Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF962), putative

Species:

Leishmania infantum

UniProt:

E9AGF9_LEIIN

TriTrypDb:

LINF_120012350

Length:

108

Annotations

LeishMANIAdb annotations

This small protein is closely similar to a large group of poorly-studied prokaryotic proteins (annotated as DUF962 domain proteins). Some members are also found in plants and slime molds.. Duplicated in Leishmaniids

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized LINJ.12.0680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AGF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGF9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.280
CLV_NRD_NRD_1	78	80	PF00675	0.273
CLV_PCSK_KEX2_1	32	34	PF00082	0.280
DEG_APCC_DBOX_1	51	59	PF00400	0.211
DOC_PP4_FxxP_1	84	87	PF00568	0.504
DOC_WW_Pin1_4	2	7	PF00397	0.630
LIG_14-3-3_CanoR_1	56	66	PF00244	0.237
LIG_14-3-3_CanoR_1	79	85	PF00244	0.507
LIG_LIR_Apic_2	83	87	PF02991	0.505
LIG_LIR_Nem_3	13	18	PF02991	0.486
LIG_PDZ_Class_3	103	108	PF00595	0.543
LIG_SH2_STAT5	66	69	PF00017	0.279
LIG_WRC_WIRS_1	1	6	PF05994	0.426
MOD_CK1_1	11	17	PF00069	0.387
MOD_CK1_1	60	66	PF00069	0.279
MOD_CK2_1	11	17	PF00069	0.279
MOD_NEK2_1	36	41	PF00069	0.347
MOD_NEK2_1	57	62	PF00069	0.354
MOD_NEK2_1	8	13	PF00069	0.608
MOD_PKA_2	31	37	PF00069	0.363
MOD_ProDKin_1	2	8	PF00069	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C1	Leptomonas seymouri	40%	100%
A0A0N1HYH1	Leptomonas seymouri	54%	100%
A0A1X0NMC7	Trypanosomatidae	30%	99%
A0A3Q8IHQ7	Leishmania donovani	99%	100%
A0A3R7N4G9	Trypanosoma rangeli	37%	99%
A0A3S5H6L3	Leishmania donovani	38%	100%
A4H6Y4	Leishmania braziliensis	36%	100%
A4H6Y5	Leishmania braziliensis	87%	100%
E9AGF8	Leishmania infantum	38%	100%
E9ANZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
Q4QGM2	Leishmania major	39%	100%