Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative integral membrane protein conserved region (DUF2404) - putative

Species:

Leishmania infantum

UniProt:

E9AGI1_LEIIN

TriTrypDb:

LINF_120015900

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	8
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AGI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGI1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0006869	lipid transport	5	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0071702	organic substance transport	4	9

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	538	542	PF00656	0.603
CLV_MEL_PAP_1	418	424	PF00089	0.325
CLV_NRD_NRD_1	194	196	PF00675	0.446
CLV_NRD_NRD_1	197	199	PF00675	0.470
CLV_NRD_NRD_1	28	30	PF00675	0.409
CLV_NRD_NRD_1	300	302	PF00675	0.368
CLV_NRD_NRD_1	39	41	PF00675	0.395
CLV_NRD_NRD_1	456	458	PF00675	0.381
CLV_NRD_NRD_1	568	570	PF00675	0.567
CLV_PCSK_FUR_1	195	199	PF00082	0.448
CLV_PCSK_FUR_1	566	570	PF00082	0.449
CLV_PCSK_KEX2_1	194	196	PF00082	0.453
CLV_PCSK_KEX2_1	197	199	PF00082	0.470
CLV_PCSK_KEX2_1	300	302	PF00082	0.368
CLV_PCSK_KEX2_1	568	570	PF00082	0.568
CLV_PCSK_SKI1_1	177	181	PF00082	0.422
CLV_PCSK_SKI1_1	338	342	PF00082	0.349
CLV_PCSK_SKI1_1	41	45	PF00082	0.444
CLV_PCSK_SKI1_1	503	507	PF00082	0.446
CLV_PCSK_SKI1_1	85	89	PF00082	0.283
DEG_SPOP_SBC_1	605	609	PF00917	0.640
DOC_CDC14_PxL_1	595	603	PF14671	0.640
DOC_CKS1_1	311	316	PF01111	0.596
DOC_CKS1_1	655	660	PF01111	0.644
DOC_CYCLIN_RxL_1	300	313	PF00134	0.609
DOC_CYCLIN_RxL_1	500	509	PF00134	0.531
DOC_MAPK_DCC_7	427	436	PF00069	0.502
DOC_MAPK_gen_1	371	380	PF00069	0.578
DOC_MAPK_gen_1	427	436	PF00069	0.502
DOC_MAPK_HePTP_8	410	422	PF00069	0.499
DOC_MAPK_HePTP_8	424	436	PF00069	0.444
DOC_MAPK_MEF2A_6	158	165	PF00069	0.626
DOC_MAPK_MEF2A_6	289	297	PF00069	0.554
DOC_MAPK_MEF2A_6	371	380	PF00069	0.503
DOC_MAPK_MEF2A_6	413	422	PF00069	0.500
DOC_MAPK_MEF2A_6	427	436	PF00069	0.447
DOC_MAPK_NFAT4_5	158	166	PF00069	0.585
DOC_MAPK_NFAT4_5	373	381	PF00069	0.498
DOC_MAPK_NFAT4_5	413	421	PF00069	0.531
DOC_PP1_RVXF_1	336	342	PF00149	0.516
DOC_PP1_RVXF_1	417	423	PF00149	0.566
DOC_PP1_RVXF_1	468	474	PF00149	0.597
DOC_PP1_RVXF_1	501	508	PF00149	0.527
DOC_PP1_RVXF_1	67	74	PF00149	0.615
DOC_PP2B_LxvP_1	259	262	PF13499	0.586
DOC_PP4_FxxP_1	518	521	PF00568	0.574
DOC_SPAK_OSR1_1	421	425	PF12202	0.537
DOC_SPAK_OSR1_1	448	452	PF12202	0.561
DOC_USP7_MATH_1	262	266	PF00917	0.662
DOC_USP7_MATH_1	362	366	PF00917	0.581
DOC_USP7_MATH_1	396	400	PF00917	0.681
DOC_USP7_MATH_1	492	496	PF00917	0.555
DOC_USP7_MATH_1	545	549	PF00917	0.731
DOC_USP7_MATH_1	694	698	PF00917	0.743
DOC_USP7_UBL2_3	356	360	PF12436	0.543
DOC_USP7_UBL2_3	41	45	PF12436	0.614
DOC_WW_Pin1_4	198	203	PF00397	0.651
DOC_WW_Pin1_4	275	280	PF00397	0.694
DOC_WW_Pin1_4	310	315	PF00397	0.592
DOC_WW_Pin1_4	637	642	PF00397	0.759
DOC_WW_Pin1_4	654	659	PF00397	0.818
DOC_WW_Pin1_4	690	695	PF00397	0.733
LIG_14-3-3_CanoR_1	139	148	PF00244	0.620
LIG_14-3-3_CanoR_1	251	257	PF00244	0.611
LIG_14-3-3_CanoR_1	29	35	PF00244	0.602
LIG_14-3-3_CanoR_1	345	350	PF00244	0.526
LIG_14-3-3_CanoR_1	363	369	PF00244	0.538
LIG_14-3-3_CanoR_1	421	425	PF00244	0.545
LIG_14-3-3_CanoR_1	549	554	PF00244	0.644
LIG_14-3-3_CanoR_1	668	675	PF00244	0.826
LIG_Actin_WH2_2	32	47	PF00022	0.601
LIG_APCC_ABBA_1	161	166	PF00400	0.577
LIG_APCC_ABBA_1	504	509	PF00400	0.632
LIG_APCC_ABBAyCdc20_2	373	379	PF00400	0.592
LIG_APCC_ABBAyCdc20_2	503	509	PF00400	0.632
LIG_BIR_III_4	561	565	PF00653	0.686
LIG_BRCT_BRCA1_1	223	227	PF00533	0.600
LIG_BRCT_BRCA1_1	619	623	PF00533	0.641
LIG_BRCT_BRCA1_1	670	674	PF00533	0.695
LIG_CaM_NSCaTE_8	306	313	PF13499	0.614
LIG_deltaCOP1_diTrp_1	516	523	PF00928	0.571
LIG_FHA_1	16	22	PF00498	0.433
LIG_FHA_1	29	35	PF00498	0.577
LIG_FHA_1	297	303	PF00498	0.532
LIG_FHA_1	472	478	PF00498	0.606
LIG_FHA_1	90	96	PF00498	0.557
LIG_FHA_2	101	107	PF00498	0.624
LIG_FHA_2	202	208	PF00498	0.606
LIG_FHA_2	346	352	PF00498	0.625
LIG_FHA_2	398	404	PF00498	0.628
LIG_GBD_Chelix_1	497	505	PF00786	0.310
LIG_LIR_Apic_2	516	521	PF02991	0.563
LIG_LIR_Gen_1	18	28	PF02991	0.388
LIG_LIR_Gen_1	288	298	PF02991	0.550
LIG_LIR_Gen_1	304	314	PF02991	0.509
LIG_LIR_Gen_1	316	327	PF02991	0.575
LIG_LIR_Gen_1	330	340	PF02991	0.469
LIG_LIR_Gen_1	405	416	PF02991	0.540
LIG_LIR_Gen_1	48	57	PF02991	0.646
LIG_LIR_Gen_1	534	542	PF02991	0.751
LIG_LIR_Nem_3	142	148	PF02991	0.618
LIG_LIR_Nem_3	18	23	PF02991	0.326
LIG_LIR_Nem_3	288	293	PF02991	0.551
LIG_LIR_Nem_3	304	309	PF02991	0.495
LIG_LIR_Nem_3	316	322	PF02991	0.559
LIG_LIR_Nem_3	330	335	PF02991	0.498
LIG_LIR_Nem_3	405	411	PF02991	0.524
LIG_LIR_Nem_3	423	429	PF02991	0.599
LIG_LIR_Nem_3	48	52	PF02991	0.640
LIG_LIR_Nem_3	517	523	PF02991	0.671
LIG_LIR_Nem_3	534	539	PF02991	0.785
LIG_LIR_Nem_3	620	626	PF02991	0.642
LIG_MYND_1	599	603	PF01753	0.702
LIG_MYND_1	641	645	PF01753	0.637
LIG_NRBOX	348	354	PF00104	0.567
LIG_PCNA_yPIPBox_3	328	338	PF02747	0.539
LIG_Pex14_2	20	24	PF04695	0.347
LIG_PTAP_UEV_1	595	600	PF05743	0.638
LIG_SH2_CRK	11	15	PF00017	0.436
LIG_SH2_CRK	145	149	PF00017	0.608
LIG_SH2_STAP1	536	540	PF00017	0.657
LIG_SH3_2	663	668	PF14604	0.777
LIG_SH3_3	390	396	PF00018	0.561
LIG_SH3_3	447	453	PF00018	0.486
LIG_SH3_3	461	467	PF00018	0.510
LIG_SH3_3	55	61	PF00018	0.649
LIG_SH3_3	593	599	PF00018	0.796
LIG_SH3_3	612	618	PF00018	0.736
LIG_SH3_3	660	666	PF00018	0.781
LIG_SH3_3	693	699	PF00018	0.800
LIG_TRAF2_1	281	284	PF00917	0.607
LIG_TYR_ITIM	424	429	PF00017	0.454
LIG_TYR_ITSM	141	148	PF00017	0.534
LIG_UBA3_1	22	30	PF00899	0.351
LIG_UBA3_1	434	439	PF00899	0.398
LIG_UBA3_1	490	496	PF00899	0.560
LIG_WRC_WIRS_1	623	628	PF05994	0.621
LIG_WW_3	662	666	PF00397	0.725
MOD_CK1_1	201	207	PF00069	0.506
MOD_CK1_1	254	260	PF00069	0.603
MOD_CK1_1	266	272	PF00069	0.566
MOD_CK1_1	288	294	PF00069	0.410
MOD_CK1_1	33	39	PF00069	0.468
MOD_CK1_1	391	397	PF00069	0.459
MOD_CK1_1	552	558	PF00069	0.742
MOD_CK1_1	572	578	PF00069	0.756
MOD_CK1_1	579	585	PF00069	0.616
MOD_CK1_1	590	596	PF00069	0.590
MOD_CK1_1	609	615	PF00069	0.785
MOD_CK1_1	622	628	PF00069	0.656
MOD_CK1_1	653	659	PF00069	0.798
MOD_CK2_1	201	207	PF00069	0.521
MOD_CK2_1	309	315	PF00069	0.573
MOD_GlcNHglycan	256	259	PF01048	0.575
MOD_GlcNHglycan	265	268	PF01048	0.524
MOD_GlcNHglycan	315	318	PF01048	0.460
MOD_GlcNHglycan	528	534	PF01048	0.622
MOD_GlcNHglycan	554	557	PF01048	0.649
MOD_GlcNHglycan	578	581	PF01048	0.731
MOD_GlcNHglycan	589	592	PF01048	0.807
MOD_GlcNHglycan	596	599	PF01048	0.717
MOD_GlcNHglycan	608	611	PF01048	0.687
MOD_GlcNHglycan	619	622	PF01048	0.702
MOD_GlcNHglycan	652	655	PF01048	0.789
MOD_GlcNHglycan	671	674	PF01048	0.792
MOD_GlcNHglycan	696	699	PF01048	0.767
MOD_GSK3_1	126	133	PF00069	0.506
MOD_GSK3_1	197	204	PF00069	0.528
MOD_GSK3_1	262	269	PF00069	0.589
MOD_GSK3_1	271	278	PF00069	0.619
MOD_GSK3_1	309	316	PF00069	0.502
MOD_GSK3_1	341	348	PF00069	0.407
MOD_GSK3_1	397	404	PF00069	0.484
MOD_GSK3_1	492	499	PF00069	0.410
MOD_GSK3_1	545	552	PF00069	0.709
MOD_GSK3_1	568	575	PF00069	0.679
MOD_GSK3_1	590	597	PF00069	0.729
MOD_GSK3_1	605	612	PF00069	0.786
MOD_GSK3_1	633	640	PF00069	0.766
MOD_GSK3_1	650	657	PF00069	0.765
MOD_GSK3_1	690	697	PF00069	0.682
MOD_N-GLC_1	139	144	PF02516	0.540
MOD_N-GLC_1	391	396	PF02516	0.412
MOD_N-GLC_1	573	578	PF02516	0.568
MOD_NEK2_1	309	314	PF00069	0.477
MOD_NEK2_1	341	346	PF00069	0.433
MOD_NEK2_1	35	40	PF00069	0.488
MOD_NEK2_1	675	680	PF00069	0.632
MOD_NEK2_1	88	93	PF00069	0.423
MOD_PIKK_1	126	132	PF00454	0.398
MOD_PIKK_1	212	218	PF00454	0.586
MOD_PIKK_1	471	477	PF00454	0.454
MOD_PK_1	30	36	PF00069	0.378
MOD_PKA_1	197	203	PF00069	0.415
MOD_PKA_1	568	574	PF00069	0.554
MOD_PKA_2	130	136	PF00069	0.522
MOD_PKA_2	197	203	PF00069	0.533
MOD_PKA_2	271	277	PF00069	0.692
MOD_PKA_2	28	34	PF00069	0.579
MOD_PKA_2	362	368	PF00069	0.461
MOD_PKA_2	420	426	PF00069	0.461
MOD_PKA_2	556	562	PF00069	0.662
MOD_PKA_2	568	574	PF00069	0.538
MOD_PKB_1	137	145	PF00069	0.531
MOD_PKB_1	195	203	PF00069	0.455
MOD_PKB_1	249	257	PF00069	0.445
MOD_PKB_1	566	574	PF00069	0.602
MOD_Plk_4	150	156	PF00069	0.475
MOD_Plk_4	16	22	PF00069	0.341
MOD_Plk_4	30	36	PF00069	0.372
MOD_ProDKin_1	198	204	PF00069	0.570
MOD_ProDKin_1	275	281	PF00069	0.629
MOD_ProDKin_1	310	316	PF00069	0.487
MOD_ProDKin_1	637	643	PF00069	0.722
MOD_ProDKin_1	654	660	PF00069	0.806
MOD_ProDKin_1	690	696	PF00069	0.684
MOD_SUMO_for_1	62	65	PF00179	0.516
MOD_SUMO_rev_2	205	215	PF00179	0.474
MOD_SUMO_rev_2	351	357	PF00179	0.512
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.442
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.557
TRG_DiLeu_BaLyEn_6	638	643	PF01217	0.635
TRG_DiLeu_BaLyEn_6	686	691	PF01217	0.579
TRG_ENDOCYTIC_2	11	14	PF00928	0.349
TRG_ENDOCYTIC_2	145	148	PF00928	0.502
TRG_ENDOCYTIC_2	426	429	PF00928	0.425
TRG_ENDOCYTIC_2	536	539	PF00928	0.697
TRG_ER_diArg_1	194	196	PF00400	0.565
TRG_ER_diArg_1	300	302	PF00400	0.508
TRG_ER_diArg_1	446	449	PF00400	0.316
TRG_NLS_Bipartite_1	29	44	PF00514	0.492
TRG_NLS_MonoExtN_4	356	362	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN3	Leptomonas seymouri	66%	96%
A0A3R7MWY6	Trypanosoma rangeli	31%	100%
A0A3S5H6M5	Leishmania donovani	99%	100%
A4H6Z7	Leishmania braziliensis	66%	99%
C9ZI10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZI11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AP17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
Q4QGH2	Leishmania major	88%	100%
V5DG13	Trypanosoma cruzi	31%	100%