LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Putative integral membrane protein conserved region (DUF2404) - putative
Species:
Leishmania infantum
UniProt:
E9AGI0_LEIIN
TriTrypDb:
LINF_120015800
Length:
947

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized LINJ.12.0760

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 1
GO:0016020 membrane 2 4
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

E9AGI0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGI0

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006869 lipid transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0071702 organic substance transport 4 2
Molecular functions
Term Name Level Count
GO:0005488 binding 1 4
GO:0008289 lipid binding 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 379 383 PF00656 0.765
CLV_C14_Caspase3-7 388 392 PF00656 0.722
CLV_C14_Caspase3-7 399 403 PF00656 0.629
CLV_C14_Caspase3-7 404 408 PF00656 0.635
CLV_C14_Caspase3-7 711 715 PF00656 0.689
CLV_C14_Caspase3-7 768 772 PF00656 0.793
CLV_NRD_NRD_1 180 182 PF00675 0.380
CLV_NRD_NRD_1 412 414 PF00675 0.544
CLV_NRD_NRD_1 426 428 PF00675 0.525
CLV_NRD_NRD_1 503 505 PF00675 0.375
CLV_PCSK_KEX2_1 412 414 PF00082 0.536
CLV_PCSK_KEX2_1 426 428 PF00082 0.537
CLV_PCSK_KEX2_1 913 915 PF00082 0.570
CLV_PCSK_PC1ET2_1 913 915 PF00082 0.570
CLV_PCSK_SKI1_1 170 174 PF00082 0.541
CLV_PCSK_SKI1_1 203 207 PF00082 0.589
CLV_PCSK_SKI1_1 326 330 PF00082 0.426
CLV_PCSK_SKI1_1 34 38 PF00082 0.370
CLV_PCSK_SKI1_1 484 488 PF00082 0.323
CLV_PCSK_SKI1_1 571 575 PF00082 0.352
CLV_PCSK_SKI1_1 631 635 PF00082 0.433
CLV_PCSK_SKI1_1 636 640 PF00082 0.379
CLV_PCSK_SKI1_1 693 697 PF00082 0.388
CLV_PCSK_SKI1_1 759 763 PF00082 0.485
CLV_PCSK_SKI1_1 914 918 PF00082 0.518
CLV_PCSK_SKI1_1 922 926 PF00082 0.418
CLV_PCSK_SKI1_1 933 937 PF00082 0.363
CLV_PCSK_SKI1_1 95 99 PF00082 0.405
DEG_APCC_DBOX_1 503 511 PF00400 0.574
DEG_APCC_DBOX_1 769 777 PF00400 0.796
DEG_MDM2_SWIB_1 7 15 PF02201 0.336
DEG_SCF_FBW7_1 737 743 PF00400 0.787
DEG_SPOP_SBC_1 882 886 PF00917 0.753
DOC_CDC14_PxL_1 638 646 PF14671 0.575
DOC_CKS1_1 737 742 PF01111 0.791
DOC_CKS1_1 825 830 PF01111 0.697
DOC_CYCLIN_yClb5_NLxxxL_5 922 928 PF00134 0.726
DOC_MAPK_DCC_7 770 778 PF00069 0.767
DOC_MAPK_gen_1 167 177 PF00069 0.728
DOC_MAPK_gen_1 181 187 PF00069 0.519
DOC_MAPK_gen_1 504 512 PF00069 0.674
DOC_MAPK_gen_1 922 930 PF00069 0.649
DOC_MAPK_MEF2A_6 615 623 PF00069 0.561
DOC_MAPK_MEF2A_6 770 778 PF00069 0.767
DOC_PP1_RVXF_1 314 321 PF00149 0.569
DOC_PP4_FxxP_1 668 671 PF00568 0.598
DOC_USP7_MATH_1 146 150 PF00917 0.715
DOC_USP7_MATH_1 2 6 PF00917 0.273
DOC_USP7_MATH_1 232 236 PF00917 0.784
DOC_USP7_MATH_1 258 262 PF00917 0.776
DOC_USP7_MATH_1 275 279 PF00917 0.669
DOC_USP7_MATH_1 289 293 PF00917 0.724
DOC_USP7_MATH_1 543 547 PF00917 0.581
DOC_USP7_MATH_1 669 673 PF00917 0.619
DOC_USP7_MATH_1 677 681 PF00917 0.653
DOC_USP7_MATH_1 722 726 PF00917 0.736
DOC_USP7_MATH_1 740 744 PF00917 0.681
DOC_USP7_MATH_1 764 768 PF00917 0.706
DOC_USP7_MATH_1 797 801 PF00917 0.710
DOC_USP7_MATH_1 816 820 PF00917 0.730
DOC_USP7_MATH_1 829 833 PF00917 0.778
DOC_USP7_MATH_1 876 880 PF00917 0.802
DOC_USP7_UBL2_3 925 929 PF12436 0.656
DOC_WW_Pin1_4 330 335 PF00397 0.789
DOC_WW_Pin1_4 368 373 PF00397 0.816
DOC_WW_Pin1_4 673 678 PF00397 0.622
DOC_WW_Pin1_4 713 718 PF00397 0.737
DOC_WW_Pin1_4 733 738 PF00397 0.734
DOC_WW_Pin1_4 748 753 PF00397 0.814
DOC_WW_Pin1_4 821 826 PF00397 0.768
DOC_WW_Pin1_4 840 845 PF00397 0.822
DOC_WW_Pin1_4 87 92 PF00397 0.703
LIG_14-3-3_CanoR_1 233 241 PF00244 0.678
LIG_14-3-3_CanoR_1 34 40 PF00244 0.570
LIG_14-3-3_CanoR_1 342 350 PF00244 0.693
LIG_14-3-3_CanoR_1 451 456 PF00244 0.571
LIG_14-3-3_CanoR_1 544 551 PF00244 0.658
LIG_14-3-3_CanoR_1 571 577 PF00244 0.667
LIG_14-3-3_CanoR_1 636 644 PF00244 0.585
LIG_14-3-3_CanoR_1 742 746 PF00244 0.710
LIG_14-3-3_CanoR_1 850 859 PF00244 0.724
LIG_14-3-3_CanoR_1 914 924 PF00244 0.644
LIG_APCC_ABBA_1 492 497 PF00400 0.562
LIG_APCC_ABBA_1 654 659 PF00400 0.570
LIG_APCC_ABBA_1 661 666 PF00400 0.568
LIG_APCC_ABBAyCdc20_2 653 659 PF00400 0.569
LIG_BIR_II_1 1 5 PF00653 0.502
LIG_BRCT_BRCA1_1 165 169 PF00533 0.761
LIG_BRCT_BRCA1_1 249 253 PF00533 0.742
LIG_BRCT_BRCA1_1 354 358 PF00533 0.701
LIG_BRCT_BRCA1_1 482 486 PF00533 0.559
LIG_BRCT_BRCA1_1 566 570 PF00533 0.530
LIG_BRCT_BRCA1_1 605 609 PF00533 0.582
LIG_Clathr_ClatBox_1 121 125 PF01394 0.638
LIG_Clathr_ClatBox_1 590 594 PF01394 0.530
LIG_CSL_BTD_1 860 863 PF09270 0.734
LIG_EVH1_2 335 339 PF00568 0.699
LIG_FHA_1 24 30 PF00498 0.491
LIG_FHA_1 312 318 PF00498 0.623
LIG_FHA_1 345 351 PF00498 0.751
LIG_FHA_1 376 382 PF00498 0.807
LIG_FHA_1 594 600 PF00498 0.538
LIG_FHA_1 606 612 PF00498 0.575
LIG_FHA_1 647 653 PF00498 0.660
LIG_FHA_1 825 831 PF00498 0.701
LIG_FHA_2 174 180 PF00498 0.621
LIG_FHA_2 189 195 PF00498 0.640
LIG_FHA_2 265 271 PF00498 0.769
LIG_FHA_2 397 403 PF00498 0.794
LIG_FHA_2 496 502 PF00498 0.663
LIG_LIR_Apic_2 106 110 PF02991 0.657
LIG_LIR_Apic_2 666 671 PF02991 0.593
LIG_LIR_Gen_1 130 137 PF02991 0.566
LIG_LIR_Gen_1 435 443 PF02991 0.613
LIG_LIR_Gen_1 450 459 PF02991 0.498
LIG_LIR_Gen_1 554 559 PF02991 0.532
LIG_LIR_Gen_1 680 689 PF02991 0.736
LIG_LIR_Nem_3 130 135 PF02991 0.548
LIG_LIR_Nem_3 435 439 PF02991 0.622
LIG_LIR_Nem_3 450 455 PF02991 0.505
LIG_LIR_Nem_3 463 468 PF02991 0.485
LIG_LIR_Nem_3 554 558 PF02991 0.571
LIG_LIR_Nem_3 567 572 PF02991 0.505
LIG_LIR_Nem_3 575 579 PF02991 0.608
LIG_LIR_Nem_3 680 684 PF02991 0.737
LIG_LYPXL_SIV_4 41 49 PF13949 0.590
LIG_MLH1_MIPbox_1 165 169 PF16413 0.761
LIG_MLH1_MIPbox_1 482 486 PF16413 0.559
LIG_MLH1_MIPbox_1 566 570 PF16413 0.530
LIG_MYND_1 844 848 PF01753 0.806
LIG_NRBOX 524 530 PF00104 0.642
LIG_NRBOX 923 929 PF00104 0.728
LIG_PCNA_PIPBox_1 648 657 PF02747 0.525
LIG_Pex14_2 481 485 PF04695 0.554
LIG_Pex14_2 7 11 PF04695 0.336
LIG_REV1ctd_RIR_1 166 174 PF16727 0.765
LIG_REV1ctd_RIR_1 567 575 PF16727 0.541
LIG_REV1ctd_RIR_1 70 78 PF16727 0.682
LIG_RPA_C_Fungi 829 841 PF08784 0.673
LIG_SH2_CRK 132 136 PF00017 0.569
LIG_SH2_CRK 576 580 PF00017 0.621
LIG_SH2_PTP2 42 45 PF00017 0.477
LIG_SH2_SRC 42 45 PF00017 0.441
LIG_SH2_STAP1 468 472 PF00017 0.595
LIG_SH2_STAT5 42 45 PF00017 0.452
LIG_SH2_STAT5 576 579 PF00017 0.622
LIG_SH2_STAT5 655 658 PF00017 0.444
LIG_SH3_1 841 847 PF00018 0.779
LIG_SH3_2 737 742 PF14604 0.646
LIG_SH3_3 537 543 PF00018 0.437
LIG_SH3_3 671 677 PF00018 0.507
LIG_SH3_3 734 740 PF00018 0.651
LIG_SH3_3 819 825 PF00018 0.714
LIG_SH3_3 841 847 PF00018 0.779
LIG_SUMO_SIM_anti_2 173 179 PF11976 0.535
LIG_SUMO_SIM_anti_2 496 504 PF11976 0.568
LIG_SUMO_SIM_par_1 119 125 PF11976 0.545
LIG_SUMO_SIM_par_1 589 594 PF11976 0.398
LIG_SUMO_SIM_par_1 774 780 PF11976 0.724
LIG_TYR_ITIM 574 579 PF00017 0.575
LIG_UBA3_1 455 460 PF00899 0.563
LIG_UBA3_1 499 505 PF00899 0.446
LIG_UBA3_1 647 653 PF00899 0.377
LIG_WRC_WIRS_1 478 483 PF05994 0.423
MOD_CDC14_SPxK_1 90 93 PF00782 0.726
MOD_CDK_SPK_2 673 678 PF00069 0.515
MOD_CDK_SPK_2 821 826 PF00069 0.616
MOD_CDK_SPxK_1 736 742 PF00069 0.755
MOD_CDK_SPxK_1 87 93 PF00069 0.731
MOD_CDK_SPxxK_3 713 720 PF00069 0.729
MOD_CK1_1 147 153 PF00069 0.788
MOD_CK1_1 154 160 PF00069 0.723
MOD_CK1_1 201 207 PF00069 0.690
MOD_CK1_1 222 228 PF00069 0.724
MOD_CK1_1 236 242 PF00069 0.575
MOD_CK1_1 271 277 PF00069 0.772
MOD_CK1_1 280 286 PF00069 0.620
MOD_CK1_1 292 298 PF00069 0.574
MOD_CK1_1 311 317 PF00069 0.566
MOD_CK1_1 338 344 PF00069 0.706
MOD_CK1_1 35 41 PF00069 0.555
MOD_CK1_1 377 383 PF00069 0.703
MOD_CK1_1 385 391 PF00069 0.637
MOD_CK1_1 538 544 PF00069 0.466
MOD_CK1_1 705 711 PF00069 0.772
MOD_CK1_1 736 742 PF00069 0.738
MOD_CK1_1 744 750 PF00069 0.632
MOD_CK1_1 753 759 PF00069 0.725
MOD_CK1_1 769 775 PF00069 0.577
MOD_CK1_1 800 806 PF00069 0.655
MOD_CK1_1 809 815 PF00069 0.549
MOD_CK1_1 824 830 PF00069 0.613
MOD_CK1_1 857 863 PF00069 0.739
MOD_CK1_1 877 883 PF00069 0.522
MOD_CK1_1 908 914 PF00069 0.604
MOD_CK1_1 915 921 PF00069 0.547
MOD_CK2_1 173 179 PF00069 0.532
MOD_CK2_1 188 194 PF00069 0.546
MOD_CK2_1 222 228 PF00069 0.760
MOD_CK2_1 264 270 PF00069 0.770
MOD_CK2_1 495 501 PF00069 0.572
MOD_GlcNHglycan 12 15 PF01048 0.405
MOD_GlcNHglycan 139 142 PF01048 0.656
MOD_GlcNHglycan 146 149 PF01048 0.610
MOD_GlcNHglycan 221 224 PF01048 0.757
MOD_GlcNHglycan 230 233 PF01048 0.631
MOD_GlcNHglycan 249 252 PF01048 0.459
MOD_GlcNHglycan 255 258 PF01048 0.648
MOD_GlcNHglycan 273 276 PF01048 0.598
MOD_GlcNHglycan 286 289 PF01048 0.579
MOD_GlcNHglycan 291 294 PF01048 0.519
MOD_GlcNHglycan 3 7 PF01048 0.395
MOD_GlcNHglycan 305 308 PF01048 0.560
MOD_GlcNHglycan 456 459 PF01048 0.434
MOD_GlcNHglycan 545 548 PF01048 0.459
MOD_GlcNHglycan 628 631 PF01048 0.531
MOD_GlcNHglycan 643 647 PF01048 0.441
MOD_GlcNHglycan 66 69 PF01048 0.648
MOD_GlcNHglycan 698 701 PF01048 0.680
MOD_GlcNHglycan 707 710 PF01048 0.628
MOD_GlcNHglycan 731 734 PF01048 0.653
MOD_GlcNHglycan 779 784 PF01048 0.659
MOD_GlcNHglycan 797 800 PF01048 0.626
MOD_GlcNHglycan 870 873 PF01048 0.688
MOD_GlcNHglycan 885 888 PF01048 0.500
MOD_GlcNHglycan 908 911 PF01048 0.613
MOD_GlcNHglycan 914 917 PF01048 0.604
MOD_GlcNHglycan 99 102 PF01048 0.440
MOD_GSK3_1 135 142 PF00069 0.727
MOD_GSK3_1 147 154 PF00069 0.609
MOD_GSK3_1 228 235 PF00069 0.667
MOD_GSK3_1 264 271 PF00069 0.680
MOD_GSK3_1 280 287 PF00069 0.561
MOD_GSK3_1 340 347 PF00069 0.656
MOD_GSK3_1 352 359 PF00069 0.624
MOD_GSK3_1 382 389 PF00069 0.768
MOD_GSK3_1 396 403 PF00069 0.561
MOD_GSK3_1 593 600 PF00069 0.391
MOD_GSK3_1 642 649 PF00069 0.443
MOD_GSK3_1 669 676 PF00069 0.526
MOD_GSK3_1 704 711 PF00069 0.628
MOD_GSK3_1 729 736 PF00069 0.774
MOD_GSK3_1 740 747 PF00069 0.783
MOD_GSK3_1 750 757 PF00069 0.630
MOD_GSK3_1 800 807 PF00069 0.721
MOD_GSK3_1 830 837 PF00069 0.726
MOD_GSK3_1 850 857 PF00069 0.721
MOD_GSK3_1 870 877 PF00069 0.762
MOD_GSK3_1 894 901 PF00069 0.689
MOD_GSK3_1 908 915 PF00069 0.613
MOD_GSK3_1 936 943 PF00069 0.621
MOD_GSK3_1 95 102 PF00069 0.515
MOD_N-GLC_1 188 193 PF02516 0.611
MOD_N-GLC_1 198 203 PF02516 0.543
MOD_N-GLC_1 268 273 PF02516 0.731
MOD_N-GLC_1 344 349 PF02516 0.757
MOD_N-GLC_1 386 391 PF02516 0.577
MOD_N-GLC_1 816 821 PF02516 0.762
MOD_N-GLC_1 868 873 PF02516 0.751
MOD_N-GLC_1 874 879 PF02516 0.703
MOD_N-GLC_1 895 900 PF02516 0.742
MOD_NEK2_1 137 142 PF00069 0.583
MOD_NEK2_1 168 173 PF00069 0.720
MOD_NEK2_1 188 193 PF00069 0.364
MOD_NEK2_1 198 203 PF00069 0.568
MOD_NEK2_1 23 28 PF00069 0.576
MOD_NEK2_1 247 252 PF00069 0.688
MOD_NEK2_1 253 258 PF00069 0.711
MOD_NEK2_1 268 273 PF00069 0.605
MOD_NEK2_1 303 308 PF00069 0.715
MOD_NEK2_1 32 37 PF00069 0.455
MOD_NEK2_1 328 333 PF00069 0.578
MOD_NEK2_1 358 363 PF00069 0.669
MOD_NEK2_1 495 500 PF00069 0.567
MOD_NEK2_1 529 534 PF00069 0.434
MOD_NEK2_1 572 577 PF00069 0.587
MOD_NEK2_1 593 598 PF00069 0.404
MOD_NEK2_1 754 759 PF00069 0.758
MOD_NEK2_1 830 835 PF00069 0.729
MOD_NEK2_1 883 888 PF00069 0.744
MOD_NEK2_2 151 156 PF00069 0.615
MOD_NEK2_2 308 313 PF00069 0.630
MOD_OFUCOSY 894 899 PF10250 0.741
MOD_PIKK_1 277 283 PF00454 0.614
MOD_PIKK_1 52 58 PF00454 0.556
MOD_PIKK_1 529 535 PF00454 0.426
MOD_PIKK_1 834 840 PF00454 0.782
MOD_PKA_1 912 918 PF00069 0.710
MOD_PKA_2 151 157 PF00069 0.657
MOD_PKA_2 163 169 PF00069 0.605
MOD_PKA_2 232 238 PF00069 0.603
MOD_PKA_2 375 381 PF00069 0.694
MOD_PKA_2 543 549 PF00069 0.580
MOD_PKA_2 702 708 PF00069 0.639
MOD_PKA_2 723 729 PF00069 0.673
MOD_PKA_2 741 747 PF00069 0.487
MOD_PKA_2 769 775 PF00069 0.733
MOD_PKA_2 854 860 PF00069 0.767
MOD_PKA_2 936 942 PF00069 0.621
MOD_Plk_1 188 194 PF00069 0.605
MOD_Plk_1 2 8 PF00069 0.311
MOD_Plk_1 264 270 PF00069 0.749
MOD_Plk_1 344 350 PF00069 0.757
MOD_Plk_1 396 402 PF00069 0.679
MOD_Plk_1 593 599 PF00069 0.392
MOD_Plk_1 816 822 PF00069 0.653
MOD_Plk_1 874 880 PF00069 0.642
MOD_Plk_2-3 396 402 PF00069 0.762
MOD_Plk_4 103 109 PF00069 0.413
MOD_Plk_4 127 133 PF00069 0.411
MOD_Plk_4 173 179 PF00069 0.600
MOD_Plk_4 188 194 PF00069 0.466
MOD_Plk_4 308 314 PF00069 0.663
MOD_Plk_4 44 50 PF00069 0.630
MOD_Plk_4 451 457 PF00069 0.443
MOD_Plk_4 477 483 PF00069 0.443
MOD_Plk_4 495 501 PF00069 0.456
MOD_Plk_4 564 570 PF00069 0.528
MOD_Plk_4 605 611 PF00069 0.562
MOD_Plk_4 669 675 PF00069 0.528
MOD_Plk_4 857 863 PF00069 0.783
MOD_ProDKin_1 330 336 PF00069 0.758
MOD_ProDKin_1 368 374 PF00069 0.792
MOD_ProDKin_1 673 679 PF00069 0.521
MOD_ProDKin_1 713 719 PF00069 0.680
MOD_ProDKin_1 733 739 PF00069 0.675
MOD_ProDKin_1 748 754 PF00069 0.791
MOD_ProDKin_1 821 827 PF00069 0.724
MOD_ProDKin_1 840 846 PF00069 0.799
MOD_ProDKin_1 87 93 PF00069 0.629
MOD_SUMO_for_1 441 444 PF00179 0.532
MOD_SUMO_rev_2 159 169 PF00179 0.736
MOD_SUMO_rev_2 712 722 PF00179 0.773
TRG_DiLeu_BaEn_2 2 8 PF01217 0.355
TRG_ENDOCYTIC_2 132 135 PF00928 0.556
TRG_ENDOCYTIC_2 42 45 PF00928 0.477
TRG_ENDOCYTIC_2 576 579 PF00928 0.613
TRG_ENDOCYTIC_2 9 12 PF00928 0.336
TRG_ER_diArg_1 684 687 PF00400 0.573
TRG_ER_diLys_1 944 947 PF00400 0.780
TRG_Pf-PMV_PEXEL_1 326 330 PF00026 0.525
TRG_Pf-PMV_PEXEL_1 517 522 PF00026 0.553

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILD4 Leptomonas seymouri 45% 100%
A0A3S7WS71 Leishmania donovani 100% 100%
E9AP16 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QGH3 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS