LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

N-ethylmaleimide reductase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
N-ethylmaleimide reductase-like protein
Gene product:
n-ethylmaleimide reductase-like protein
Species:
Leishmania infantum
UniProt:
E9AGH8_LEIIN
TriTrypDb:
LINF_120015600
Length:
828

Annotations

Annotations by Jardim et al.

Oxidoreductase, N-ethylmaleimide reductase-like LINJ.12.0740

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9AGH8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGH8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 6
GO:0003824 catalytic activity 1 6
GO:0005488 binding 1 6
GO:0010181 FMN binding 4 6
GO:0016491 oxidoreductase activity 2 6
GO:0032553 ribonucleotide binding 3 6
GO:0036094 small molecule binding 2 6
GO:0043167 ion binding 2 6
GO:0043168 anion binding 3 6
GO:0097159 organic cyclic compound binding 2 6
GO:0097367 carbohydrate derivative binding 2 6
GO:1901265 nucleoside phosphate binding 3 6
GO:1901363 heterocyclic compound binding 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 227 231 PF00656 0.535
CLV_C14_Caspase3-7 391 395 PF00656 0.742
CLV_C14_Caspase3-7 633 637 PF00656 0.636
CLV_C14_Caspase3-7 688 692 PF00656 0.636
CLV_C14_Caspase3-7 85 89 PF00656 0.427
CLV_MEL_PAP_1 647 653 PF00089 0.380
CLV_NRD_NRD_1 298 300 PF00675 0.435
CLV_NRD_NRD_1 397 399 PF00675 0.749
CLV_NRD_NRD_1 460 462 PF00675 0.435
CLV_NRD_NRD_1 496 498 PF00675 0.380
CLV_NRD_NRD_1 609 611 PF00675 0.433
CLV_NRD_NRD_1 645 647 PF00675 0.435
CLV_NRD_NRD_1 678 680 PF00675 0.435
CLV_NRD_NRD_1 784 786 PF00675 0.671
CLV_PCSK_KEX2_1 298 300 PF00082 0.435
CLV_PCSK_KEX2_1 397 399 PF00082 0.749
CLV_PCSK_KEX2_1 460 462 PF00082 0.435
CLV_PCSK_KEX2_1 532 534 PF00082 0.352
CLV_PCSK_KEX2_1 644 646 PF00082 0.435
CLV_PCSK_KEX2_1 727 729 PF00082 0.321
CLV_PCSK_PC1ET2_1 532 534 PF00082 0.352
CLV_PCSK_PC1ET2_1 727 729 PF00082 0.321
CLV_PCSK_SKI1_1 172 176 PF00082 0.435
CLV_PCSK_SKI1_1 223 227 PF00082 0.435
CLV_PCSK_SKI1_1 344 348 PF00082 0.435
CLV_PCSK_SKI1_1 497 501 PF00082 0.397
CLV_PCSK_SKI1_1 658 662 PF00082 0.435
CLV_PCSK_SKI1_1 704 708 PF00082 0.380
CLV_PCSK_SKI1_1 820 824 PF00082 0.601
CLV_PCSK_SKI1_1 91 95 PF00082 0.321
CLV_Separin_Metazoa 564 568 PF03568 0.580
DEG_APCC_DBOX_1 222 230 PF00400 0.636
DEG_COP1_1 39 46 PF00400 0.636
DEG_SCF_FBW7_1 243 250 PF00400 0.636
DOC_ANK_TNKS_1 285 292 PF00023 0.582
DOC_CYCLIN_RxL_1 220 230 PF00134 0.636
DOC_CYCLIN_yCln2_LP_2 822 828 PF00134 0.695
DOC_MAPK_gen_1 221 228 PF00069 0.636
DOC_MAPK_gen_1 460 468 PF00069 0.636
DOC_MAPK_gen_1 572 581 PF00069 0.636
DOC_MAPK_gen_1 644 651 PF00069 0.636
DOC_MAPK_gen_1 679 686 PF00069 0.636
DOC_MAPK_MEF2A_6 572 581 PF00069 0.636
DOC_MAPK_MEF2A_6 644 651 PF00069 0.636
DOC_PP1_RVXF_1 271 278 PF00149 0.636
DOC_PP1_RVXF_1 570 576 PF00149 0.636
DOC_PP2B_LxvP_1 822 825 PF13499 0.691
DOC_PP4_FxxP_1 378 381 PF00568 0.763
DOC_USP7_MATH_1 161 165 PF00917 0.611
DOC_USP7_MATH_1 254 258 PF00917 0.483
DOC_USP7_MATH_1 354 358 PF00917 0.482
DOC_USP7_MATH_1 459 463 PF00917 0.542
DOC_USP7_MATH_1 687 691 PF00917 0.524
DOC_USP7_MATH_1 793 797 PF00917 0.615
DOC_USP7_UBL2_3 574 578 PF12436 0.580
DOC_WW_Pin1_4 113 118 PF00397 0.636
DOC_WW_Pin1_4 243 248 PF00397 0.636
DOC_WW_Pin1_4 28 33 PF00397 0.543
DOC_WW_Pin1_4 620 625 PF00397 0.636
DOC_WW_Pin1_4 649 654 PF00397 0.636
DOC_WW_Pin1_4 801 806 PF00397 0.650
DOC_WW_Pin1_4 809 814 PF00397 0.820
LIG_14-3-3_CanoR_1 113 117 PF00244 0.521
LIG_14-3-3_CanoR_1 298 302 PF00244 0.636
LIG_14-3-3_CanoR_1 460 465 PF00244 0.547
LIG_14-3-3_CanoR_1 519 523 PF00244 0.580
LIG_14-3-3_CanoR_1 55 59 PF00244 0.636
LIG_14-3-3_CanoR_1 567 575 PF00244 0.580
LIG_Actin_WH2_2 561 576 PF00022 0.630
LIG_BIR_II_1 1 5 PF00653 0.784
LIG_BIR_III_4 271 275 PF00653 0.483
LIG_BRCT_BRCA1_1 356 360 PF00533 0.545
LIG_CaMK_CASK_1 294 299 PF00069 0.636
LIG_deltaCOP1_diTrp_1 294 301 PF00928 0.636
LIG_FHA_1 261 267 PF00498 0.636
LIG_FHA_1 498 504 PF00498 0.575
LIG_FHA_1 537 543 PF00498 0.616
LIG_FHA_1 61 67 PF00498 0.606
LIG_FHA_1 92 98 PF00498 0.521
LIG_FHA_2 161 167 PF00498 0.615
LIG_FHA_2 244 250 PF00498 0.636
LIG_FHA_2 310 316 PF00498 0.608
LIG_FHA_2 613 619 PF00498 0.636
LIG_FHA_2 661 667 PF00498 0.636
LIG_FHA_2 778 784 PF00498 0.552
LIG_Integrin_RGD_1 282 284 PF01839 0.435
LIG_LIR_Apic_2 377 381 PF02991 0.723
LIG_LIR_Apic_2 543 549 PF02991 0.552
LIG_LIR_Apic_2 691 697 PF02991 0.636
LIG_LIR_Apic_2 801 806 PF02991 0.571
LIG_LIR_Gen_1 780 788 PF02991 0.572
LIG_LIR_Nem_3 340 346 PF02991 0.615
LIG_LIR_Nem_3 364 370 PF02991 0.481
LIG_LIR_Nem_3 413 419 PF02991 0.514
LIG_LIR_Nem_3 462 467 PF02991 0.545
LIG_LIR_Nem_3 477 481 PF02991 0.473
LIG_LIR_Nem_3 772 778 PF02991 0.657
LIG_LIR_Nem_3 780 784 PF02991 0.524
LIG_LIR_Nem_3 88 93 PF02991 0.636
LIG_MLH1_MIPbox_1 356 360 PF16413 0.506
LIG_PTB_Apo_2 345 352 PF02174 0.595
LIG_REV1ctd_RIR_1 171 180 PF16727 0.483
LIG_REV1ctd_RIR_1 357 366 PF16727 0.578
LIG_RPA_C_Fungi 455 467 PF08784 0.530
LIG_SH2_CRK 464 468 PF00017 0.530
LIG_SH2_CRK 511 515 PF00017 0.530
LIG_SH2_CRK 546 550 PF00017 0.413
LIG_SH2_CRK 694 698 PF00017 0.368
LIG_SH2_CRK 803 807 PF00017 0.589
LIG_SH2_PTP2 683 686 PF00017 0.491
LIG_SH2_SRC 77 80 PF00017 0.530
LIG_SH2_SRC 781 784 PF00017 0.451
LIG_SH2_STAP1 10 14 PF00017 0.650
LIG_SH2_STAT3 265 268 PF00017 0.452
LIG_SH2_STAT5 10 13 PF00017 0.528
LIG_SH2_STAT5 197 200 PF00017 0.530
LIG_SH2_STAT5 265 268 PF00017 0.530
LIG_SH2_STAT5 311 314 PF00017 0.491
LIG_SH2_STAT5 367 370 PF00017 0.482
LIG_SH2_STAT5 416 419 PF00017 0.628
LIG_SH2_STAT5 481 484 PF00017 0.530
LIG_SH2_STAT5 511 514 PF00017 0.530
LIG_SH2_STAT5 580 583 PF00017 0.530
LIG_SH2_STAT5 603 606 PF00017 0.530
LIG_SH2_STAT5 683 686 PF00017 0.423
LIG_SH3_3 124 130 PF00018 0.530
LIG_SH3_3 16 22 PF00018 0.461
LIG_SH3_3 333 339 PF00018 0.413
LIG_SH3_3 369 375 PF00018 0.600
LIG_SH3_3 416 422 PF00018 0.629
LIG_SH3_3 432 438 PF00018 0.311
LIG_SH3_3 756 762 PF00018 0.592
LIG_SUMO_SIM_par_1 224 230 PF11976 0.530
LIG_TRAF2_2 440 445 PF00917 0.530
LIG_TYR_ITIM 509 514 PF00017 0.530
LIG_TYR_ITIM 681 686 PF00017 0.530
LIG_WRC_WIRS_1 199 204 PF05994 0.530
LIG_WRC_WIRS_1 248 253 PF05994 0.530
MOD_CDK_SPxxK_3 28 35 PF00069 0.401
MOD_CDK_SPxxK_3 620 627 PF00069 0.530
MOD_CK1_1 31 37 PF00069 0.434
MOD_CK1_1 477 483 PF00069 0.316
MOD_CK1_1 54 60 PF00069 0.530
MOD_CK1_1 777 783 PF00069 0.498
MOD_CK1_1 801 807 PF00069 0.610
MOD_CK2_1 160 166 PF00069 0.530
MOD_CK2_1 254 260 PF00069 0.491
MOD_CK2_1 718 724 PF00069 0.530
MOD_CK2_1 777 783 PF00069 0.556
MOD_Cter_Amidation 642 645 PF01082 0.530
MOD_DYRK1A_RPxSP_1 113 117 PF00069 0.530
MOD_GlcNHglycan 130 133 PF01048 0.400
MOD_GlcNHglycan 163 166 PF01048 0.452
MOD_GlcNHglycan 2 5 PF01048 0.778
MOD_GlcNHglycan 301 304 PF01048 0.410
MOD_GlcNHglycan 390 393 PF01048 0.712
MOD_GlcNHglycan 542 545 PF01048 0.471
MOD_GlcNHglycan 568 571 PF01048 0.384
MOD_GlcNHglycan 687 690 PF01048 0.384
MOD_GlcNHglycan 72 75 PF01048 0.525
MOD_GlcNHglycan 795 798 PF01048 0.712
MOD_GlcNHglycan 82 85 PF01048 0.360
MOD_GSK3_1 243 250 PF00069 0.530
MOD_GSK3_1 354 361 PF00069 0.538
MOD_GSK3_1 388 395 PF00069 0.722
MOD_GSK3_1 397 404 PF00069 0.606
MOD_GSK3_1 42 49 PF00069 0.413
MOD_GSK3_1 536 543 PF00069 0.487
MOD_N-GLC_1 118 123 PF02516 0.530
MOD_N-GLC_1 219 224 PF02516 0.530
MOD_N-GLC_1 524 529 PF02516 0.491
MOD_N-GLC_1 70 75 PF02516 0.433
MOD_N-GLC_1 718 723 PF02516 0.530
MOD_N-GLC_1 798 803 PF02516 0.559
MOD_N-GLC_1 808 813 PF02516 0.596
MOD_N-GLC_1 818 823 PF02516 0.673
MOD_NEK2_1 198 203 PF00069 0.428
MOD_NEK2_1 417 422 PF00069 0.533
MOD_NEK2_1 425 430 PF00069 0.353
MOD_NEK2_1 808 813 PF00069 0.612
MOD_NEK2_2 426 431 PF00069 0.530
MOD_PIKK_1 417 423 PF00454 0.624
MOD_PIKK_1 536 542 PF00454 0.413
MOD_PKA_1 397 403 PF00069 0.710
MOD_PKA_1 460 466 PF00069 0.530
MOD_PKA_1 497 503 PF00069 0.452
MOD_PKA_1 610 616 PF00069 0.394
MOD_PKA_2 112 118 PF00069 0.369
MOD_PKA_2 20 26 PF00069 0.316
MOD_PKA_2 297 303 PF00069 0.530
MOD_PKA_2 361 367 PF00069 0.611
MOD_PKA_2 397 403 PF00069 0.825
MOD_PKA_2 459 465 PF00069 0.404
MOD_PKA_2 518 524 PF00069 0.452
MOD_PKA_2 54 60 PF00069 0.530
MOD_PKA_2 566 572 PF00069 0.447
MOD_PKA_2 793 799 PF00069 0.712
MOD_Plk_1 219 225 PF00069 0.530
MOD_Plk_1 354 360 PF00069 0.551
MOD_Plk_1 717 723 PF00069 0.519
MOD_Plk_1 798 804 PF00069 0.546
MOD_Plk_1 818 824 PF00069 0.602
MOD_Plk_2-3 374 380 PF00069 0.719
MOD_Plk_2-3 718 724 PF00069 0.530
MOD_Plk_4 198 204 PF00069 0.530
MOD_Plk_4 261 267 PF00069 0.355
MOD_Plk_4 355 361 PF00069 0.624
MOD_Plk_4 477 483 PF00069 0.530
MOD_Plk_4 763 769 PF00069 0.663
MOD_ProDKin_1 113 119 PF00069 0.530
MOD_ProDKin_1 243 249 PF00069 0.530
MOD_ProDKin_1 28 34 PF00069 0.401
MOD_ProDKin_1 620 626 PF00069 0.530
MOD_ProDKin_1 649 655 PF00069 0.530
MOD_ProDKin_1 801 807 PF00069 0.654
MOD_ProDKin_1 809 815 PF00069 0.818
MOD_SUMO_rev_2 147 152 PF00179 0.530
TRG_DiLeu_BaLyEn_6 419 424 PF01217 0.530
TRG_DiLeu_BaLyEn_6 626 631 PF01217 0.530
TRG_ENDOCYTIC_2 10 13 PF00928 0.551
TRG_ENDOCYTIC_2 416 419 PF00928 0.492
TRG_ENDOCYTIC_2 464 467 PF00928 0.400
TRG_ENDOCYTIC_2 511 514 PF00928 0.530
TRG_ENDOCYTIC_2 683 686 PF00928 0.428
TRG_ENDOCYTIC_2 72 75 PF00928 0.530
TRG_ENDOCYTIC_2 781 784 PF00928 0.650
TRG_ER_diArg_1 221 224 PF00400 0.530
TRG_ER_diArg_1 297 299 PF00400 0.530
TRG_ER_diArg_1 397 399 PF00400 0.710
TRG_ER_diArg_1 440 443 PF00400 0.530
TRG_ER_diArg_1 627 630 PF00400 0.460
TRG_ER_diArg_1 644 646 PF00400 0.249
TRG_Pf-PMV_PEXEL_1 223 227 PF00026 0.530
TRG_Pf-PMV_PEXEL_1 397 402 PF00026 0.748
TRG_Pf-PMV_PEXEL_1 497 501 PF00026 0.452
TRG_Pf-PMV_PEXEL_1 629 633 PF00026 0.530
TRG_Pf-PMV_PEXEL_1 91 95 PF00026 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8I8C3 Leishmania donovani 100% 100%
A4H6Z4 Leishmania braziliensis 81% 100%
E9AP14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QGH5 Leishmania major 93% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS