LeishMANIAdb
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Serine/threonine-protein phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
protein phosphatase with EF-Hand domains (PPEF)
Species:
Leishmania infantum
UniProt:
E9AGF3_LEIIN
TriTrypDb:
LINF_120011800
Length:
961

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Annotations by Jardim et al.

Phosphatase, Serine/threonine- phosphatase LINJ.12.0610

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AGF3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGF3

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016311 dephosphorylation 5 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 14
GO:0004721 phosphoprotein phosphatase activity 3 14
GO:0004722 protein serine/threonine phosphatase activity 4 14
GO:0005488 binding 1 9
GO:0005509 calcium ion binding 5 9
GO:0016787 hydrolase activity 2 14
GO:0016788 hydrolase activity, acting on ester bonds 3 14
GO:0016791 phosphatase activity 5 14
GO:0017018 myosin phosphatase activity 5 14
GO:0042578 phosphoric ester hydrolase activity 4 14
GO:0043167 ion binding 2 9
GO:0043169 cation binding 3 9
GO:0046872 metal ion binding 4 9
GO:0140096 catalytic activity, acting on a protein 2 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 614 618 PF00656 0.774
CLV_MEL_PAP_1 337 343 PF00089 0.616
CLV_NRD_NRD_1 123 125 PF00675 0.590
CLV_NRD_NRD_1 190 192 PF00675 0.680
CLV_NRD_NRD_1 195 197 PF00675 0.720
CLV_NRD_NRD_1 33 35 PF00675 0.804
CLV_NRD_NRD_1 473 475 PF00675 0.407
CLV_NRD_NRD_1 656 658 PF00675 0.564
CLV_NRD_NRD_1 673 675 PF00675 0.364
CLV_NRD_NRD_1 78 80 PF00675 0.611
CLV_NRD_NRD_1 884 886 PF00675 0.582
CLV_NRD_NRD_1 924 926 PF00675 0.662
CLV_PCSK_KEX2_1 123 125 PF00082 0.624
CLV_PCSK_KEX2_1 190 192 PF00082 0.680
CLV_PCSK_KEX2_1 262 264 PF00082 0.622
CLV_PCSK_KEX2_1 33 35 PF00082 0.818
CLV_PCSK_KEX2_1 472 474 PF00082 0.387
CLV_PCSK_KEX2_1 656 658 PF00082 0.552
CLV_PCSK_KEX2_1 673 675 PF00082 0.365
CLV_PCSK_KEX2_1 924 926 PF00082 0.689
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.652
CLV_PCSK_PC7_1 669 675 PF00082 0.457
CLV_PCSK_SKI1_1 170 174 PF00082 0.572
CLV_PCSK_SKI1_1 190 194 PF00082 0.335
CLV_PCSK_SKI1_1 217 221 PF00082 0.546
CLV_PCSK_SKI1_1 300 304 PF00082 0.536
CLV_PCSK_SKI1_1 305 309 PF00082 0.464
CLV_PCSK_SKI1_1 315 319 PF00082 0.314
CLV_PCSK_SKI1_1 410 414 PF00082 0.426
CLV_PCSK_SKI1_1 440 444 PF00082 0.380
CLV_PCSK_SKI1_1 565 569 PF00082 0.431
CLV_PCSK_SKI1_1 651 655 PF00082 0.651
CLV_PCSK_SKI1_1 702 706 PF00082 0.437
CLV_PCSK_SKI1_1 886 890 PF00082 0.550
CLV_PCSK_SKI1_1 96 100 PF00082 0.489
DEG_APCC_DBOX_1 714 722 PF00400 0.569
DEG_APCC_DBOX_1 851 859 PF00400 0.527
DEG_SPOP_SBC_1 275 279 PF00917 0.625
DOC_CDC14_PxL_1 727 735 PF14671 0.546
DOC_CYCLIN_RxL_1 645 658 PF00134 0.707
DOC_CYCLIN_yCln2_LP_2 707 713 PF00134 0.476
DOC_MAPK_gen_1 300 308 PF00069 0.580
DOC_MAPK_gen_1 472 478 PF00069 0.393
DOC_MAPK_gen_1 483 492 PF00069 0.393
DOC_MAPK_MEF2A_6 390 399 PF00069 0.368
DOC_MAPK_MEF2A_6 702 709 PF00069 0.467
DOC_MAPK_NFAT4_5 702 710 PF00069 0.483
DOC_PP1_RVXF_1 173 179 PF00149 0.679
DOC_PP2B_LxvP_1 621 624 PF13499 0.646
DOC_PP2B_LxvP_1 707 710 PF13499 0.464
DOC_PP4_FxxP_1 192 195 PF00568 0.662
DOC_USP7_MATH_1 15 19 PF00917 0.720
DOC_USP7_MATH_1 261 265 PF00917 0.620
DOC_USP7_MATH_1 275 279 PF00917 0.559
DOC_USP7_MATH_1 339 343 PF00917 0.620
DOC_USP7_MATH_1 375 379 PF00917 0.447
DOC_USP7_MATH_1 66 70 PF00917 0.678
DOC_USP7_UBL2_3 166 170 PF12436 0.587
DOC_USP7_UBL2_3 248 252 PF12436 0.555
DOC_USP7_UBL2_3 80 84 PF12436 0.614
DOC_WW_Pin1_4 331 336 PF00397 0.509
LIG_14-3-3_CanoR_1 263 268 PF00244 0.671
LIG_14-3-3_CanoR_1 315 324 PF00244 0.439
LIG_14-3-3_CanoR_1 33 37 PF00244 0.803
LIG_14-3-3_CanoR_1 628 633 PF00244 0.671
LIG_14-3-3_CanoR_1 749 753 PF00244 0.541
LIG_14-3-3_CanoR_1 860 868 PF00244 0.616
LIG_14-3-3_CanoR_1 885 891 PF00244 0.590
LIG_14-3-3_CanoR_1 924 928 PF00244 0.682
LIG_14-3-3_CanoR_1 950 955 PF00244 0.665
LIG_Actin_WH2_2 355 372 PF00022 0.497
LIG_BRCT_BRCA1_1 278 282 PF00533 0.538
LIG_BRCT_BRCA1_1 637 641 PF00533 0.772
LIG_BRCT_BRCA1_1 769 773 PF00533 0.597
LIG_BRCT_BRCA1_2 769 775 PF00533 0.599
LIG_CaM_IQ_9 209 224 PF13499 0.501
LIG_Clathr_ClatBox_1 718 722 PF01394 0.566
LIG_deltaCOP1_diTrp_1 708 713 PF00928 0.464
LIG_deltaCOP1_diTrp_1 742 748 PF00928 0.592
LIG_EH1_1 292 300 PF00400 0.593
LIG_FHA_1 183 189 PF00498 0.536
LIG_FHA_1 631 637 PF00498 0.703
LIG_FHA_2 434 440 PF00498 0.377
LIG_FHA_2 62 68 PF00498 0.720
LIG_FHA_2 791 797 PF00498 0.472
LIG_FHA_2 860 866 PF00498 0.618
LIG_Integrin_isoDGR_2 343 345 PF01839 0.624
LIG_LIR_Apic_2 506 512 PF02991 0.390
LIG_LIR_Apic_2 573 578 PF02991 0.488
LIG_LIR_Apic_2 725 731 PF02991 0.499
LIG_LIR_Gen_1 242 249 PF02991 0.512
LIG_LIR_Gen_1 501 512 PF02991 0.390
LIG_LIR_Gen_1 599 607 PF02991 0.611
LIG_LIR_Gen_1 782 790 PF02991 0.473
LIG_LIR_Gen_1 894 905 PF02991 0.536
LIG_LIR_Gen_1 909 920 PF02991 0.507
LIG_LIR_Nem_3 227 233 PF02991 0.506
LIG_LIR_Nem_3 242 247 PF02991 0.425
LIG_LIR_Nem_3 278 284 PF02991 0.606
LIG_LIR_Nem_3 377 383 PF02991 0.370
LIG_LIR_Nem_3 580 585 PF02991 0.457
LIG_LIR_Nem_3 594 600 PF02991 0.434
LIG_LIR_Nem_3 708 714 PF02991 0.463
LIG_LIR_Nem_3 782 786 PF02991 0.473
LIG_LIR_Nem_3 909 915 PF02991 0.494
LIG_MLH1_MIPbox_1 278 282 PF16413 0.538
LIG_PCNA_PIPBox_1 111 120 PF02747 0.536
LIG_Pex14_1 728 732 PF04695 0.467
LIG_Pex14_2 732 736 PF04695 0.429
LIG_PTB_Apo_2 177 184 PF02174 0.658
LIG_PTB_Apo_2 381 388 PF02174 0.368
LIG_PTB_Apo_2 422 429 PF02174 0.390
LIG_PTB_Apo_2 948 955 PF02174 0.619
LIG_PTB_Phospho_1 381 387 PF10480 0.501
LIG_PTB_Phospho_1 422 428 PF10480 0.390
LIG_SH2_CRK 575 579 PF00017 0.542
LIG_SH2_CRK 582 586 PF00017 0.468
LIG_SH2_GRB2like 36 39 PF00017 0.650
LIG_SH2_GRB2like 423 426 PF00017 0.386
LIG_SH2_NCK_1 495 499 PF00017 0.426
LIG_SH2_PTP2 411 414 PF00017 0.401
LIG_SH2_SRC 558 561 PF00017 0.495
LIG_SH2_SRC 607 610 PF00017 0.726
LIG_SH2_STAP1 438 442 PF00017 0.390
LIG_SH2_STAT5 281 284 PF00017 0.482
LIG_SH2_STAT5 381 384 PF00017 0.389
LIG_SH2_STAT5 387 390 PF00017 0.374
LIG_SH2_STAT5 411 414 PF00017 0.401
LIG_SH2_STAT5 680 683 PF00017 0.463
LIG_SH2_STAT5 712 715 PF00017 0.446
LIG_SH2_STAT5 717 720 PF00017 0.412
LIG_SH2_STAT5 792 795 PF00017 0.496
LIG_SH2_STAT5 920 923 PF00017 0.553
LIG_SH3_3 255 261 PF00018 0.657
LIG_SH3_3 269 275 PF00018 0.504
LIG_SH3_3 303 309 PF00018 0.487
LIG_SH3_4 151 158 PF00018 0.616
LIG_SH3_5 82 86 PF00018 0.638
LIG_SUMO_SIM_anti_2 396 403 PF11976 0.393
LIG_SUMO_SIM_par_1 351 357 PF11976 0.382
LIG_SUMO_SIM_par_1 396 403 PF11976 0.408
LIG_SUMO_SIM_par_1 565 571 PF11976 0.444
LIG_SUMO_SIM_par_1 608 618 PF11976 0.709
LIG_SUMO_SIM_par_1 717 723 PF11976 0.582
LIG_UBA3_1 298 303 PF00899 0.568
LIG_UBA3_1 365 370 PF00899 0.398
LIG_UBA3_1 401 410 PF00899 0.408
LIG_UBA3_1 896 901 PF00899 0.623
LIG_WRC_WIRS_1 585 590 PF05994 0.545
LIG_WRC_WIRS_1 629 634 PF05994 0.666
LIG_WRC_WIRS_1 803 808 PF05994 0.588
LIG_WW_3 193 197 PF00397 0.394
LIG_WW_3 469 473 PF00397 0.402
MOD_CK1_1 16 22 PF00069 0.782
MOD_CK1_1 37 43 PF00069 0.800
MOD_CK1_1 47 53 PF00069 0.742
MOD_CK1_1 532 538 PF00069 0.518
MOD_CK1_1 596 602 PF00069 0.557
MOD_CK1_1 6 12 PF00069 0.787
MOD_CK1_1 630 636 PF00069 0.727
MOD_CK1_1 932 938 PF00069 0.655
MOD_CK2_1 2 8 PF00069 0.744
MOD_CK2_1 493 499 PF00069 0.399
MOD_CK2_1 553 559 PF00069 0.531
MOD_CK2_1 802 808 PF00069 0.567
MOD_CK2_1 812 818 PF00069 0.603
MOD_CMANNOS 101 104 PF00535 0.565
MOD_Cter_Amidation 121 124 PF01082 0.614
MOD_Cter_Amidation 31 34 PF01082 0.743
MOD_GlcNHglycan 15 18 PF01048 0.734
MOD_GlcNHglycan 371 374 PF01048 0.471
MOD_GlcNHglycan 46 49 PF01048 0.794
MOD_GlcNHglycan 555 558 PF01048 0.554
MOD_GlcNHglycan 570 573 PF01048 0.320
MOD_GlcNHglycan 769 772 PF01048 0.595
MOD_GlcNHglycan 814 817 PF01048 0.530
MOD_GlcNHglycan 954 957 PF01048 0.740
MOD_GSK3_1 11 18 PF00069 0.720
MOD_GSK3_1 2 9 PF00069 0.723
MOD_GSK3_1 225 232 PF00069 0.625
MOD_GSK3_1 34 41 PF00069 0.764
MOD_GSK3_1 369 376 PF00069 0.518
MOD_GSK3_1 607 614 PF00069 0.696
MOD_GSK3_1 615 622 PF00069 0.627
MOD_GSK3_1 628 635 PF00069 0.663
MOD_GSK3_1 643 650 PF00069 0.660
MOD_GSK3_1 66 73 PF00069 0.618
MOD_GSK3_1 684 691 PF00069 0.471
MOD_GSK3_1 763 770 PF00069 0.623
MOD_GSK3_1 850 857 PF00069 0.574
MOD_GSK3_1 930 937 PF00069 0.714
MOD_GSK3_1 945 952 PF00069 0.410
MOD_GSK3_1 96 103 PF00069 0.492
MOD_N-GLC_1 37 42 PF02516 0.769
MOD_N-GLC_1 493 498 PF02516 0.501
MOD_N-GLC_1 643 648 PF02516 0.735
MOD_N-GLC_1 950 955 PF02516 0.643
MOD_NEK2_1 159 164 PF00069 0.518
MOD_NEK2_1 205 210 PF00069 0.590
MOD_NEK2_1 369 374 PF00069 0.501
MOD_NEK2_1 570 575 PF00069 0.443
MOD_NEK2_1 615 620 PF00069 0.647
MOD_NEK2_1 632 637 PF00069 0.590
MOD_NEK2_1 684 689 PF00069 0.460
MOD_NEK2_1 859 864 PF00069 0.575
MOD_NEK2_1 930 935 PF00069 0.726
MOD_NEK2_1 949 954 PF00069 0.684
MOD_NEK2_2 697 702 PF00069 0.516
MOD_NMyristoyl 1 7 PF02799 0.661
MOD_OFUCOSY 93 100 PF10250 0.490
MOD_PIKK_1 493 499 PF00454 0.408
MOD_PIKK_1 519 525 PF00454 0.462
MOD_PIKK_1 607 613 PF00454 0.756
MOD_PIKK_1 763 769 PF00454 0.596
MOD_PIKK_1 850 856 PF00454 0.549
MOD_PIKK_1 886 892 PF00454 0.551
MOD_PK_1 263 269 PF00069 0.598
MOD_PK_1 474 480 PF00069 0.471
MOD_PKA_2 144 150 PF00069 0.568
MOD_PKA_2 19 25 PF00069 0.754
MOD_PKA_2 32 38 PF00069 0.803
MOD_PKA_2 339 345 PF00069 0.628
MOD_PKA_2 519 525 PF00069 0.393
MOD_PKA_2 627 633 PF00069 0.698
MOD_PKA_2 655 661 PF00069 0.594
MOD_PKA_2 748 754 PF00069 0.550
MOD_PKA_2 859 865 PF00069 0.638
MOD_PKA_2 923 929 PF00069 0.684
MOD_PKA_2 949 955 PF00069 0.715
MOD_PKB_1 472 480 PF00069 0.518
MOD_Plk_1 205 211 PF00069 0.594
MOD_Plk_1 225 231 PF00069 0.442
MOD_Plk_1 479 485 PF00069 0.426
MOD_Plk_1 532 538 PF00069 0.441
MOD_Plk_1 607 613 PF00069 0.727
MOD_Plk_1 66 72 PF00069 0.663
MOD_Plk_1 722 728 PF00069 0.515
MOD_Plk_1 908 914 PF00069 0.582
MOD_Plk_1 950 956 PF00069 0.645
MOD_Plk_1 96 102 PF00069 0.498
MOD_Plk_2-3 908 914 PF00069 0.597
MOD_Plk_4 168 174 PF00069 0.615
MOD_Plk_4 225 231 PF00069 0.515
MOD_Plk_4 454 460 PF00069 0.380
MOD_Plk_4 565 571 PF00069 0.419
MOD_Plk_4 584 590 PF00069 0.430
MOD_Plk_4 688 694 PF00069 0.469
MOD_Plk_4 782 788 PF00069 0.453
MOD_Plk_4 854 860 PF00069 0.565
MOD_Plk_4 87 93 PF00069 0.555
MOD_ProDKin_1 331 337 PF00069 0.519
MOD_SPalmitoyl_4 1 7 PF01529 0.718
MOD_SUMO_for_1 203 206 PF00179 0.532
MOD_SUMO_for_1 239 242 PF00179 0.492
TRG_DiLeu_BaLyEn_6 441 446 PF01217 0.408
TRG_DiLeu_BaLyEn_6 673 678 PF01217 0.509
TRG_ENDOCYTIC_2 234 237 PF00928 0.582
TRG_ENDOCYTIC_2 281 284 PF00928 0.592
TRG_ENDOCYTIC_2 380 383 PF00928 0.370
TRG_ENDOCYTIC_2 411 414 PF00928 0.401
TRG_ENDOCYTIC_2 582 585 PF00928 0.501
TRG_ENDOCYTIC_2 600 603 PF00928 0.410
TRG_ENDOCYTIC_2 729 732 PF00928 0.420
TRG_ENDOCYTIC_2 780 783 PF00928 0.449
TRG_ER_diArg_1 190 192 PF00400 0.678
TRG_ER_diArg_1 471 474 PF00400 0.393
TRG_ER_diArg_1 673 676 PF00400 0.532
TRG_NES_CRM1_1 227 242 PF08389 0.538
TRG_NES_CRM1_1 357 371 PF08389 0.393
TRG_NES_CRM1_1 908 923 PF08389 0.457
TRG_NLS_MonoExtN_4 261 266 PF00514 0.629
TRG_Pf-PMV_PEXEL_1 664 668 PF00026 0.476
TRG_Pf-PMV_PEXEL_1 755 759 PF00026 0.585

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IGT4 Leptomonas seymouri 81% 99%
A0A0S4JAH8 Bodo saltans 30% 76%
A0A0S4JE35 Bodo saltans 57% 100%
A0A1X0NNZ8 Trypanosomatidae 62% 100%
A0A3Q8I989 Leishmania donovani 100% 100%
A0A422MRT7 Trypanosoma rangeli 59% 100%
A4H6X9 Leishmania braziliensis 90% 100%
C9ZHY0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
C9ZUN2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 67%
E9ANZ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QGM7 Leishmania major 97% 99%
V5BP95 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS