Secreted protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

E9AGG6_LEIIN

TriTrypDb:

Length:

257

Annotations

LeishMANIAdb annotations

This is a highly disordered Cys-rich prote8in with spurious hydrophobic segments. Very low conservation.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGG6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051537	2 iron, 2 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	164	170	PF00089	0.550
CLV_NRD_NRD_1	184	186	PF00675	0.794
CLV_NRD_NRD_1	209	211	PF00675	0.691
CLV_NRD_NRD_1	234	236	PF00675	0.635
CLV_NRD_NRD_1	247	249	PF00675	0.670
CLV_NRD_NRD_1	44	46	PF00675	0.529
CLV_NRD_NRD_1	56	58	PF00675	0.498
CLV_NRD_NRD_1	87	89	PF00675	0.621
CLV_PCSK_FUR_1	42	46	PF00082	0.522
CLV_PCSK_KEX2_1	184	186	PF00082	0.794
CLV_PCSK_KEX2_1	209	211	PF00082	0.691
CLV_PCSK_KEX2_1	234	236	PF00082	0.635
CLV_PCSK_KEX2_1	247	249	PF00082	0.670
CLV_PCSK_KEX2_1	44	46	PF00082	0.529
CLV_PCSK_KEX2_1	56	58	PF00082	0.498
CLV_PCSK_KEX2_1	87	89	PF00082	0.621
CLV_PCSK_SKI1_1	237	241	PF00082	0.580
DEG_Nend_Nbox_1	1	3	PF02207	0.564
DEG_SPOP_SBC_1	139	143	PF00917	0.589
DOC_CDC14_PxL_1	225	233	PF14671	0.553
DOC_CKS1_1	95	100	PF01111	0.592
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.577
DOC_MAPK_gen_1	125	135	PF00069	0.584
DOC_MAPK_gen_1	56	63	PF00069	0.574
DOC_MAPK_gen_1	87	96	PF00069	0.606
DOC_MAPK_MEF2A_6	128	137	PF00069	0.580
DOC_PP2B_LxvP_1	129	132	PF13499	0.576
DOC_PP2B_LxvP_1	135	138	PF13499	0.544
DOC_USP7_MATH_1	139	143	PF00917	0.589
DOC_USP7_MATH_1	224	228	PF00917	0.541
DOC_USP7_MATH_1	35	39	PF00917	0.480
DOC_WW_Pin1_4	127	132	PF00397	0.583
DOC_WW_Pin1_4	152	157	PF00397	0.638
DOC_WW_Pin1_4	94	99	PF00397	0.593
LIG_14-3-3_CanoR_1	165	171	PF00244	0.548
LIG_14-3-3_CanoR_1	237	246	PF00244	0.592
LIG_14-3-3_CanoR_1	247	251	PF00244	0.593
LIG_14-3-3_CanoR_1	65	70	PF00244	0.574
LIG_CtBP_PxDLS_1	121	125	PF00389	0.588
LIG_FHA_1	139	145	PF00498	0.595
LIG_FHA_1	98	104	PF00498	0.588
LIG_FHA_2	202	208	PF00498	0.836
LIG_LIR_Nem_3	62	67	PF02991	0.552
LIG_MYND_1	152	156	PF01753	0.568
LIG_PDZ_Wminus1_1	255	257	PF00595	0.597
LIG_SH2_STAT5	2	5	PF00017	0.551
LIG_SH2_STAT5	66	69	PF00017	0.573
LIG_SH3_2	148	153	PF14604	0.583
LIG_SH3_2	229	234	PF14604	0.801
LIG_SH3_3	145	151	PF00018	0.829
LIG_SH3_3	223	229	PF00018	0.739
LIG_SH3_3	249	255	PF00018	0.588
LIG_SH3_3	78	84	PF00018	0.862
LIG_SH3_3	92	98	PF00018	0.587
LIG_SH3_CIN85_PxpxPR_1	148	153	PF14604	0.583
LIG_SUMO_SIM_par_1	130	136	PF11976	0.737
LIG_SUMO_SIM_par_1	223	230	PF11976	0.541
LIG_WW_3	150	154	PF00397	0.787
MOD_CK1_1	142	148	PF00069	0.602
MOD_CK1_1	227	233	PF00069	0.758
MOD_CK2_1	201	207	PF00069	0.604
MOD_CMANNOS	40	43	PF00535	0.497
MOD_Cter_Amidation	207	210	PF01082	0.596
MOD_Cter_Amidation	54	57	PF01082	0.590
MOD_GlcNHglycan	144	147	PF01048	0.609
MOD_GlcNHglycan	53	56	PF01048	0.639
MOD_GSK3_1	138	145	PF00069	0.746
MOD_GSK3_1	210	217	PF00069	0.719
MOD_GSK3_1	237	244	PF00069	0.586
MOD_GSK3_1	65	72	PF00069	0.728
MOD_NEK2_1	133	138	PF00069	0.754
MOD_NEK2_1	67	72	PF00069	0.700
MOD_PIKK_1	175	181	PF00454	0.769
MOD_PK_1	65	71	PF00069	0.576
MOD_PKA_1	209	215	PF00069	0.573
MOD_PKA_2	166	172	PF00069	0.554
MOD_PKA_2	209	215	PF00069	0.573
MOD_PKA_2	246	252	PF00069	0.685
MOD_PKB_1	235	243	PF00069	0.584
MOD_Plk_4	35	41	PF00069	0.496
MOD_ProDKin_1	127	133	PF00069	0.582
MOD_ProDKin_1	152	158	PF00069	0.640
MOD_ProDKin_1	94	100	PF00069	0.592
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.798
TRG_ENDOCYTIC_2	66	69	PF00928	0.564
TRG_ER_diArg_1	164	167	PF00400	0.550
TRG_ER_diArg_1	184	186	PF00400	0.771
TRG_ER_diArg_1	196	199	PF00400	0.567
TRG_ER_diArg_1	234	237	PF00400	0.624
TRG_ER_diArg_1	246	248	PF00400	0.549
TRG_ER_diArg_1	43	45	PF00400	0.525
TRG_ER_diArg_1	56	58	PF00400	0.492
TRG_ER_diArg_1	86	88	PF00400	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AP09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	96%