LeishMANIAdb
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Putative surface antigen protein 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein 2
Gene product:
surface antigen protein 2 - putative
Species:
Leishmania infantum
UniProt:
E9AGG2_LEIIN
TriTrypDb:
LINF_120014000 , LINF_120015000 *
Length:
664

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 105
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 36, no: 5
NetGPI no yes: 0, no: 41
Cellular components
Term Name Level Count
GO:0005929 cilium 4 42
GO:0042995 cell projection 2 42
GO:0043226 organelle 2 42
GO:0043227 membrane-bounded organelle 3 42
GO:0110165 cellular anatomical entity 1 42
GO:0120025 plasma membrane bounded cell projection 3 42
GO:0016020 membrane 2 24
GO:0005886 plasma membrane 3 6

Expansion

Sequence features

E9AGG2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGG2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 282 284 PF00675 0.490
CLV_NRD_NRD_1 6 8 PF00675 0.726
CLV_NRD_NRD_1 61 63 PF00675 0.463
CLV_PCSK_KEX2_1 282 284 PF00082 0.475
CLV_PCSK_KEX2_1 6 8 PF00082 0.721
CLV_PCSK_SKI1_1 154 158 PF00082 0.603
CLV_PCSK_SKI1_1 190 194 PF00082 0.580
CLV_PCSK_SKI1_1 228 232 PF00082 0.623
CLV_PCSK_SKI1_1 300 304 PF00082 0.641
CLV_PCSK_SKI1_1 7 11 PF00082 0.721
DEG_SCF_FBW7_2 592 597 PF00400 0.472
DEG_SPOP_SBC_1 474 478 PF00917 0.592
DEG_SPOP_SBC_1 484 488 PF00917 0.477
DEG_SPOP_SBC_1 492 496 PF00917 0.458
DEG_SPOP_SBC_1 507 511 PF00917 0.587
DEG_SPOP_SBC_1 515 519 PF00917 0.403
DEG_SPOP_SBC_1 525 529 PF00917 0.419
DEG_SPOP_SBC_1 533 537 PF00917 0.413
DEG_SPOP_SBC_1 548 552 PF00917 0.618
DEG_SPOP_SBC_1 556 560 PF00917 0.455
DEG_SPOP_SBC_1 571 575 PF00917 0.594
DOC_AGCK_PIF_2 69 74 PF00069 0.296
DOC_CYCLIN_RxL_1 107 116 PF00134 0.292
DOC_CYCLIN_RxL_1 3 13 PF00134 0.557
DOC_CYCLIN_yCln2_LP_2 267 273 PF00134 0.274
DOC_MAPK_gen_1 228 238 PF00069 0.238
DOC_MAPK_gen_1 240 249 PF00069 0.233
DOC_MAPK_gen_1 351 358 PF00069 0.243
DOC_MAPK_MEF2A_6 231 238 PF00069 0.239
DOC_MAPK_MEF2A_6 446 453 PF00069 0.445
DOC_PP1_RVXF_1 108 115 PF00149 0.349
DOC_USP7_MATH_1 373 377 PF00917 0.414
DOC_USP7_MATH_1 641 645 PF00917 0.297
DOC_USP7_MATH_2 224 230 PF00917 0.424
DOC_USP7_MATH_2 320 326 PF00917 0.281
DOC_WW_Pin1_4 584 589 PF00397 0.506
DOC_WW_Pin1_4 590 595 PF00397 0.473
LIG_14-3-3_CanoR_1 154 162 PF00244 0.416
LIG_14-3-3_CanoR_1 209 214 PF00244 0.242
LIG_14-3-3_CanoR_1 43 48 PF00244 0.435
LIG_BIR_II_1 1 5 PF00653 0.607
LIG_Clathr_ClatBox_1 425 429 PF01394 0.234
LIG_Clathr_ClatBox_1 450 454 PF01394 0.304
LIG_deltaCOP1_diTrp_1 177 185 PF00928 0.250
LIG_DLG_GKlike_1 209 216 PF00625 0.241
LIG_FHA_1 169 175 PF00498 0.407
LIG_FHA_1 208 214 PF00498 0.369
LIG_FHA_1 377 383 PF00498 0.414
LIG_FHA_1 42 48 PF00498 0.401
LIG_FHA_1 477 483 PF00498 0.461
LIG_FHA_1 628 634 PF00498 0.394
LIG_FHA_1 641 647 PF00498 0.181
LIG_FHA_2 254 260 PF00498 0.263
LIG_FHA_2 301 307 PF00498 0.435
LIG_FHA_2 486 492 PF00498 0.422
LIG_FHA_2 527 533 PF00498 0.417
LIG_FHA_2 572 578 PF00498 0.610
LIG_FHA_2 596 602 PF00498 0.549
LIG_FHA_2 63 69 PF00498 0.462
LIG_FHA_2 73 79 PF00498 0.384
LIG_FHA_2 92 98 PF00498 0.468
LIG_LIR_Gen_1 103 112 PF02991 0.293
LIG_LIR_Gen_1 113 121 PF02991 0.455
LIG_LIR_Gen_1 128 135 PF02991 0.399
LIG_LIR_Gen_1 177 186 PF02991 0.352
LIG_LIR_Gen_1 232 243 PF02991 0.325
LIG_LIR_Gen_1 322 330 PF02991 0.325
LIG_LIR_Gen_1 370 378 PF02991 0.335
LIG_LIR_Gen_1 417 426 PF02991 0.427
LIG_LIR_Nem_3 103 107 PF02991 0.459
LIG_LIR_Nem_3 113 117 PF02991 0.425
LIG_LIR_Nem_3 128 132 PF02991 0.397
LIG_LIR_Nem_3 152 156 PF02991 0.411
LIG_LIR_Nem_3 232 238 PF02991 0.325
LIG_LIR_Nem_3 297 302 PF02991 0.341
LIG_LIR_Nem_3 370 374 PF02991 0.368
LIG_NRBOX 352 358 PF00104 0.233
LIG_PCNA_PIPBox_1 326 335 PF02747 0.224
LIG_PDZ_Class_2 659 664 PF00595 0.297
LIG_PTAP_UEV_1 567 572 PF05743 0.407
LIG_SH2_CRK 104 108 PF00017 0.288
LIG_SH2_SRC 235 238 PF00017 0.236
LIG_SH2_STAP1 104 108 PF00017 0.265
LIG_SH2_STAT5 104 107 PF00017 0.413
LIG_SH2_STAT5 186 189 PF00017 0.319
LIG_SH2_STAT5 235 238 PF00017 0.339
LIG_SH2_STAT5 285 288 PF00017 0.298
LIG_SH2_STAT5 623 626 PF00017 0.416
LIG_SH2_STAT5 634 637 PF00017 0.474
LIG_SH2_STAT5 74 77 PF00017 0.245
LIG_SH3_3 267 273 PF00018 0.268
LIG_SH3_3 479 485 PF00018 0.512
LIG_SH3_3 565 571 PF00018 0.569
LIG_SH3_3 576 582 PF00018 0.524
LIG_SH3_3 93 99 PF00018 0.468
LIG_Sin3_3 648 655 PF02671 0.293
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.402
LIG_SUMO_SIM_par_1 209 215 PF11976 0.462
LIG_TYR_ITIM 102 107 PF00017 0.408
LIG_TYR_ITIM 184 189 PF00017 0.236
LIG_TYR_ITIM 233 238 PF00017 0.321
LIG_UBA3_1 449 458 PF00899 0.308
MOD_CK1_1 203 209 PF00069 0.412
MOD_CK1_1 217 223 PF00069 0.362
MOD_CK1_1 229 235 PF00069 0.333
MOD_CK1_1 241 247 PF00069 0.340
MOD_CK1_1 265 271 PF00069 0.311
MOD_CK1_1 277 283 PF00069 0.343
MOD_CK1_1 325 331 PF00069 0.306
MOD_CK1_1 376 382 PF00069 0.365
MOD_CK1_1 385 391 PF00069 0.376
MOD_CK1_1 396 402 PF00069 0.408
MOD_CK1_1 580 586 PF00069 0.496
MOD_CK1_1 627 633 PF00069 0.266
MOD_CK2_1 253 259 PF00069 0.277
MOD_CK2_1 334 340 PF00069 0.237
MOD_CK2_1 485 491 PF00069 0.423
MOD_CK2_1 526 532 PF00069 0.602
MOD_CK2_1 571 577 PF00069 0.641
MOD_CK2_1 595 601 PF00069 0.577
MOD_CK2_1 91 97 PF00069 0.444
MOD_Cter_Amidation 60 63 PF01082 0.456
MOD_GlcNHglycan 121 124 PF01048 0.619
MOD_GlcNHglycan 140 143 PF01048 0.544
MOD_GlcNHglycan 194 197 PF01048 0.609
MOD_GlcNHglycan 218 222 PF01048 0.511
MOD_GlcNHglycan 243 246 PF01048 0.614
MOD_GlcNHglycan 25 28 PF01048 0.707
MOD_GlcNHglycan 267 270 PF01048 0.532
MOD_GlcNHglycan 290 294 PF01048 0.579
MOD_GlcNHglycan 315 318 PF01048 0.584
MOD_GlcNHglycan 363 366 PF01048 0.611
MOD_GlcNHglycan 370 374 PF01048 0.579
MOD_GlcNHglycan 382 385 PF01048 0.588
MOD_GlcNHglycan 387 390 PF01048 0.596
MOD_GlcNHglycan 395 398 PF01048 0.592
MOD_GlcNHglycan 410 414 PF01048 0.623
MOD_GlcNHglycan 611 614 PF01048 0.604
MOD_GlcNHglycan 643 646 PF01048 0.430
MOD_GlcNHglycan 84 87 PF01048 0.584
MOD_GSK3_1 121 128 PF00069 0.391
MOD_GSK3_1 145 152 PF00069 0.377
MOD_GSK3_1 200 207 PF00069 0.377
MOD_GSK3_1 258 265 PF00069 0.323
MOD_GSK3_1 273 280 PF00069 0.333
MOD_GSK3_1 291 298 PF00069 0.285
MOD_GSK3_1 32 39 PF00069 0.597
MOD_GSK3_1 369 376 PF00069 0.417
MOD_GSK3_1 396 403 PF00069 0.367
MOD_GSK3_1 473 480 PF00069 0.586
MOD_GSK3_1 483 490 PF00069 0.506
MOD_GSK3_1 491 498 PF00069 0.519
MOD_GSK3_1 502 509 PF00069 0.526
MOD_GSK3_1 510 517 PF00069 0.572
MOD_GSK3_1 520 527 PF00069 0.472
MOD_GSK3_1 528 535 PF00069 0.528
MOD_GSK3_1 536 543 PF00069 0.496
MOD_GSK3_1 547 554 PF00069 0.515
MOD_GSK3_1 555 562 PF00069 0.521
MOD_GSK3_1 566 573 PF00069 0.510
MOD_GSK3_1 577 584 PF00069 0.555
MOD_GSK3_1 586 593 PF00069 0.565
MOD_GSK3_1 623 630 PF00069 0.383
MOD_GSK3_1 68 75 PF00069 0.325
MOD_GSK3_1 87 94 PF00069 0.455
MOD_N-GLC_1 136 141 PF02516 0.520
MOD_N-GLC_2 466 468 PF02516 0.713
MOD_NEK2_1 10 15 PF00069 0.553
MOD_NEK2_1 119 124 PF00069 0.401
MOD_NEK2_1 138 143 PF00069 0.300
MOD_NEK2_1 170 175 PF00069 0.367
MOD_NEK2_1 192 197 PF00069 0.394
MOD_NEK2_1 21 26 PF00069 0.501
MOD_NEK2_1 236 241 PF00069 0.367
MOD_NEK2_1 262 267 PF00069 0.349
MOD_NEK2_1 310 315 PF00069 0.418
MOD_NEK2_1 332 337 PF00069 0.312
MOD_NEK2_1 358 363 PF00069 0.379
MOD_NEK2_1 380 385 PF00069 0.410
MOD_PIKK_1 154 160 PF00454 0.399
MOD_PIKK_1 562 568 PF00454 0.411
MOD_PKA_1 62 68 PF00069 0.343
MOD_PKA_2 241 247 PF00069 0.241
MOD_PKA_2 262 268 PF00069 0.339
MOD_PKA_2 468 474 PF00069 0.590
MOD_Plk_1 102 108 PF00069 0.309
MOD_Plk_1 136 142 PF00069 0.250
MOD_Plk_1 176 182 PF00069 0.334
MOD_Plk_1 258 264 PF00069 0.310
MOD_Plk_1 369 375 PF00069 0.294
MOD_Plk_1 627 633 PF00069 0.349
MOD_Plk_2-3 253 259 PF00069 0.247
MOD_Plk_2-3 68 74 PF00069 0.384
MOD_Plk_4 229 235 PF00069 0.360
MOD_Plk_4 334 340 PF00069 0.310
MOD_Plk_4 358 364 PF00069 0.324
MOD_Plk_4 373 379 PF00069 0.388
MOD_Plk_4 445 451 PF00069 0.319
MOD_ProDKin_1 584 590 PF00069 0.505
MOD_SUMO_rev_2 220 230 PF00179 0.237
MOD_SUMO_rev_2 306 316 PF00179 0.251
TRG_DiLeu_BaEn_1 628 633 PF01217 0.328
TRG_DiLeu_BaLyEn_6 151 156 PF01217 0.235
TRG_ENDOCYTIC_2 104 107 PF00928 0.406
TRG_ENDOCYTIC_2 186 189 PF00928 0.212
TRG_ENDOCYTIC_2 235 238 PF00928 0.321
TRG_ER_diArg_1 281 283 PF00400 0.276
TRG_ER_diArg_1 5 7 PF00400 0.621
TRG_Pf-PMV_PEXEL_1 154 158 PF00026 0.458
TRG_Pf-PMV_PEXEL_1 214 218 PF00026 0.441
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.574

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0R0HPY5 Glycine max 25% 68%
A0A0S4ILX2 Bodo saltans 26% 67%
A0A0S4IQA7 Bodo saltans 26% 67%
A0A0S4IRQ2 Bodo saltans 33% 78%
A0A0S4IV96 Bodo saltans 32% 100%
A0A0S4J100 Bodo saltans 25% 79%
A0A0S4J206 Bodo saltans 35% 100%
A0A0S4J5I5 Bodo saltans 24% 66%
A0A0S4J954 Bodo saltans 24% 90%
A0A0S4J985 Bodo saltans 32% 67%
A0A0S4JBV9 Bodo saltans 31% 100%
A0A0S4JQZ4 Bodo saltans 30% 66%
A0A0S4KEC2 Bodo saltans 35% 75%
A0A0S4KF94 Bodo saltans 24% 76%
A0A0S4KGV4 Bodo saltans 24% 100%
A0A1P8ATR9 Arabidopsis thaliana 23% 71%
A0A1X0ND37 Trypanosomatidae 25% 70%
A0A3Q8IC27 Leishmania donovani 34% 100%
A0A3S5H6M3 Leishmania donovani 91% 97%
A0A3S5H6M4 Leishmania donovani 60% 100%
A0A3S7WS66 Leishmania donovani 59% 100%
A4H6Y8 Leishmania braziliensis 45% 73%
A4HBX3 Leishmania braziliensis 36% 100%
A4HM88 Leishmania braziliensis 26% 77%
A4HZ93 Leishmania infantum 34% 100%
D1GJ51 Leishmania infantum 60% 100%
E9AGG7 Leishmania infantum 54% 100%
E9AGG9 Leishmania infantum 59% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 94%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
F4HTV4 Arabidopsis thaliana 24% 68%
F4I9S3 Arabidopsis thaliana 24% 71%
F4J8G2 Arabidopsis thaliana 26% 76%
F4JGB6 Arabidopsis thaliana 24% 82%
I1Z695 Oryza sativa subsp. japonica 25% 67%
O49879 Solanum lycopersicum 25% 79%
Q4QC79 Leishmania major 35% 100%
Q4QGI0 Leishmania major 58% 100%
Q4QGI2 Leishmania major 55% 100%
Q4QGI4 Leishmania major 52% 100%
Q4QGI6 Leishmania major 54% 100%
Q4QGI8 Leishmania major 51% 87%
Q4QGJ0 Leishmania major 82% 100%
Q4QGJ2 Leishmania major 59% 100%
Q4QGJ9 Leishmania major 62% 100%
Q4QGK0 Leishmania major 57% 100%
Q4QGK1 Leishmania major 80% 94%
Q4QGK2 Leishmania major 54% 100%
Q4QGK4 Leishmania major 59% 100%
Q4QGK8 Leishmania major 54% 100%
Q4QGL2 Leishmania major 54% 100%
Q4QGL8 Leishmania major 54% 100%
Q4QGM1 Leishmania major 54% 86%
Q69SP5 Oryza sativa subsp. japonica 24% 68%
Q93YT3 Arabidopsis thaliana 25% 75%
Q9LY03 Arabidopsis thaliana 25% 69%
Q9SHI3 Arabidopsis thaliana 22% 91%
Q9SVM3 Arabidopsis thaliana 25% 79%
Q9SVN2 Arabidopsis thaliana 24% 83%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS