LeishMANIAdb
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Lipoprotein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Lipoprotein
Gene product:
Protein of unknown function (DUF962) - putative
Species:
Leishmania infantum
UniProt:
E9AGF8_LEIIN
TriTrypDb:
LINF_120012300
Length:
108

Annotations

LeishMANIAdb annotations

This small protein is closely similar to a large group of poorly-studied prokaryotic proteins (annotated as DUF962 domain proteins). Some members are also found in plants and slime molds.. Duplicated in Leishmaniids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

E9AGF8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGF8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 32 34 PF00675 0.261
CLV_PCSK_KEX2_1 32 34 PF00082 0.261
DOC_ANK_TNKS_1 51 58 PF00023 0.270
DOC_PP4_FxxP_1 84 87 PF00568 0.493
DOC_USP7_MATH_1 24 28 PF00917 0.532
DOC_USP7_MATH_1 46 50 PF00917 0.415
DOC_USP7_MATH_1 58 62 PF00917 0.257
LIG_BRCT_BRCA1_1 4 8 PF00533 0.580
LIG_FHA_2 72 78 PF00498 0.413
LIG_GBD_Chelix_1 98 106 PF00786 0.317
LIG_LIR_Apic_2 82 87 PF02991 0.477
LIG_LIR_Nem_3 17 22 PF02991 0.472
LIG_LIR_Nem_3 93 98 PF02991 0.512
LIG_SH2_STAT5 19 22 PF00017 0.466
MOD_CK1_1 90 96 PF00069 0.470
MOD_CK2_1 71 77 PF00069 0.413
MOD_GlcNHglycan 10 13 PF01048 0.262
MOD_GlcNHglycan 4 7 PF01048 0.390
MOD_GlcNHglycan 48 51 PF01048 0.416
MOD_GSK3_1 24 31 PF00069 0.513
MOD_GSK3_1 76 83 PF00069 0.470
MOD_LATS_1 26 32 PF00433 0.491
MOD_N-GLC_1 2 7 PF02516 0.512
MOD_NEK2_1 36 41 PF00069 0.341
MOD_NEK2_1 8 13 PF00069 0.611
MOD_NEK2_1 97 102 PF00069 0.515
MOD_PIKK_1 76 82 PF00454 0.470
MOD_Plk_4 71 77 PF00069 0.327
MOD_Plk_4 97 103 PF00069 0.490
TRG_ER_diArg_1 32 34 PF00400 0.491

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2C1 Leptomonas seymouri 70% 100%
A0A0N1HYH1 Leptomonas seymouri 36% 100%
A0A0S4IVD1 Bodo saltans 33% 96%
A0A1X0NMC7 Trypanosomatidae 47% 99%
A0A3Q8IHQ7 Leishmania donovani 39% 100%
A0A3R7N4G9 Trypanosoma rangeli 43% 99%
A0A3S5H6L3 Leishmania donovani 100% 100%
A4H6Y4 Leishmania braziliensis 85% 100%
A4H6Y5 Leishmania braziliensis 39% 100%
E9AGF9 Leishmania infantum 38% 100%
E9ANZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QGM2 Leishmania major 99% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS