Putative surface antigen protein 2

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGG1_LEIIN

TriTrypDb:

LINF_120012500

Length:

219

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

Annotations by Jardim et al.

Plasma membrane, surface antigen 2 LINJ.12.0662

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 4
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0016020	membrane	2	3
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

E9AGG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	76	80	PF00082	0.238
CLV_PCSK_SKI1_1	97	101	PF00082	0.299
DEG_SCF_FBW7_2	147	152	PF00400	0.571
DOC_MAPK_gen_1	97	105	PF00069	0.479
DOC_MAPK_MEF2A_6	97	105	PF00069	0.479
DOC_USP7_MATH_1	195	199	PF00917	0.235
DOC_USP7_MATH_1	78	82	PF00917	0.421
DOC_WW_Pin1_4	139	144	PF00397	0.608
DOC_WW_Pin1_4	145	150	PF00397	0.588
LIG_Actin_WH2_2	46	61	PF00022	0.437
LIG_FHA_1	114	120	PF00498	0.620
LIG_FHA_1	127	133	PF00498	0.694
LIG_FHA_1	14	20	PF00498	0.461
LIG_FHA_1	53	59	PF00498	0.428
LIG_FHA_1	98	104	PF00498	0.493
LIG_FHA_2	151	157	PF00498	0.522
LIG_LIR_Gen_1	22	29	PF02991	0.452
LIG_LIR_Gen_1	55	63	PF02991	0.576
LIG_LIR_Gen_1	69	78	PF02991	0.468
LIG_LIR_Nem_3	55	60	PF02991	0.607
LIG_PCNA_PIPBox_1	1	10	PF02747	0.459
LIG_PCNA_PIPBox_1	50	59	PF02747	0.431
LIG_PDZ_Class_2	214	219	PF00595	0.337
LIG_SH2_STAT5	178	181	PF00017	0.445
LIG_SH2_STAT5	57	60	PF00017	0.452
LIG_SH3_3	122	128	PF00018	0.595
LIG_SH3_3	131	137	PF00018	0.711
LIG_SUMO_SIM_par_1	99	104	PF11976	0.504
MOD_CK1_1	182	188	PF00069	0.475
MOD_CK1_1	22	28	PF00069	0.479
MOD_CK1_1	3	9	PF00069	0.468
MOD_CK1_1	48	54	PF00069	0.558
MOD_CK1_1	66	72	PF00069	0.458
MOD_CK2_1	150	156	PF00069	0.551
MOD_GlcNHglycan	166	169	PF01048	0.303
MOD_GlcNHglycan	198	201	PF01048	0.207
MOD_GlcNHglycan	39	42	PF01048	0.301
MOD_GlcNHglycan	63	66	PF01048	0.241
MOD_GlcNHglycan	71	74	PF01048	0.253
MOD_GSK3_1	128	135	PF00069	0.625
MOD_GSK3_1	137	144	PF00069	0.592
MOD_GSK3_1	15	22	PF00069	0.550
MOD_GSK3_1	178	185	PF00069	0.493
MOD_GSK3_1	45	52	PF00069	0.514
MOD_GSK3_1	63	70	PF00069	0.569
MOD_NEK2_1	34	39	PF00069	0.555
MOD_NEK2_1	58	63	PF00069	0.603
MOD_PIKK_1	34	40	PF00454	0.457
MOD_PKA_1	97	103	PF00069	0.469
MOD_PKA_2	13	19	PF00069	0.458
MOD_PKA_2	58	64	PF00069	0.438
MOD_Plk_4	3	9	PF00069	0.447
MOD_Plk_4	52	58	PF00069	0.562
MOD_Plk_4	91	97	PF00069	0.550
MOD_ProDKin_1	139	145	PF00069	0.607
TRG_ENDOCYTIC_2	57	60	PF00928	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ17	Leptomonas seymouri	29%	76%
A0A0S4JHM1	Bodo saltans	26%	68%
A0A3S7WP69	Leishmania donovani	23%	77%
A4H5P0	Leishmania braziliensis	27%	76%
A4HSL2	Leishmania infantum	23%	77%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	77%
E9AP01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4QJB2	Leishmania major	23%	77%