LeishMANIAdb
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Putative surface antigen protein 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein 2
Gene product:
surface antigen protein 2 - putative
Species:
Leishmania infantum
UniProt:
E9AGG7_LEIIN
TriTrypDb:
LINF_120015000
Length:
627

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 110
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 39, no: 8
NetGPI no yes: 0, no: 47
Cellular components
Term Name Level Count
GO:0005929 cilium 4 48
GO:0042995 cell projection 2 48
GO:0043226 organelle 2 48
GO:0043227 membrane-bounded organelle 3 48
GO:0110165 cellular anatomical entity 1 48
GO:0120025 plasma membrane bounded cell projection 3 48
GO:0016020 membrane 2 25
GO:0005886 plasma membrane 3 6

Expansion

Sequence features

E9AGG7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGG7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 123 127 PF00656 0.419
CLV_NRD_NRD_1 6 8 PF00675 0.754
CLV_PCSK_KEX2_1 6 8 PF00082 0.737
CLV_PCSK_SKI1_1 153 157 PF00082 0.627
CLV_PCSK_SKI1_1 184 188 PF00082 0.594
CLV_PCSK_SKI1_1 7 11 PF00082 0.735
CLV_PCSK_SKI1_1 87 91 PF00082 0.473
DEG_APCC_DBOX_1 398 406 PF00400 0.286
DEG_SCF_FBW7_2 555 560 PF00400 0.457
DEG_SPOP_SBC_1 456 460 PF00917 0.584
DEG_SPOP_SBC_1 464 468 PF00917 0.627
DEG_SPOP_SBC_1 474 478 PF00917 0.437
DEG_SPOP_SBC_1 482 486 PF00917 0.581
DEG_SPOP_SBC_1 492 496 PF00917 0.428
DEG_SPOP_SBC_1 500 504 PF00917 0.401
DEG_SPOP_SBC_1 508 512 PF00917 0.496
DEG_SPOP_SBC_1 518 522 PF00917 0.431
DEG_SPOP_SBC_1 526 530 PF00917 0.412
DEG_SPOP_SBC_1 534 538 PF00917 0.441
DOC_AGCK_PIF_2 69 74 PF00069 0.271
DOC_CKS1_1 115 120 PF01111 0.230
DOC_CYCLIN_RxL_1 105 117 PF00134 0.274
DOC_CYCLIN_RxL_1 184 196 PF00134 0.300
DOC_CYCLIN_RxL_1 254 264 PF00134 0.240
DOC_CYCLIN_RxL_1 3 13 PF00134 0.548
DOC_CYCLIN_yCln2_LP_2 266 272 PF00134 0.273
DOC_MAPK_gen_1 153 163 PF00069 0.250
DOC_MAPK_MEF2A_6 421 428 PF00069 0.506
DOC_PP1_RVXF_1 276 283 PF00149 0.233
DOC_PP4_FxxP_1 115 118 PF00568 0.233
DOC_USP7_MATH_1 214 218 PF00917 0.288
DOC_USP7_MATH_1 249 253 PF00917 0.339
DOC_USP7_MATH_1 604 608 PF00917 0.470
DOC_WW_Pin1_4 114 119 PF00397 0.228
DOC_WW_Pin1_4 261 266 PF00397 0.252
DOC_WW_Pin1_4 547 552 PF00397 0.610
DOC_WW_Pin1_4 553 558 PF00397 0.603
LIG_14-3-3_CanoR_1 153 159 PF00244 0.372
LIG_14-3-3_CanoR_1 194 198 PF00244 0.448
LIG_14-3-3_CanoR_1 278 283 PF00244 0.240
LIG_Actin_WH2_2 179 196 PF00022 0.260
LIG_Actin_WH2_2 249 264 PF00022 0.353
LIG_Actin_WH2_2 71 89 PF00022 0.225
LIG_BIR_II_1 1 5 PF00653 0.685
LIG_BRCT_BRCA1_1 70 74 PF00533 0.409
LIG_BRCT_BRCA1_2 70 76 PF00533 0.233
LIG_Clathr_ClatBox_1 207 211 PF01394 0.233
LIG_DLG_GKlike_1 278 285 PF00625 0.217
LIG_FHA_1 115 121 PF00498 0.291
LIG_FHA_1 168 174 PF00498 0.366
LIG_FHA_1 183 189 PF00498 0.301
LIG_FHA_1 203 209 PF00498 0.397
LIG_FHA_1 217 223 PF00498 0.416
LIG_FHA_1 265 271 PF00498 0.346
LIG_FHA_1 289 295 PF00498 0.298
LIG_FHA_1 304 310 PF00498 0.279
LIG_FHA_1 328 334 PF00498 0.403
LIG_FHA_1 44 50 PF00498 0.416
LIG_FHA_1 591 597 PF00498 0.432
LIG_FHA_2 121 127 PF00498 0.417
LIG_FHA_2 535 541 PF00498 0.616
LIG_FHA_2 559 565 PF00498 0.411
LIG_FHA_2 63 69 PF00498 0.447
LIG_GBD_Chelix_1 617 625 PF00786 0.182
LIG_LIR_Apic_2 113 118 PF02991 0.230
LIG_LIR_Gen_1 126 134 PF02991 0.358
LIG_LIR_Gen_1 176 183 PF02991 0.342
LIG_LIR_Gen_1 281 290 PF02991 0.324
LIG_LIR_Gen_1 393 402 PF02991 0.450
LIG_LIR_Gen_1 71 78 PF02991 0.448
LIG_LIR_Nem_3 103 107 PF02991 0.413
LIG_LIR_Nem_3 126 131 PF02991 0.371
LIG_LIR_Nem_3 281 285 PF02991 0.294
LIG_LIR_Nem_3 71 75 PF02991 0.347
LIG_NRBOX 182 188 PF00104 0.240
LIG_SH2_STAT5 586 589 PF00017 0.326
LIG_SH2_STAT5 597 600 PF00017 0.370
LIG_SH3_3 539 545 PF00018 0.592
LIG_SH3_3 93 99 PF00018 0.386
LIG_SUMO_SIM_anti_2 350 356 PF11976 0.256
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.431
LIG_SUMO_SIM_par_1 205 211 PF11976 0.274
LIG_SUMO_SIM_par_1 424 430 PF11976 0.493
LIG_SUMO_SIM_par_1 616 622 PF11976 0.186
LIG_TYR_ITIM 102 107 PF00017 0.457
MOD_CK1_1 151 157 PF00069 0.356
MOD_CK1_1 206 212 PF00069 0.330
MOD_CK1_1 227 233 PF00069 0.364
MOD_CK1_1 252 258 PF00069 0.307
MOD_CK1_1 264 270 PF00069 0.343
MOD_CK1_1 300 306 PF00069 0.313
MOD_CK1_1 323 329 PF00069 0.351
MOD_CK1_1 347 353 PF00069 0.391
MOD_CK1_1 36 42 PF00069 0.349
MOD_CK1_1 371 377 PF00069 0.380
MOD_CK1_1 543 549 PF00069 0.543
MOD_CK2_1 113 119 PF00069 0.252
MOD_CK2_1 534 540 PF00069 0.611
MOD_CK2_1 558 564 PF00069 0.563
MOD_GlcNHglycan 139 142 PF01048 0.604
MOD_GlcNHglycan 144 147 PF01048 0.624
MOD_GlcNHglycan 25 28 PF01048 0.705
MOD_GlcNHglycan 314 317 PF01048 0.633
MOD_GlcNHglycan 338 341 PF01048 0.625
MOD_GlcNHglycan 362 365 PF01048 0.575
MOD_GlcNHglycan 370 373 PF01048 0.571
MOD_GlcNHglycan 385 389 PF01048 0.559
MOD_GlcNHglycan 39 42 PF01048 0.482
MOD_GlcNHglycan 393 397 PF01048 0.566
MOD_GlcNHglycan 439 442 PF01048 0.599
MOD_GlcNHglycan 574 577 PF01048 0.653
MOD_GlcNHglycan 606 609 PF01048 0.415
MOD_GlcNHglycan 79 82 PF01048 0.583
MOD_GSK3_1 120 127 PF00069 0.377
MOD_GSK3_1 133 140 PF00069 0.290
MOD_GSK3_1 144 151 PF00069 0.371
MOD_GSK3_1 202 209 PF00069 0.379
MOD_GSK3_1 210 217 PF00069 0.379
MOD_GSK3_1 224 231 PF00069 0.338
MOD_GSK3_1 238 245 PF00069 0.277
MOD_GSK3_1 286 293 PF00069 0.368
MOD_GSK3_1 296 303 PF00069 0.322
MOD_GSK3_1 320 327 PF00069 0.354
MOD_GSK3_1 33 40 PF00069 0.431
MOD_GSK3_1 334 341 PF00069 0.350
MOD_GSK3_1 344 351 PF00069 0.411
MOD_GSK3_1 371 378 PF00069 0.366
MOD_GSK3_1 437 444 PF00069 0.479
MOD_GSK3_1 445 452 PF00069 0.539
MOD_GSK3_1 455 462 PF00069 0.490
MOD_GSK3_1 463 470 PF00069 0.533
MOD_GSK3_1 473 480 PF00069 0.520
MOD_GSK3_1 481 488 PF00069 0.459
MOD_GSK3_1 491 498 PF00069 0.476
MOD_GSK3_1 499 506 PF00069 0.519
MOD_GSK3_1 507 514 PF00069 0.458
MOD_GSK3_1 517 524 PF00069 0.478
MOD_GSK3_1 525 532 PF00069 0.452
MOD_GSK3_1 536 543 PF00069 0.574
MOD_GSK3_1 545 552 PF00069 0.565
MOD_GSK3_1 586 593 PF00069 0.405
MOD_GSK3_1 87 94 PF00069 0.457
MOD_N-GLC_2 435 437 PF02516 0.572
MOD_NEK2_1 10 15 PF00069 0.673
MOD_NEK2_1 120 125 PF00069 0.345
MOD_NEK2_1 137 142 PF00069 0.318
MOD_NEK2_1 182 187 PF00069 0.313
MOD_NEK2_1 193 198 PF00069 0.357
MOD_NEK2_1 21 26 PF00069 0.625
MOD_NEK2_1 210 215 PF00069 0.293
MOD_NEK2_1 242 247 PF00069 0.368
MOD_NEK2_1 285 290 PF00069 0.361
MOD_NEK2_1 309 314 PF00069 0.424
MOD_NEK2_1 333 338 PF00069 0.448
MOD_NEK2_1 357 362 PF00069 0.358
MOD_NEK2_1 386 391 PF00069 0.401
MOD_PIKK_1 357 363 PF00454 0.369
MOD_PK_1 165 171 PF00069 0.249
MOD_PKA_2 193 199 PF00069 0.375
MOD_Plk_1 238 244 PF00069 0.393
MOD_Plk_1 309 315 PF00069 0.354
MOD_Plk_1 392 398 PF00069 0.408
MOD_Plk_1 590 596 PF00069 0.345
MOD_Plk_2-3 68 74 PF00069 0.407
MOD_Plk_4 182 188 PF00069 0.362
MOD_Plk_4 203 209 PF00069 0.353
MOD_Plk_4 249 255 PF00069 0.349
MOD_Plk_4 278 284 PF00069 0.359
MOD_ProDKin_1 114 120 PF00069 0.225
MOD_ProDKin_1 261 267 PF00069 0.255
MOD_ProDKin_1 547 553 PF00069 0.610
MOD_SUMO_rev_2 427 433 PF00179 0.299
TRG_DiLeu_BaEn_1 591 596 PF01217 0.321
TRG_DiLeu_BaLyEn_6 178 183 PF01217 0.226
TRG_ENDOCYTIC_2 104 107 PF00928 0.443
TRG_ER_diArg_1 398 401 PF00400 0.305
TRG_ER_diArg_1 5 7 PF00400 0.697
TRG_Pf-PMV_PEXEL_1 377 382 PF00026 0.472
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.556

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I661 Leptomonas seymouri 35% 100%
A0A0S4IRQ2 Bodo saltans 29% 73%
A0A0S4IU91 Bodo saltans 24% 71%
A0A0S4IVQ8 Bodo saltans 32% 100%
A0A0S4IWB9 Bodo saltans 29% 76%
A0A0S4J014 Bodo saltans 27% 88%
A0A0S4J6M1 Bodo saltans 29% 68%
A0A0S4JAQ3 Bodo saltans 25% 70%
A0A0S4JAW7 Bodo saltans 25% 100%
A0A0S4JBI6 Bodo saltans 24% 74%
A0A0S4JTM6 Bodo saltans 29% 85%
A0A0S4KEG2 Bodo saltans 25% 75%
A0A0S4KF94 Bodo saltans 24% 72%
A0A0S4KIR5 Bodo saltans 24% 75%
A0A3Q8IC27 Leishmania donovani 32% 100%
A0A3S5H6M3 Leishmania donovani 59% 91%
A0A3S5H6M4 Leishmania donovani 47% 95%
A0A3S7WS66 Leishmania donovani 51% 95%
A4HBX3 Leishmania braziliensis 31% 100%
A4HM88 Leishmania braziliensis 26% 73%
A4HZ93 Leishmania infantum 32% 100%
C0LGE4 Arabidopsis thaliana 24% 71%
D1GJ51 Leishmania infantum 57% 100%
E9AGG2 Leishmania infantum 54% 100%
E9AGG5 Leishmania infantum 41% 94%
E9AGG9 Leishmania infantum 57% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 63% 89%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 90%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 95%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
F4JTU7 Arabidopsis thaliana 23% 77%
Q1PEN0 Arabidopsis thaliana 23% 87%
Q4QC79 Leishmania major 34% 100%
Q4QGI0 Leishmania major 57% 100%
Q4QGI2 Leishmania major 59% 100%
Q4QGI4 Leishmania major 59% 100%
Q4QGI6 Leishmania major 59% 100%
Q4QGI8 Leishmania major 59% 82%
Q4QGJ0 Leishmania major 53% 100%
Q4QGJ2 Leishmania major 54% 100%
Q4QGJ9 Leishmania major 58% 100%
Q4QGK0 Leishmania major 61% 100%
Q4QGK1 Leishmania major 57% 89%
Q4QGK2 Leishmania major 57% 100%
Q4QGK4 Leishmania major 49% 100%
Q4QGK8 Leishmania major 54% 100%
Q4QGL2 Leishmania major 54% 100%
Q4QGL8 Leishmania major 58% 100%
Q4QGM1 Leishmania major 59% 81%
Q9C9H6 Arabidopsis thaliana 21% 80%
Q9SHI3 Arabidopsis thaliana 23% 86%
Q9SVM3 Arabidopsis thaliana 21% 74%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS