LeishMANIAdb
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Surface antigen protein 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen protein 2
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGH0_LEIIN
TriTrypDb:
LINF_120012800 *
Length:
377

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Annotations by Jardim et al.

Plasma membrane, Surface antigen 2 LINJ.12.0690

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 150
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 59, no: 9
NetGPI no yes: 0, no: 68
Cellular components
TermNameLevelCount
GO:0005886 plasma membrane 3 5
GO:0005929 cilium 4 69
GO:0016020 membrane 2 24
GO:0042995 cell projection 2 69
GO:0043226 organelle 2 69
GO:0043227 membrane-bounded organelle 3 69
GO:0110165 cellular anatomical entity 1 69
GO:0120025 plasma membrane bounded cell projection 3 69
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Expansion

Sequence features

E9AGH0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGH0

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 6 8 PF00675 0.713
CLV_PCSK_KEX2_1 6 8 PF00082 0.713
CLV_PCSK_SKI1_1 255 259 PF00082 0.543
CLV_PCSK_SKI1_1 31 35 PF00082 0.605
CLV_PCSK_SKI1_1 7 11 PF00082 0.689
DEG_APCC_KENBOX_2 33 37 PF00400 0.346
DEG_SCF_FBW7_2 305 310 PF00400 0.402
DOC_AGCK_PIF_2 69 74 PF00069 0.263
DOC_CYCLIN_RxL_1 3 13 PF00134 0.474
DOC_MAPK_MEF2A_6 277 284 PF00069 0.348
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P276 Leptomonas seymouri 30% 100%
A0A0N0P2L4 Leptomonas seymouri 40% 100%
A0A0N0P4M2 Leptomonas seymouri 27% 100%
A0A0N1I121 Leptomonas seymouri 30% 75%
A0A0N1I661 Leptomonas seymouri 36% 66%
A0A0N1I7S5 Leptomonas seymouri 31% 74%
A0A0S4IZC7 Bodo saltans 24% 92%
A0A0S4J1A6 Bodo saltans 23% 87%
A0A0S4JBV9 Bodo saltans 27% 77%
A0A0S4JL29 Bodo saltans 32% 74%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS