01048 0.636
MOD_GlcNHglycan 215 218 PF01048 0.504
MOD_GlcNHglycan 41 44 PF01048 0.621
MOD_GlcNHglycan 522 525 PF01048 0.531
MOD_GlcNHglycan 58 61 PF01048 0.577
MOD_GlcNHglycan 739 742 PF01048 0.460
MOD_GlcNHglycan 743 746 PF01048 0.418
MOD_GlcNHglycan 786 789 PF01048 0.534
MOD_GSK3_1 131 138 PF00069 0.590
MOD_GSK3_1 19 26 PF00069 0.551
MOD_GSK3_1 35 42 PF00069 0.587
MOD_GSK3_1 378 385 PF00069 0.545
MOD_GSK3_1 387 394 PF00069 0.447
MOD_GSK3_1 407 414 PF00069 0.362
MOD_GSK3_1 444 451 PF00069 0.485
MOD_GSK3_1 6 13 PF00069 0.620
MOD_GSK3_1 737 744 PF00069 0.458
MOD_GSK3_1 817 824 PF00069 0.480
MOD_GSK3_1 829 836 PF00069 0.469
MOD_LATS_1 583 589 PF00433 0.631
MOD_LATS_1 776 782 PF00433 0.453
MOD_N-GLC_1 585 590 PF02516 0.604
MOD_N-GLC_1 778 783 PF02516 0.468
MOD_N-GLC_1 816 821 PF02516 0.443
MOD_NEK2_1 10 15 PF00069 0.615
MOD_NEK2_1 131 136 PF00069 0.567
MOD_NEK2_1 191 196 PF00069 0.479
MOD_NEK2_1 208 213 PF00069 0.370
MOD_NEK2_1 351 356 PF00069 0.400
MOD_NEK2_1 444 449 PF00069 0.533
MOD_NEK2_1 579 584 PF00069 0.509
MOD_NEK2_1 714 719 PF00069 0.492
MOD_NEK2_1 809 814 PF00069 0.492
MOD_NEK2_2 821 826 PF00069 0.412
MOD_PIKK_1 208 214 PF00454 0.538
MOD_PIKK_1 228 234 PF00454 0.382
MOD_PIKK_1 423 429 PF00454 0.588
MOD_PIKK_1 444 450 PF00454 0.535
MOD_PIKK_1 501 507 PF00454 0.426
MOD_PIKK_1 585 591 PF00454 0.625
MOD_PIKK_1 714 720 PF00454 0.494
MOD_PIKK_1 95 101 PF00454 0.527
MOD_PK_1 100 106 PF00069 0.535
MOD_PKA_1 332 338 PF00069 0.412
MOD_PKA_1 391 397 PF00069 0.503
MOD_PKA_1 5 11 PF00069 0.637
MOD_PKA_1 854 860 PF00069 0.490
MOD_PKA_2 112 118 PF00069 0.538
MOD_PKA_2 285 291 PF00069 0.508
MOD_PKA_2 332 338 PF00069 0.489
MOD_PKA_2 378 384 PF00069 0.517
MOD_PKA_2 391 397 PF00069 0.410
MOD_PKA_2 493 499 PF00069 0.514
MOD_PKA_2 5 11 PF00069 0.637
MOD_PKA_2 698 704 PF00069 0.460
MOD_PKB_1 611 619 PF00069 0.456
MOD_Plk_1 10 16 PF00069 0.615
MOD_Plk_1 411 417 PF00069 0.571
MOD_Plk_1 778 784 PF00069 0.509
MOD_Plk_1 809 815 PF00069 0.508
MOD_Plk_4 149 155 PF00069 0.512
MOD_Plk_4 273 279 PF00069 0.530
MOD_Plk_4 821 827 PF00069 0.491
MOD_Plk_4 834 840 PF00069 0.545
MOD_ProDKin_1 69 75 PF00069 0.617
MOD_ProDKin_1 78 84 PF00069 0.507
MOD_ProDKin_1 817 823 PF00069 0.592
MOD_SUMO_rev_2 432 441 PF00179 0.548
TRG_DiLeu_BaLyEn_6 126 131 PF01217 0.566
TRG_DiLeu_BaLyEn_6 187 192 PF01217 0.477
TRG_DiLeu_BaLyEn_6 362 367 PF01217 0.463
TRG_ER_diArg_1 125 127 PF00400 0.558
TRG_ER_diArg_1 157 160 PF00400 0.417
TRG_ER_diArg_1 263 266 PF00400 0.589
TRG_ER_diArg_1 320 322 PF00400 0.504
TRG_ER_diArg_1 328 331 PF00400 0.470
TRG_ER_diArg_1 391 393 PF00400 0.543
TRG_ER_diArg_1 438 441 PF00400 0.552
TRG_ER_diArg_1 456 458 PF00400 0.382
TRG_ER_diArg_1 474 476 PF00400 0.372
TRG_ER_diArg_1 562 565 PF00400 0.475
TRG_ER_diArg_1 611 614 PF00400 0.481
TRG_Pf-PMV_PEXEL_1 306 310 PF00026 0.578
TRG_Pf-PMV_PEXEL_1 322 326 PF00026 0.359
TRG_Pf-PMV_PEXEL_1 391 395 PF00026 0.414
TRG_Pf-PMV_PEXEL_1 476 481 PF00026 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WSB7 Leishmania donovani 99% 100%
A4H704 Leishmania braziliensis 64% 99%
E9AP24 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4QGG5 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS