LeishMANIAdb
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Putative surface antigen protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein
Gene product:
surface antigen protein 2 - putative
Species:
Leishmania infantum
UniProt:
E9AGG9_LEIIN
TriTrypDb:
LINF_120013500
Length:
541

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Annotations by Jardim et al.

Plasma membrane, surface antigen LINJ.12.0671

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 150
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 66, no: 12
NetGPI no yes: 0, no: 78
Cellular components
Term Name Level Count
GO:0005929 cilium 4 79
GO:0042995 cell projection 2 79
GO:0043226 organelle 2 79
GO:0043227 membrane-bounded organelle 3 79
GO:0110165 cellular anatomical entity 1 79
GO:0120025 plasma membrane bounded cell projection 3 79
GO:0016020 membrane 2 34
GO:0005886 plasma membrane 3 6

Expansion

Sequence features

E9AGG9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGG9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 311 313 PF00675 0.496
CLV_NRD_NRD_1 359 361 PF00675 0.247
CLV_NRD_NRD_1 43 45 PF00675 0.541
CLV_NRD_NRD_1 6 8 PF00675 0.697
CLV_PCSK_KEX2_1 311 313 PF00082 0.486
CLV_PCSK_KEX2_1 359 361 PF00082 0.247
CLV_PCSK_KEX2_1 43 45 PF00082 0.251
CLV_PCSK_KEX2_1 6 8 PF00082 0.697
CLV_PCSK_SKI1_1 154 158 PF00082 0.283
CLV_PCSK_SKI1_1 231 235 PF00082 0.431
CLV_PCSK_SKI1_1 300 304 PF00082 0.479
CLV_PCSK_SKI1_1 375 379 PF00082 0.472
CLV_PCSK_SKI1_1 399 403 PF00082 0.475
CLV_PCSK_SKI1_1 7 11 PF00082 0.650
DEG_APCC_DBOX_1 43 51 PF00400 0.264
DEG_SPOP_SBC_1 522 526 PF00917 0.681
DOC_CYCLIN_RxL_1 107 116 PF00134 0.283
DOC_CYCLIN_RxL_1 187 197 PF00134 0.284
DOC_CYCLIN_RxL_1 3 13 PF00134 0.691
DOC_CYCLIN_yClb5_NLxxxL_5 286 295 PF00134 0.440
DOC_CYCLIN_yClb5_NLxxxL_5 454 463 PF00134 0.251
DOC_MAPK_gen_1 154 164 PF00069 0.232
DOC_MAPK_gen_1 43 49 PF00069 0.341
DOC_MAPK_MEF2A_6 494 501 PF00069 0.435
DOC_PP1_RVXF_1 108 115 PF00149 0.315
DOC_USP7_MATH_1 203 207 PF00917 0.404
DOC_USP7_MATH_1 274 278 PF00917 0.524
DOC_USP7_MATH_2 175 181 PF00917 0.440
DOC_USP7_MATH_2 224 230 PF00917 0.416
DOC_USP7_MATH_2 296 302 PF00917 0.393
DOC_USP7_MATH_2 344 350 PF00917 0.281
DOC_USP7_MATH_2 368 374 PF00917 0.342
LIG_14-3-3_CanoR_1 300 306 PF00244 0.365
LIG_14-3-3_CanoR_1 359 367 PF00244 0.344
LIG_14-3-3_CanoR_1 418 423 PF00244 0.446
LIG_14-3-3_CanoR_1 43 48 PF00244 0.529
LIG_Actin_WH2_2 298 313 PF00022 0.532
LIG_BIR_II_1 1 5 PF00653 0.660
LIG_BRCT_BRCA1_1 303 307 PF00533 0.423
LIG_DLG_GKlike_1 418 425 PF00625 0.230
LIG_FHA_1 120 126 PF00498 0.262
LIG_FHA_1 184 190 PF00498 0.340
LIG_FHA_1 218 224 PF00498 0.370
LIG_FHA_1 281 287 PF00498 0.335
LIG_FHA_1 292 298 PF00498 0.338
LIG_FHA_1 328 334 PF00498 0.355
LIG_FHA_1 401 407 PF00498 0.295
LIG_FHA_1 44 50 PF00498 0.537
LIG_FHA_2 122 128 PF00498 0.422
LIG_FHA_2 445 451 PF00498 0.425
LIG_FHA_2 46 52 PF00498 0.254
LIG_FHA_2 526 532 PF00498 0.555
LIG_FHA_2 63 69 PF00498 0.445
LIG_FHA_2 92 98 PF00498 0.542
LIG_LIR_Gen_1 103 112 PF02991 0.550
LIG_LIR_Gen_1 113 121 PF02991 0.533
LIG_LIR_Gen_1 127 137 PF02991 0.357
LIG_LIR_Gen_1 176 184 PF02991 0.389
LIG_LIR_Gen_1 201 208 PF02991 0.352
LIG_LIR_Gen_1 226 233 PF02991 0.326
LIG_LIR_Gen_1 304 315 PF02991 0.343
LIG_LIR_Gen_1 346 355 PF02991 0.283
LIG_LIR_Gen_1 370 379 PF02991 0.299
LIG_LIR_Gen_1 442 451 PF02991 0.413
LIG_LIR_Gen_1 455 464 PF02991 0.520
LIG_LIR_Gen_1 466 473 PF02991 0.508
LIG_LIR_Nem_3 103 107 PF02991 0.568
LIG_LIR_Nem_3 127 132 PF02991 0.407
LIG_LIR_Nem_3 136 140 PF02991 0.321
LIG_LIR_Nem_3 289 295 PF02991 0.445
LIG_LIR_Nem_3 304 310 PF02991 0.292
LIG_LIR_Nem_3 455 459 PF02991 0.268
LIG_NRBOX 183 189 PF00104 0.453
LIG_PCNA_PIPBox_1 156 165 PF02747 0.419
LIG_PCNA_PIPBox_1 230 239 PF02747 0.484
LIG_PTB_Apo_2 426 433 PF02174 0.307
LIG_PTB_Phospho_1 426 432 PF10480 0.350
LIG_SH2_CRK 104 108 PF00017 0.539
LIG_SH2_CRK 292 296 PF00017 0.267
LIG_SH2_CRK 384 388 PF00017 0.383
LIG_SH2_CRK 432 436 PF00017 0.238
LIG_SH2_CRK 456 460 PF00017 0.255
LIG_SH2_GRB2like 104 107 PF00017 0.244
LIG_SH2_NCK_1 384 388 PF00017 0.242
LIG_SH2_NCK_1 432 436 PF00017 0.235
LIG_SH2_STAP1 104 108 PF00017 0.260
LIG_SH2_STAT5 104 107 PF00017 0.557
LIG_SH2_STAT5 309 312 PF00017 0.378
LIG_SH2_STAT5 384 387 PF00017 0.331
LIG_SH2_STAT5 432 435 PF00017 0.354
LIG_SH2_STAT5 456 459 PF00017 0.409
LIG_SH3_2 96 101 PF14604 0.253
LIG_SH3_3 93 99 PF00018 0.408
LIG_SUMO_SIM_anti_2 327 333 PF11976 0.501
LIG_SUMO_SIM_anti_2 376 381 PF11976 0.388
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.365
LIG_SUMO_SIM_par_1 45 51 PF11976 0.361
LIG_TYR_ITIM 102 107 PF00017 0.566
LIG_TYR_ITIM 382 387 PF00017 0.491
LIG_TYR_ITIM 430 435 PF00017 0.367
LIG_TYR_ITIM 454 459 PF00017 0.493
LIG_UBA3_1 379 386 PF00899 0.229
LIG_UBA3_1 427 434 PF00899 0.224
LIG_WRC_WIRS_1 134 139 PF05994 0.317
LIG_WW_3 415 419 PF00397 0.239
MOD_CK1_1 152 158 PF00069 0.466
MOD_CK1_1 173 179 PF00069 0.392
MOD_CK1_1 207 213 PF00069 0.359
MOD_CK1_1 229 235 PF00069 0.376
MOD_CK1_1 241 247 PF00069 0.299
MOD_CK1_1 265 271 PF00069 0.323
MOD_CK1_1 276 282 PF00069 0.331
MOD_CK1_1 301 307 PF00069 0.344
MOD_CK1_1 324 330 PF00069 0.363
MOD_CK1_1 349 355 PF00069 0.293
MOD_CK1_1 373 379 PF00069 0.350
MOD_CK1_1 397 403 PF00069 0.358
MOD_CK1_1 420 426 PF00069 0.308
MOD_CK1_1 444 450 PF00069 0.455
MOD_CK2_1 121 127 PF00069 0.422
MOD_CK2_1 444 450 PF00069 0.494
MOD_CK2_1 45 51 PF00069 0.259
MOD_CK2_1 525 531 PF00069 0.586
MOD_CK2_1 91 97 PF00069 0.403
MOD_Cter_Amidation 60 63 PF01082 0.265
MOD_GlcNHglycan 140 143 PF01048 0.431
MOD_GlcNHglycan 145 148 PF01048 0.419
MOD_GlcNHglycan 170 173 PF01048 0.376
MOD_GlcNHglycan 194 197 PF01048 0.395
MOD_GlcNHglycan 243 246 PF01048 0.345
MOD_GlcNHglycan 25 28 PF01048 0.604
MOD_GlcNHglycan 267 270 PF01048 0.360
MOD_GlcNHglycan 315 318 PF01048 0.391
MOD_GlcNHglycan 339 342 PF01048 0.401
MOD_GlcNHglycan 363 366 PF01048 0.416
MOD_GlcNHglycan 387 390 PF01048 0.362
MOD_GlcNHglycan 411 414 PF01048 0.331
MOD_GlcNHglycan 435 438 PF01048 0.437
MOD_GlcNHglycan 447 450 PF01048 0.409
MOD_GlcNHglycan 459 462 PF01048 0.431
MOD_GlcNHglycan 466 470 PF01048 0.549
MOD_GlcNHglycan 84 87 PF01048 0.434
MOD_GSK3_1 121 128 PF00069 0.403
MOD_GSK3_1 145 152 PF00069 0.367
MOD_GSK3_1 166 173 PF00069 0.420
MOD_GSK3_1 179 186 PF00069 0.351
MOD_GSK3_1 203 210 PF00069 0.412
MOD_GSK3_1 225 232 PF00069 0.336
MOD_GSK3_1 273 280 PF00069 0.351
MOD_GSK3_1 32 39 PF00069 0.534
MOD_GSK3_1 321 328 PF00069 0.370
MOD_GSK3_1 345 352 PF00069 0.317
MOD_GSK3_1 354 361 PF00069 0.269
MOD_GSK3_1 369 376 PF00069 0.301
MOD_GSK3_1 393 400 PF00069 0.406
MOD_GSK3_1 417 424 PF00069 0.319
MOD_GSK3_1 441 448 PF00069 0.465
MOD_GSK3_1 517 524 PF00069 0.685
MOD_GSK3_1 87 94 PF00069 0.467
MOD_N-GLC_1 143 148 PF02516 0.373
MOD_N-GLC_1 238 243 PF02516 0.288
MOD_N-GLC_1 457 462 PF02516 0.351
MOD_N-GLC_2 514 516 PF02516 0.675
MOD_NEK2_1 10 15 PF00069 0.532
MOD_NEK2_1 119 124 PF00069 0.384
MOD_NEK2_1 138 143 PF00069 0.354
MOD_NEK2_1 149 154 PF00069 0.338
MOD_NEK2_1 192 197 PF00069 0.399
MOD_NEK2_1 21 26 PF00069 0.538
MOD_NEK2_1 211 216 PF00069 0.308
MOD_NEK2_1 262 267 PF00069 0.313
MOD_NEK2_1 286 291 PF00069 0.296
MOD_NEK2_1 310 315 PF00069 0.378
MOD_NEK2_1 334 339 PF00069 0.399
MOD_NEK2_1 358 363 PF00069 0.315
MOD_NEK2_1 382 387 PF00069 0.326
MOD_NEK2_1 406 411 PF00069 0.301
MOD_NEK2_1 430 435 PF00069 0.417
MOD_NEK2_1 459 464 PF00069 0.465
MOD_NEK2_1 71 76 PF00069 0.521
MOD_NEK2_2 204 209 PF00069 0.268
MOD_NEK2_2 351 356 PF00069 0.280
MOD_PIKK_1 262 268 PF00454 0.416
MOD_PIKK_1 334 340 PF00454 0.463
MOD_PIKK_1 358 364 PF00454 0.453
MOD_PIKK_1 406 412 PF00454 0.427
MOD_PKA_1 43 49 PF00069 0.219
MOD_PKA_1 62 68 PF00069 0.324
MOD_PKA_2 310 316 PF00069 0.490
MOD_PKA_2 358 364 PF00069 0.366
MOD_PKA_2 417 423 PF00069 0.304
MOD_PKA_2 43 49 PF00069 0.368
MOD_Plk_1 176 182 PF00069 0.394
MOD_Plk_1 225 231 PF00069 0.307
MOD_Plk_1 238 244 PF00069 0.317
MOD_Plk_1 345 351 PF00069 0.281
MOD_Plk_1 369 375 PF00069 0.324
MOD_Plk_1 441 447 PF00069 0.527
MOD_Plk_1 465 471 PF00069 0.602
MOD_Plk_1 474 480 PF00069 0.452
MOD_Plk_4 133 139 PF00069 0.272
MOD_Plk_4 183 189 PF00069 0.380
MOD_Plk_4 232 238 PF00069 0.346
MOD_Plk_4 327 333 PF00069 0.366
MOD_Plk_4 351 357 PF00069 0.295
MOD_Plk_4 375 381 PF00069 0.343
MOD_Plk_4 45 51 PF00069 0.376
MOD_Plk_4 71 77 PF00069 0.318
MOD_SUMO_rev_2 509 518 PF00179 0.657
TRG_ENDOCYTIC_2 104 107 PF00928 0.558
TRG_ENDOCYTIC_2 292 295 PF00928 0.266
TRG_ENDOCYTIC_2 384 387 PF00928 0.356
TRG_ENDOCYTIC_2 432 435 PF00928 0.403
TRG_ENDOCYTIC_2 456 459 PF00928 0.538
TRG_ER_diArg_1 310 312 PF00400 0.523
TRG_ER_diArg_1 358 360 PF00400 0.247
TRG_ER_diArg_1 5 7 PF00400 0.692
TRG_Pf-PMV_PEXEL_1 157 161 PF00026 0.232
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.563

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 30% 85%
A0A0N1I661 Leptomonas seymouri 38% 95%
A0A0N1I7S5 Leptomonas seymouri 34% 100%
A0A0S4IHI7 Bodo saltans 31% 70%
A0A0S4IJN2 Bodo saltans 29% 80%
A0A0S4ILC9 Bodo saltans 39% 98%
A0A0S4IN27 Bodo saltans 38% 100%
A0A0S4IQE4 Bodo saltans 26% 95%
A0A0S4ISU4 Bodo saltans 36% 82%
A0A0S4IT62 Bodo saltans 45% 73%
A0A0S4IU23 Bodo saltans 29% 91%
A0A0S4IU73 Bodo saltans 41% 100%
A0A0S4IV96 Bodo saltans 39% 89%
A0A0S4IVQ8 Bodo saltans 36% 90%
A0A0S4IW93 Bodo saltans 29% 89%
A0A0S4IY44 Bodo saltans 26% 81%
A0A0S4J014 Bodo saltans 30% 76%
A0A0S4J206 Bodo saltans 34% 88%
A0A0S4J2H8 Bodo saltans 30% 92%
A0A0S4J4L7 Bodo saltans 25% 73%
A0A0S4J5A0 Bodo saltans 39% 95%
A0A0S4J954 Bodo saltans 29% 73%
A0A0S4JAQ6 Bodo saltans 29% 100%
A0A0S4JAS1 Bodo saltans 33% 85%
A0A0S4JB95 Bodo saltans 25% 89%
A0A0S4JBV9 Bodo saltans 29% 100%
A0A0S4JD35 Bodo saltans 31% 90%
A0A0S4JDS1 Bodo saltans 26% 100%
A0A0S4JDT0 Bodo saltans 33% 82%
A0A0S4JEK1 Bodo saltans 28% 100%
A0A0S4JL29 Bodo saltans 35% 100%
A0A0S4JQZ0 Bodo saltans 25% 72%
A0A0S4JS89 Bodo saltans 27% 100%
A0A0S4JSD2 Bodo saltans 28% 67%
A0A0S4JTM6 Bodo saltans 35% 73%
A0A0S4JTQ7 Bodo saltans 37% 100%
A0A0S4JVI0 Bodo saltans 30% 76%
A0A0S4KGV4 Bodo saltans 26% 99%
A0A0S4KH41 Bodo saltans 32% 78%
A0A0S4KJA7 Bodo saltans 28% 81%
A0A0S4KK37 Bodo saltans 32% 93%
A0A3Q8I9A6 Leishmania donovani 46% 100%
A0A3Q8IC27 Leishmania donovani 35% 100%
A0A3S5H6M3 Leishmania donovani 54% 79%
A0A3S5H6M4 Leishmania donovani 62% 82%
A0A3S7WS66 Leishmania donovani 62% 82%
A4HBX3 Leishmania braziliensis 35% 100%
A4HVB0 Leishmania infantum 49% 100%
A4HZ93 Leishmania infantum 37% 100%
A6QLV3 Bos taurus 25% 93%
B3LWU3 Drosophila ananassae 22% 84%
B4N9T4 Drosophila willistoni 23% 84%
B5DX45 Drosophila pseudoobscura pseudoobscura 21% 86%
D1GJ51 Leishmania infantum 63% 100%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AGG2 Leishmania infantum 59% 100%
E9AGG5 Leishmania infantum 44% 100%
E9AGG7 Leishmania infantum 57% 100%
E9AGH0 Leishmania infantum 50% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 100%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 98%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
F4IUU1 Arabidopsis thaliana 23% 67%
F4JGB6 Arabidopsis thaliana 26% 67%
F4JTU7 Arabidopsis thaliana 24% 67%
F4KHA2 Arabidopsis thaliana 21% 68%
O48851 Arabidopsis thaliana 22% 70%
O49325 Arabidopsis thaliana 24% 70%
O49328 Arabidopsis thaliana 23% 68%
O80809 Arabidopsis thaliana 27% 75%
O88520 Mus musculus 25% 93%
Q1PEN0 Arabidopsis thaliana 23% 75%
Q25331 Leishmania major 56% 100%
Q4QC79 Leishmania major 38% 100%
Q4QGI0 Leishmania major 79% 95%
Q4QGI2 Leishmania major 60% 100%
Q4QGI4 Leishmania major 65% 100%
Q4QGI6 Leishmania major 54% 100%
Q4QGI8 Leishmania major 59% 100%
Q4QGJ0 Leishmania major 56% 100%
Q4QGJ2 Leishmania major 51% 100%
Q4QGJ4 Leishmania major 56% 100%
Q4QGJ7 Leishmania major 56% 100%
Q4QGJ9 Leishmania major 59% 100%
Q4QGK0 Leishmania major 60% 100%
Q4QGK1 Leishmania major 56% 100%
Q4QGK2 Leishmania major 57% 100%
Q4QGK4 Leishmania major 52% 100%
Q4QGK6 Leishmania major 57% 100%
Q4QGK8 Leishmania major 60% 99%
Q4QGL2 Leishmania major 60% 99%
Q4QGL4 Leishmania major 56% 100%
Q4QGL8 Leishmania major 59% 100%
Q4QGM1 Leishmania major 60% 70%
Q5RAV5 Pongo abelii 25% 93%
Q6AYI5 Rattus norvegicus 25% 93%
Q7FZR1 Arabidopsis thaliana 25% 67%
Q940E8 Zea mays 27% 88%
Q9C9H6 Arabidopsis thaliana 25% 69%
Q9LJW7 Arabidopsis thaliana 25% 76%
Q9LS79 Arabidopsis thaliana 22% 69%
Q9MA83 Arabidopsis thaliana 25% 69%
Q9SHI3 Arabidopsis thaliana 24% 74%
Q9SHI4 Arabidopsis thaliana 21% 72%
Q9SKK5 Arabidopsis thaliana 23% 81%
Q9SVN2 Arabidopsis thaliana 25% 68%
Q9UQ13 Homo sapiens 25% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS