Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)
by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role
Plasma membrane, Surface antigen 2 LINJ.12.0690
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | yes | yes: 150 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 16 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | yes | yes: 59, no: 9 |
NetGPI | no | yes: 0, no: 68 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005929 | cilium | 4 | 69 |
GO:0042995 | cell projection | 2 | 69 |
GO:0043226 | organelle | 2 | 69 |
GO:0043227 | membrane-bounded organelle | 3 | 69 |
GO:0110165 | cellular anatomical entity | 1 | 69 |
GO:0120025 | plasma membrane bounded cell projection | 3 | 69 |
GO:0016020 | membrane | 2 | 24 |
GO:0005886 | plasma membrane | 3 | 5 |
Related structures:
AlphaFold database: E9AGH0
Term | Name | Level | Count |
---|---|---|---|
GO:0003824 | catalytic activity | 1 | 3 |
GO:0004672 | protein kinase activity | 3 | 3 |
GO:0004674 | protein serine/threonine kinase activity | 4 | 3 |
GO:0016301 | kinase activity | 4 | 3 |
GO:0016740 | transferase activity | 2 | 3 |
GO:0016772 | transferase activity, transferring phosphorus-containing groups | 3 | 3 |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 4 | 3 |
GO:0140096 | catalytic activity, acting on a protein | 2 | 3 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_NRD_NRD_1 | 6 | 8 | PF00675 | 0.713 |
CLV_PCSK_KEX2_1 | 6 | 8 | PF00082 | 0.713 |
CLV_PCSK_SKI1_1 | 255 | 259 | PF00082 | 0.543 |
CLV_PCSK_SKI1_1 | 31 | 35 | PF00082 | 0.605 |
CLV_PCSK_SKI1_1 | 7 | 11 | PF00082 | 0.689 |
DEG_APCC_KENBOX_2 | 33 | 37 | PF00400 | 0.346 |
DEG_SCF_FBW7_2 | 305 | 310 | PF00400 | 0.402 |
DOC_AGCK_PIF_2 | 69 | 74 | PF00069 | 0.263 |
DOC_CYCLIN_RxL_1 | 3 | 13 | PF00134 | 0.474 |
DOC_MAPK_MEF2A_6 | 277 | 284 | PF00069 | 0.348 |
DOC_USP7_MATH_1 | 192 | 196 | PF00917 | 0.411 |
DOC_USP7_MATH_1 | 216 | 220 | PF00917 | 0.262 |
DOC_USP7_MATH_1 | 257 | 261 | PF00917 | 0.441 |
DOC_USP7_MATH_1 | 353 | 357 | PF00917 | 0.470 |
DOC_USP7_MATH_1 | 41 | 45 | PF00917 | 0.478 |
DOC_WW_Pin1_4 | 301 | 306 | PF00397 | 0.406 |
LIG_14-3-3_CanoR_1 | 43 | 48 | PF00244 | 0.445 |
LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.603 |
LIG_FHA_1 | 103 | 109 | PF00498 | 0.314 |
LIG_FHA_1 | 131 | 137 | PF00498 | 0.337 |
LIG_FHA_1 | 145 | 151 | PF00498 | 0.351 |
LIG_FHA_1 | 341 | 347 | PF00498 | 0.377 |
LIG_FHA_1 | 44 | 50 | PF00498 | 0.423 |
LIG_FHA_2 | 108 | 114 | PF00498 | 0.331 |
LIG_FHA_2 | 183 | 189 | PF00498 | 0.355 |
LIG_FHA_2 | 207 | 213 | PF00498 | 0.346 |
LIG_FHA_2 | 309 | 315 | PF00498 | 0.494 |
LIG_FHA_2 | 37 | 43 | PF00498 | 0.292 |
LIG_FHA_2 | 92 | 98 | PF00498 | 0.404 |
LIG_LIR_Gen_1 | 101 | 112 | PF02991 | 0.439 |
LIG_LIR_Gen_1 | 113 | 121 | PF02991 | 0.388 |
LIG_LIR_Gen_1 | 128 | 136 | PF02991 | 0.316 |
LIG_LIR_Gen_1 | 153 | 160 | PF02991 | 0.356 |
LIG_LIR_Gen_1 | 248 | 257 | PF02991 | 0.405 |
LIG_LIR_Nem_3 | 101 | 107 | PF02991 | 0.427 |
LIG_PCNA_PIPBox_1 | 132 | 141 | PF02747 | 0.245 |
LIG_PDZ_Class_2 | 372 | 377 | PF00595 | 0.282 |
LIG_SH2_CRK | 104 | 108 | PF00017 | 0.459 |
LIG_SH2_GRB2like | 104 | 107 | PF00017 | 0.458 |
LIG_SH2_STAP1 | 104 | 108 | PF00017 | 0.460 |
LIG_SH2_STAP1 | 78 | 82 | PF00017 | 0.296 |
LIG_SH2_STAT5 | 104 | 107 | PF00017 | 0.364 |
LIG_SH2_STAT5 | 336 | 339 | PF00017 | 0.467 |
LIG_SH2_STAT5 | 347 | 350 | PF00017 | 0.341 |
LIG_SH2_STAT5 | 74 | 77 | PF00017 | 0.367 |
LIG_SH3_3 | 93 | 99 | PF00018 | 0.428 |
LIG_SUMO_SIM_anti_2 | 182 | 188 | PF11976 | 0.264 |
LIG_SUMO_SIM_anti_2 | 206 | 212 | PF11976 | 0.254 |
LIG_SUMO_SIM_par_1 | 107 | 113 | PF11976 | 0.245 |
LIG_TYR_ITIM | 102 | 107 | PF00017 | 0.440 |
LIG_UBA3_1 | 186 | 193 | PF00899 | 0.246 |
LIG_UBA3_1 | 210 | 217 | PF00899 | 0.250 |
MOD_CK1_1 | 128 | 134 | PF00069 | 0.396 |
MOD_CK1_1 | 153 | 159 | PF00069 | 0.361 |
MOD_CK1_1 | 179 | 185 | PF00069 | 0.393 |
MOD_CK1_1 | 203 | 209 | PF00069 | 0.401 |
MOD_CK1_1 | 221 | 227 | PF00069 | 0.377 |
MOD_CK1_1 | 245 | 251 | PF00069 | 0.378 |
MOD_CK1_1 | 340 | 346 | PF00069 | 0.267 |
MOD_CK1_1 | 80 | 86 | PF00069 | 0.330 |
MOD_CK2_1 | 308 | 314 | PF00069 | 0.384 |
MOD_CK2_1 | 36 | 42 | PF00069 | 0.354 |
MOD_CK2_1 | 53 | 59 | PF00069 | 0.293 |
MOD_CK2_1 | 91 | 97 | PF00069 | 0.410 |
MOD_Cter_Amidation | 60 | 63 | PF01082 | 0.461 |
MOD_GlcNHglycan | 113 | 117 | PF01048 | 0.532 |
MOD_GlcNHglycan | 121 | 124 | PF01048 | 0.568 |
MOD_GlcNHglycan | 170 | 173 | PF01048 | 0.597 |
MOD_GlcNHglycan | 194 | 197 | PF01048 | 0.557 |
MOD_GlcNHglycan | 218 | 221 | PF01048 | 0.633 |
MOD_GlcNHglycan | 225 | 229 | PF01048 | 0.637 |
MOD_GlcNHglycan | 230 | 233 | PF01048 | 0.614 |
MOD_GlcNHglycan | 241 | 245 | PF01048 | 0.582 |
MOD_GlcNHglycan | 25 | 28 | PF01048 | 0.745 |
MOD_GlcNHglycan | 250 | 253 | PF01048 | 0.573 |
MOD_GlcNHglycan | 324 | 327 | PF01048 | 0.563 |
MOD_GlcNHglycan | 356 | 359 | PF01048 | 0.290 |
MOD_GlcNHglycan | 79 | 82 | PF01048 | 0.535 |
MOD_GSK3_1 | 121 | 128 | PF00069 | 0.374 |
MOD_GSK3_1 | 130 | 137 | PF00069 | 0.377 |
MOD_GSK3_1 | 146 | 153 | PF00069 | 0.321 |
MOD_GSK3_1 | 176 | 183 | PF00069 | 0.356 |
MOD_GSK3_1 | 200 | 207 | PF00069 | 0.412 |
MOD_GSK3_1 | 224 | 231 | PF00069 | 0.395 |
MOD_GSK3_1 | 242 | 249 | PF00069 | 0.356 |
MOD_GSK3_1 | 336 | 343 | PF00069 | 0.439 |
MOD_GSK3_1 | 76 | 83 | PF00069 | 0.358 |
MOD_N-GLC_2 | 297 | 299 | PF02516 | 0.544 |
MOD_NEK2_1 | 10 | 15 | PF00069 | 0.601 |
MOD_NEK2_1 | 112 | 117 | PF00069 | 0.368 |
MOD_NEK2_1 | 121 | 126 | PF00069 | 0.428 |
MOD_NEK2_1 | 165 | 170 | PF00069 | 0.337 |
MOD_NEK2_1 | 21 | 26 | PF00069 | 0.578 |
MOD_NEK2_1 | 242 | 247 | PF00069 | 0.365 |
MOD_NEK2_1 | 53 | 58 | PF00069 | 0.349 |
MOD_PIKK_1 | 165 | 171 | PF00454 | 0.259 |
MOD_PKA_2 | 119 | 125 | PF00069 | 0.345 |
MOD_PKA_2 | 144 | 150 | PF00069 | 0.384 |
MOD_Plk_1 | 112 | 118 | PF00069 | 0.365 |
MOD_Plk_1 | 340 | 346 | PF00069 | 0.435 |
MOD_Plk_4 | 131 | 137 | PF00069 | 0.364 |
MOD_Plk_4 | 182 | 188 | PF00069 | 0.382 |
MOD_Plk_4 | 206 | 212 | PF00069 | 0.337 |
MOD_Plk_4 | 80 | 86 | PF00069 | 0.435 |
MOD_ProDKin_1 | 301 | 307 | PF00069 | 0.407 |
MOD_SUMO_rev_2 | 283 | 291 | PF00179 | 0.303 |
TRG_DiLeu_BaEn_1 | 341 | 346 | PF01217 | 0.271 |
TRG_ENDOCYTIC_2 | 104 | 107 | PF00928 | 0.445 |
TRG_ER_diArg_1 | 5 | 7 | PF00400 | 0.640 |
TRG_Pf-PMV_PEXEL_1 | 55 | 59 | PF00026 | 0.511 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0N0P276 | Leptomonas seymouri | 30% | 100% |
A0A0N0P2L4 | Leptomonas seymouri | 40% | 100% |
A0A0N0P4M2 | Leptomonas seymouri | 27% | 100% |
A0A0N1I121 | Leptomonas seymouri | 30% | 75% |
A0A0N1I661 | Leptomonas seymouri | 36% | 66% |
A0A0N1I7S5 | Leptomonas seymouri | 31% | 74% |
A0A0S4IZC7 | Bodo saltans | 24% | 92% |
A0A0S4J1A6 | Bodo saltans | 23% | 87% |
A0A0S4JBV9 | Bodo saltans | 27% | 77% |
A0A0S4JL29 | Bodo saltans | 32% | 74% |
A0A0S4KMV2 | Bodo saltans | 30% | 96% |
A0A3Q8I9A6 | Leishmania donovani | 83% | 98% |
A0A3Q8I9D0 | Leishmania donovani | 60% | 100% |
A0A3Q8IFC2 | Leishmania donovani | 38% | 86% |
A0A3Q8IIJ9 | Leishmania donovani | 35% | 100% |
A0A3Q8IK15 | Leishmania donovani | 37% | 72% |
A0A3S5H6D6 | Leishmania donovani | 29% | 100% |
A0A3S7WP69 | Leishmania donovani | 21% | 100% |
A0A3S7WPB2 | Leishmania donovani | 26% | 100% |
A0A3S7X4J4 | Leishmania donovani | 34% | 100% |
A4H4D2 | Leishmania braziliensis | 22% | 100% |
A4H4G6 | Leishmania braziliensis | 24% | 100% |
A4H5P0 | Leishmania braziliensis | 30% | 100% |
A4HBX3 | Leishmania braziliensis | 33% | 83% |
A4HJC8 | Leishmania braziliensis | 34% | 100% |
A4HJX1 | Leishmania braziliensis | 41% | 86% |
A4HSL2 | Leishmania infantum | 21% | 100% |
A4HTX9 | Leishmania infantum | 29% | 100% |
A4HVB0 | Leishmania infantum | 56% | 100% |
A4I6S2 | Leishmania infantum | 37% | 86% |
A4I6S3 | Leishmania infantum | 37% | 75% |
A4I6S4 | Leishmania infantum | 35% | 100% |
D1GJ51 | Leishmania infantum | 56% | 100% |
E8NHG5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 85% |
E8NHP8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
E9ACQ0 | Leishmania major | 27% | 100% |
E9AEF4 | Leishmania major | 41% | 82% |
E9AG65 | Leishmania infantum | 26% | 100% |
E9AGG5 | Leishmania infantum | 76% | 100% |
E9AGG9 | Leishmania infantum | 50% | 70% |
E9AKJ6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 21% | 100% |
E9AKM8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 100% |
E9AMQ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 96% |
E9AP00 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 36% | 99% |
E9AP02 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 63% | 93% |
E9AP03 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 69% | 100% |
E9AP05 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 48% | 73% |
E9AP07 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 65% | 94% |
E9AP08 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 63% | 100% |
E9AVA1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 82% |
E9B1U3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 41% | 83% |
E9B1U4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 33% | 100% |
E9B1U5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 90% |
E9B1U6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 34% | 100% |
P21978 | Leishmania amazonensis | 48% | 79% |
P35334 | Phaseolus vulgaris | 20% | 100% |
P58822 | Phaseolus vulgaris | 21% | 100% |
Q25331 | Leishmania major | 55% | 89% |
Q4PSE6 | Arabidopsis thaliana | 23% | 87% |
Q4Q6B6 | Leishmania major | 35% | 100% |
Q4Q6B7 | Leishmania major | 35% | 100% |
Q4Q6B8 | Leishmania major | 38% | 71% |
Q4QGI0 | Leishmania major | 49% | 74% |
Q4QGI2 | Leishmania major | 45% | 67% |
Q4QGI4 | Leishmania major | 48% | 70% |
Q4QGI6 | Leishmania major | 48% | 69% |
Q4QGJ4 | Leishmania major | 55% | 89% |
Q4QGJ7 | Leishmania major | 56% | 89% |
Q4QGK0 | Leishmania major | 53% | 66% |
Q4QGK2 | Leishmania major | 51% | 67% |
Q4QGK6 | Leishmania major | 55% | 89% |
Q4QGK8 | Leishmania major | 50% | 74% |
Q4QGL2 | Leishmania major | 50% | 74% |
Q4QGL4 | Leishmania major | 64% | 99% |
Q4QGL5 | Leishmania major | 51% | 69% |
Q4QHW6 | Leishmania major | 28% | 100% |
Q4QJB2 | Leishmania major | 21% | 100% |