LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGI4_LEIIN
TriTrypDb:
LINF_120016200 *
Length:
433

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGI4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGI4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 236 240 PF00656 0.510
CLV_C14_Caspase3-7 247 251 PF00656 0.626
CLV_C14_Caspase3-7 384 388 PF00656 0.649
CLV_NRD_NRD_1 293 295 PF00675 0.575
CLV_NRD_NRD_1 299 301 PF00675 0.582
CLV_NRD_NRD_1 320 322 PF00675 0.612
CLV_NRD_NRD_1 365 367 PF00675 0.676
CLV_NRD_NRD_1 81 83 PF00675 0.706
CLV_PCSK_KEX2_1 121 123 PF00082 0.477
CLV_PCSK_KEX2_1 276 278 PF00082 0.735
CLV_PCSK_KEX2_1 293 295 PF00082 0.532
CLV_PCSK_KEX2_1 299 301 PF00082 0.582
CLV_PCSK_KEX2_1 320 322 PF00082 0.609
CLV_PCSK_KEX2_1 365 367 PF00082 0.676
CLV_PCSK_PC1ET2_1 121 123 PF00082 0.443
CLV_PCSK_PC1ET2_1 276 278 PF00082 0.619
CLV_PCSK_SKI1_1 137 141 PF00082 0.512
CLV_PCSK_SKI1_1 288 292 PF00082 0.628
CLV_PCSK_SKI1_1 293 297 PF00082 0.602
CLV_PCSK_SKI1_1 325 329 PF00082 0.751
CLV_PCSK_SKI1_1 62 66 PF00082 0.517
DEG_Nend_UBRbox_2 1 3 PF02207 0.497
DEG_SCF_FBW7_2 375 382 PF00400 0.591
DOC_CKS1_1 183 188 PF01111 0.540
DOC_CKS1_1 423 428 PF01111 0.595
DOC_CKS1_1 65 70 PF01111 0.603
DOC_CYCLIN_RxL_1 59 67 PF00134 0.498
DOC_CYCLIN_yCln2_LP_2 65 71 PF00134 0.607
DOC_MAPK_gen_1 365 372 PF00069 0.683
DOC_MAPK_gen_1 50 59 PF00069 0.468
DOC_MAPK_gen_1 97 105 PF00069 0.499
DOC_PP2B_LxvP_1 281 284 PF13499 0.610
DOC_PP2B_LxvP_1 69 72 PF13499 0.730
DOC_USP7_MATH_1 298 302 PF00917 0.619
DOC_USP7_MATH_1 352 356 PF00917 0.708
DOC_USP7_MATH_1 404 408 PF00917 0.622
DOC_USP7_MATH_1 43 47 PF00917 0.513
DOC_USP7_UBL2_3 314 318 PF12436 0.650
DOC_USP7_UBL2_3 83 87 PF12436 0.666
DOC_WW_Pin1_4 182 187 PF00397 0.591
DOC_WW_Pin1_4 190 195 PF00397 0.496
DOC_WW_Pin1_4 375 380 PF00397 0.711
DOC_WW_Pin1_4 422 427 PF00397 0.595
DOC_WW_Pin1_4 64 69 PF00397 0.584
LIG_14-3-3_CanoR_1 277 282 PF00244 0.783
LIG_14-3-3_CanoR_1 293 298 PF00244 0.587
LIG_14-3-3_CanoR_1 365 372 PF00244 0.661
LIG_Actin_WH2_2 324 339 PF00022 0.548
LIG_BRCT_BRCA1_1 17 21 PF00533 0.508
LIG_deltaCOP1_diTrp_1 117 127 PF00928 0.462
LIG_FHA_1 173 179 PF00498 0.610
LIG_FHA_1 223 229 PF00498 0.589
LIG_FHA_1 23 29 PF00498 0.543
LIG_FHA_1 230 236 PF00498 0.528
LIG_FHA_1 327 333 PF00498 0.599
LIG_FHA_1 391 397 PF00498 0.580
LIG_FHA_2 105 111 PF00498 0.483
LIG_FHA_2 245 251 PF00498 0.677
LIG_FHA_2 423 429 PF00498 0.595
LIG_LIR_Apic_2 189 194 PF02991 0.505
LIG_LIR_Gen_1 104 113 PF02991 0.487
LIG_LIR_Gen_1 195 206 PF02991 0.450
LIG_LIR_Nem_3 104 108 PF02991 0.603
LIG_LIR_Nem_3 128 134 PF02991 0.483
LIG_LIR_Nem_3 185 190 PF02991 0.563
LIG_LIR_Nem_3 195 201 PF02991 0.477
LIG_PDZ_Class_3 428 433 PF00595 0.595
LIG_Pex14_1 123 127 PF04695 0.476
LIG_REV1ctd_RIR_1 207 216 PF16727 0.605
LIG_SH2_SRC 166 169 PF00017 0.677
LIG_SH2_STAP1 286 290 PF00017 0.587
LIG_SH2_STAT5 126 129 PF00017 0.491
LIG_SH2_STAT5 131 134 PF00017 0.464
LIG_SH2_STAT5 166 169 PF00017 0.677
LIG_SH2_STAT5 203 206 PF00017 0.492
LIG_SH2_STAT5 220 223 PF00017 0.463
LIG_SH2_STAT5 230 233 PF00017 0.588
LIG_SH3_3 396 402 PF00018 0.600
LIG_SH3_3 65 71 PF00018 0.607
LIG_SH3_5 186 190 PF00018 0.505
LIG_SUMO_SIM_par_1 112 117 PF11976 0.446
LIG_SUMO_SIM_par_1 241 250 PF11976 0.603
LIG_TRAF2_1 251 254 PF00917 0.624
LIG_TRAF2_1 268 271 PF00917 0.752
LIG_TRAF2_1 42 45 PF00917 0.538
LIG_TRAF2_1 92 95 PF00917 0.725
MOD_CDK_SPK_2 422 427 PF00069 0.595
MOD_CDK_SPxK_1 375 381 PF00069 0.703
MOD_CDK_SPxK_1 64 70 PF00069 0.709
MOD_CK1_1 193 199 PF00069 0.433
MOD_CK1_1 255 261 PF00069 0.724
MOD_CK1_1 392 398 PF00069 0.653
MOD_CK2_1 246 252 PF00069 0.663
MOD_CK2_1 255 261 PF00069 0.563
MOD_CK2_1 39 45 PF00069 0.457
MOD_CK2_1 422 428 PF00069 0.596
MOD_CMANNOS 120 123 PF00535 0.466
MOD_GlcNHglycan 195 198 PF01048 0.477
MOD_GlcNHglycan 252 257 PF01048 0.695
MOD_GlcNHglycan 300 303 PF01048 0.567
MOD_GlcNHglycan 41 44 PF01048 0.654
MOD_GlcNHglycan 45 48 PF01048 0.620
MOD_GSK3_1 15 22 PF00069 0.496
MOD_GSK3_1 170 177 PF00069 0.671
MOD_GSK3_1 210 217 PF00069 0.511
MOD_GSK3_1 352 359 PF00069 0.623
MOD_GSK3_1 39 46 PF00069 0.564
MOD_GSK3_1 404 411 PF00069 0.601
MOD_N-GLC_2 8 10 PF02516 0.499
MOD_NEK2_1 15 20 PF00069 0.676
MOD_NEK2_1 39 44 PF00069 0.550
MOD_PIKK_1 172 178 PF00454 0.644
MOD_PIKK_1 288 294 PF00454 0.666
MOD_PKA_1 293 299 PF00069 0.611
MOD_PKA_2 222 228 PF00069 0.514
MOD_PKA_2 293 299 PF00069 0.616
MOD_PKA_2 336 342 PF00069 0.697
MOD_PKA_2 352 358 PF00069 0.606
MOD_PKA_2 364 370 PF00069 0.626
MOD_Plk_1 214 220 PF00069 0.494
MOD_Plk_1 356 362 PF00069 0.609
MOD_Plk_2-3 104 110 PF00069 0.493
MOD_Plk_4 15 21 PF00069 0.492
MOD_Plk_4 306 312 PF00069 0.678
MOD_Plk_4 32 38 PF00069 0.583
MOD_ProDKin_1 182 188 PF00069 0.582
MOD_ProDKin_1 190 196 PF00069 0.490
MOD_ProDKin_1 375 381 PF00069 0.703
MOD_ProDKin_1 422 428 PF00069 0.596
MOD_ProDKin_1 64 70 PF00069 0.591
MOD_SUMO_for_1 98 101 PF00179 0.596
MOD_SUMO_rev_2 42 52 PF00179 0.475
MOD_SUMO_rev_2 90 98 PF00179 0.667
TRG_DiLeu_BaEn_2 100 106 PF01217 0.494
TRG_DiLeu_BaEn_4 141 147 PF01217 0.540
TRG_DiLeu_BaEn_4 356 362 PF01217 0.654
TRG_ENDOCYTIC_2 198 201 PF00928 0.464
TRG_ENDOCYTIC_2 203 206 PF00928 0.456
TRG_ER_diArg_1 293 295 PF00400 0.602
TRG_ER_diArg_1 319 321 PF00400 0.623
TRG_ER_diArg_1 364 366 PF00400 0.668

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY24 Leptomonas seymouri 45% 75%
A0A3Q8I9I2 Leishmania donovani 100% 77%
A4H700 Leishmania braziliensis 51% 100%
E9AP20 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
Q4QGG9 Leishmania major 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS