Bardet-Biedl syndrome 5 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1448) - putative

Species:

Leishmania infantum

UniProt:

E9AGF5_LEIIN

TriTrypDb:

LINF_120012000

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005815	microtubule organizing center	2	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0031253	cell projection membrane	4	11
GO:0032991	protein-containing complex	1	11
GO:0034464	BBSome	2	11
GO:0060170	ciliary membrane	5	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098590	plasma membrane region	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0012506	vesicle membrane	4	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

E9AGF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGF5

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030001	metal ion transport	6	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0033572	transferrin transport	5	1
GO:0044782	cilium organization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0032266	phosphatidylinositol-3-phosphate binding	6	1
GO:0035091	phosphatidylinositol binding	4	1
GO:1901981	phosphatidylinositol phosphate binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	1	3	PF00675	0.683
CLV_NRD_NRD_1	165	167	PF00675	0.325
CLV_NRD_NRD_1	395	397	PF00675	0.219
CLV_NRD_NRD_1	4	6	PF00675	0.676
CLV_NRD_NRD_1	401	403	PF00675	0.191
CLV_NRD_NRD_1	416	418	PF00675	0.209
CLV_PCSK_FUR_1	162	166	PF00082	0.219
CLV_PCSK_FUR_1	2	6	PF00082	0.560
CLV_PCSK_KEX2_1	164	166	PF00082	0.328
CLV_PCSK_KEX2_1	3	5	PF00082	0.558
CLV_PCSK_KEX2_1	401	403	PF00082	0.235
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.494
CLV_PCSK_SKI1_1	17	21	PF00082	0.422
CLV_PCSK_SKI1_1	316	320	PF00082	0.302
DEG_Nend_UBRbox_1	1	4	PF02207	0.546
DOC_MAPK_gen_1	79	88	PF00069	0.447
DOC_MAPK_HePTP_8	76	88	PF00069	0.419
DOC_MAPK_MEF2A_6	316	325	PF00069	0.437
DOC_MAPK_MEF2A_6	402	411	PF00069	0.435
DOC_MAPK_MEF2A_6	79	88	PF00069	0.485
DOC_PP1_RVXF_1	241	248	PF00149	0.404
DOC_PP1_RVXF_1	27	34	PF00149	0.417
DOC_PP1_RVXF_1	73	79	PF00149	0.460
DOC_USP7_MATH_1	145	149	PF00917	0.530
DOC_USP7_MATH_1	167	171	PF00917	0.349
DOC_USP7_MATH_1	187	191	PF00917	0.417
DOC_WW_Pin1_4	8	13	PF00397	0.622
LIG_14-3-3_CanoR_1	110	117	PF00244	0.451
LIG_14-3-3_CanoR_1	311	319	PF00244	0.550
LIG_APCC_ABBA_1	323	328	PF00400	0.419
LIG_APCC_ABBAyCdc20_2	322	328	PF00400	0.419
LIG_Clathr_ClatBox_1	209	213	PF01394	0.450
LIG_FHA_1	110	116	PF00498	0.437
LIG_FHA_1	219	225	PF00498	0.543
LIG_FHA_1	234	240	PF00498	0.380
LIG_FHA_1	327	333	PF00498	0.418
LIG_FHA_1	382	388	PF00498	0.403
LIG_FHA_1	44	50	PF00498	0.491
LIG_FHA_1	66	72	PF00498	0.450
LIG_FHA_2	50	56	PF00498	0.451
LIG_FHA_2	97	103	PF00498	0.450
LIG_HCF-1_HBM_1	47	50	PF13415	0.499
LIG_LIR_Gen_1	124	133	PF02991	0.405
LIG_LIR_Gen_1	256	265	PF02991	0.417
LIG_LIR_Gen_1	301	309	PF02991	0.504
LIG_LIR_Gen_1	47	56	PF02991	0.499
LIG_LIR_Nem_3	124	129	PF02991	0.405
LIG_LIR_Nem_3	191	197	PF02991	0.457
LIG_LIR_Nem_3	251	255	PF02991	0.431
LIG_LIR_Nem_3	256	262	PF02991	0.405
LIG_LIR_Nem_3	301	306	PF02991	0.463
LIG_LIR_Nem_3	47	53	PF02991	0.499
LIG_LIR_Nem_3	89	95	PF02991	0.435
LIG_Pex14_2	126	130	PF04695	0.417
LIG_Pex14_2	287	291	PF04695	0.481
LIG_SH2_CRK	178	182	PF00017	0.498
LIG_SH2_NCK_1	303	307	PF00017	0.499
LIG_SH2_SRC	303	306	PF00017	0.545
LIG_SH2_SRC	405	408	PF00017	0.474
LIG_SH2_STAT5	259	262	PF00017	0.462
LIG_SH2_STAT5	93	96	PF00017	0.502
LIG_SH3_3	252	258	PF00018	0.435
LIG_SH3_3	329	335	PF00018	0.380
LIG_SH3_3	401	407	PF00018	0.460
LIG_SUMO_SIM_par_1	208	213	PF11976	0.512
LIG_SUMO_SIM_par_1	67	72	PF11976	0.459
LIG_TRAF2_1	99	102	PF00917	0.499
LIG_TYR_ITIM	90	95	PF00017	0.282
LIG_UBA3_1	318	322	PF00899	0.443
LIG_WRC_WIRS_1	234	239	PF05994	0.294
LIG_WRC_WIRS_1	50	55	PF05994	0.352
MOD_CK1_1	10	16	PF00069	0.623
MOD_CK1_1	143	149	PF00069	0.246
MOD_CK1_1	168	174	PF00069	0.397
MOD_CK1_1	219	225	PF00069	0.336
MOD_CK1_1	267	273	PF00069	0.362
MOD_CK2_1	225	231	PF00069	0.338
MOD_CK2_1	96	102	PF00069	0.372
MOD_CMANNOS	310	313	PF00535	0.282
MOD_Cter_Amidation	394	397	PF01082	0.260
MOD_GlcNHglycan	12	15	PF01048	0.587
MOD_GlcNHglycan	142	145	PF01048	0.407
MOD_GlcNHglycan	149	152	PF01048	0.454
MOD_GlcNHglycan	200	203	PF01048	0.437
MOD_GlcNHglycan	221	224	PF01048	0.260
MOD_GlcNHglycan	347	351	PF01048	0.278
MOD_GSK3_1	109	116	PF00069	0.333
MOD_GSK3_1	139	146	PF00069	0.409
MOD_GSK3_1	218	225	PF00069	0.391
MOD_GSK3_1	233	240	PF00069	0.231
MOD_GSK3_1	305	312	PF00069	0.396
MOD_GSK3_1	417	424	PF00069	0.295
MOD_GSK3_1	425	432	PF00069	0.456
MOD_GSK3_1	65	72	PF00069	0.362
MOD_GSK3_1	8	15	PF00069	0.628
MOD_N-GLC_1	160	165	PF02516	0.260
MOD_N-GLC_1	168	173	PF02516	0.203
MOD_N-GLC_1	253	258	PF02516	0.239
MOD_N-GLC_1	86	91	PF02516	0.239
MOD_N-GLC_2	63	65	PF02516	0.260
MOD_NEK2_1	128	133	PF00069	0.274
MOD_NEK2_1	177	182	PF00069	0.283
MOD_NEK2_1	237	242	PF00069	0.281
MOD_NEK2_1	253	258	PF00069	0.284
MOD_NEK2_1	309	314	PF00069	0.379
MOD_NEK2_1	425	430	PF00069	0.506
MOD_NEK2_1	69	74	PF00069	0.239
MOD_PIKK_1	264	270	PF00454	0.372
MOD_PKA_1	165	171	PF00069	0.302
MOD_PKA_1	417	423	PF00069	0.260
MOD_PKA_2	109	115	PF00069	0.248
MOD_PKA_2	165	171	PF00069	0.338
MOD_PKA_2	219	225	PF00069	0.352
MOD_PKB_1	41	49	PF00069	0.205
MOD_Plk_1	188	194	PF00069	0.257
MOD_Plk_1	253	259	PF00069	0.243
MOD_Plk_1	278	284	PF00069	0.319
MOD_Plk_1	304	310	PF00069	0.282
MOD_Plk_1	426	432	PF00069	0.598
MOD_Plk_1	86	92	PF00069	0.239
MOD_Plk_4	233	239	PF00069	0.278
MOD_Plk_4	305	311	PF00069	0.239
MOD_Plk_4	421	427	PF00069	0.317
MOD_Plk_4	65	71	PF00069	0.303
MOD_ProDKin_1	8	14	PF00069	0.618
MOD_SUMO_for_1	321	324	PF00179	0.360
MOD_SUMO_rev_2	102	108	PF00179	0.260
MOD_SUMO_rev_2	294	299	PF00179	0.303
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.303
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.317
TRG_ENDOCYTIC_2	178	181	PF00928	0.370
TRG_ENDOCYTIC_2	194	197	PF00928	0.239
TRG_ENDOCYTIC_2	259	262	PF00928	0.317
TRG_ENDOCYTIC_2	303	306	PF00928	0.372
TRG_ENDOCYTIC_2	50	53	PF00928	0.372
TRG_ENDOCYTIC_2	92	95	PF00928	0.257
TRG_ER_diArg_1	1	4	PF00400	0.555
TRG_ER_diArg_1	162	165	PF00400	0.421
TRG_ER_diArg_1	197	200	PF00400	0.293
TRG_ER_diArg_1	40	43	PF00400	0.205
TRG_ER_diArg_1	401	403	PF00400	0.282
TRG_NES_CRM1_1	268	279	PF08389	0.372
TRG_NLS_MonoCore_2	1	6	PF00514	0.490
TRG_NLS_MonoExtN_4	2	7	PF00514	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P9	Leptomonas seymouri	60%	100%
A0A0S4JE34	Bodo saltans	41%	100%
A0A1X0NMY8	Trypanosomatidae	40%	100%
A0A3Q8ICM0	Leishmania donovani	100%	100%
A0A3R7K3V6	Trypanosoma rangeli	38%	100%
A4H6Y1	Leishmania braziliensis	68%	96%
C9ZHY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ANZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
Q21626	Caenorhabditis elegans	32%	100%
Q4QGM5	Leishmania major	91%	100%
Q4R649	Macaca fascicularis	36%	100%
Q66IS6	Xenopus laevis	39%	100%
Q7ZWB7	Danio rerio	37%	100%
Q8N3I7	Homo sapiens	36%	100%
Q9CZQ9	Mus musculus	37%	100%
V5BJR9	Trypanosoma cruzi	41%	100%