DnaJ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein - putative

Species:

Leishmania infantum

UniProt:

E9AGH2_LEIIN

TriTrypDb:

LINF_120015200

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGH2

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0035966	response to topologically incorrect protein	3	1
GO:0035967	cellular response to topologically incorrect protein	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0051788	response to misfolded protein	4	1
GO:0061077	chaperone-mediated protein folding	3	1
GO:0070887	cellular response to chemical stimulus	3	1
GO:0071218	cellular response to misfolded protein	5	1
GO:0071310	cellular response to organic substance	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.614
CLV_NRD_NRD_1	132	134	PF00675	0.642
CLV_NRD_NRD_1	175	177	PF00675	0.500
CLV_NRD_NRD_1	21	23	PF00675	0.361
CLV_NRD_NRD_1	25	27	PF00675	0.358
CLV_NRD_NRD_1	307	309	PF00675	0.638
CLV_NRD_NRD_1	487	489	PF00675	0.461
CLV_NRD_NRD_1	60	62	PF00675	0.371
CLV_PCSK_FUR_1	173	177	PF00082	0.490
CLV_PCSK_FUR_1	58	62	PF00082	0.239
CLV_PCSK_KEX2_1	132	134	PF00082	0.642
CLV_PCSK_KEX2_1	175	177	PF00082	0.500
CLV_PCSK_KEX2_1	21	23	PF00082	0.308
CLV_PCSK_KEX2_1	25	27	PF00082	0.308
CLV_PCSK_KEX2_1	307	309	PF00082	0.638
CLV_PCSK_KEX2_1	350	352	PF00082	0.531
CLV_PCSK_KEX2_1	487	489	PF00082	0.442
CLV_PCSK_KEX2_1	58	60	PF00082	0.308
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.531
CLV_PCSK_PC7_1	21	27	PF00082	0.239
CLV_PCSK_SKI1_1	26	30	PF00082	0.312
CLV_PCSK_SKI1_1	282	286	PF00082	0.539
CLV_PCSK_SKI1_1	323	327	PF00082	0.503
CLV_PCSK_SKI1_1	332	336	PF00082	0.495
CLV_PCSK_SKI1_1	386	390	PF00082	0.476
DEG_SPOP_SBC_1	207	211	PF00917	0.554
DEG_SPOP_SBC_1	369	373	PF00917	0.656
DOC_ANK_TNKS_1	145	152	PF00023	0.573
DOC_CYCLIN_RxL_1	21	34	PF00134	0.400
DOC_CYCLIN_RxL_1	4	12	PF00134	0.292
DOC_MAPK_gen_1	21	31	PF00069	0.308
DOC_MAPK_gen_1	297	305	PF00069	0.522
DOC_PP4_FxxP_1	103	106	PF00568	0.604
DOC_PP4_FxxP_1	189	192	PF00568	0.632
DOC_PP4_FxxP_1	464	467	PF00568	0.636
DOC_USP7_MATH_1	141	145	PF00917	0.682
DOC_USP7_MATH_1	205	209	PF00917	0.660
DOC_USP7_MATH_1	245	249	PF00917	0.645
DOC_USP7_MATH_1	369	373	PF00917	0.656
DOC_USP7_MATH_1	465	469	PF00917	0.588
DOC_USP7_MATH_1	489	493	PF00917	0.463
DOC_USP7_MATH_1	507	511	PF00917	0.500
DOC_USP7_MATH_1	593	597	PF00917	0.625
DOC_USP7_MATH_1	69	73	PF00917	0.673
DOC_WW_Pin1_4	104	109	PF00397	0.569
DOC_WW_Pin1_4	201	206	PF00397	0.650
DOC_WW_Pin1_4	344	349	PF00397	0.557
DOC_WW_Pin1_4	497	502	PF00397	0.601
DOC_WW_Pin1_4	544	549	PF00397	0.430
DOC_WW_Pin1_4	584	589	PF00397	0.587
DOC_WW_Pin1_4	72	77	PF00397	0.576
LIG_14-3-3_CanoR_1	181	189	PF00244	0.607
LIG_14-3-3_CanoR_1	220	224	PF00244	0.677
LIG_14-3-3_CanoR_1	244	254	PF00244	0.747
LIG_14-3-3_CanoR_1	323	328	PF00244	0.633
LIG_14-3-3_CanoR_1	332	341	PF00244	0.588
LIG_14-3-3_CanoR_1	4	10	PF00244	0.359
LIG_14-3-3_CanoR_1	460	467	PF00244	0.544
LIG_14-3-3_CanoR_1	488	496	PF00244	0.482
LIG_14-3-3_CanoR_1	93	103	PF00244	0.467
LIG_AP2alpha_2	455	457	PF02296	0.598
LIG_APCC_ABBA_1	29	34	PF00400	0.309
LIG_BRCT_BRCA1_1	208	212	PF00533	0.653
LIG_eIF4E_1	24	30	PF01652	0.308
LIG_FHA_1	151	157	PF00498	0.642
LIG_FHA_1	6	12	PF00498	0.379
LIG_FHA_2	111	117	PF00498	0.563
LIG_FHA_2	317	323	PF00498	0.520
LIG_FHA_2	372	378	PF00498	0.625
LIG_GBD_Chelix_1	520	528	PF00786	0.417
LIG_Integrin_RGD_1	474	476	PF01839	0.560
LIG_LIR_Apic_2	188	192	PF02991	0.632
LIG_LIR_Apic_2	324	330	PF02991	0.535
LIG_LIR_Apic_2	462	467	PF02991	0.572
LIG_LIR_Gen_1	67	76	PF02991	0.527
LIG_LIR_Nem_3	3	9	PF02991	0.308
LIG_LIR_Nem_3	67	73	PF02991	0.522
LIG_PCNA_yPIPBox_3	525	538	PF02747	0.387
LIG_RPA_C_Fungi	233	245	PF08784	0.485
LIG_SH2_CRK	6	10	PF00017	0.308
LIG_SH2_SRC	50	53	PF00017	0.379
LIG_SH2_STAP1	50	54	PF00017	0.308
LIG_SH2_STAT3	277	280	PF00017	0.597
LIG_SH2_STAT5	277	280	PF00017	0.597
LIG_SH2_STAT5	327	330	PF00017	0.516
LIG_SH2_STAT5	499	502	PF00017	0.642
LIG_SH2_STAT5	555	558	PF00017	0.402
LIG_SH3_1	585	591	PF00018	0.533
LIG_SH3_2	197	202	PF14604	0.535
LIG_SH3_3	190	196	PF00018	0.634
LIG_SH3_3	197	203	PF00018	0.637
LIG_SH3_3	585	591	PF00018	0.559
LIG_SH3_3	77	83	PF00018	0.597
LIG_SH3_3	98	104	PF00018	0.617
LIG_TRAF2_1	113	116	PF00917	0.522
LIG_TRAF2_1	258	261	PF00917	0.609
LIG_TRAF2_1	598	601	PF00917	0.508
MOD_CDC14_SPxK_1	347	350	PF00782	0.516
MOD_CDK_SPK_2	544	549	PF00069	0.417
MOD_CDK_SPxK_1	344	350	PF00069	0.520
MOD_CDK_SPxxK_3	344	351	PF00069	0.522
MOD_CK1_1	161	167	PF00069	0.570
MOD_CK1_1	201	207	PF00069	0.642
MOD_CK1_1	208	214	PF00069	0.678
MOD_CK1_1	228	234	PF00069	0.636
MOD_CK1_1	313	319	PF00069	0.583
MOD_CK1_1	343	349	PF00069	0.583
MOD_CK1_1	364	370	PF00069	0.758
MOD_CK1_1	570	576	PF00069	0.500
MOD_CK1_1	72	78	PF00069	0.622
MOD_CK2_1	110	116	PF00069	0.599
MOD_CK2_1	182	188	PF00069	0.576
MOD_CK2_1	246	252	PF00069	0.742
MOD_CK2_1	316	322	PF00069	0.634
MOD_CK2_1	371	377	PF00069	0.623
MOD_CK2_1	409	415	PF00069	0.552
MOD_CK2_1	507	513	PF00069	0.477
MOD_CK2_1	516	522	PF00069	0.457
MOD_CK2_1	559	565	PF00069	0.386
MOD_CK2_1	594	600	PF00069	0.772
MOD_CK2_1	68	74	PF00069	0.536
MOD_GlcNHglycan	143	146	PF01048	0.666
MOD_GlcNHglycan	184	187	PF01048	0.767
MOD_GlcNHglycan	188	192	PF01048	0.620
MOD_GlcNHglycan	249	252	PF01048	0.585
MOD_GlcNHglycan	292	295	PF01048	0.525
MOD_GlcNHglycan	311	315	PF01048	0.637
MOD_GlcNHglycan	417	421	PF01048	0.694
MOD_GlcNHglycan	428	431	PF01048	0.588
MOD_GlcNHglycan	437	440	PF01048	0.485
MOD_GlcNHglycan	445	448	PF01048	0.518
MOD_GlcNHglycan	461	464	PF01048	0.708
MOD_GlcNHglycan	569	572	PF01048	0.417
MOD_GSK3_1	201	208	PF00069	0.715
MOD_GSK3_1	212	219	PF00069	0.607
MOD_GSK3_1	225	232	PF00069	0.575
MOD_GSK3_1	340	347	PF00069	0.535
MOD_GSK3_1	355	362	PF00069	0.606
MOD_GSK3_1	364	371	PF00069	0.628
MOD_GSK3_1	539	546	PF00069	0.381
MOD_GSK3_1	589	596	PF00069	0.704
MOD_GSK3_1	68	75	PF00069	0.654
MOD_N-GLC_1	156	161	PF02516	0.608
MOD_N-GLC_1	343	348	PF02516	0.591
MOD_N-GLC_1	364	369	PF02516	0.590
MOD_N-GLC_2	160	162	PF02516	0.660
MOD_NEK2_1	118	123	PF00069	0.649
MOD_NEK2_1	212	217	PF00069	0.601
MOD_NEK2_1	340	345	PF00069	0.523
MOD_NEK2_1	443	448	PF00069	0.588
MOD_NEK2_1	516	521	PF00069	0.525
MOD_NEK2_1	556	561	PF00069	0.470
MOD_PIKK_1	161	167	PF00454	0.555
MOD_PIKK_1	214	220	PF00454	0.690
MOD_PIKK_1	229	235	PF00454	0.525
MOD_PKA_2	219	225	PF00069	0.696
MOD_PKA_2	228	234	PF00069	0.558
MOD_PKA_2	290	296	PF00069	0.527
MOD_PKA_2	316	322	PF00069	0.516
MOD_PKA_2	393	399	PF00069	0.505
MOD_PKA_2	459	465	PF00069	0.598
MOD_PKA_2	534	540	PF00069	0.513
MOD_PKB_1	236	244	PF00069	0.560
MOD_Plk_1	252	258	PF00069	0.627
MOD_Plk_1	321	327	PF00069	0.499
MOD_Plk_1	396	402	PF00069	0.516
MOD_Plk_2-3	150	156	PF00069	0.587
MOD_Plk_2-3	252	258	PF00069	0.672
MOD_Plk_4	219	225	PF00069	0.555
MOD_Plk_4	323	329	PF00069	0.506
MOD_Plk_4	527	533	PF00069	0.464
MOD_ProDKin_1	104	110	PF00069	0.567
MOD_ProDKin_1	201	207	PF00069	0.651
MOD_ProDKin_1	344	350	PF00069	0.559
MOD_ProDKin_1	497	503	PF00069	0.600
MOD_ProDKin_1	544	550	PF00069	0.426
MOD_ProDKin_1	584	590	PF00069	0.591
MOD_ProDKin_1	72	78	PF00069	0.576
MOD_SUMO_for_1	258	261	PF00179	0.609
TRG_ENDOCYTIC_2	6	9	PF00928	0.312
TRG_ER_diArg_1	174	176	PF00400	0.495
TRG_ER_diArg_1	20	22	PF00400	0.337
TRG_ER_diArg_1	236	239	PF00400	0.554
TRG_ER_diArg_1	24	26	PF00400	0.331
TRG_ER_diArg_1	307	309	PF00400	0.632
TRG_ER_diArg_1	487	489	PF00400	0.480
TRG_ER_diArg_1	58	61	PF00400	0.403
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC79	Leptomonas seymouri	37%	100%
A0A3S7WS81	Leishmania donovani	100%	100%
A4H6Z1	Leishmania braziliensis	61%	100%
E9AP11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QGH8	Leishmania major	83%	100%