LeishMANIAdb
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CSD domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CSD domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGI2_LEIIN
TriTrypDb:
LINF_120016000
Length:
877

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized LINJ.12.0780

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGI2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGI2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 127 131 PF00656 0.758
CLV_C14_Caspase3-7 201 205 PF00656 0.723
CLV_C14_Caspase3-7 502 506 PF00656 0.806
CLV_C14_Caspase3-7 730 734 PF00656 0.631
CLV_C14_Caspase3-7 789 793 PF00656 0.541
CLV_NRD_NRD_1 186 188 PF00675 0.625
CLV_NRD_NRD_1 195 197 PF00675 0.686
CLV_NRD_NRD_1 77 79 PF00675 0.791
CLV_NRD_NRD_1 821 823 PF00675 0.739
CLV_NRD_NRD_1 854 856 PF00675 0.673
CLV_PCSK_KEX2_1 185 187 PF00082 0.654
CLV_PCSK_KEX2_1 195 197 PF00082 0.733
CLV_PCSK_KEX2_1 761 763 PF00082 0.548
CLV_PCSK_KEX2_1 77 79 PF00082 0.791
CLV_PCSK_KEX2_1 820 822 PF00082 0.745
CLV_PCSK_KEX2_1 856 858 PF00082 0.659
CLV_PCSK_PC1ET2_1 761 763 PF00082 0.649
CLV_PCSK_PC1ET2_1 856 858 PF00082 0.659
CLV_PCSK_PC7_1 181 187 PF00082 0.756
CLV_PCSK_SKI1_1 200 204 PF00082 0.707
CLV_PCSK_SKI1_1 221 225 PF00082 0.690
CLV_PCSK_SKI1_1 449 453 PF00082 0.442
CLV_PCSK_SKI1_1 762 766 PF00082 0.618
CLV_PCSK_SKI1_1 78 82 PF00082 0.784
CLV_PCSK_SKI1_1 8 12 PF00082 0.563
CLV_PCSK_SKI1_1 856 860 PF00082 0.734
DEG_COP1_1 508 519 PF00400 0.510
DEG_SPOP_SBC_1 150 154 PF00917 0.612
DEG_SPOP_SBC_1 489 493 PF00917 0.613
DEG_SPOP_SBC_1 678 682 PF00917 0.812
DOC_CKS1_1 516 521 PF01111 0.504
DOC_CYCLIN_RxL_1 75 83 PF00134 0.786
DOC_CYCLIN_yClb1_LxF_4 805 811 PF00134 0.724
DOC_CYCLIN_yCln2_LP_2 378 384 PF00134 0.790
DOC_CYCLIN_yCln2_LP_2 402 405 PF00134 0.635
DOC_MAPK_gen_1 761 770 PF00069 0.524
DOC_MAPK_MEF2A_6 273 280 PF00069 0.592
DOC_MAPK_MEF2A_6 636 645 PF00069 0.558
DOC_PP2B_LxvP_1 402 405 PF13499 0.635
DOC_PP2B_LxvP_1 549 552 PF13499 0.505
DOC_PP2B_LxvP_1 643 646 PF13499 0.527
DOC_PP4_FxxP_1 426 429 PF00568 0.485
DOC_USP7_MATH_1 101 105 PF00917 0.722
DOC_USP7_MATH_1 150 154 PF00917 0.721
DOC_USP7_MATH_1 245 249 PF00917 0.602
DOC_USP7_MATH_1 251 255 PF00917 0.624
DOC_USP7_MATH_1 265 269 PF00917 0.607
DOC_USP7_MATH_1 276 280 PF00917 0.633
DOC_USP7_MATH_1 322 326 PF00917 0.710
DOC_USP7_MATH_1 327 331 PF00917 0.754
DOC_USP7_MATH_1 345 349 PF00917 0.534
DOC_USP7_MATH_1 476 480 PF00917 0.724
DOC_USP7_MATH_1 489 493 PF00917 0.509
DOC_USP7_MATH_1 64 68 PF00917 0.758
DOC_USP7_MATH_1 679 683 PF00917 0.779
DOC_USP7_MATH_1 700 704 PF00917 0.709
DOC_USP7_MATH_1 844 848 PF00917 0.791
DOC_USP7_UBL2_3 221 225 PF12436 0.612
DOC_USP7_UBL2_3 4 8 PF12436 0.639
DOC_USP7_UBL2_3 761 765 PF12436 0.599
DOC_WW_Pin1_4 137 142 PF00397 0.824
DOC_WW_Pin1_4 151 156 PF00397 0.590
DOC_WW_Pin1_4 331 336 PF00397 0.639
DOC_WW_Pin1_4 425 430 PF00397 0.592
DOC_WW_Pin1_4 478 483 PF00397 0.733
DOC_WW_Pin1_4 515 520 PF00397 0.715
DOC_WW_Pin1_4 737 742 PF00397 0.722
LIG_14-3-3_CanoR_1 611 615 PF00244 0.503
LIG_14-3-3_CanoR_1 769 775 PF00244 0.524
LIG_Actin_WH2_2 443 460 PF00022 0.578
LIG_Actin_WH2_2 591 609 PF00022 0.536
LIG_APCC_ABBA_1 866 871 PF00400 0.732
LIG_APCC_Cbox_1 180 186 PF00515 0.607
LIG_APCC_Cbox_2 180 186 PF00515 0.607
LIG_BIR_III_2 262 266 PF00653 0.628
LIG_BIR_III_4 191 195 PF00653 0.606
LIG_deltaCOP1_diTrp_1 648 656 PF00928 0.503
LIG_FHA_1 156 162 PF00498 0.699
LIG_FHA_1 309 315 PF00498 0.777
LIG_FHA_1 588 594 PF00498 0.615
LIG_FHA_1 702 708 PF00498 0.710
LIG_FHA_1 710 716 PF00498 0.530
LIG_FHA_1 738 744 PF00498 0.682
LIG_FHA_1 87 93 PF00498 0.681
LIG_FHA_2 167 173 PF00498 0.594
LIG_FHA_2 201 207 PF00498 0.839
LIG_FHA_2 393 399 PF00498 0.599
LIG_FHA_2 492 498 PF00498 0.630
LIG_FHA_2 500 506 PF00498 0.709
LIG_FHA_2 507 513 PF00498 0.691
LIG_FHA_2 569 575 PF00498 0.680
LIG_FHA_2 787 793 PF00498 0.439
LIG_FHA_2 800 806 PF00498 0.651
LIG_Integrin_isoDGR_2 626 628 PF01839 0.719
LIG_LIR_Apic_2 648 654 PF02991 0.603
LIG_LIR_Gen_1 12 23 PF02991 0.591
LIG_LIR_Gen_1 446 455 PF02991 0.559
LIG_LIR_Nem_3 12 18 PF02991 0.512
LIG_LIR_Nem_3 348 352 PF02991 0.585
LIG_LIR_Nem_3 435 440 PF02991 0.581
LIG_LIR_Nem_3 446 450 PF02991 0.416
LIG_LIR_Nem_3 518 524 PF02991 0.602
LIG_LIR_Nem_3 650 655 PF02991 0.518
LIG_LYPXL_yS_3 874 877 PF13949 0.749
LIG_PALB2_WD40_1 647 655 PF16756 0.605
LIG_Pex14_2 11 15 PF04695 0.562
LIG_Pex14_2 652 656 PF04695 0.516
LIG_SH2_CRK 349 353 PF00017 0.582
LIG_SH2_SRC 746 749 PF00017 0.514
LIG_SH2_STAP1 746 750 PF00017 0.509
LIG_SH2_STAT5 151 154 PF00017 0.750
LIG_SH2_STAT5 411 414 PF00017 0.490
LIG_SH2_STAT5 456 459 PF00017 0.513
LIG_SH2_STAT5 711 714 PF00017 0.492
LIG_SH2_STAT5 726 729 PF00017 0.392
LIG_SH2_STAT5 783 786 PF00017 0.509
LIG_SH3_1 673 679 PF00018 0.751
LIG_SH3_3 428 434 PF00018 0.501
LIG_SH3_3 459 465 PF00018 0.632
LIG_SH3_3 511 517 PF00018 0.708
LIG_SH3_3 563 569 PF00018 0.701
LIG_SH3_3 651 657 PF00018 0.475
LIG_SH3_3 671 677 PF00018 0.487
LIG_SH3_3 694 700 PF00018 0.806
LIG_SUMO_SIM_anti_2 398 404 PF11976 0.501
LIG_TRAF2_1 572 575 PF00917 0.672
LIG_TRAF2_2 117 122 PF00917 0.539
LIG_WW_1 148 151 PF00397 0.826
MOD_CDK_SPxK_1 151 157 PF00069 0.608
MOD_CDK_SPxxK_3 331 338 PF00069 0.523
MOD_CK1_1 104 110 PF00069 0.682
MOD_CK1_1 140 146 PF00069 0.823
MOD_CK1_1 491 497 PF00069 0.700
MOD_CK1_1 515 521 PF00069 0.705
MOD_CK1_1 584 590 PF00069 0.626
MOD_CK1_1 680 686 PF00069 0.840
MOD_CK1_1 703 709 PF00069 0.595
MOD_CK1_1 732 738 PF00069 0.701
MOD_CK2_1 200 206 PF00069 0.841
MOD_CK2_1 27 33 PF00069 0.603
MOD_CK2_1 280 286 PF00069 0.706
MOD_CK2_1 392 398 PF00069 0.616
MOD_CK2_1 42 48 PF00069 0.678
MOD_CK2_1 491 497 PF00069 0.664
MOD_CK2_1 568 574 PF00069 0.695
MOD_CK2_1 679 685 PF00069 0.760
MOD_CK2_1 690 696 PF00069 0.715
MOD_CK2_1 799 805 PF00069 0.542
MOD_Cter_Amidation 193 196 PF01082 0.617
MOD_GlcNHglycan 105 109 PF01048 0.615
MOD_GlcNHglycan 142 145 PF01048 0.777
MOD_GlcNHglycan 162 165 PF01048 0.574
MOD_GlcNHglycan 175 180 PF01048 0.590
MOD_GlcNHglycan 247 250 PF01048 0.763
MOD_GlcNHglycan 253 256 PF01048 0.649
MOD_GlcNHglycan 282 285 PF01048 0.659
MOD_GlcNHglycan 289 292 PF01048 0.584
MOD_GlcNHglycan 325 328 PF01048 0.766
MOD_GlcNHglycan 329 332 PF01048 0.744
MOD_GlcNHglycan 364 367 PF01048 0.771
MOD_GlcNHglycan 458 461 PF01048 0.464
MOD_GlcNHglycan 54 57 PF01048 0.775
MOD_GlcNHglycan 554 557 PF01048 0.666
MOD_GlcNHglycan 587 590 PF01048 0.633
MOD_GlcNHglycan 66 69 PF01048 0.662
MOD_GlcNHglycan 664 667 PF01048 0.753
MOD_GlcNHglycan 682 685 PF01048 0.759
MOD_GlcNHglycan 692 695 PF01048 0.828
MOD_GlcNHglycan 733 737 PF01048 0.781
MOD_GlcNHglycan 82 85 PF01048 0.739
MOD_GlcNHglycan 832 835 PF01048 0.808
MOD_GlcNHglycan 846 849 PF01048 0.572
MOD_GlcNHglycan 95 98 PF01048 0.592
MOD_GSK3_1 136 143 PF00069 0.762
MOD_GSK3_1 151 158 PF00069 0.627
MOD_GSK3_1 23 30 PF00069 0.626
MOD_GSK3_1 265 272 PF00069 0.727
MOD_GSK3_1 276 283 PF00069 0.600
MOD_GSK3_1 295 302 PF00069 0.743
MOD_GSK3_1 304 311 PF00069 0.650
MOD_GSK3_1 323 330 PF00069 0.520
MOD_GSK3_1 43 50 PF00069 0.470
MOD_GSK3_1 439 446 PF00069 0.478
MOD_GSK3_1 488 495 PF00069 0.693
MOD_GSK3_1 564 571 PF00069 0.650
MOD_GSK3_1 581 588 PF00069 0.392
MOD_GSK3_1 610 617 PF00069 0.530
MOD_GSK3_1 702 709 PF00069 0.690
MOD_GSK3_1 770 777 PF00069 0.467
MOD_N-GLC_1 476 481 PF02516 0.688
MOD_N-GLC_1 506 511 PF02516 0.704
MOD_N-GLC_1 64 69 PF02516 0.729
MOD_N-GLC_1 799 804 PF02516 0.627
MOD_NEK2_1 23 28 PF00069 0.693
MOD_NEK2_1 42 47 PF00069 0.460
MOD_NEK2_1 445 450 PF00069 0.443
MOD_NEK2_1 585 590 PF00069 0.622
MOD_NEK2_1 614 619 PF00069 0.485
MOD_NEK2_1 647 652 PF00069 0.512
MOD_NEK2_1 701 706 PF00069 0.635
MOD_NEK2_1 770 775 PF00069 0.525
MOD_PKA_2 156 162 PF00069 0.699
MOD_PKA_2 564 570 PF00069 0.651
MOD_PKA_2 610 616 PF00069 0.520
MOD_PKA_2 709 715 PF00069 0.608
MOD_PKA_2 93 99 PF00069 0.660
MOD_Plk_1 285 291 PF00069 0.709
MOD_Plk_1 647 653 PF00069 0.494
MOD_Plk_1 799 805 PF00069 0.649
MOD_Plk_2-3 799 805 PF00069 0.542
MOD_Plk_4 581 587 PF00069 0.616
MOD_Plk_4 610 616 PF00069 0.604
MOD_Plk_4 647 653 PF00069 0.494
MOD_Plk_4 703 709 PF00069 0.486
MOD_Plk_4 746 752 PF00069 0.500
MOD_Plk_4 783 789 PF00069 0.499
MOD_ProDKin_1 137 143 PF00069 0.824
MOD_ProDKin_1 151 157 PF00069 0.591
MOD_ProDKin_1 331 337 PF00069 0.638
MOD_ProDKin_1 425 431 PF00069 0.598
MOD_ProDKin_1 478 484 PF00069 0.736
MOD_ProDKin_1 515 521 PF00069 0.716
MOD_ProDKin_1 737 743 PF00069 0.703
MOD_SUMO_for_1 31 34 PF00179 0.691
MOD_SUMO_rev_2 849 858 PF00179 0.766
TRG_DiLeu_BaEn_1 398 403 PF01217 0.562
TRG_DiLeu_BaEn_1 862 867 PF01217 0.720
TRG_DiLeu_BaLyEn_6 373 378 PF01217 0.775
TRG_DiLeu_BaLyEn_6 589 594 PF01217 0.532
TRG_DiLeu_BaLyEn_6 625 630 PF01217 0.696
TRG_ENDOCYTIC_2 349 352 PF00928 0.583
TRG_ENDOCYTIC_2 874 877 PF00928 0.647
TRG_ER_diArg_1 185 187 PF00400 0.631
TRG_ER_diArg_1 76 78 PF00400 0.800
TRG_ER_diArg_1 820 822 PF00400 0.816
TRG_ER_diArg_1 855 858 PF00400 0.713
TRG_NLS_MonoExtN_4 855 860 PF00514 0.641
TRG_Pf-PMV_PEXEL_1 187 191 PF00026 0.697
TRG_Pf-PMV_PEXEL_1 207 212 PF00026 0.465
TRG_Pf-PMV_PEXEL_1 592 597 PF00026 0.523
TRG_Pf-PMV_PEXEL_1 628 633 PF00026 0.469

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IHU8 Leishmania donovani 99% 100%
A4H6Z8 Leishmania braziliensis 69% 99%
C9ZI14 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AP18 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 99%
Q4QGH1 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS