Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

primase 2 - putative

Species:

Leishmania infantum

UniProt:

E9AGF1_LEIIN

TriTrypDb:

LINF_120011600

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGF1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0003896	DNA primase activity	7	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034062	5'-3' RNA polymerase activity	5	1
GO:0097747	RNA polymerase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.430
CLV_MEL_PAP_1	477	483	PF00089	0.343
CLV_NRD_NRD_1	197	199	PF00675	0.438
CLV_NRD_NRD_1	218	220	PF00675	0.456
CLV_NRD_NRD_1	328	330	PF00675	0.416
CLV_NRD_NRD_1	382	384	PF00675	0.503
CLV_NRD_NRD_1	455	457	PF00675	0.444
CLV_NRD_NRD_1	514	516	PF00675	0.343
CLV_NRD_NRD_1	531	533	PF00675	0.258
CLV_PCSK_KEX2_1	197	199	PF00082	0.436
CLV_PCSK_KEX2_1	330	332	PF00082	0.360
CLV_PCSK_KEX2_1	455	457	PF00082	0.444
CLV_PCSK_KEX2_1	51	53	PF00082	0.480
CLV_PCSK_KEX2_1	531	533	PF00082	0.446
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.405
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.345
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.480
CLV_PCSK_SKI1_1	131	135	PF00082	0.363
CLV_PCSK_SKI1_1	174	178	PF00082	0.443
CLV_PCSK_SKI1_1	202	206	PF00082	0.400
CLV_PCSK_SKI1_1	272	276	PF00082	0.368
CLV_PCSK_SKI1_1	302	306	PF00082	0.368
CLV_PCSK_SKI1_1	355	359	PF00082	0.580
CLV_PCSK_SKI1_1	377	381	PF00082	0.635
CLV_PCSK_SKI1_1	384	388	PF00082	0.517
CLV_PCSK_SKI1_1	455	459	PF00082	0.459
CLV_PCSK_SKI1_1	91	95	PF00082	0.443
DEG_APCC_DBOX_1	328	336	PF00400	0.443
DEG_Nend_Nbox_1	1	3	PF02207	0.405
DOC_CYCLIN_RxL_1	128	135	PF00134	0.480
DOC_CYCLIN_RxL_1	88	97	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.480
DOC_MAPK_DCC_7	59	68	PF00069	0.428
DOC_MAPK_gen_1	329	335	PF00069	0.401
DOC_MAPK_gen_1	515	521	PF00069	0.443
DOC_MAPK_MEF2A_6	59	68	PF00069	0.404
DOC_MAPK_RevD_3	501	517	PF00069	0.443
DOC_PP1_RVXF_1	262	269	PF00149	0.343
DOC_PP1_RVXF_1	89	96	PF00149	0.368
DOC_PP4_FxxP_1	149	152	PF00568	0.343
DOC_USP7_MATH_1	122	126	PF00917	0.443
DOC_USP7_MATH_1	160	164	PF00917	0.456
DOC_USP7_MATH_1	183	187	PF00917	0.416
DOC_USP7_MATH_1	188	192	PF00917	0.405
DOC_USP7_MATH_1	208	212	PF00917	0.491
DOC_USP7_MATH_1	391	395	PF00917	0.674
DOC_USP7_MATH_1	397	401	PF00917	0.618
DOC_USP7_MATH_1	471	475	PF00917	0.428
DOC_USP7_UBL2_3	195	199	PF12436	0.411
DOC_USP7_UBL2_3	380	384	PF12436	0.596
DOC_USP7_UBL2_3	504	508	PF12436	0.343
DOC_WW_Pin1_4	209	214	PF00397	0.286
DOC_WW_Pin1_4	259	264	PF00397	0.455
DOC_WW_Pin1_4	502	507	PF00397	0.443
DOC_WW_Pin1_4	58	63	PF00397	0.446
DOC_WW_Pin1_4	74	79	PF00397	0.287
LIG_14-3-3_CanoR_1	174	183	PF00244	0.428
LIG_14-3-3_CanoR_1	198	204	PF00244	0.397
LIG_14-3-3_CanoR_1	302	310	PF00244	0.337
LIG_14-3-3_CanoR_1	346	354	PF00244	0.576
LIG_14-3-3_CanoR_1	355	360	PF00244	0.573
LIG_14-3-3_CanoR_1	500	504	PF00244	0.337
LIG_Actin_WH2_2	46	61	PF00022	0.405
LIG_Actin_WH2_2	492	510	PF00022	0.480
LIG_AP2alpha_1	149	153	PF02296	0.443
LIG_AP2alpha_2	151	153	PF02296	0.443
LIG_APCC_ABBA_1	92	97	PF00400	0.443
LIG_APCC_ABBAyCdc20_2	91	97	PF00400	0.443
LIG_BIR_III_4	246	250	PF00653	0.305
LIG_BIR_III_4	438	442	PF00653	0.545
LIG_BRCT_BRCA1_1	8	12	PF00533	0.343
LIG_deltaCOP1_diTrp_1	496	501	PF00928	0.343
LIG_eIF4E_1	271	277	PF01652	0.368
LIG_FHA_1	156	162	PF00498	0.346
LIG_FHA_1	260	266	PF00498	0.423
LIG_FHA_1	348	354	PF00498	0.589
LIG_FHA_1	367	373	PF00498	0.302
LIG_FHA_1	385	391	PF00498	0.340
LIG_FHA_1	430	436	PF00498	0.607
LIG_FHA_1	459	465	PF00498	0.541
LIG_FHA_2	335	341	PF00498	0.438
LIG_FHA_2	354	360	PF00498	0.309
LIG_HCF-1_HBM_1	314	317	PF13415	0.430
LIG_LIR_Gen_1	114	122	PF02991	0.343
LIG_LIR_Gen_1	151	162	PF02991	0.480
LIG_LIR_Gen_1	175	184	PF02991	0.480
LIG_LIR_Gen_1	232	242	PF02991	0.446
LIG_LIR_Gen_1	476	485	PF02991	0.336
LIG_LIR_Gen_1	496	506	PF02991	0.155
LIG_LIR_Gen_1	9	19	PF02991	0.343
LIG_LIR_Nem_3	114	119	PF02991	0.343
LIG_LIR_Nem_3	150	156	PF02991	0.477
LIG_LIR_Nem_3	232	238	PF02991	0.446
LIG_LIR_Nem_3	270	274	PF02991	0.328
LIG_LIR_Nem_3	436	440	PF02991	0.522
LIG_LIR_Nem_3	476	481	PF02991	0.324
LIG_LIR_Nem_3	496	501	PF02991	0.155
LIG_LIR_Nem_3	539	545	PF02991	0.481
LIG_LIR_Nem_3	83	87	PF02991	0.443
LIG_LIR_Nem_3	9	15	PF02991	0.343
LIG_LYPXL_yS_3	84	87	PF13949	0.443
LIG_Pex14_1	530	534	PF04695	0.434
LIG_Pex14_2	149	153	PF04695	0.443
LIG_RPA_C_Fungi	378	390	PF08784	0.500
LIG_SH2_CRK	271	275	PF00017	0.368
LIG_SH2_CRK	440	444	PF00017	0.609
LIG_SH2_GRB2like	536	539	PF00017	0.441
LIG_SH2_NCK_1	116	120	PF00017	0.462
LIG_SH2_SRC	116	119	PF00017	0.462
LIG_SH2_SRC	139	142	PF00017	0.343
LIG_SH2_SRC	536	539	PF00017	0.497
LIG_SH2_STAP1	475	479	PF00017	0.339
LIG_SH2_STAP1	509	513	PF00017	0.438
LIG_SH2_STAT3	317	320	PF00017	0.465
LIG_SH2_STAT5	139	142	PF00017	0.343
LIG_SH2_STAT5	536	539	PF00017	0.441
LIG_SH2_STAT5	57	60	PF00017	0.443
LIG_SH2_STAT5	98	101	PF00017	0.355
LIG_SH3_3	139	145	PF00018	0.433
LIG_SH3_3	210	216	PF00018	0.305
LIG_SH3_3	440	446	PF00018	0.589
LIG_Sin3_3	153	160	PF02671	0.443
LIG_SUMO_SIM_par_1	361	366	PF11976	0.585
LIG_SxIP_EBH_1	55	69	PF03271	0.451
LIG_TRAF2_1	3	6	PF00917	0.443
LIG_TYR_ITIM	137	142	PF00017	0.343
LIG_WW_3	467	471	PF00397	0.368
MOD_CDC14_SPxK_1	505	508	PF00782	0.443
MOD_CDK_SPK_2	259	264	PF00069	0.427
MOD_CDK_SPxK_1	502	508	PF00069	0.443
MOD_CK1_1	252	258	PF00069	0.480
MOD_CK1_1	259	265	PF00069	0.366
MOD_CK1_1	502	508	PF00069	0.363
MOD_CK2_1	183	189	PF00069	0.405
MOD_CK2_1	355	361	PF00069	0.438
MOD_GlcNHglycan	124	127	PF01048	0.362
MOD_GlcNHglycan	199	202	PF01048	0.369
MOD_GlcNHglycan	242	245	PF01048	0.459
MOD_GlcNHglycan	258	261	PF01048	0.382
MOD_GlcNHglycan	305	308	PF01048	0.431
MOD_GlcNHglycan	310	313	PF01048	0.443
MOD_GlcNHglycan	399	402	PF01048	0.651
MOD_GSK3_1	236	243	PF00069	0.494
MOD_GSK3_1	252	259	PF00069	0.328
MOD_GSK3_1	345	352	PF00069	0.604
MOD_GSK3_1	47	54	PF00069	0.378
MOD_GSK3_1	6	13	PF00069	0.332
MOD_LATS_1	172	178	PF00433	0.443
MOD_N-GLC_1	281	286	PF02516	0.343
MOD_N-GLC_1	486	491	PF02516	0.343
MOD_N-GLC_1	537	542	PF02516	0.416
MOD_NEK2_1	155	160	PF00069	0.424
MOD_NEK2_1	347	352	PF00069	0.531
MOD_NEK2_1	363	368	PF00069	0.445
MOD_NEK2_1	410	415	PF00069	0.576
MOD_NEK2_1	537	542	PF00069	0.428
MOD_NEK2_2	64	69	PF00069	0.443
MOD_PIKK_1	429	435	PF00454	0.638
MOD_PKA_1	197	203	PF00069	0.428
MOD_PKA_1	51	57	PF00069	0.430
MOD_PKA_1	7	13	PF00069	0.443
MOD_PKA_2	197	203	PF00069	0.414
MOD_PKA_2	345	351	PF00069	0.556
MOD_PKA_2	499	505	PF00069	0.345
MOD_PKA_2	51	57	PF00069	0.430
MOD_Plk_1	281	287	PF00069	0.343
MOD_Plk_1	363	369	PF00069	0.516
MOD_Plk_1	537	543	PF00069	0.439
MOD_Plk_4	349	355	PF00069	0.628
MOD_Plk_4	363	369	PF00069	0.359
MOD_Plk_4	385	391	PF00069	0.632
MOD_Plk_4	537	543	PF00069	0.439
MOD_Plk_4	64	70	PF00069	0.433
MOD_ProDKin_1	209	215	PF00069	0.286
MOD_ProDKin_1	259	265	PF00069	0.455
MOD_ProDKin_1	502	508	PF00069	0.443
MOD_ProDKin_1	58	64	PF00069	0.448
MOD_ProDKin_1	74	80	PF00069	0.291
MOD_SUMO_rev_2	212	221	PF00179	0.245
MOD_SUMO_rev_2	373	379	PF00179	0.607
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.386
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.346
TRG_ENDOCYTIC_2	116	119	PF00928	0.480
TRG_ENDOCYTIC_2	139	142	PF00928	0.343
TRG_ENDOCYTIC_2	235	238	PF00928	0.443
TRG_ENDOCYTIC_2	271	274	PF00928	0.368
TRG_ENDOCYTIC_2	440	443	PF00928	0.620
TRG_ENDOCYTIC_2	84	87	PF00928	0.443
TRG_ER_diArg_1	329	332	PF00400	0.415
TRG_ER_diArg_1	415	418	PF00400	0.599
TRG_ER_diArg_1	421	424	PF00400	0.524
TRG_ER_diArg_1	454	456	PF00400	0.454
TRG_ER_diArg_1	530	532	PF00400	0.450
TRG_NLS_MonoExtN_4	195	201	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T3	Leptomonas seymouri	67%	71%
A0A1X0NMZ0	Trypanosomatidae	48%	71%
A0A3R7JWW2	Trypanosoma rangeli	48%	78%
A0A3S7WS08	Leishmania donovani	100%	100%
A4H6X7	Leishmania braziliensis	81%	100%
E9ANZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QGM9	Leishmania major	93%	100%
V5DG34	Trypanosoma cruzi	46%	91%